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Topic: IgA nephritis

Related Topics

IgA nephropathy

Oliguria

Hematuria

Coeliac disease

Hyperkalaemia

Impetigo

Group A streptococcal infection

Prednisolone

Liver failure

Proteinuria

Autoimmune disease

Aplastic anemia

Renal function

Myasthenia gravis

Hematemesis

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	What IgAN is (a summary)
		IgA nephropathy (or Berger's Disease, IgA nephritis) is an immune complex disorder (or immune-system mediated disease) which causes IgA immune complexes to be deposited and trapped in the glomeruli (the filters in the kidneys), where they cause inflammation (called glomerulonephritis), proliferation of cells in the mesangial matrix, and eventual scarring of the glomeruli (called glomerulosclerosis).
		IgA nephropathy is probably most accurately described as a circulating immune complex glomerulonephritis in which there is glomerular trapping of predominantly IgA immune complexes.
		Why it is more aggressive in some than others is simply not known, although it is safe to say that, as far as is known, it has nothing to do with what the person eats or doesn't eat, or with anything a person does or doesn't do.
	www.igan.ca /id45.htm (1165 words)

	NationMaster - Encyclopedia: Nephropathy
		This form of nephropathy is "chronic analgesic nephritis," a chronic inflammatory change characterized by loss and atrophy of tubules and interstitial fibrosis and inflammation (BRS Pathology, 2nd edition).
		In kidney, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the wall of small arteries and arterioles, producing the thickening of their walls and the narrowing of the lumens - hyaline arteriolosclerosis.
		IgA nephropathy (also known as IgA nephritis, IgAN, Bergers disease and synpharyngitic glomerulonephritis) is a form of glomerulonephritis (inflammation of the glomeruli of the kidney).
	www.nationmaster.com /encyclopedia/Nephropathy (491 words)

	eMedicine - Nephritis : Article by Sahar Fathallah-Shaykh, MD
		Background: Nephritis is an older term used to clinically denote a child with hypertension, decreased renal function, hematuria, and edema.
		In general, nephritis (nonsuppurative) is produced by the trapping of antigen-antibody complexes (or some other unknown mechanism) in the renal parenchyma.
		Outpatient care may be as simple as observation in a child with tubulointerstitial nephritis or resolving poststreptococcal GN, or it may involve antihypertensives, diuretics, and diet modification as in a child with IgA nephropathy or membranoproliferative GN and preserved renal function.
	www.emedicine.com /PED/topic1561.htm (2876 words)

	Nephritis: Free Encyclopedia Articles at Questia.com Online Library
		by Michal Abrahamowicz, Todd...prognostic factors for mortality in lupus nephritis, a rare rheumatologic disease that affects...untreated disease and survival in lupus nephritis and analyze a well-known primary biliary...
		...significant increase in mortality for nephritis and nephrosis in the 1985 follow-up study...association between respirable fibers and nephritis or nephrosis in a case-control study...Bender JR, Chiazze M. Mortality from nephritis and nephrosis in the fibreglass manufacturing...
		...lumped together under the generic term nephritis, meaning inflammation of the kidney...prospects for preventing the various forms of nephritis, whose causes are even less well understood...have a bearing on the risk of developing nephritis.
	www.questia.com /library/encyclopedia/101260921 (1475 words)

	Renal Pathology Learning - F. Ferrario - Henoch-Schönlein nephritis
		The variable pattern of organ involvement and the wide range of severity of the clinical and pathologic manifestations are considered to be consequences of variations in individual responses to differing loads of IgA-rich immune complexes.
		HSP nephritis is characterized, as in idiopathic IgAN, by mesangial damage with different degrees of hypercellularity with changes ranging from focal-segmental endocapillary proliferation to crescent formation.
		Long-term prognosis of Henoch-Schönlein nephritis in adults and in children.
	www.ndt-educational.org /ferrario3.asp (766 words)

	NEJM -- Evidence for the superiority of immunosuppressive drugs and prednisone over prednisone alone in lupus ...
		In an effort to clarify the role of immunosuppressive drugs in the management of lupus nephritis, we pooled data from all published clinical trials in which patients had been randomly assigned to receive either prednisone alone or prednisone plus cyclophosphamide or azathioprine.
		A power analysis showed that a study of 100 high-risk patients (development of renal insufficiency in 50 per cent) would be needed to prove that an immunosuppressive agent is 50 per cent superior to steroids alone in preventing renal deterioration.
		Predictors of poor renal outcome in patients with lupus nephritis treated with combined pulses of cyclophosphamide and methylprednisolone.
	content.nejm.org /cgi/content/abstract/311/24/1528 (768 words)

	Glomerulonephritis (Nephritic Syndrome): Kidney Filtering Disorders: Merck Manual Home Edition
		One is immunoglobulin A (IgA) nephropathy, a type of nephritis caused by deposition of immune complexes (combinations of antibodies and antigens) in the kidney that can be very mild and nonprogressive or become a severe disease leading to kidney failure.
		Hereditary nephritis (Alport's syndrome) is a genetic disorder in which kidney function is poor, blood is present in the urine, and deafness and eye abnormalities sometimes occur.
		Hereditary nephritis is usually caused by a defective gene on the X chromosome, but it sometimes results from an abnormal gene on a nonsex (autosomal) chromosome.
	www.merck.com /mmhe/print/sec11/ch144/ch144b.html (2520 words)

	Deutsches Ärzteblatt: Artikel Druckversion
		Die SK wird in den Epithelzellen gebildet und dient dem transzellulären Transport des IgA.
		Das sekretorische IgA-Globulin liegt als polymeres IgA vor und besteht meist aus IgA2- und IgA1-Molekülen.
		Das Serum-IgA (rechts) wird dagegen in den Plasmazellen des Knochenmarks vorwiegend als monomeres IgA (mIgA) synthetisiert, entweder katabolisiert oder nach Bindung an Asialoglykoprotein-Rezeptoren (ASGP-R) in der Leber über die Gallengänge ausgeschieden.
	www.aerzteblatt.de /v4/archiv/artikeldruck.asp?id=24615 (1985 words)

	The Foundation for IgA Nephropathy
		It is a very active, friendly and positive group, and we invite everyone with an interest in IgA nephropathy and chronic renal failure to participate.
		A peer support group is one in which the participants and the moderators are also patients, as opposed to health professionals.
		It is impossible to provide useful support without at least some discussion of medical issues, potential treatments, etc. The Foundation for IgA Nephropathy does not under any circumstances advise making medical decisions about treatment without consulting with your own doctors (this includes medications, diet, exercise, supplements, and all aspects of having kidney disease).
	www.igan.ca (481 words)

	History - Berger's disease before Berger
		Thus, ideas about nephritis were dominated from 1840 onwards by the combination of clinical observation and the macroscopic and microscopic observation of renal tissue obtained after the death of the patient.
		To place IgA nephropathy (Berger’s disease) in context we must go back and trace the evolution of three layers of description in nephritis, which overlap as shown in the Venn diagram: the clinical syndrome of recurrent haematuria, the histological appearance of focal/mesangial nephritis, and the immunohistochemical appearance of predominant IgA deposition.
		IgA was found by Berger also in patients with lupus nephritis, an observation made previously in the US by Koffler and others in 1969.
	www.igan-world.org /bergercameron.htm (2618 words)

	The Frequency of IgA Nephropathy at a Single Center in Pakistan (Site not responding. Last check: )
		IgA nephropathy is recognized as the most prevalent form of primary glomerulonephritis worldwide and a major cause of end-stage kidney disease and chronic renal insufficiency.
		It is well known that the incidence and prevalence of IgA nephropathy largely depends on the policy used in performing the renal biopsy in patients with persistent microscopic hematuria and in subjects with recurrent gross hematuria with normal renal function.
		In two earlier studies the frequency of IgA nephropathy was reported to be 4% and 10% in the UK.25,26 In a more recent study, the authors noted that the disease was detected in 7.1% of biopsies during 1972 to 1986 whereas the frequency for 1979 to end-1986 was 21.1%.
	jpma.org.pk /JPMA/7july03/fulltext10.htm (2080 words)

	IgA nephritis -- Facts, Info, and Encyclopedia article (Site not responding. Last check: )
		IgA is the (Any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response) antibody which accumulates in the kidney and probably plays a central role in the disease.
		The classic presentation (in 40-50% of the cases) is frank (The presence of blood in the urine; often a symptom of urinary tract disease) hematuria which starts one or more days after an (Click link for more info and facts about upper respiratory tract infection) upper respiratory tract infection (sore throat).
		Exogenous (Any substance (as a toxin or enzyme) that stimulates the production of antibodies) antigens for IgA have not been identified in the kidney, but it is possible that this antigen has been cleared before the disease manifests itself.
	www.absoluteastronomy.com /encyclopedia/i/ig/iga_nephritis1.htm (1058 words)

	aarogya.com "The Wellness Site" - Conditions & Concerns - Specialties - Nephrology (Site not responding. Last check: )
		IGA nephropathy is a condition which is caused by deposition of immunoglobin(IGA) in the glomerulus The condition was first described long back in 1968 by Berger and Hinglais.
		Systemic lupus erythematosus or SLE is an auto immune disease and it is characterized by abnormalities by immune system and the organ which is targeted are the skin, joints, nervous system, the kidneys, and the blood.
		The condition is called lupus nephritis when the kidney is affected by the disease.
	user1014172.wx19.registeredsite.com /Conditions/Specialties/nephrology/faqlupus.asp (475 words)

	IgA Nephropathy
		...Glomerular Diseases IgA nephropathy is a kidney disorder...glomeruli.
		IgA nephropathy or Berger's disease is a clinical/pathological entity defined by the presence of macroscopic or microscopic hematuria and mesangial IgA deposits.
		The IgA is deposited mainly in mesangium, which then increases mesangial cellularity as shown at the arrow.
	www.health-nexus.com /iga_nephropathy.htm (286 words)

	IGAN
		IgA nephropathy or Berger's disease is a worldwide primary glomerulonephritis characterized by recurrent episodes of macroscopic hematuria which usually occur in concomitance with mucosal infections of upper respiratory tract or other infections, or asymptomatic microscopic hematuria with or without proteinuria (1).
		It is characterized by mesangial deposits of IgA in glomeruli and a wide range of lesions (from minimal change lesions to glomerular extracapillary lesions and interstitial lesions) in the renal biopsy.
		The incidence of the IgA nephropathy ranges from 8.4 patients/pmp in Italy to 26 patients/pmp in France (3,4).
	www.igan.net /iga.html (756 words)

	Nephritis -- Recommendations and Resources (Site not responding. Last check: )
		Nephritis has the effect of damaging and closing up the microscopic filters in the kidney.
		Therefore the characteristic symptom of nephritis is proteinuria — meaning the excessive removal of protein from the blood and its excretion in urine.
		Sufferers of lupus nephritis may, or may not have symptoms of kidney disease, but it can manifest itself through weight gain, high blood pressure, dark urine, or swelling around the eyes, legs, ankles, or fingers.
	www.becomingapediatrician.com /health/103/nephritis.html (829 words)

	Nephritis
		Nephritis is a potentially dangerous condition that results in inflammation of the kidneys.
		Nephritis can cause kidney failure, which affects ability of the kidneys to adequately filter blood and regulate the normal balance of fluids.
		Nephritis is caused by an infection somewhere in the body.
	www.herbalremedies.com /herbal-remedies-usa/nephritis.html (1360 words)

	Specialty Laboratories ::: we help doctors help patients
		The eluted IgA from renal biopsies of primary IgAN patients is anionic and multimeric and forms circulating or in situ IgA complexes.
		The ability of polymeric IgA to directly bind to Fn in a normal binding process is involved in the formation of circulating IgA-Fn complexes; this binding is not observed with IgG or IgM.
		The chronic nephritis rats were treated with injections of Fn; Fn reduces the proteinuria and histologic lesions due to improved clearance of immune complexes, decreased glomerular deposition, and perhaps, to better renal processing of immune complexes.
	www.specialtylabs.com /books/print_view.asp?id=65 (1155 words)

	nephritis
		This suggests that the measurement of serum IgA and C3 may predict the diagnosis of patients with IgA nephropathy prior to renal biopsy.
		METHODS: Sixteen patients with IgA nephropathy and a vasculitic/crescentic glomerulonephritis diagnosed by renal histology were treated with a reducing course of prednisolone (initial dose 60 mg/day).
		The causes for the apparently worse prognosis and poorer responses to treatment of lupus nephritis in Black patients are currently unexplained and require further study.
	www.ais.up.ac.za /med/nephritis.htm (7986 words)

	IgA Nephropathy
		IgA Nephropathy is a kidney disorder occuring during childhood and young adulthood.
		The first recognizable symptom of IgA Nephropathy is bloody urine (hematuria) caused by inflammation of the kidney (acute nephritis or glomerulonephritis).
		SLE Nephritis is a kidney disease associated with Lupus.
	hw.healthdialog.com /kbase/nord/nord587.htm (1136 words)

	Building the case for biopsy in IgA nephropathy - College of American Pathologists (Site not responding. Last check: )
		A typical presentation of IgA nephropathy is the discovery in a younger person of abnormal urinary sediment—red blood cells, usually dysmorphic, and sometimes casts—on routine examination.
		IgA nephropathy also may present with recurrent episodes of hematuria, either gross or microscopic, sometimes in conjunction with upper respiratory or gastrointestinal infections.
		"IgA nephropathy can be mild or severe," he says, "and that correlates greatly with histology." IgA nephropathy historically has been regarded as a relatively benign disease, with Japanese and European studies from the 1980s quoting 10-year renal survival rates of 80 to 90 percent.
	www.cap.org /apps/docs/cap_today/feature_stories/feat2_1101.html (2642 words)

	Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schonlein ...
		Henoch-Schönlein purpura nephritis is a common cause of chronic glomerulonephritis in children.
		nephritis, the incidence of moderate to heavy proteinuria in the
		In this study, a fifth of the patients with Henoch-Schönlein purpura nephritis had the DD genotype of the ACE gene.
	adc.bmjjournals.com /cgi/content/full/79/5/394 (3493 words)

	JN - Vol 12 no 2-1999, pp 66-75 (Site not responding. Last check: )
		More important to individual prognosis is the extent to which that IgA deposition (with or without IgG and C3) leads on to glomerular inflammation and injury and the extent to which that injury resolves or goes on to glomerular, and subsequently tubulointerstitial, scarring.
		While mesangial IgA deposition may be the initiating and specific event for IgAN, it seems probable that the ensuing glomerular inflammation and the subsequent processes of injury and resolution are generic, and will be seen in mesangial proliferative glomerulonephritis whether or not associated with IgA.
		In health the mucosal and systemic IgA systems are separate; there is little or no spillage of mucosally synthesised IgA into the IgA system (2), although there is some trafficking of cells involved in IgA synthesis between the marrow and mucosa and some evidence for a mucosa-marrow communication axis, perhaps cytokine controlled.
	www.sin-italy.org /jnonline/VOL12N2/59.html (4125 words)

	Berger's Disease
		IgA nephropathy also known as Berger's disease, a look at what it is, causes, incidence and risk factors.
		...Psychosocial Nephrology IgA NEPHROPATHY IgA nephropathy or Berger's disease is a clinical/pathological entity defined by the presence...indices.
		A kidney disorder characterized by blood in the urine; caused by inflammation of the internal kidney structures and deposits of IgA antibodies in the kidney mesangial tissue...
	www.health-nexus.com /berger's_disease.htm (312 words)

	MRB: Hypertension and nephritis (Site not responding. Last check: )
		eMedicine - Nephritis : Article by Richard Neiberger, MD, PhD - Nephritis - Nephritis is an older term used to clinically denote a child with hypertension, decreased renal function, hematuria, and edema.
		Nephritis (Acute Interstitial (Allergic) Nephritis, Nephritis - Interstitial, Tubulointerstitial...
		Acute Interstitial Nephritis (AIN) - nephrologychannel - Acute interstitial nephritis (AIN) is rapidly developing inflammation that occurs within the...
	www.medical-research-books.com /mrb-books-reviewed/B00085G97U.html (558 words)

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