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Topic: Imidazopyridine

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	Imidazopyridyl-alkylthio-pyridines and anti-peptic ulcer compositions containing the same - Patent 4880815 (Site not responding. Last check: 2007-11-07)
		Novel tetrahydroquinoline derivatives and salts thereof and novel imidazopyridine derivatives and salts thereof, both having excellent anti-peptic ulcer activities, and are useful as treating agents for peptic ulcers such as gastric ulcer, duodenum ulcer and the like.
		Imidazopyridine compounds and salts thereof represented by the formula ##STR29## wherein any one of Z and Y is a group of the formula --CH.dbd.
		Novel tetrahydroquinoline derivatives and salts thereof represented by the general formula (1) and novel imidazopyridine derivatives and salts thereof represented by the general formula (20) possess excellent anti-peptic ulcerative activities, and are useful as treating agents for peptic ulcers such as gastric ulcer, duodenum ulcer and the like.
	www.freepatentsonline.com:9003 /4880815.html (9414 words)

	United States Patent Application: 0040014779
		The method of claim 1 wherein the compound comprises an imidazopyridine amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, a thiazoloquinoline amine, an oxazoloquinoline amine, a 1,2-bridged imidazoquinoline amine, a thiazolonaphthyridine amine, an imidazothienopyridine, a sulfonamido-substituted imidazoquinoline amine, a urea-substituted imidazoquinoline amine, a heteroaryl ether-substituted imidazoquinoline amine, N-[4-(4-amino-2-ethyl-1H-[4,5-c]quinolin-1-yl)but- yl]methanesulfonamide, or 4-amino-2-(ethoxymethyl).alpha.,.alpha.-dimethyl- -6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-ethanol hydrate.
		The method of claim 49 wherein the IRM compound is an imidazoquinoline amine, an imidazopyridine amine, a 6,7-fused cycloalkylimidazopyridine amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, an oxazoloquinoline amine, a thiazoloquinoline amine, a 1,2-bridged imidazoquinoline amine, a thiazolonaphthyridine amine, or an imidazothienopyridine.
		The use of claim 56 wherein the IRM comprises is an imidazoquinoline amine, an imidazopyridine amine, a 6,7-fused cycloalkylimidazopyridine amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, an oxazoloquinoline amine, a thiazoloquinoline amine, a 1,2-bridged imidazoquinoline amine, a thiazolonaphthyridine amine, or an imidazothienopyridine.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1='20040014779' (10764 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ... (Site not responding. Last check: 2007-11-07)
		Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice.
		In contrast, the results indicated that zolpidem was more potent at reducing locomotion than at interfering with fear conditioning, a result which may reflect the preferential sedative action of zolpidem.
		Zolpidem is a novel non-benzodiazepine related hypnotic, which possesses an imidazopyridine structure.
	xenical-online-usa.com /ambien-online-rx/ambien-online-rx5.37.html (1057 words)

	[No title] (Site not responding. Last check: 2007-11-07)
		Pharmacological Profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticograin in rats: Arch Pharm 1985, 330: 246-248.
		A double blind study of zolpidem a new imidazopyridine hypnotic on contingent negative variation in patients with situational insomnia.
		In: Imidazopyridines in Sleep Disorders: A Novel Experimental and Therapeutic Approach, Sauvanet JP, Langer SZ, Morselli PL eds.
	www.rlsnet.ru /ivadal/mats/monogrph/10m.php3 (6977 words)

	Hajak (Site not responding. Last check: 2007-11-07)
		There is evidence from an epidemiological study on 550 physicians in Germany that newer hypnotics (i.e., imidazopyridine, cyclopyrrolone) are prescribed for a significantly shorter average duration than benzodiazepine hypnotics.
		During a period of 5 years 29,302 patients were treated with hypnotics, 24,571 of the patients were drug naive before treatment.
		Some sleep experts underline that intermittent use of hypnotics is advisable for long term treatment, as this may benefit patients and prevent the development of dependence.
	www.websciences.org /sleepandhealth/hajak.html (1190 words)

	The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines -- ...
		Atoms are colored as follows: N, blue; O, red; F, light blue; and the C atoms of the inhibitor are yellow and those of the protein are gray.
		Imidazopyridine 1d induces cell cycle arrest and apoptosis in HCT 116 cells.
		A, Western blot analysis of inhibition of CDK2 by imidazopyridine 1d in HCT 116 tumor cells.
	mct.aacrjournals.org /cgi/content/full/3/1/1 (4274 words)

	BioInfoBank Institute
		One of the imidazopyridine rings was in the ionic form, while the other was in the meso-ionic form.
		The averaging of ionic and meso-ionic forms of imidazopyridine rings within the same molecule is hindered because of an attractive interaction between them.
		Analysis of electronic density revealed that, indeed, a new type of bonding is formed as the result of an overlap between Pi aromatic and Pi* C=O molecular orbitals.
	www.bioinfo.pl (379 words)

	EPA: Federal Register: Notice of Filing of Pesticide Petitions
		Postemergence applications result in residues that are mostly made up of parent compound, with small amounts of five to six metabolites that together make up less than 15% of the total radioactive residue (TRR).
		Preemergence application result in soil degradation of the parent compound followed by uptake primarily of the imidazopyridine ring- containing metabolites and small amounts of the parent compound.
		The pyrimidine ring-containing metabolites under these conditions are tightly bound to the soil, resulting in negligible uptake of these residues.
	www.epa.gov /fedrgstr/EPA-PEST/1998/December/Day-23/p33834.htm (5118 words)

	Gallileus - Imidazopyridine in Anxiety Disorders: a Novel Experimental and Therapeutic Approach (Site not responding. Last check: 2007-11-07)
		Imidazopyridine in Anxiety Disorders: a Novel Experimental and Therapeutic Approach
		This is the first book to bring together the extensive pharmacological, preclinical, and clinical studies that have been done in the United States and Europe on alpidem (Ananxyl), a new nonbenzodiazepine anxiolytic which, like the hypnotic agent zolpidem (Stilnox), belongs to the imidazopyridine family of drugs.
		The book presents original research articles on the receptors involved in the action of anxiolytics, particularly benzodiazepines; the selective action of alpidem on a specific subtype of receptors; the psychopharmacological profile of alpidem; its safety; and the clinical experience with alpidem for treatment of anxiety disorders.
	www.gallileus.info /search/lob_detail?isbn=0781700876 (264 words)

	Patri's Journal: Zolpidem for the treatment of chronic insomnia (5/25/02) (Site not responding. Last check: 2007-11-07)
		Recent investigations in our sleep outpatient clinic demonstrated that 30% of patients exhibited organic and 70% nonorganic sleep disorders, with 41% showing as an additional diagnosis neurotic, stress-related, and somatoform disorders, 31% affective disorders and 15% mental and behavioral disorders due to psychoactive substance use.
		Thus, the aim of the study was to investigate the acute effects of the imidazopyridine zolpidem on objective and subjective sleep and awakening quality in the largest of the above-mentioned groups.
		The zolpidem group was bracketed by a placebo group and a positive control group taking 0.5 mg of triazolam (twice the recommended dose), which is known to produce rebound insomnia.
	www.patrifriedman.com /writing/journal/expat/974zolpidem.html (3319 words)

	Fused imidazopyridine derivatives as antihyperlipidemic agents - Patent 6235731
		The present invention relates to novel fused imidazopyridine derivatives which are useful for prophylaxis and/or therapy of hyperlipemia, their production and use.
		It has been shown by many epidemiological surveys that, alongside of hypertension and smoking, hypercholesterolemia is one of the three major risk factors for atherosclerotic diseases such as myocardial infarction, angina pectoris, and cerebral infarction.
		The novel fused imidazopyridine derivatives represented by the following formula (I) have been found to possess an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating action.
	www.freepatentsonline.com /6235731.html (15519 words)

	One rare side effect of zolpidem–sleepwalking: a case report. (Site not responding. Last check: 2007-11-07)
		2005 Jun; 86(6): 1265-6; Yang W, Dollear M, Muthukrishnan SR Zolpidem is an imidazopyridine agent indicated for the short-term treatment of insomnia.
		We report a case of a male rehabilitation inpatient in his mid […]
		Yang W, Dollear M, Muthukrishnan SR Zolpidem is an imidazopyridine agent indicated for the short-term treatment of insomnia.
	counsellingresource.com /medications-research/2005/07/17/one-rare-side-effect-of-zolpidem-sleepwalking-a-case-report (369 words)

	Indian Journal of Psychiatry
		In both cases, the reaction was to a dosage of 10 mg occurring about 15 minutes after intake of the drug.
		Zolpidem is an imidazopyridine differing in structure from benzodiazepines and zopiclone.
		It has been primarily used as a hypnotic with minimal anxiolytic, relaxant or anticonvulsant properties.
	www.ijponline.org /Jan/indIJPJanAdverseEvents.html (930 words)

	Synthesis of imidazo[1,2-a] pyridines by rearrangement of 2-pyridyl-3-arylaminoisoxazol-5-(2H)-ones (Site not responding. Last check: 2007-11-07)
		With a number of imidazopyridine structures in hand, the structures of all imidazopyridines were confirmed by
		All compounds 13a-13e showed H-7 to have meta coupling with H-5, but the resonance for H-5 could not be clearly observed in compounds 13a-13e. The reason for the extreme broadening of this peak is unknown, though quadrupole coupling with N-4 is implicated.
		The reaction pathway resulting in the imidazopyridines is consistent with our earlier suggestion (Scheme 3).
	www.arkat-usa.org /ark/journal/2005/I14_General/1375/05-1375B.asp (3757 words)

	Dihydrostilbene alkanoic acid derivatives - US Patent 6720315 (Site not responding. Last check: 2007-11-07)
		The monocyclic ring systems such as imidazole, thiazole, oxazole, and the like, may contain an amino or alkylamino substituent at any position within the ring.
		is an aryl or a heteroaryl group selected from phenyl, benzofuran, benzothiophene, indole, quinoline, isoquinoline, benzimidazole, benzoxazole, 1,3-benzodioxole, 1,4-benzodioxane, benzopyran, quinolone, imidazopyridine, tetrahydroquinoline, benzotriazole, dihydroindole, dihydrobenzofuran, furan, thiophene, phenyl, oxazole, thiazole, isoxazole, pyrazole, imidazole, pyrrole, pyridine, pyrimidine, pyridone, triazole, thiadiazole and the like.
		The aryl system can be optionally substituted at one or more position with alkyl, alkoxy, hydroxy, cyano, halogen or haloalkyl.
	www.patentstorm.us /patents/6720315.html (15740 words)

	Thieme-connect - Abstract (Site not responding. Last check: 2007-11-07)
		A catalytic Fe(III)/Fe(II) redox cycling approach has been examined and applied towards synthesis of a wide range of benzimidazole, bis-benzimidazole and imidazopyridine derivatives from oxidative coupling of aromatic ortho-diamines with aromatic as well as heterocyclic aldehydes bearing different types of substituents.
		This versatile and convenient method has further proven to be particularly useful in expeditiously affording a number of novel bis-benzimidazole class of Hoechst 33 258 analogs towards potential development as fluorescent nucleic acid binding probes.
		Successful preparation and characterization of a diverse set of thirty different compounds is presented here.
	www.thieme-connect.com /ejournals/abstract/synthesis/doi/10.1055/s-2000-7111 (169 words)

	Medications - Ambien (Site not responding. Last check: 2007-11-07)
		Description: Ambien is a non-benzodiazepine hypnotic of the imidazopyridine class.
		It exhibits hypnotic activity, but has no muscle relaxant or anticonvulsant properties.
		Send mail to ropa@redoakpsychiatry.com with questions or comments about this web site.
	www.redoakpsychiatry.com /medications/Ambien.html (170 words)

	Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and ...
		The imidazopyridine hypnotic zolpidem was successfully established as a DS in nonhuman primates.
		Sanger DJ, Perrault G, Morel E, Joly D and Zivkovic B (1987) The behavioral profile of zolpidem, a novel hypnotic drug of imidazopyridine structure.
		Sanger DJ and Zivkovic B (1986) The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic.
	jpet.aspetjournals.org /cgi/content/full/291/3/1233 (5205 words)

	Discriminative Stimulus Effects of Zolpidem in Pentobarbital-Trained Subjects: II. Comparison with Triazolam and ...
		Biggio, G., Concas, A., Corda, M. and Serra, M.: Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors.
		Sanger, D. Joly, D. and Zivkovic, B.: Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice: Comparison with triazolam and CL 218,872.
		Sanger, D. and Zivkovic, B.: The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic.
	jpet.aspetjournals.org /cgi/content/full/280/1/174 (7555 words)

	Ambien (Site not responding. Last check: 2007-11-07)
		What Zolpidem is:Zolpidem is a non-benzodiazepine hypnotic of the imidazopyridine class.
		How Zolpidem works:Zolpidem works by binding to specific GABA receptors in the brain to reduce brain function and promote sleep.
		Insomnia:Insomnia is characterized by the inability to fall asleep, waking up several times during the night, and/or, waking up too early.
	academic.evergreen.edu /curricular/humanbio/Ambien.htm (549 words)

	British Medical Journal: Hepatotoxicity associated with zolpidem treatment (Site not responding. Last check: 2007-11-07)
		Save a personal copy of this article and quickly find it again with Furl.net.
		Zolpidem is a hypnotic drug of the imidazopyridine group.
		A 53 year old woman was admitted in June 1997 for investigation of recurrent abdominal pain.
	www.findarticles.com /p/articles/mi_m0999/is_7192_318/ai_54795998 (557 words)

	Functional GABAA Receptor Heterogeneity of Acutely Dissociated Hippocampal CA1 Pyramidal Cells -- Tietz et al. 81 (4): ...
		The imidazopyridine zolpidem enhanced GABAR currents in 70% of
		The imidazopyridine, zolpidem had variable effects on GABAR currents recorded from acutely dissociated CA1 pyramidal cells
		GABA currents in 7 of 21 cells tested with 1 µM zolpidem were insensitive to or inhibited by the imidazopyridine.
	jn.physiology.org /cgi/content/full/81/4/1575 (6616 words)

	Zolpidem (Ambien ®)in Pregnancy and Breastfeeding (Site not responding. Last check: 2007-11-07)
		Non-benzodiazepine of the imidazopyridine class, shares some of the pharmacological properties of the benzodiazepines.
		Reproductive studies conducted in rats and rabbits showed no teratogenic effects after zolpidem administration.
		Keep in mind the limitations of this information.
	www.perinatology.com /exposures/Drugs/Zolpidem.htm (440 words)

	GABAA Receptor {alpha}1 Subunit Deletion Prevents Developmental Changes of Inhibitory Synaptic Currents in Cerebellar ...
		cells during development, we used the imidazopyridine Zolpidem.
		of the action of the imidazopyridine on the duration of the mISPCs.
		As illustrated in Figure 3, mIPSCs were recorded in the presence
	www.jneurosci.org /cgi/content/full/21/9/3009 (5235 words)

	Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones
		Medicinal Chemistry Research Laboratories, Biomedical Research Laboratories, and Pharmacology and Molecular Biology Research Laboratories, Sankyo Company, Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan, and Sankyo Pharma Research Institute, 4250 Executive Square, Suite 420, La Jolla, California 92037
		A series of imidazopyridine thiazolidine-2,4-diones were designed and synthesized from their corresponding pyridines.
		These compounds represent conformationally restricted analogues of the novel hypoglycemic compound rosiglitazone (5).
	pubs.acs.org /cgi-bin/jtext?jmcmar/43/i16/abs/jm990522t (149 words)

	Mechanism of Action for This Short-term Treatment for Insomnia — AMBIEN® (zolpidem tartrate) CIV — Ambien.com (Site not responding. Last check: 2007-11-07)
		Can patients taking an SSRI get a restful night?
		AMBIEN is not a benzodiazepine—in fact, it’s a distinct non-benzodiazepine hypnotic of the imidazopyridine class.
		It has a chemical structure (shown below) that is different from those of benzodiazepines, barbiturates, or other drugs with known hypnotic properties.
	www.ambien.com /hcp/about/moa.asp (413 words)

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