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Topic: Imidazole

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	Definition of imidazole - Merriam-Webster Online Dictionary
		Learn more about "imidazole" and related topics at Britannica.com
		Find more about "imidazole" instantly with Live Search
		See a map of "imidazole" in the Visual Thesaurus
	www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=imidazole (40 words)

	1-BUTYLIMIDAZOLE
		Imidazole is a heterocyclic compound of five-membered diunsaturated ring structure composed of three carbon atoms and two nitrogen atoms at nonadjacent positions.
		Imidazole ring is found in histidine (an essential amino acid) and histamine, the decarboxylated compound from histamine.
		Imidazole and its derivatives are widely used as intermediates in synthesis of organic target compounds including pharmaceuticals, agrochemicals, dyes, photographic chemicals, corrosion inhibitors, epoxy curing agents, adhesives and plastic modifiers.
	www.chemicalland21.com /specialtychem/finechem/1-BUTYLIMIDAZOLE.htm (298 words)

	Spartanburg SC \| GoUpstate.com \| Spartanburg Herald-Journal
		Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column.
		Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, which stimulates the central nervous system.
		Salts of imidazole where the imidazole ring is in the cation are known as imidazolium salts (for example, imidazolium chloride).
	www.goupstate.com /apps/pbcs.dll/section?category=NEWS&template=wiki&text=imidazole (1069 words)

	Escherichia coli imidazole glycerol phosphate synthase (Site not responding. Last check: )
		Subunit of imidazole glycerol phosphate synthase: imidazole glycerol phosphate synthase, HisH subunit
		Subunit of imidazole glycerol phosphate synthase: imidazole glycerol phosphate synthase, HisF subunit
		"Imidazole glycerol phosphate synthase: the glutamine amidotransferase in histidine biosynthesis." Biochemistry 1993;32(19);5177-86.
	scocyc.jic.bbsrc.ac.uk:1555 /ECOLI/NEW-IMAGE?type=ENZYME&object=GLUTAMIDOTRANS-CPLX (584 words)

	Get To Know Histidine (Site not responding. Last check: )
		Release of proton from the upper nitrogen of B produces the imidazole tautomer A, and release of proton from the lower nitrogen produces imidazole tautomer C. The tautomers equilibrate by way of the protonated form B. At pH values near 7, all three forms, A, B, and C, are present in equilibrium.
		Because the base form, imidazole, exists as two equilibrating tautomers A and C, it is plausible to write either tautomer in proposing a reaction mechanism involving the imidazole form as a general base.
		Imidazolate ion can be produced in organic solvents by the action of strong irreversible bases, such as hydride ion.
	www.usm.maine.edu /~rhodes/Goodies/Get2NoHistidine.html (561 words)

	InterPro: IPR010139 Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H
		P48262 Imidazole glycerol phosphate synthase subunit hisH (EC 2.4.2.-) (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH) (IGPS subunit hisH)
		Q7SIC0 Imidazole glycerol phosphate synthase subunit hisH (EC 2.4.2.-) (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH) (IGPS subunit hisH)
		Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H
	www.ebi.ac.uk /interpro/IEntry?ac=IPR010139 (3285 words)

	BioPortfolio News : Imidazole in loading buffer improves recovery of herpesvirus vectors
		2006 AUG 30 - (NewsRx.com) -- The presence of imidazole in the loading buffer prevents formation of free radical in immobilized metal affinity chromatography and improves the recovery of herpes simplex virus type 1 gene therapy vectors.
		The results also demonstrated that virus inactivation was dramatically reduced by inclusion of 20 mM imidazole in the loading buffer.
		Journal of Chromatography A (Presence of imidazole in loading buffer prevents formation of free radical in immobilized metal affinity chromatography and dramatically improves the recovery of herpes simplex virus type 1 gene therapy vectors.
	www.bioportfolio.com /august_06/31_08_2006/Imidazole_in_loading_buffer.html (404 words)

	imidazole derivatives
		Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities...
		Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed.
		Metabolite gene regulation: imidazole and imidazole derivatives which circumvent cyclic adenosine 3',5'-monophosphate in induction of the Escherichia coli...
	www.chezmoi.it /search/imidazole-derivatives.htm (243 words)

	The Science Advisory Board
		Is it the imidazole or your protein that is precipitating or is it all of your protein that precipitates?
		Is it the imidazole or your protein that is precipitating...
		it is obvious that the protein precipitates upon concentration and removing the imidazole.
	www.scienceboard.net /forum/post.asp?method=ReplyQuote&REPLY_ID=11133&TOPIC_ID=620&FORUM_ID=40&CAT_ID=10&Forum_Title=Protocol+Reviews&Topic_Title=Problem+with+Imidazole&M= (840 words)

	Replacement of the Axial Histidine Ligand with Imidazole in Cytochrome c Peroxidase. 1. Effects on Structure,
		Replacement of the axial histidine ligand with exogenous imidazole has been accomplished in a number of heme protein mutants, where it often serves to complement the functional properties of the protein.
		The structures show that imidazole can occupy the proximal H175G cavity under a number of experimental conditions, but that the details of the interaction with the protein and the coordination to the heme are markedly dependent on conditions.
		H175G crystallized from both high phosphate and imidazole concentrations exists as a novel, 5-coordinate phosphate bound state, in which the proximal imidazole is dissociated and the distal phosphate is coordinated to the iron.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2001/40/i05/abs/bi002089r.html (496 words)

	Adolf Windaus - Biography
		The production of imidazole derivatives as a result of this reaction induced him to demonstrate the presence of a prototype of the imidazole ring in proteins.
		This in turn led to his demonstration that histidine, a building-stone of proteins, is an imidazole alanine, and to his discovery of histamine (imidazole-ethylalanine), a hormone of great importance in physiology and pharmacology, which was the reason for the interest shown by German chemical industry in his work.
		It was also his interest in the imidazole derivatives that prompted him to examine the structure of the antineuritic vitamin.
	nobelprize.org /nobel_prizes/chemistry/laureates/1928/windaus-bio.html (770 words)

	imidazole pka
		The hypothesis tested in these experiments was that imidazole (pKa= 6.7 at 37 degrees C), a commonly used buffer in physiology and microbiology,...
		This catalytic triad involves the aspartate carboxylate (pka of the acid is 3.9 in solution) removing a proton from the histidine imidazole (pka 6.1 in...
		adjusted the imidazole pH to 7.5, and he revealed that Imidazole has very high buffering capacity at pH 8.0 (a bit strange) as Imidazole pKa is 6.9.
	www.marketline.it /market/imidazole-pka.htm (1090 words)

	Hampton Research (Site not responding. Last check: )
		If one finds that imidazole is an important variable in maintaining sample homogeneity, one can also simply reduce the concentration of imidazole from 1 M to a more reasonable level (0.02 – 0.2 M) for inclusion of crystallization reagents.
		Sometimes the reason Ni column purified proteins precipitate without imidazole is that the Ni ions leak from the Ni column.
		The presence of imidazole may have been chelating this excess and trace Ni and once removed the remaining Ni Ni may cause the protein with a His tag to aggregate in solution.
	www.hamptonresearch.com /support/TipDetail.aspx?tid=70 (318 words)

	Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin -- Helmick et al. 49 ...
		Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin -- Helmick et al.
		Imidazole inhibition of microbial NOD is suggested as
		Imidazoles were investigated for their ability to inhibit NO metabolism by intact cells.
	aac.asm.org /cgi/content/full/49/5/1837 (3988 words)

	imidazole 4 (Site not responding. Last check: )
		Informazioni gratis su imidazole 4, scopri tutto su imidazole 4 doc
		Imidazole 4(5)-carboxylie acid hydrazide (5.9 g: 76.7%) was obtained as...
		imidazole 4(5)-carboxylic acid was soluble in alcohol and acetone and very...
	primi-su-google.nuz.it /notizie/imidazole-4.htm (316 words)

	vinyl imidazole (Site not responding. Last check: )
		Informazioni gratis su vinyl imidazole, scopri tutto su vinyl imidazole
		Crosslinked poly(N-vinyl imidazole) (PVIm) hydrogels in the form of rods have been prepared by 60Co gamma -radiation initiated simultaneous polymerization...
		Vinyl imidazole is used as an intermediate for copolymers, dyeing auxiliaries, antistatics, fuel oil additives, ion exchange resins.
	www.settepercento.it /case/vinyl-imidazole.htm (613 words)

	Science Fair Projects - Imidazole
		Imidazoles exists in two tautomeric forms with a hydrogen atom moving between the two nitrogens.
		Many drugs contain an imidazole ring, see for instance antifungal drugs and nitroimidazole.
		Benzimidazole, an analog with a fused benzene ring.
	www.all-science-fair-projects.com /science_fair_projects_encyclopedia/Imidazole (259 words)

	why get rid of imidazole in his tag protein purification-Protein and Proteomics
		Imidazole is a ring molecule similar to amino acid histidine.
		If there is a catalytic triad in your active site that requires histidine, I do know by experience that imidazole can affect your assays.
		When it is not studied, better to dialyse it out and be sure, that you will have nice antibodies against your protein (and not mostly against imidazole for example).
	www.protocol-online.org /archive/posts/11876.html (272 words)

	Why use imidazole as a buffer?-Molecular Biology
		The original extraction procedure using imidazole was developed elsewhere.
		I would like to change the buffer, but before I do, I would like to know what is special about imidazole as a buffer and why it was likely chosen for this application.
		This may allow the auxin to bind to the column at pH X while the imidazole flows through.
	www.protocol-online.org /archive/posts/319.html (130 words)

	HIV-1 integrase inhibition by pyrrole/imidazole-containing polyamides. (Site not responding. Last check: )
		A second family, the (b) series are 'bifunctional PAs' that contained two linear chains of oligocarboxamides in opposite orientation, each with 3 or 4 pyrrole or imidazole units connected with a flexible spacer.
		The inhibition of integrase activity by the (a) series depended on their sequence and increased with the number of rings, especially imidazole residues.
		Bifunctional compounds were tripyrroles with different spacers, or different combinations of pyrroles and imidazoles keeping the same spacer.
	www.galenicom.com /medline/article/16650070/jo:1397-002X (338 words)

	Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity patent invention (Site not responding. Last check: )
		Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt.
		[0007] This invention relates to novel imidazole compounds, which have pharmaceutical activity such as ADA inhibiting activity, to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
		[0011] Still further object of this invention is to provide a use of the imidazole compound for manufacturing a medicament for treating or preventing various diseases, or a method of treating or preventing various diseases by administering the imidazole compound in an effective amount to elevate adenosine concentration.
	www.freshpatents.com /Imidazole-4-carboxamide-compounds-with-adenosine-deaminase-inhibiting-activity-dt20050721ptan20050159462.php (716 words)

	Synthesis of the Lewis Adduct of Co(II) with Imidazole; Stoichiometry of Reaction
		Synthesis of the Lewis Adduct of Co(II) with Imidazole; Stoichiometry of Reaction
		This reaction is yet another example of a class of reaction that permeates chemistry: the donation of an electron pair by a Lewis base to a Lewis acid to form an adduct in which acid and base are joined by a covalent bond.
		The adduct of Co with imidazole is called a transition metal complex to indicate that it is a complex molecule involving an electron pair donor and a transition metal ion (Co Imidazole is an important biological molecule.
	www.wpi.edu /Academics/Depts/Chemistry/Courses/General/coim.html (1084 words)

	Industrial grade imidazole\|Superfine imidazole\|N-methyl imidazole\|1,2-dimethyl imidazole\|N,N'-carbonyl ...
		Imidazole is an important intermediate of antifongin and is an indispensable material medicine in people's daily life.
		The imidazole content is more than 99.5% and the moisture content less than 0.2%.
		With two imidazole producing lines, one for 1-methyl imidazole and the other for N,N'-carbonyl dimidazole, Kaile now possesses an area of 6,500 square meter which is divided into two production areas.
	www.kailechem.com /pages/about.htm (301 words)

	Imidazole, Reagent Advance Scientific and chemical - Imidazole, Reagent, chemical company, chemical compound, spectrum ...
		Imidazole, Reagent Advance Scientific and chemical - Imidazole, Reagent, chemical company, chemical compound, spectrum chemical, chemical distributor, laboratory chemical, specialty chemical, chemical catalog, chemical supply, science project, acid, solvent, fine chemicals, research chemicals, laboratory equipment, sodium, potassium, USP, NF, FCC, reagent, ACS
		For Bulk quotations on "Imidazole, Reagent", be sure to contact our Bulk Chemical Department at 1-800-524-2436.
		MSDS for Imidazole, Reagent, is available upon request.
	www.advance-scientific.com /Properties.asp?code=IM105+++++&name=Imidazole%2C+Reagent (114 words)

	Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives -- Zhang et al. 30 (3): 314 -- Drug Metabolism and ...
		The purpose of this study was to investigate and compare the P450 interaction profiles of various antifungal imidazole derivatives.
		Ballard SA, Lodola A and Tarbit MH (1988) A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalyzed by mouse microsomal cytochromes P450.
		Reidy GF, Mehta I and Murray M (1989) Inhibition of oxidative drug metabolism by orphenadrine and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics.
	dmd.aspetjournals.org /cgi/content/full/30/3/314 (3076 words)

	Antihypertensive substituted imidazole derivatives (Site not responding. Last check: )
		The present invention relates to substituted imidazole derivatives and their non-toxic, pharmaceutically acceptable acid addition salts, and their preparation, to pharmaceutical compositions containing the same, and to their use.
		Because of the tautomerism in the imidazole ring the compounds of the general formula I and II are 4(5)-substituted imidazole derivatives.
		Preferably, the hydrolysis is carried out by boiling the starting material, an N-acylated imidazole derivative, in an aqueous solution of an inorganic acid until the reaction is completed.
	www.stickebana.com /scitech/shim_cable_clamp/antihypertensive_substituted_imidazole_derivatives.html (5036 words)

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