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Topic: Immune cells


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  Teachers' Domain: Immune Cells in Action
The immune system is a collection of molecules, cells, and organs whose complex interactions form a defense network capable of protecting the body from organisms that cause disease.
Immune cells like the macrophages, for example, are very good at cleansing the body of invading organisms whenever they happen upon them.
Memory cells also produce huge quantities of antibody molecules, but more important is their role in "immune memory." Memory cells are extremely long-lived and retain the ability to recognize and fight invaders they've seen before -- often for as long as the host organism remains alive.
www.teachersdomain.org /9-12/sci/life/cell/immune/index.html   (543 words)

  
  White blood cell - Wikipedia, the free encyclopedia
Granulocytes are a category of white blood cells, characterised by the fact that all types have differently staining granules in their cytoplasm on light microscopy.
B cells make antibodies that bind to pathogens to enable their destruction.
A type of cancer in which white blood cells multiply out of control is called leukemia.
en.wikipedia.org /wiki/Immune_cell   (444 words)

  
 Immune System - NIAID Net News
The immune system is a complex of organs--highly specialized cells and even a circulatory system separate from blood vessels--all of which work together to clear infection from the body.
The two major classes of lymphocytes are B cells, which grow to maturity in the bone marrow, and T cells, which mature in the thymus, high in the chest behind the breastbone.
B cells produce antibodies that circulate in the blood and lymph streams and attach to foreign antigens to mark them for destruction by other immune cells.
www.niaid.nih.gov /final/immun/immun.htm   (979 words)

  
 MedlinePlus Medical Encyclopedia: Immune response
The immune response is how your body recognizes and defends itself against bacteria, viruses, and substances that appear foreign and harmful to the body.
This allows the immune system to respond faster and more efficiently the next time you are exposed to the same antigen, and in many cases will prevent you from getting sick.
A blood differential count may reveal an high percentage of phagocytes (white blood cells that eat other cells), meaning that the body is responding to a need to fight infection.
www.nlm.nih.gov /medlineplus/ency/article/000821.htm   (1151 words)

  
 Immune System
Parts of the immune system are antigen-specific (they recognize and act against particular antigens), systemic (not confined to the initial infection site, but work throughout the body), and have memory (recognize and mount an even stronger attack to the same antigen the next time).
A phagocyte is a cell that attracts (by chemotaxis), adheres to, engulfs, and ingests foreign bodies.
T cells are nonantibody-producing lymphocytes which are also produced in the bone marrow but sensitized in the thymus and constitute the basis of cell-mediated immunity.
uhaweb.hartford.edu /BUGL/immune.htm   (3339 words)

  
 Immune System
T cells are like the soldiers, destroying the invaders that the intelligence system has identified.
The T cells are part of the system that destroys antigens that have been tagged by antibodies or cells that have been infected or somehow changed.
T cells are also involved in helping signal other cells (like phagocytes) to do their jobs.
www.kidshealth.org /parent/general/body_basics/immune.html   (2141 words)

  
 GMHC: Immune Basics
Your immune system is a complex network of cells and organs that work together to defend your body from viruses, bacteria, fungi, and protozoa.
Antigen-presenting cells are already in your body and digest these intruders and display the antigen on their surface.
Although CD8 T cells have many roles, one of the most important is to kill the cells that have become infected by an antigen.
gmhc.org /health/treatment/immune_basics.html   (844 words)

  
 Future of Stem Cells and Stem Cell Research
Stem cell investment, research effort, and treatment focus is moving rapidly away from embryonic stem cells (ethical and technical challenges) to adult stem cells which are turning out to be far easier to convert into different tissues than we thought in 2000-2003.
I have met a number of leading researchers, and their progress in stem cell research is now astonishing, while over 2,000 new research papers on embryonic or adult stem cells are published in reputable scientific journals every year.
Using embryos as a source of spare-part cells will always be far more controversial than using adult tissue, or perhaps cells from umbilical cord after birth, and investors will wish to reduce uneccessary risk, both to the projects they fund, and to their own organisations by association.
www.globalchange.com /stemcells2.htm   (2440 words)

  
 HRF Greenpapers: Boosting Immunity
Memory cells, as the name implies, remember specific foreign cells or chemicals to which they have been exposed, and react immediately when they are next exposed to those compounds.
They increase the activity of the immune system but are not specific to a particular disease or "antigen" (a protein against which immune cells act).
It increases the number of "stem cells" in the marrow and lymph tissue, and stimulates their development into active immune cells which are released into the body.
www.herbs.org /greenpapers/immune.html   (1989 words)

  
 BBC NEWS | Health | Immune cells 'beat cancer'
To prime patients for the treatment, they were first given chemotherapy to knock-out their own immune cells which had been unable to fight the cancer, making room for the new, improved cells.
These T cells multiplied in the body and were able to attack the tumour cells, and took over the patient's immune system enabling it to fight the cancer for several months.
But he said improvements in the way immune cells are generated in the laboratory and the way patients' bodies are prepared to receive them, have led to more successful treatments.
news.bbc.co.uk /1/hi/health/2268735.stm   (617 words)

  
 Cancer disarms immune stystem cells
However, some cancers do produce antigens, the proteins that act as red flags for the immune system, and anti-cancer immune cells are occasionally found in tumors or the lymph nodes.
In six out of 11 patients, there were significant numbers of killer T cells targeted against the melanoma, and in one patient, some 2 percent of all the killer T cells in the blood were aimed at the cancer.
For example, when T cells from one patient were placed in a miniature arena with melanoma cells, the T cells refused to attack.
mednews.stanford.edu /releases/1999/junreleases/immune.html   (836 words)

  
 Donor Immune Cells Attack Metastatic Breast Cancer - National Cancer Institute
Tumor regression has been observed in the past in some patients with metastatic breast cancer who received stem cell transplants, but it was unclear whether immune cells had attacked the tumor or the tumor was shrinking in response to chemotherapy drugs administered prior to the transplant.
HLA-matched donor cells, which have the same set of proteins (known as human leukocyte-associated antigens) on their surface as the patient's own cells, are much more likely to be accepted by the patient's body.
T cells, specialized immune cells that recognize and kill foreign cells that have invaded the body, were removed from the pool of donated stem cells prior to transplant.
cancer.gov /newscenter/pressreleases/bishop   (489 words)

  
 NIH News--Donor Immune Cells Attack Metastatic Breast Cancer--06/01/2003
Tumor regression has been observed in the past in some patients with metastatic breast cancer who received stem cell transplants, but it was unclear whether immune cells had attacked the tumor or the tumor was shrinking in response to chemotherapy drugs administered prior to the transplant.
HLA-matched donor cells, which have the same set of proteins (known as human leukocyte-associated antigens) on their surface as the patient's own cells, are much more likely to be accepted by the patient's body.
T cells, specialized immune cells that recognize and kill foreign cells that have invaded the body, were removed from the pool of donated stem cells prior to transplant.
www.nih.gov /news/pr/jun2003/nci-01.htm   (487 words)

  
 The Immune System
The immune system protects us from invaders in the form of bacteria, viruses and so on, if we supply it with the proper materials.
These are found in the blood, thymus gland, bone marrow, spleen, and lymph notes in the neck, groin, and armpits as well as near the intestines.
Immune cells rely upon micro-electrical fields to communicate with each other.
immune.altmedangel.com /immune.htm   (1218 words)

  
 Medical College of Wisconsin - Immune System Cells Identified as Potential Tool to Improve Transplants
These cells are normally produced by the thymus gland, but in bone marrow transplant patients they may not be present in sufficient numbers immediately after transplant to prevent the harmful adverse immune reaction that leads to graft-vs-host disease.
The thymus has to be repopulated with the progenitor cells in the donor bone marrow that give rise to regulatory T-cells.
The goal would be to supply patients with functioning cells to correct the defect and turn off the body's immune response to its own tissue.
www.mcw.edu /display/router.asp?docid=1921   (1018 words)

  
 HIV and AIDS Tutorial
These cells called dendritic cells or Langerhans cells can move through out our body, and are particularly rich in our skin and mucus membranes of our body that are exposed to foreign material, including our disgestive systems, airways, and sexual apparatuses.
The significance of the dendritic cells is that they can prevent you from reacting against your own tissues, against food that you ingest or harmless materials from your environment, or they can tell the rest of your immune system to make an adaptive immune response.
Memory helper T cells are labeled CD4+ CCR5+, to note that the chemokine receptor (CCR5) is present on the surface of the helper T cell.
www.biology.arizona.edu /immunology/tutorials/AIDS/response.html   (701 words)

  
 Cell Wars
Immune cells vs. invaders: it's a war going on in every healthy human body.
There are many kinds of immune cells; two of the most important are B-cells, which send out antibodies -- proteins that latch onto germs or other problem-causing invaders, flagging them as invaders to be destroyed, and T-cells, which are the soldiers of the system, physically attacking and destroying pathogens.
The two major classes of lymphocytes are B cells and T cells.
science.nasa.gov /headlines/y2002/23jan_cellwars.htm   (1381 words)

  
 Americans for Medical Progress : Tumor-targeted immune cells cure prostate cancer in mice
In a major breakthrough in cancer gene therapy, a Northwestern University researcher has endowed immune cells with the ability to specifically target metastatic prostate cancer in mice without causing the toxic immune suppression that has been associated with earlier forms of cancer gene therapy.
The researchers first rendered immune cells known as CD8+ T cells insensitive to transforming growth factor beta (TGF-beta), a powerful, naturally occurring substance in the body that enables cancer cells to evade surveillance by the body's immune system.
TRAMP-C2 prostate cancer cells produce large amounts of TGF-beta, and possess such potent immunosuppressive power that regular CD8+ T cells are unable to infiltrate tumor tissues, Lee explained.
www.ampef.org /News/News.cfm?ID=792&c=62   (374 words)

  
 Medical College of Wisconsin - Researchers identify immune regulation cells, harness their power to improve transplants
Bone marrow transplant is used to treat cancers of the blood, such as leukemia and lymphoma, as well as congenital immune deficiency diseases and aplastic anemia.
The immune system is activated by foreign bodies such as viruses; and when the threat has passed, it must turn off.
When a patient is prepared for a bone marrow transplant, the cells of his or her immune system, including those in the thymus, are completely wiped out.
www.mcw.edu /display/router.asp?docid=2805   (982 words)

  
 September 25, 2003 - Researchers Solve the Mystery of a Key Structure in Immune System Cells
The immune cell structure acts much like the iris in the eye, which adjusts to let vision function from very dark to very bright conditions, explains Michael Dustin, Ph.D., the Irene Diamond Associate Professor of Immunology at NYU School of Medicine, one of the study’s lead authors.
Researchers are hopeful that now that the role of this channel of communication has been identified, it may serve as a potential target for treating diseases — those in which the body attacks itself, such as in arthritis, as well as those in which the body doesn’t recognize the attacker, such as tumors.
In this process, the receptors are pulled inside of the cell, and sorted according to their signaling history: If they were part of intense signaling, they’re degraded, but if not, they’re returned to the surface.
www.med.nyu.edu /communications/news/pr_26.html   (1332 words)

  
 Information on the immune system - InnerVibrance.Com
It is thought that the infectious agents remain dormant in the body tissue and once aware of a weakness in the immune system, attack the body's cells.
To be effective, the immune system must have the ability to recognize these clever, camouflaged intruders and destroy them before they do any damage to the body.
Proper digestion is key to a healthy immune system, by exercising you are also promoting better digestive function which will aid in keeping your body clean of toxins and keep the immune system healthy.
www.innervibrance.com /immune_system   (828 words)

  
 Cell biology glossary
Cells seeded on patterned surfaces are only able to attach to the adhesive areas and consequently adopt the shape of the adhesive island.
Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp).
Cell rupture caused by physical or chemical means, or by phage infection and propagation leading to the release of the cell content; also the death of microorganisms after the stationary phase of a batch fermentation.
www.genomicglossaries.com /content/cell_bio.asp   (6668 words)

  
 Cells Stop Immune Inflammation 071003   (Site not responding. Last check: 2007-10-15)
Boston, MA Scientists at Schepens Eye Research have found that the iris pigment epithelium (IPE), a thin layer of cells lining the iris of the eye, produces a molecule that disables T Cells, the cells that normally attack and kill foreign microbes invading the body.
CD86 is normally used by cells of the immune system to stimulate T cells, but CD86 on iris PE has the opposite effect.
The researchers concluded that iris PE cells achieve immune privilege by high-jacking CD86 from the immune system, and then using this molecule to fool T cells into submission.
www.theschepens.org /cells_stop_immune_inflammation_071003.htm   (597 words)

  
 The Immune System - Overview
The cells of the immune system work together with different proteins to seek out and destroy anything foreign or dangerous that enters our body.
It takes some time for the immune cells to be activated - but once they're operating at full strength, there are very few hostile organisms that stand a chance.
Immune cells are white blood cells produced in huge quantities in the bone marrow.
nobelprize.org /educational_games/medicine/immunity/immune-overview.html   (790 words)

  
 Genetically modified natural killer immune cells attack, kill leukemia cells
Progress in adapting NK cells to the treatment of ALL had been significantly hampered because researchers were not able to grow large numbers of these immune cells in the laboratory, and because NK cells normally have only weak anti-leukemic activity.
The technique triggered growth of NK cells specifically, which greatly simplified the ability of the researchers to collect a pure population of these immune cells.
In another application, NK cells could be obtained from a patient while in remission and then reinfused after genetic modification if the patient suffers a resurgence of the leukemia.
www.medicalnewstoday.com /medicalnews.php?newsid=21818   (764 words)

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