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Topic: Ifosfamide

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	Ifex Warnings, Precautions, Pregnancy, Nursing, Abuse - Ifosfamide - RxList Monographs
		If IFEX (ifosfamide for injection) is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
		Because of the potential for serious adverse events and the tumorigenicity shown for ifosfamide in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
		In vivo, ifosfamide has induced mutagenic effects in mice and Drosophila melanogaster germ cells, and has induced a significant increase in dominant lethal mutations in male mice as well as recessive sex-linked lethal mutations in Drosophila.
	www.rxlist.com /cgi/generic/ifosfamide_wcp.htm (678 words)

	Ifosfamide: Encyclopedia of Cancer
		Ifosfamide chemically interferes with the synthesis of the genetic material (DNA and RNA) of cancer cells by cross-linking of DNA strands, which prevents these cells from being able to reproduce and continue the growth of the cancer.
		Ifosfamide can cause serious birth defects if either the man or the woman is taking this drug at the time of conception or if the woman is taking this drug during pregnancy.
		Ifosfamide suppresses the immune system, and its excretion from the body is dependent on a normal functioning kidney and liver.
	health.enotes.com /cancer-encyclopedia/ifosfamide (622 words)

	Ifosfamide : BC Cancer Agency
		Ifosfamide is a structural analogue of cyclophosphamide and its mechanism of action is presumed to be identical.
		Mesna is generally given by IV injection concurrently with ifosfamide (20% of ifosfamide dose) and 4-8 hours after to protect the urinary tract.
		Ifosfamide with mesna uroprotection and etoposide: An effective regimen in the treatment of recurrent sarcomas and other tumors of children and young adults.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Ifosfamide.htm (1924 words)

	Ifosfamide [Ifex]
		Ifosfamide might actually be the agent of choice, given equal effectiveness with Adriamycin, if there is to be radiation to the left chest or mediastinum.
		Ifosfamide is well absorbed from the GI tract, but is only given intravenously because the oral form is highly neurotoxic.
		Ifosfamide is mutagenic [causes mutations], teratogenic [harms the developing fetus], and carcinogenic [causes cancer].
	www.bctonline.com /~dwhiting/lms/chemo55ifos.htm (1581 words)

	Ifex - Drugs & Vitamins - Drug Library - DrugDigest
		Ifosfamide is changed by the liver into a substance that interferes with the growth of rapidly dividing cells, like cancer cells, and eventually causes these cells to die.
		Ifosfamide is used in combination with other chemotherapy agents to treat cancer of the testes and other cancers.
		Ifosfamide may also be given as part of regimen prior to stem cell transplantation.
	www.drugdigest.org /DD/DVH/Uses/0,3915,338\|Ifex,00.html (887 words)

	Ifosfamide Drug Information
		Ifosfamide interferes with the growth of cancer cells, which are eventually destroyed.
		Because ifosfamide may cause serious side effects in the nursing infant, breast-feeding is generally not recommended while you are receiving it.
		Ifosfamide may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
	www.drugs.com /cons/Ifosfamide_Systemic.html (2056 words)

	Ifosfamide (Site not responding. Last check: 2007-09-22)
		Ifosfamide can decrease the number of white blood cells in your body, cells that usually help you fight infections.
		Ifosfamide might change how you think, feel, or act.
		Ifosfamide may cause side effects that do not occur for months or years after you finish chemotherapy, including leukemia.
	www.hci.utah.edu /patientdocs/hci/drugs/ifosfamide.htm (356 words)

	ACS :: Cancer Drug Guide: ifosfamide
		Ifosfamide belongs to a general group of chemotherapy drugs known as alkylating agents.
		Ifosfamide is given as an injection in a vein over a period of time from 1 hour to 24 hours for a few days.
		Ifosfamide can cause serious bleeding in the bladder, so it is ALWAYS given with fluids in the vein and mesna, a drug that protects the bladder.
	www.cancer.org /docroot/CDG/content/CDG_ifosfamide.asp (831 words)

	Ifosfamide [Ifex]
		Ifosfamide might actually be the agent of choice, given equal effectiveness with Adriamycin, if there is to be radiation to the left chest or mediastinum.
		Ifosfamide is well absorbed from the GI tract, but is only given intravenously because the oral form is highly neurotoxic.
		Ifosfamide is mutagenic [causes mutations], teratogenic [harms the developing fetus], and carcinogenic [causes cancer].
	www.leiomyosarcoma.info /chemo55ifos.htm (1581 words)

	IFOSFAMIDE (Site not responding. Last check: 2007-09-22)
		The ratio of the fraction of ifosfamide metabolised to each metabolite to the volume of distribution of that metabolite, and the elimination rate constant, of 2- and 3-dechloroethyl-ifosfamide and 4-hydroxy-ifosfamide were 0.0976 +/- 0.0556, 0.0328 +/- 0.0102 and 0.0230 +/- 0.0083 m2/L and 3.64 +/- 2.04, 0.445 +/- 0.174 and 7.67 +/- 2.87 h(-1), respectively.
		Ifosfamide, a structural analog of cyclophosphamide, belongs to the oxazaphosphorine class of antitumor alkylating agents which must be activated by the mixed function oxidase system of the liver.
		Vapor-phase ifosfamide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 hrs(SRC), calculated from its rate constant of 4.3X10-11 cu cm/molecule-sec at 25 deg C(SRC) that was derived using a structure estimation method(3).
	www.frankmckinnon.com /ifosfamide.htm (10066 words)

	Ifosphamide
		Ifosfamide is one of the newer chemotherapy drugs which has been around and in use for many years.
		Ifosfamide is a white powder which, when prepared for use becomes a clear, colorless liquid.
		Ifosfamide is normally given over three to four days, every three to four weeks.
	www.tirgan.com /ifosph.htm (153 words)

	NDI Article: 16 (Site not responding. Last check: 2007-09-22)
		Therefore, we studied a cohort of children treated with ifosfamide for the frequency, nature, and severity of chronic nephrotoxicity and for the relevance of patient-related and treatment-related risk factors.
		Before ifosfamide treatment, all children had normal serum creatinine and phosphate concentrations and alkaline phosphatase activity, and urinalysis; none had radiological evidence of renal involvement by tumour.
		Ifosfamide was discontinued early due to nephrotoxicity in two patients (one with nephrogenic diabetes insipidus, one with acute renal failure); one of these received no further treatment, the other continued cyclophosphamide-based chemotherapy.
	www.ndif.org /Article/jar-16.html (1853 words)

	Ifosfamide
		Ifosfamide (Ifex™ or Mitoxana™) directly interacts with DNA in order to build covalent links through its alkyl radicals.
		The action of Ifosfamide is dependent of the cell-cycle and there is no action on cells in G0.
		Ifosfamide is toxic by itself on the urinary bladder.
	www.oncoprof.net /Generale2000/g09_Chimiotherapie/Complements/g09-gb_comp16.html (355 words)

	Rx Product Guide - Ifosfamide
		Ifosfamide requires metabolic activation by microsomal liver enzymes to produce biologically active metabolites.
		Ifosfamide may increase the hypoprothrombinemic effect of warfarin.
		Use ifosfamide with a protector, such as mesna, to prevent hemorrhagic cystitis.
	www.factsandcomparisons.com /atoz/viewmonograph.asp?fid=fandc-atoz0435&cs=ncpa (527 words)

	MedlinePlus Drug Information: Ifosfamide
		Ifosfamide is in a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in your body.
		The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.
		Ifosfamide also is used to treat lung cancer, cervical cancer, and ovarian cancer.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a695023.html (531 words)

	Ifosfamide - Family factsheets - GOSH and ICH
		Ifosfamide is a chemotherapy drug used to treat certain types of cancer.
		As ifosfamide is similar, its effect on fertility is currently being studied.
		Fluid retention: Ifosfamide may cause the kidneys to retain water leading to the dilution of the salts in the body.
	www.gosh.nhs.uk /factsheets/families/F000254/index.html (704 words)

	Ifosfamide-induced Nephrotoxicity in Children: Critical Review of Predictive Risk Factors -- Loebstein and Koren 101 ...
		Ifosfamide is widely used in the treatment of pediatric solid tumors.
		Ifosfamide, a structural analogue of cyclophosphamide, is widely used as a first-line agent in the treatment of a variety
		Ifosfamide is metabolized to 4-hydroxyifosfamide, chloroacetaldehyde, and acrolein, all reactive metabolites that have been
	pediatrics.aappublications.org /cgi/content/full/101/6/e8 (1964 words)

	ZIOPHARM Oncology, Inc. \| Clinical Development
		Ifosfamide has been shown to be effective in high doses in treating testicular cancer, sarcoma and lymphoma.
		In the U.S., ifosfamide is regularly included in combination regimens (more than one treatment) for the treatment of sarcomas, testicular cancers, head and neck cancer and some types of lymphomas.
		Ifosfamide doses at this level are rarely given because of substantial bladder and central nervous system (CNS) toxicity, which were not evident in this trial with ZIO-201.
	www.ziopharm.com /clinical_zio201.php (488 words)

	Ifosfamide (Mitoxana®) : Cancerbackup
		Ifosfamide (pronounced i-fos-fa-mide) is a chemotherapy drug that is given as a treatment for many different types of cancer.
		If you have any further questions you can ask your doctor or nurse at the hospital where you are having your treatment, or speak to one of our cancer support service nurses.
		Ifosfamide is a clear fluid after being dissolved from powder with sterile water.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Ifosfamide (1061 words)

	Ifosfamide Extends Life in Uterine Sarcoma - National Cancer Institute
		In a preliminary study, the drug ifosfamide showed promising results in patients with mixed tumors that had either come back or spread beyond the uterus.
		Women treated with ifosfamide plus paclitaxel survived for a median of 13.5 months, compared with 8.4 months for those treated with ifosfamide alone.
		into account, the risk of death for patients who received ifosfamide plus paclitaxel was 31 percent lower than for those who received ifosfamide alone.
	www.nci.nih.gov /clinicaltrials/results/ifosfamide0307 (557 words)

	Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion -- ...
		Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion -- Kuppner et al.
		Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion
		Differential effects of ifosfamide on the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels.
	www.bloodjournal.org /cgi/content/full/102/10/3668 (5037 words)

	Ifosfamide
		Ifosfamide is an intravenous (IV) medication usually given in a dose based on body surface area.
		Ifosfamide interferes with the DNA of cancer cells.
		Ifosfamide should be administered only under the supervision of a medical oncologist or gynecological oncologist.
	www.webmd.com /cancer/Ifosfamide (330 words)

	Medical Dictionary: Ifosfamide - WrongDiagnosis.com
		Ifosfamide: An anticancer drug that belongs to the family of drugs called alkylating agents.
		Ifosfamide: A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity.
		Ifosfamide : 2\-oxo\-N,3\-bis\-(2\-chloroethyl) tetrahydro\-2H\-1,3,2\-oxazaphosphorin\- 2\-amine; cyclophosphamide analog with two alkylating groups, used as a DNA strand crosslinker and antineoplastic.
	www.wrongdiagnosis.com /medical/ifosfamide.htm (244 words)

	Ifosfamide - Talk Medical
		Ifosfamide interferes with the growth of cancer cells and slows their growth and spread in the body.
		· Ifosfamide is in the FDA pregnancy category D. This means that Ifosfamide is known to cause birth defects in an unborn baby.
		If you are storing Ifosfamide injection at home, follow the directions provided by your healthcare provider.
	www.talkmedical.com /medications/3151/Ifosfamide (665 words)

	Ifosfamide
		Ifosfamide is one of a group of anti-cancer medicines called 'alkylating agents'.
		Ifosfamide is used in the treatment of a wide variety of cancers including cancer of the lymph nodes (lymphoma) and blood cells (leukaemias).
		Ifosfamide is usually given as a slow infusion in to the veins (intravenously).
	www2.netdoctor.co.uk /medicines/100003424.html (621 words)

	[No title] (Site not responding. Last check: 2007-09-22)
		Ifosfamide, used in combination with certain other approved antineoplastic agents, is indicated for third line chemotherapy of germ cell testicular cancer.
		In addition, we will offer ifosfamide in a powdered form and obviates the need for refrigeration storage as is currently required for the ifosfamide/mesna kits," Soon-Shiong added.
		As with all new APP products, Ifosfamide for Injection, USP will be bar coded at the individual unit-of-use level, in an attempt to increase patient safety by reducing the possibility of medical errors.
	www.appdrugs.com /PressDetailText.cfm?ID=302985 (505 words)

	CancerQuest : Cancer Treatments : Chemotherapy
		Ifosfamide (Ifex) is an alkylating agent used mainly to treat germ cell testicular cancer.
		A very serious problem that may result with treatment is hemorrhagic cystitis, which is prevented by administering ifosfamide in combination with a compound called Mesna (Uromitexan, Mesnex), which inactivates the toxic compounds, minimizing the problem.
		Patients considering ifosfamide as cancer therapy should talk to their doctor about the drug's effects on fertility, potential or current pregnancy, breast-feeding, chickenpox status, shingles status, kidney disease, liver disease, and all other medications currently taken.
	www.cancerquest.org /index.cfm?page=489 (115 words)

	Ifosfamide (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-09-22)
		Although there is no specific information comparing use of ifosfamide in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		If you are receiving ifosfamide at home, follow your doctor's orders or the directions on the label.
		While you are being treated with ifosfamide, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval.
	www.mayoclinic.com /health/drug-information/DR202293 (1813 words)

	My Non Hodgkin’s Lymphoma (Cancer) experience
		Ifosfamide is chemotherapy that is given as a treatment for many different types of cancer.
		Ifosfamide may be given:as an infusion (drip) into the vein through a cannula, central line, which is inserted under the skin into a vein near the collarbone or into a PICC line which is inserted into a vein in the crook of the arm
		Your liver may be temporarily affected Ifosfamide may cause changes in the way that your liver works, which will return to normal when the treatment is finished.
	www.lawrencewray.co.uk /ifosfamide (929 words)

	Ifex Online, Description, Chemistry, Ingredients, Blackbox - Ifosfamide - RxList Monographs
		IFEX® (ifosfamide for injection) single-dose vials for constitution and administration by intravenous infusion each contain 1 gram or 3 grams of sterile ifosfamide.
		Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide.
		Ifosfamide is a white crystalline powder that is soluble in water.
	www.rxlist.com /cgi/generic/ifosfamide.htm (156 words)

	Ifosfamide (Site not responding. Last check: 2007-09-22)
		Another medicine, called mesna, may be given at the same time to prevent ifosfamide from causing bladder problems.
		Ifosfamide can decrease the number of white blood cells in your body, cells that usually help you fight infections.
		Ifosfamide may cause side effects that do not occur for months or years after you finish chemotherapy, including leukemia.
	www.huntsmancancer.org /patientdocs/hci/drugs/ifosfamide.htm (356 words)

	Ifosfamide - Wikipedia, the free encyclopedia
		Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid.
		The delivery is intravenous, and is given as a treatment for a variety of cancers, including:
		Ifosfamide is often used in conjunction with mesna to avoid internal bleeding in the patient.
	en.wikipedia.org /wiki/Ifosfamide (118 words)

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