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Topic: Immunodeficiency


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In the News (Thu 3 Dec 09)

  
  Immunodeficiency - Wikipedia, the free encyclopedia
In medicine, immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.
Most cases of immunodeficiency are either congenital or acquired.
Although elderly people are generally more susceptible to infections, this can be increased in the presence of a number of blood disorders (see hematology); important examples are multiple myeloma and chronic lymphatic leukemia (CLL).
en.wikipedia.org /wiki/Immunodeficiency   (226 words)

  
 MedlinePlus Medical Encyclopedia: Immunodeficiency disorders
Immunodeficiency disorders occur when the immune response is reduced or absent.
Immunodeficiency causes persistent or recurrent infections, severe infections by organisms that are normally mild, incomplete recovery from illness or poor response to treatment, and an increased incidence of cancer and other tumors.
Acquired immunodeficiency may be a complication of diseases such as HIV infection and AIDS (acquired immunodeficiency syndrome).
www.nlm.nih.gov /medlineplus/ency/article/000818.htm   (1210 words)

  
 THE MERCK MANUAL--SECOND HOME EDITION, Introduction in Ch. 184, Immunodeficiency Disorders
Immunodeficiency disorders impair the immune system's ability to defend the body against foreign or abnormal cells that invade or attack it (such as bacteria, viruses, fungi, and cancer cells).
An immunodeficiency disorder may be present at birth (congenital, or primary) or may develop later in life, often as a result of another disorder (acquired, or secondary).
Immunodeficiency disorders are grouped by which part of the immune system (see Biology of the Immune System: Introduction) is affected.
www.merck.com /mmhe/sec16/ch184/ch184a.html   (1453 words)

  
 Immunodeficiency
Acquired immunodeficiency is most commonly caused by disease, such as malnutrition, sickle cell anemia, cancers, and diabetes; infections, such as measles, bacterial and fungal infections, and cytomegalovirus; or as a side effect of certain drugs and therapies used in the treatment of chronic disease.
It is common for children with immunodeficiencies to develop thrush, a fungal infection of the mouth, and other infections of the skin and mucous membranes in the eyes, mouth, and genital area.
Immunodeficiency disorders are diagnosed through blood tests, which are studied for the presence of immune components such as antibodies, lymphocytes, and phagocytes.
www.hmc.psu.edu /healthinfo/i/immunodeficiency.htm   (858 words)

  
 Home | aHealthyme.com
Immunodeficiency disorders are a group of disorders in which part of the immune system is missing or defective.
Acquired immunodeficiency is the result of a disease process, and it occurs later in life.
However, someone with a congenital immunodeficiency disorder might want to consider getting genetic counseling before having children to find out if there is a chance they will pass the defect on to their children.
www.ahealthyme.com /article/gale/100084769   (2628 words)

  
 IDF - Clinical Manifestations of the Primary Immunodeficiency Diseases   (Site not responding. Last check: 2007-10-20)
Although the initial description of patients with primary immunodeficiency diseases focused on their increased susceptibility to infection, these patients may also present with a variety of other clinical manifestations.
An increased susceptibility to infection is the hallmark of the primary immunodeficiency diseases.
In other patients with primary immunodeficiency, however, the clinical manifestations of the autoimmune disease may be more global and involve a number of different target organs, have an associated vasculitis, or resemble "classic" rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, and/or dermatomyositis.
www.primaryimmune.org /pubs/book_phys/phys_p04.htm   (813 words)

  
 ► Immunodeficiency disorders
This causes persistent or recurrent infections, severe infections by organisms that are normally mild, incomplete recovery from illness or poor response to treatment, and an increased incidence of cancer and other tumors.
Examples of congenital immunodeficiency disorders of antibody production (B lymphocyte abnormalities) include hypogammaglobulinemia (lack of one or more specific antibodies) -- which usually causes repeated mild respiratory infections, and agammaglobulinemia (lack of all or most antibody production) -- which results in frequent severe infections and is often fatal.
People are said to be "immunosuppressed" when they experience immunodeficiency that is caused by medications such as corticosteroids or other immunosuppressant medications.
www.umm.edu /ency/article/000818.htm   (675 words)

  
 IDF - Immunodeficiency Diseases   (Site not responding. Last check: 2007-10-20)
Although the exact etiology of many immunodeficiency diseases is unknown, several etiologic factors have been identified in specific disorders.
The primary immunodeficiency diseases are not limited to infancy or early childhood.
The average age at diagnosis of common variable immunodeficiency is 27 years.
www.primaryimmune.org /pubs/book_nurse/nurse_p08.htm   (414 words)

  
 National Primary Immunodeficiency ResourceCenter   (Site not responding. Last check: 2007-10-20)
Less commonly, immunodeficient patients may have abscesses of their internal organs, such as the liver, or infections of their blood; however, the common theme is that they have more infections than they or their doctor believes is appropriate.
Primary Immunodeficiencies are a diverse group of disorders that predisposes patients to develop recurrent infections.
If the gene for a Primary Immunodeficiency disease is passed on from parent to child, it may then be passed on from that child to some of their children, and so on and so on.
npi.jmfworld.org /faq/index.cfm?section=faq&CFID=3169571&...   (5770 words)

  
 The Severe Combined Immunodeficiency (scid) Mutation - The Jackson Laboratory
The mice were determined to lack both T and B cells resulting in a disease similar to severe combined immunodeficiency as reported in humans (Giblett, et al., 1972; Hirshhorn, et al., 1979; McKusick, 1990) and Arabian foals (McGuire, et al., 1974).
The severe immunodeficiency in scid/scid mice results in increased susceptibility to opportunistic microorganisms, requiring specific pathogen free facilities for their maintenance.
Severe combined immunodeficiency occurs in humans as an autosomal recessive trait (Hirschhorn, et al., 1979; McKusick, 1990) or X-linked characteristic (McKusick, 1990) that is clinically very similar to the mouse scid mutation.
jaxmice.jax.org /library/notes/453a.html   (1752 words)

  
 Immunodeficiency disorders
Even deliberate immunosuppression (in the treatment of autoimmune disorders for example) attempts to maintain a balance between suppression of parts of the immune system and the ability to fight disease and infection.
Passive immunity (administration of antibodies produced by another person or animal) may occasionally be recommended to prevent illness after exposure to a microorganism.
Suppression of the immune system may be desired in the treatment of certain disorders, or it may be a side effect of some treatments.
www.jrmc.org /adam/ency/article/000818.htm   (1114 words)

  
 The Immunodeficiency Clinic - University Health Network
The Immunodeficiency Clinic is part of the Toronto Hospital, which is a teaching hospital affiliated with the University of Toronto.
The Immunodeficiency Clinic is not responsible for coverage (payment) of medications, although we will help you to get any and all coverage that you may be entitled to under social and community programs.
The Immunodeficiency Clinic is open Monday to Friday from 8:00 a.m., to 5:00 p.m.
www.tthhivclinic.com /about.htm   (1226 words)

  
 Common Variable Immunodeficiency
Common Variable Immunodeficiency (CVI) is a group of rare genetic (primary) immunodeficiency disorders in which abnormalities in immune cell development (maturation) result in a decreased ability to appropriately produce antibodies in response to invading microorganisms, toxins, or other foreign substances.
The term "Common Variable Immunodeficiency" is used to designate an immune defect in which there is a substantial reduction of the level of immunizing agents (immunoglobulins) in the fluid portion of the blood (serum).
In some cases, individuals with Common Variable Immunodeficiency have an increased tendency to develop certain diseases characterized by abnormal tissue growths (neoplasms) that may be benign or malignant.
my.webmd.com /hw/health_guide_atoz/nord807.asp   (630 words)

  
 Immunodeficiency
Individuals with immunodeficiencies are susceptible to a variety of infections and the type of infection depends on the nature of immunodeficiency (Table 1).
There are variety of immunodeficiencies which result from defects in stem cells differentiation and may involve T-cells, B-cells, and/or immunoglobulins of different classes and subclasses (Table 2).
IgA deficiency is the commonest of all immunodeficiencies (1/700 of all Caucasians).
pathmicro.med.sc.edu /ghaffar/immunodef2000.htm   (1717 words)

  
 MSN Encarta - Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome (AIDS), human viral disease that ravages the immune system, undermining the body’s ability to defend itself from infection and disease.
Caused by the human immunodeficiency virus (HIV), AIDS leaves an infected person vulnerable to opportunistic infections.
Such infections are harmless in healthy people, but in those whose immune systems have been greatly weakened, they can prove fatal.
encarta.msn.com /encnet/refpages/RefArticle.aspx?refid=761554539   (840 words)

  
 Primary Immunodeficiency   (Site not responding. Last check: 2007-10-20)
The focus of this booklet is primary immunodeficiency disease that is heritable.
Immunodeficiency: a condition where the immune response is deficient or subnormal.
Secondary immunodeficiency: immunodeficiency that is acquired and not inherited.
www.nichd.nih.gov /publications/pubs/primaryimmunobooklet.htm   (13987 words)

  
 [No title]
Immunodeficiency is a disorder or condition where the immune response is reduced or absent.
Immunodeficiency can be traced to the failure of one or more parts of the immune system.
Examples of congenital immunodeficiency disorders of antibody production (B lymphocyte abnormalities) include hypogammaglobulinemia (decrease of one or more specific antibodies) which usually causes repeated mild respiratory infections, and x-linked agammaglobulinemia (lack of all or most antibody production) which results in frequent severe infections and is often fatal.
www.utoronto.ca /kids/Immunodeficiency.htm   (994 words)

  
 THE MERCK MANUAL, Sec. 12, Ch. 147, Immunodeficiency Diseases
A cellular immunodeficiency characterized by persistent Candida infection of the mucous membranes, scalp, skin, and nails and often associated with an endocrinopathy, particularly hypoparathyroidism and hypoadrenalism.
Malnutrition with immunodeficiency and infection is the world's leading cause of infant and child death.
The immunologic defect is primarily a T-cell immunodeficiency with cutaneous anergy, low T-cell levels, poor proliferative responses to mitogens and antigens, and deficiency of lymphokines (interferon) and cytotoxic activity.
www.merck.com /pubs/mmanual/section12/chapter147/147c.htm   (3186 words)

  
 acquired immunodeficiency syndrome on Encyclopedia.com   (Site not responding. Last check: 2007-10-20)
Longitudinal patterns of California Medicaid recipients with acquired immunodeficiency syndrome.
New Jersey's Medicaid waiver for acquired immunodeficiency syndrome.
State policies and the financing of acquired immunodeficiency syndrome care.
www.encyclopedia.com /html/X/X-acqimmu.asp   (273 words)

  
 Immunodeficiency -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-20)
Most cases of immunodeficiency are either (additional info and facts about congenital) congenital or acquired.
A number of (additional info and facts about rare disease) rare diseases feature a heightened susceptibility to (The pathological state resulting from the invasion of the body by pathogenic microorganisms) infections from childhood onward.
This feature is used to suppress immune activity in (Any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues) autoimmune disorders with (additional info and facts about DMARD) DMARDs.
www.absoluteastronomy.com /encyclopedia/i/im/immunodeficiency.htm   (196 words)

  
 Primary Immunodeficiency Diseases - What Are Primary Immunodeficiency Diseases?
Primary immunodeficiency diseases are caused by intrinsic defects in the cells of the immune system and are often caused by inherited genetic defects.
This is in contrast to secondary immunodeficiency diseases such as acquired immunodeficiency syndrome caused by infection with human immunodeficiency virus.
The hallmark of primary immunodeficiency diseases is increased susceptibility to infection, but they can cause other problems as well.
www.medhelp.org /NIHlib/GF-739.html   (375 words)

  
 X-linked severe combined immunodeficiency - Genetics Home Reference
X-linked severe combined immunodeficiency (SCID) is an inherited disorder of the immune system that occurs almost exclusively in males.
Boys with X-linked SCID are prone to recurrent and persistent infections caused by certain bacteria, viruses, and fungi.
The exact incidence is unknown, but the condition probably affects at least 1 in 50,000 to 100,000 births.
ghr.nlm.nih.gov /condition=xlinkedseverecombinedimmunodeficiency   (718 words)

  
 Autoimmunity in human primary immunodeficiency diseases -- Arkwright et al. 99 (8): 2694 -- Blood
Human primary immunodeficiency diseases are experiments of nature characterized by an increased susceptibility to infection.
Classification of autoimmune phenomena in primary immunodeficiency diseases is problematic.
Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency.
www.bloodjournal.org /cgi/content/full/99/8/2694   (6156 words)

  
 Immune System Immunodeficiency Diseases
Very rarely, infants are born lacking all the major immune defenses; this is known as severe combined immunodeficiency disease (SCID).
The devastating immunodeficiency disorder known as the acquired immunodeficiency syndrome (AIDS) was first recognized in 1981.
Caused by a virus (the human immunodeficiency virus, or HIV) that destroys T4 cells and that is harbored in macrophages as well as T4 cells, AIDS is characterized by a variety of unusual infections and otherwise rare cancers.
www.immunecentral.com /immune-system/iss21.cfm   (577 words)

  
 Immunodeficiency
These immunodeficiency disorders are also called primary immunodeficiencies.
In 2003, a new infection emerged that is produces immunodeficiency.
Congenital immunodeficiency is caused by genetic defects, which generally occur while the fetus is developing in the womb.
www.healthatoz.com /healthatoz/Atoz/ency/immunodeficiency.jsp   (2969 words)

  
 Immunodeficiency Disorders -- Cooper et al. 2003 (1): 314 -- Hematology
Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM.
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.
Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells.
www.asheducationbook.org /cgi/content/full/2003/1/314   (8908 words)

  
 Severe combined immunodeficiency
It is a group of congenital disorders in which both the humoral part of the patient's immune system and the cells involved in immune responses fail to work properly.
Children with this form of SCID are lacking a type of white blood cell called a granulocyte.
In order to understand why SCID is considered the most severe immunodeficiency disorder, it is helpful to have an outline of the parts of the human immune system.
www.lifesteps.com /gm/Atoz/ency/severe_combined_immunodeficiency.jsp   (1008 words)

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