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Imiquimod 5 percent cream and the treatment of cutaneous malignancy Imiquimod resembles a nucleoside analogue and is known for its potent induction of endogenous antiviral pro-inflammatory mediators. Imiquimod resembles a nucleoside analogue (fig.1) and is known for its potent induction of endogenous antiviral pro-inflammatory mediators [1]. The addition of imiquimod resulted in the induction of Fas receptors on tumor cells, and is postulated to lead to their subsequent apoptosis via binding of FasR to the Fas ligand, induction by neighboring BCC cells, and infiltration of lymphocytes. dermatology.cdlib.org /101/reviews/imiquimod/navi.html   (3824 words)

Imiquimod for genital warts With imiquimod 5%, 72% (67% to 78%) of patients had the outcome, compared with 20% (15% to 25%) with placebo. This means that two patients have to be treated with 5% imiquimod for 8 to 16 weeks for one of them to have wart area reduced by at least 50%. This means that three patients have to be treated with 5% imiquimod for 8 to 16 weeks for one of them to have warts completely cleared, and for them not to recur. www.jr2.ox.ac.uk /bandolier/booth/SexHlth/imigw.html   (623 words)

Imiquimod. DermNet NZ Imiquimod is mainly used to treat genital warts, solar keratoses and basal cell skin cancers. Imiquimod works by stimulating the immune system to release a number of chemicals called cytokines, which are important in fighting viruses and destroying cancer cells. Imiquimod is particularly useful on areas where surgery or other treatments may be difficult, complicated or otherwise undesirable, especially the face and lower legs. dermnetnz.org /treatments/imiquimod.html   (818 words)

Imiquimod - [Medication] - Quest Diagnostics Patient Health Library   (Site not responding. Last check: 2007-10-17) Imiquimod is thought to work by helping the body's immune system produce interferon and similar substances that attack abnormal cells, viruses, and cancerous cells. Imiquimod is approved to treat genital warts, actinic keratosis, and superficial basal cell carcinoma. Imiquimod may prove to be beneficial in treating large, superficial basal cell carcinomas on the trunk of the body, where surgical treatment can cause severe scarring. www.questdiagnostics.com /kbase/topic/detail/drug/hw104786/detail.htm   (463 words)

imiquimod topical - [Medication] Imiquimod topical is used in the treatment of external genital and perianal warts, actinic keratosis (warty overgrowths of skin) on the face and scalp and for treating superficial basal cell carcinoma. Imiquimod topical is in the FDA pregnancy category C which means that it is not known whether imiquimod topical will be harmful to an unborn baby. Imiquimod topical should be applied before bed, and left on the skin for approximately 8 hours for the treatment of actinic keratosis and 6 to 10 hours for the treatment of genital or perianal warts. www.peacehealth.org /kbase/multum/d04125a1.htm   (1899 words)

Imiquimod : by Ray Sahelian, M.D. Imiquimod side effect and benefit Imiquimod is used topically to treat warts on the skin of the genital and anal areas. Imiquimod cream should be applied 3 times per week to the cleaned wart area, prior to sleeping and should remain on the skin for 6 to 10 hours. Imiquimod cream treatment should continue until there is clearance of visible genital or perianal warts or for a maximum of 16 weeks per episode of warts. www.raysahelian.com /imiquimod.html   (1249 words)

ACS :: Cancer Drug Guide: imiquimod 5% cream Imiquimod is also used to treat superficial basal cell carcinoma of the skin on the trunk, neck, arms, and legs when surgery is not a good option, and the person treated can come in for follow-up exams. Imiquimod 5% cream is also used to treat warts on the genital area (called condyloma acuminata) in people at least 12 years old. Imiquimod 5% cream must be applied to skin that is clean and intact. www.cancer.org /docroot/CDG/content/CDG_imiquimod_5percent_cream.asp   (825 words)

Imiquimod tlr The synthesis of CpG DNA and imiquimod molecules. Imiquimod, approved for topical treatment of virus-induced papillomae in genital regions is an antagonist for TLR-7 and TLR-8 present in dendritic cells. Imiquimod is the first of the immune response modifiers to stimulate a localized immune response to treat infectious skin conditions. www.angelfire.com /planet/gary34/imiquimodtlr.html   (787 words)

IMIQUIMOD Imiquimod is a new topical treatment licensed for self-administration for the treatment of external genital and perianal warts. Imiquimod 5% cream for the treatment of anogenital warts has been evaluated in one phase II and two phase III randomised, double-blind, placebo-controlled trials in a total of 698 immunocompetent adult patients. Imiquimod is not recommended in uncircumcised males for the treatment of foreskin associated warts, due to isolated cases of stricture and phimosis. www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/summaries/I/IMIQUIMODs.html   (1027 words)

Imiquimod. DermNet NZ Imiquimod is mainly used to treat genital warts, solar keratoses and basal cell skin cancers. Imiquimod works by stimulating the immune system to release a number of chemicals called cytokines, which are important in fighting viruses and destroying cancer cells. Imiquimod is particularly useful on areas where surgery or other treatments may be difficult, complicated or otherwise undesirable, especially the face and lower legs. www.dermnetnz.org /treatments/imiquimod.html   (844 words)

IMIQUIMOD Imiquimod 5% cream has been evaluated in 3 randomised, double-blind, placebo-controlled trials in a total of 698 immunocompetent patients. Further data are required before imiquimod can be recommended in uncircumcised males, for the treatment of foreskin associated warts, due to isolated cases of stricture and phimosis. Imiquimod 5% cream should be self-applied, 3 days per week, to cleaned wart area prior to sleeping and should remain on the skin for 6-10 hours. www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/I/IMIQUIMODv.html   (459 words)

Treatment of limited extent extramammary Paget's Disease with 5 percent imiquimod cream Imiquimod is an imidazoquinoline amine with immune response modifying effects and potent anti-viral and anti-tumor activity in animal models [11]. Imiquimod is currently FDA approved for topical treatment of external genital warts, actinic keratosis, and superficial basal cell cancer [12]. Furthermore, imiquimod may involve an activation of the immune response via modulation of Langerhans' cell function, specifically enhancing viral and tumor antigen presentation to na•ve T lymphocytes by inducing migration of Langerhans' cells to regional lymph nodes [11]. dermatology.cdlib.org /121/pearls/extramammary/rosen.html   (1797 words)

BioMed Central | Full text | Imiquimod for the treatment of genital warts: a quantitative systematic review Three trials with 5% imiquimod reported the number of patients randomised, the number completely cleared at the end of treatment, and the number of those who were completely clear at the end of treatment and in whom new warts were observed in the subsequent 10-16 weeks. Imiquimod 5% cream was significantly more effective than imiquimod 1% cream in ensuring that warts were completely cleared by the end of treatment and did not recur (Table 1), with no overlap of confidence intervals of the NNTs (z = 5.2, p < 0.001). Sensitivity analysis therefore examined the highest concentration of imiquimod in all trials, that is data on 2% or 5% creams (Figure 1), and with 5% and 1% imiquimod creams separately. www.biomedcentral.com /1471-2334/1/3   (5045 words)

Complete Imiquimod information from Drugs.com If you are using Imiquimod to treat genital warts, remove Imiquimod 6 to 10 hours after you apply it, unless directed otherwise by your doctor. Imiquimod may cause a lightening or darkening of the skin where it is applied. Imiquimod is to be used only by the patient for whom it is prescribed. www.drugs.com /cdi/Imiquimod.html   (1658 words)

AAD: Imiquimod (Aldara) Safe and Efficacious for Basal Cell Carcinoma   (Site not responding. Last check: 2007-10-17) Imiquimod is currently approved for the treatment of human papilloma virus (HPV). One problem with imiquimod treatment is that it restores the skin to a completely normal appearance before the end of treatment, Dr. Naylor said. Imiquimod works by releasing cytokines from inflammatory cells, and that inflammatory response produces macrophages, which in turn attack malignant cells, Dr. Naylor said. www.pslgroup.com /dg/22efba.htm   (626 words)

Imiquimod for genital warts (human papillomavirus) Imiquimod is thought to work by helping the body's immune system kill viruses and shrink the warts. Imiquimod may be used at home after a health professional instructs you in the proper way to apply the medication. It is not known whether imiquimod is safe to use during pregnancy or on children under the age of 12. hw.healthdialog.com /kbase/topic/detail/drug/hw104786/detail.htm   (416 words)

AEGiS-CATIE: TreatmentUpdate 140: IMMUNE BOOSTERS: Italian study finds immune booster useful against genital warts - ... Imiquimod seems to work by stimulating cells of the immune system in the skin, including macrophages, to produce chemical messengers such as interferons-alpha and gamma. According to the research team, the use of imiquimod resulted in about 55% of HIV positive subjects having "at least a partial reduction of genital warts." Among HIV negative people, the equivalent figure was 86%. In a previous study of imiquimod non-responders, doctors found that there were less-than-normal levels of immune cells in the skin near warts. www.aegis.com /pubs/catie/2004/cate14004.html   (971 words)

POZ - Treatment News : Imiquimod for Anal Intraepithelial Neoplasia? Imiquimod is a topical immune response modifier approved in the US for treatment of anogenital warts, superficial basal cell carcinoma, and actinic keratoses. Patients were treated with 5% imiquimod cream applied overnight three times a week for 16 weeks, during which time they were requested to refrain from receptive anal intercourse. Four patients failed to comply because of pain from the imiquimod and refusal to refrain from sex. www.poz.com /articles/761_10900.shtml   (482 words)

Imiquimod and superficial skin cancers Journal of Drugs in Dermatology - Find Articles   (Site not responding. Last check: 2007-10-17) Imiquimod, in contrast, catalyses an immune response and therefore does not necessarily need to reach large or uniform concentrations in all parts of the tumor to be effective. Before the advent of imiquimod therapy, there were few reasonable alternatives to surgery beyond other types of ablative techniques such as aggressive nitrogen treatment or radiotherapy. Although imiquimod therapy is not without risk in such patients, it may be preferable to a more stressful surgical procedure, even one done under local anesthesia. www.findarticles.com /p/articles/mi_m0PDG/is_5_4/ai_n15396467   (848 words)

Aldara - Aldara Side Effects - Aldara Information - Canada Pharmacy - Canada Drugs The cytokine inducing properties of imiquimod may be responsible for its activity against genital/perianal warts, as imiquimod does not have a direct antiviral activity in cell cultures. Imiquimod has not been evaluated for the treatment of urethral, intra-vaginal, cervical, rectal, or intra-anal human papilloma viral disease and is not recommended for these conditions. Imiquimod is to be applied 3 times/week, prior to normal sleeping hours, and left on the skin for 6 to 10 hours. www.rxcarecanada.com /Aldara.asp?prodid=52   (1214 words)

Imiquimod Topical Drug Information Imiquimod (i-MI-kwi-mod) is used to treat external warts around the genital and rectal areas called condyloma acuminatum. Imiquimod is also used to treat a skin condition of the face and scalp called actinic keratoses. Imiquimod can also be used to treat certain types of skin cancer called superficial basal cell carcinoma (sBCC). www.drugs.com /cons/Imiquimod_Topical.html   (1891 words)

Imiquimod suppositories help suppress anal warts   (Site not responding. Last check: 2007-10-17) Imiquimod (Aldara) is approved in North America and the European Union for the treatment of external genital warts and other skin conditions. Imiquimod is applied to the skin, where it stimulates the immune system to activate cells that help destroy abnormal growths and tumours. Imiquimod is supplied in sachets in a cream formulation. www.catie.ca /catienews.nsf/0714d2194eb52070852563ab006a5ac9/27c772a7b37b36c68525712200691cd2?OpenDocument   (828 words)

Skin Therapy Letter: Volume 3, Number 2   (Site not responding. Last check: 2007-10-17) Although results are not available, it seems logical to combine imiquimod with an ablative therapy so that imiquimod could induce an immune response which has the potential to affect the virus, eliminate residual lesions, and possibly reduce recurrence rates. Imiquimod cream may weaken condoms and vaginal diaphragms and should not be used concurrently. Imiquimod has no mutagenic activity, is immunomodulatory/antiviral and would appear to be the drug of choice www.derm.ubc.ca /skintherapy/stl0302.html   (1150 words)

AKNet Article - Patients' Responses to Imiquimod Vary   (Site not responding. Last check: 2007-10-17) During the trials, 436 patients who had four (4) to eight (8) AKs on their face or scalp were randomly assigned to receive either 5% imiquimod cream or a cream that resembled imiquimod but lacked the active ingredient. Recently, researchers conducted clinical trials to find out if applying imiquimod three (3) times per week instead of two (2) times per week for 16 weeks would increase AK clearance and still be well tolerated. The researchers concluded that this study and others suggest the amount of imiquimod to be applied and the frequency may need to be individually tailored. www.skincarephysicians.com /actinickeratosesnet/patients_response_imiquimod.html   (650 words)

Use of Imiquimod for Actinic Keratoses - May 1, 2003 - American Family Physician Imiquimod is an oddly named immune-response modifier that has anecdotally shown promise in the treatment of AKs. In the imiquimod group, 84 percent of patients had complete clinical clearance of lesions at 14 weeks, compared with none in the control group. A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. www.aafp.org /afp/20030501/tips/3.html   (498 words)

Imiquimod - Patient UK Imiquimod is used to treat warts of the anal and genital areas. Imiquimod is available in cream form which is supplied in individual sachets. Imiquimod occasionally causes skin irritation such as itching, pain, rashes, swelling, ulceration or scabbing. www.patient.co.uk /showdoc/30002803   (777 words)

Imiquimod 5% Cream (Aldara®) in the Treatment of Basal Cell Carcinoma Recently, imiquimod has been shown to promote the expression of cellular receptors that are associated with apoptosis.5,6 There is mounting evidence that imiquimod antitumor activity in vivo stems from the effect it has on the innate and cell-mediated immune response, including cell surface markers. Imiquimod is applied topically to the affected areas and its clinical effects are primarily localized to the skin. When imiquimod was applied 3 times per week for 16 weeks in 58 patients with actinic keratoses (AKs), the mean peak serum levels at the end of week-16 were very low, measuring approximately 0.1-3.5ng/ml depending whether one packet (12.5mg) was used or up to six packets (75mg) were used. www.skintherapyletter.com /2005/10.6/1.html   (1901 words)

Imiquimod 5% Cream is Effective Treatment for Basal Cell Cancer Imiquimod 5% is a new topical cream that is directly applied to the site of cancer and is being evaluated for the treatment of early stage basal cell cancer. Imiquimod 5% stimulates an immune response to the location in which it is applied. The physicians conducting this trial suggest that Imiquimod 5% cream may be an effective patient administered treatment option for superficial basal cell cancer. patient.cancerconsultants.com /skin_cancer_news.aspx?id=18727   (623 words)

[No title] Topical imiquimod is not intended for ophthalmic use. Topical imiquimod administration is not recommended until genital/perianal tissue is healed from any previous drug or surgical treatment. Imiquimod has the potential to exacerbate inflammatory conditions of the skin. www.musc.edu /pharmacyservices/Drugs/I/Imiquimod.doc   (155 words)

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