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Topic: Immune Mediated encephalomyelitis

	Immune-Mediated Tissue Injury
		The prototypic immune complex disease is serum sickness (e.g., a patient injected with a heterologous antiserum, such as horse serum).
		This type of lesion may be secondary to a drug (e.g., penicillin), to the presence of a foreign protein antigen in the circulation (e.g., a viral protein), or rarely, to the release of an antigen by tumor cells.
		The immune response to Mycobacterium leprae varies widely, from the "tuberculoid" leprosy pattern with potent DTH, granulomas, and low numbers of organisms in tissues, to the "lepromatous" pattern with weak or suppressed DTH and numerous organisms.
	www.medicine.mcgill.ca /mjm/issues/v01n01/bsr.html (5129 words)

	Amelioration of Immune-Mediated Experimental Colitis: Tolerance Induction in the Presence of Preexisting Immunity and ...
		immune response and secondary immune response in the presence
		Karpus WJ, Kennedy KJ, Smith WS and Miller SD (1995) Inhibition of relapsing experimental autoimmune encephalomyelitis in SLJ mice by feeding the immunodominant PLP139-151 peptide.
		Lieshman A, Garside P and Mowat A (1998) Immunological consequences of intervention in established immune responses by feeding protein antigens.
	jpet.aspetjournals.org /cgi/content/full/297/3/926 (4173 words)

	(abstract) - IMMUNE-MEDIATED BRAIN INJURY AND REPAIR: MECHANISMS AND THERAPIES
		Analysis of MS lesions showed increases in cell-death-related proteins such as the anti-apoptotic protein Bcl-2, increases in DNA oxidation, and electrophoresed DNA produced a "ladder" characteristic of apoptotic DNA cleavage.
		Furthermore, it was found that CSF from patients with aggressive MS contained soluble mediators that induce axonal damage and apoptosis of neurons in culture.
		In experimental autoimmune encephalomyelitis (EAE) model, immunocytochemical identification of glial cells revealed that substantial numbers of cells were dying by apoptotic mechanisms rather than by cell necrosis.
	www.kenes.com /ENSprecong/abscellf.htm (218 words)

	Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent ...
		immune memory and resist tumor rechallenge (2, 5).
		Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.
		Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.
	www.jimmunol.org /cgi/content/full/161/8/3957 (6108 words)

	CD4 T-Cell-Mediated Demyelination Is Increased in the Absence of Gamma Interferon in Mice Infected with Mouse Hepatitis ...
		encephalomyelitis (wobbly gait, hind limb paresis, and mild
		The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis.
		Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated.
	jvi.asm.org /cgi/content/full/76/14/7329 (2400 words)

	(abstract) - IMMUNE-MEDIATED BRAIN INJURY AND REPAIR: MECHANISMS AND THERAPIES
		Mechanisms that are operative in transendothelial migration of T cells and monocytes have been elaborated in vitro and in animal models of MS.
		In addition to AM, chemokines have been demonstrated to be crucial for T cell recruitment into the CNS during inflammation.The important functional role of these molecules in the pathogenesis has been elucidated in treatment studies in EAE.
		The clinical value of this treatment approach that aims at inhibiting transendolthelial migration of immune cells in MS is currently under investigation.
	www.kenes.com /ENSprecong/absblood.htm (249 words)

	Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors -- Schuler and Steinman 186 (8): 1183 -- The ...
		There are animal models in which it is difficult to reject established tumors with immune activated T cells (44).
		Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
		Flt 3 ligand induces tumor regression and antitumor immune responses in vivo.
	www.jem.org /cgi/content/full/186/8/1183 (4537 words)

	Suppression of induction of experimental immune mediated blepharoconjunctivitis by tolerogenic conjugates of the ...
		Suppression of induction of experimental immune mediated blepharoconjunctivitis by tolerogenic conjugates of the antigen and monomethoxypolyethylene glycol -- Fukushima et al.
		Suppression of induction of experimental immune mediated blepharoconjunctivitis by tolerogenic conjugates of the antigen and monomethoxypolyethylene glycol
		A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.
	bjo.bmjjournals.com /cgi/content/full/83/8/973 (3219 words)

	Medical Dictionary: Immune-Mediated Encephalomyelitis - WrongDiagnosis.com
		Immune-Mediated Encephalomyelitis (medical condition): Inflammation of brain and/or spinal cord myelin sheath.
		Immune-Mediated Encephalomyelitis: Another name for Acute Disseminated Encephalomyelitis (or close medical condition association).
		Immune-Mediated Encephalomyelitis: Immune-Mediated Encephalomyelitis is listed as a type of (or associated with) the following medical conditions in our database: Brain conditions, Spinal Cord Disorders
	www.wrongdiagnosis.com /medical/immune_mediated_encephalomyelitis.htm (217 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Viral infections of the central nervous system and immune responses to these infections cause a variety of neurological diseases.
		Infection with a neuroadapted strain of Sindbis virus (NSV) causes fatal encephalomyelitis, but passive transfer of immune serum after infection protects from fatal disease and infectious virus is cleared.
		To determine whether persistent NSV RNA is associated with neurological damage, we examined the brains of recovered mice and found progressive loss of the hippocampal gyrus, adjacent white matter, and deep cerebral cortex associated with mononuclear cell infiltration.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=20493654 (368 words)

	CD152-mediated T-cell migration in experimental Autoimmune Encephalomyelitis (Site not responding. Last check: 2007-10-25)
		The immune response is directed against components of the myelin sheet leading to chronic inflammation and, ultimately, to demyelination and gliosis.
		So far, the recruitment of autoreactive, inflammatory as well as antiinflammatory T-cells into the brain is not fully understood.
		Besides learning how CD152 mediates the transendothelial migration of T-cells into the CNS, we will gain knowledge how CD152 influences the composition of protective and neuroinflammatory cells at the site of inflammation in the brain.
	www.hu-berlin.de /forschung/fdb/english/PJ/PJ1999976262.html (206 words)

	NIH Guide: THE ROLE OF MICROGLIA IN NORMAL AND ABNORMAL IMMUNE RESPONSES OF THE NERVOUS SYSTEM
		This PA The Role of Microglia in Normal and Abnormal Immune Responses of the Nervous System, is related to autoimmunity response of the CNS which are vital to multiple sclerosis and immune-mediated encephalomyelitis.
		If so, they may be equally important in initiating and sustaining immune responses to CNS elements such as myelin, oligodendroglia and neoplastic astrocytes.
		Activation of microglia, so that they express Class II and other phenotypic markers, may be related to the presence of activated T cells arriving from the periphery.
	grants.nih.gov /grants/guide/pa-files/PA-00-029.html (2206 words)

	MEK-Specific Inhibitor U0126 Blocks Spread of Borna Disease Virus in Cultured Cells -- Planz et al. 75 (10): 4871 -- ...
		In the control reaction, cells were either left untreated (lane 7) or treated with 20% FCS for 1 h as a mitogenic stimulus to activate ERK2 (lane 8).
		Cell lysates were subjected to ERK2 immune complex kinase assays as described in Materials and Methods by using myclin basic protein as a substrate.
		A short leucine-rich sequence in the Borna disease virus p10 protein mediates association with the viral phospho- and nucleoproteins.
	jvi.asm.org /cgi/content/full/75/10/4871 (4244 words)

	Encephalomyelitis, Acute Disseminated
		This Web resource on acute disseminated encephalomyelitis (also known as postinfectious encephalomyelitis, or immune-mediated encephalomyelitis) is produced by the National Institute of Neurological Disorders and Stroke (NINDS).
		A description of acute disseminated encephalomyelitis is provided, and available treatments, prognosis, and current research activities are all discussed.
		Patient Education Handout [Publication Type]; Encephalomyelitis, Acute Disseminated;
	omni.ac.uk /browse/mesh/D004673.html (54 words)

	Bilateral enhancing thalamic lesions in a 10 year old boy: case report -- Olivero et al. 66 (5): 633 -- Journal of ...
		acute perivascular myelinoclasis, and allergic or immune mediated
		Epperson LW, Whitaker JN, Kapila A. Cranial MRI in acute disseminated encephalomyelitis.
		Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination.
	jnnp.bmjjournals.com /cgi/content/full/66/5/633 (1240 words)

	LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival - Nature Medicine
		An alternative approach would be to inhibit mechanisms that drive the neuropathology of MS, which often includes the death of oligodendrocytes, the cells responsible for myelinating the CNS.
		Identification of molecular mechanisms that mediate the stress response of oligodendrocytes to optimize their survival would serve this need.
		We also demonstrate that this therapeutic effect complements endogenous LIF receptor signaling, which already serves to limit oligodendrocyte loss during immune attack.
	www.nature.com /doifinder/10.1038/nm0602-613 (280 words)

	Molecular mimicry and immune-mediated diseases -- Oldstone 12 (13): 1255 -- The FASEB Journal
		New Zealand rabbits inoculated with 10 amino acid peptide from hepatitis B virus polymerase generated specific T (proliferation) and B (antibody) lymphocyte responses to myelin basic proteins.
		Rabbits developed histopathologic evidence of lesion of allergic encephalomyelitis (see ref 34 for details).
		Wucherpfennig, K. W., and Strominger, J. (1995) Molecular mimicry in T-cell mediated autoimmunity: viral peptides activate human T-cell clones specific for myelin basic protein.
	www.fasebj.org /cgi/content/full/12/13/1255 (6966 words)

	Medical Dictionary: Immune-Mediated Encephalomyelitis - CureResearch.com
		Immune-Mediated Encephalomyelitis: Another name for Acute Disseminated Encephalomyelitis.
		Immune-Mediated Encephalomyelitis (condition): Inflammation of brain and/or spinal cord myelin sheath.
		Immune-Mediated Encephalomyelitis: Acute disseminated encephalomyelitis (ADE) is a neurological disorder characterized by inflammation of the brain and spinal cord caused by damage to the myelin sheath.
	www.cureresearch.com /medical/immune_mediated_encephalomyelitis.htm (310 words)

	[Frontiers in Bioscience 7, d541-555, Feburary 1, 2002]
		Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system.
		After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease, an immune-mediated encephalomyelitis.
		The infiltrating immune cells have been characterized as CD4-positive, CD8-positive T-cells, macrophages and B cells.
	www.bioscience.org /2002/v7/d/stitz/3.htm (171 words)

	Acute Disseminated Encephalomyelitis
		Demyelinating disorder of the CNS that seems to be immune mediated.
		Virus usually is not isolated from the nervous system, an allergic or autoimmune reaction is most likely.
		The exception is measles, in which sequelae may occur in 20 to 50% of patients.
	www.neuroland.com /ms/adem.htm (295 words)

	Acute Disceminated Encephalomyelitis
		In Reply to: Acute Disceminated Encephalomyelitis posted by Jeff Scott on February 07, 1998 at 20:50:32:
		Acute Disseminated Encephalomyelitis is a "demylinating" disorder (analogous to losing the insulation around nerves) that may occur following a viral infection, rabies vaccine, or without a known preceding cause.
		Multiple sclerosis is also a "demylinating disorder" and is thought to be caused by an immune-mediated process.
	www.medhelp.org /perl6/neuro/archive/3326.html (341 words)

	Characterization of T-Cell Repertoire of the Bone Marrow in Immune-Mediated Aplastic Anemia: Evidence for the ...
		The present study reveals heterogeneity in the immune mechanisms of AA for the first time.
		Young NS: Pathophysiology II: Immune suppression of hematopoiesis, in Young NS, Alter BP (eds): Aplastic Anemia Acquired and Inherited.
		Zoumbos NC, Gascon P, Djeu JY, Young NS: Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.
	www.bloodjournal.org /cgi/content/full/93/9/3008 (5474 words)

	Medical Dictionary: Immune suppression - CureResearch.com
		Immune suppression: Another name for Immune deficiency conditions.
		Immune suppression (condition): Any of various diseases that suppress the immune system.
		More information on medical condition: Immune deficiency conditions:
	www.cureresearch.com /medical/immune_suppression.htm (205 words)

	Welcome to Medical OnLine
		The presence of oligoclonal bands, a substantial pleocytosis, or PMNs or red cells in the CSF should suggest such possibilities as acute multiple sclerosis, acute hemorrhagic leukoencephalitis, HIV-associated leukoencephalomyelopathy, multifocal VZV leukoencephalitis, or postinfectious or vaccinal immune-mediated encephalomyelitis.
		Prior to the HIV epidemic, common associated diseases included lymphoproliferative disorders, immune deficiency states, myeloproliferative disease, and chronic infectious or granulomatous diseases.
		Since 1984, the importance of these associated disorders has been dwarfed by that of AIDS.
	www.medicalonline.com.au /medical/faq.htm (1174 words)

	Immune-Mediated Encephalomyelitis Treatment and Symptoms
		Acute disseminated encephalomyelitis (ADE) is a neurological disorder characterized by inflammation of the brain and spinal cord caused by damage to the myelin sheath.
		Every day, thousands of users find businesses like yours in the GoldBamboo directory.
		Your Integrative Health and Wellness Resource for Immune-Mediated Encephalomyelitis.
	goldbamboo.com /topic-t3319.html (164 words)

	From the Cover: Delayed neuropathology after carbon monoxide poisoning is immune-mediated -- Thom et al. 101 (37): ...
		Anionic isoforms of MBP occur in a number of neurodegenerative
		oxidative stress causes alterations in MBP and that immune responses
		immune cells and resident cells in the brain as a consequence
	www.pnas.org /cgi/content/full/101/37/13660 (3739 words)

	Immune-Mediated Destruction of Melanocytes in Halo Nevi Is Associated with the Local Expansion of a Limited Number of T ...
		program of the normal nevi to which the immune system is normally
		Therefore, the destruction of melanocytes in the halo
		T lymphocyte repertoire in Theiler’s virus encephalomyelitis: the nonspecific infiltration of the central nervous system of infected SJL/J mice is associated with a selective local T cell expansion.
	www.jimmunol.org /cgi/content/full/162/3/1789 (4051 words)

	Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study -- ...
		Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study -- Rovaris et al.
		Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study
		Systemic immune mediated diseases (SIDs) can often affect theCNS.
	jnnp.bmjjournals.com /cgi/content/full/68/2/170 (5423 words)

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