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Topic: Immunogenicity

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	IMMUNOGENICITY OF FDA DTP VERSUS WHO DTP (Site not responding. Last check: 2007-11-05)
		It is possible that the response after the third dose was enhanced because children were primed with a lower dose in the FDA group, or perhaps was a reflection of the quality of the antigen which can evoke a strong priming and a good immunological memory.
		A study which was done in Australia showed that the increase in diphtheria or tetanus concentration was not associated with an increase in the reported systemic or local clinical signs associated with the first three doses.
		Immunogenicity of tetanus and diphtheria did not correlate with the antigen dose contained in the vaccine.
	www.kfshrc.edu.sa /annals/195/98-271.html (1540 words)

	University of Maryland School of Medicine - Center for Vaccine Development
		Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD 103.
		Expression and immunogenicity of a mutant diphtheria toxin molecule, CRM(197), and its fragments in Salmonella typhi vaccine strain CVD 908- htrA.
		A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fourth dose in 15- to 20-month-old children.
	medschool.umaryland.edu /cvd/publications.asp (15926 words)

	Recommendations for Use of Haemophilus b Conjugate Vaccines and a Combined Diphtheria, Tetanus, Pertussis, and ...
		For infants, the immunogenicity of PRP-OMP (which has a carrier derived from the meningococcal outer membrane protein) appears to be unaffected by the absence of prior or concurrent DTP vaccination (24).
		Immunogenicity studies among infants who received TETRAMUNETM at ages 2, 4, and 6 months (37, Lederle Laboratories/Praxis Biologics, unpublished data) indicated that antibody responses to Hib PRP, diphtheria, and tetanus toxins were comparable to or higher than those in persons who received separate, but concurrent administration of DTP and HbOC vaccines.
		Hib vaccine is immunogenic in patients with increased risk for invasive disease, such as those with sickle-cell disease (46), leukemia (47), human immunodeficiency virus (HIV) infection (48,49), and in those who have had splenectomies (50).
	www.cdc.gov /mmwr/preview/mmwrhtml/00023705.htm (5428 words)

	Haemophilus b Conjugate Vaccines for Prevention of Haemophilus influenzae Type b Disease Among Infants and Children Two ...
		After demonstration of safety, immunogenicity, and induction of serum bactericidal activity, an efficacy of 90% (95% confidence interval (CI) = 50%-95%) was shown for one dose of vaccine given to children 18-71 months old in a large trial in Finland.
		A subsequent immunogenicity study documented antibody responses that were similar to those in the Alaskan and Finnish efficacy trials ( Table_2).
		Studies suggest, however, good immunogenicity in patients with sickle cell disease (15), leukemia (16), patients who have had splenectomies (17) or who have HIV infection (18,19), and administering vaccine to these patients is not contraindicated.
	www.cdc.gov /mmwr/preview/mmwrhtml/00041736.htm (3315 words)

	EID Vol 2 No 4:
		The reason for the vaccine's poor immunogenicity and its lack of efficacy in children is thought to be the nature of the PS antigen.
		Immunogenicity in infants of a vaccine composed of Haemophilus influenzae type b capsular polysaccharide mixed with DPT or conjugated to diphtheria toxoid.
		Immunogenicity of heptavalent pneumococcal conjugate vaccine in infants.
	www.cdc.gov /ncidod/EID/vol2no4/kayhty.htm (5811 words)

	Pneumococcal Vaccination and Revaccination of Older Adults -- Artz et al. 16 (2): 308 -- Clinical Microbiology Reviews
		Immunogenicity of pneumococcal revaccination in patients with chronic disease.
		Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine.
		Immunogenicity and tolerance of a 7-valent pneumococcal conjugate vaccine in nonresponders to the 23-valent pneumococcal vaccine.
	cmr.asm.org /cgi/content/full/16/2/308 (6846 words)

	Virtual Naval Hospital: Guide to Clinical Preventive Services, Second Edition (Site not responding. Last check: 2007-11-05)
		A comparative trial of the reactogenicity and immunogenicity of Takeda acellular pertussis vaccine combined with tetanus and diphtheria toxoids: outcome in 3- to 8-month-old infants, 9- to 23-month-old infants and children, and 24- to 30-month-old children.
		Measles vaccine immunogenicity in 6- versus 15-month-old infants born to mothers in the measles vaccine era.
		Immunogenicity, safety and tolerability of varying doses and regimens of inactivated hepatitis A virus vaccine in Navajo children.
	www.vnh.org /GCPS2/75.html (6968 words)

	Hepatitis Central, Safety and Immunogenicity of Hepatitis A Vaccine in Patients With Chronic Liver Disease
		A secondary objective was to compare the safety of the hepatitis A vaccine with that of a commercial hepatitis B vaccine in subjects with chronic hepatitis C. A total of 475 subjects over the age of 18 years were enrolled into 1 of 5 groups according to history, serological data, and previous diagnosis.
		The vaccine has, however, been shown to be immunogenic for at least 2 years and to be well tolerated in adults and children with hemophilia when administered subcutaneously (to reduce risk of hematoma).
		Thus, a study was undertaken to evaluate the safety and immunogenicity of an inactivated hepatitis A vaccine in patients with chronic hepatitis B and C and with CLD of other etiologies compared with a control group of healthy adults.
	www.hepatitis-central.com /hcv/hav/vaccine/safety.html (4798 words)

	Jornal de Pediatria - Immunogenicity of hepatitis B vaccination in preterm infants started soon after birth: ... (Site not responding. Last check: 2007-11-05)
		Nevertheless, research into the immunogenicity of early vaccination (begun during the first few days of life) of preterm NB has been inconclusive with disagreement between the various studies available in published literature.
		The first implication, pointed out by Sadeck and Ramos in the conclusions of their article, is the need for serological tests after the original three-dose vaccination when the preterm NB has been vaccinated during the first week of life because of the possibility that the child will need booster doses to achieve satisfactory anti-HBs antibodies.
		Immunogenicity of hepatitis B vaccine in preterm and full term infants vaccinated within the first week of life.
	www.scielo.br /scielo.php?script=sci_arttext&pid=S0021-75572004000200003&lng=en&nrm=iso&tlng=en (1699 words)

	immunogenicity (Site not responding. Last check: 2007-11-05)
		Immunogenicity of Recombinant Biological Therapeutics: A Practical Approach October 18-19, 2004 San Francisco, CA November 8-9, 2004 Boston, MA Instructors...
		Of the 21 patients currently enrolled, 11 were tested for overall immunogenicity and all 11 exhibited a strong immune response to NeuroVax(TM).
		Vaccine immunogenicity can be boosted using carbohydrate-protein conjugates where a large "carrier" protein, usually of bacterial origin, is added as the...
	www.biometnews.com /biotechnology/immunogenicity.html (382 words)

	Comparison of Immunogenicity and Safety of a Virosome Influenza Vaccine with Those of a Subunit Influenza Vaccine in ...
		The objective of this study was to compare the immunogenicity and safety of a single-dose regimen and a two-dose regimen of
		Immunogenicity of trivalent subunit versus virosome-formulated influenza vaccines in geriatric patients.
		Immunogenicity of trivalent subunit and split influenza vaccines (1989-1990 winter season) in volunteers of different age groups.
	aac.asm.org /cgi/content/full/44/5/1163 (3090 words)

	Gerd Ritter
		For therapeutic application, the immunogenicity of the injected antibody is of paramount importance.
		For example, mouse-derived monoclonal antibodies are highly immunogenic in humans and generally can be given only for a limited period of time before onset of a human anti-mouse Ig response (HAMA), which rapidly clears the murine antibody from the blood and may trigger anaphylactic reactions.
		To attenuate or abolish immunogenicity and to allow long-term treatment of patients without the interference of an anti-immunoglobulin response, various molecular technologies have been employed that reduce the amount of foreign Ig residues in a therapeutic antibody, a factor hypothesized to inversely correlate with the immunogenicity of an antibody.
	www.cancerresearch.org /antibodies2002/gerd_ritter.html (712 words)

	Biotechnology :: Biopharmaceutical immunogenicity: association between epoetin alfa and pure red :: Pharmaceutical ... (Site not responding. Last check: 2007-11-05)
		Biopharmaceutical immunogenicity: association between epoetin alfa and pure red cell aplasia This short review discusses the possible reasons for the recent upsurge in cases of pure red cell aplasia in chronic kidney disease patients treated with epoetin alfa.
		The increase in suspected cases of epoetin-associated PRCA coincided with the removal of human serum albumin from the epoetin alfa formulation and its replacement with polysorbate 80 and glycine as stabilisers.
		The majority of recorded cases of antibody-mediated PRCA occurred in patients receiving epoetin alfa by the subcutaneous route and, in Europe, use of epoetin alfa is now restricted to the intravenous route in renal patients.
	www.pharmainfo.net /displayarticle5415.html (258 words)

	Safety and Immunogenicity of Improved Shigella O-Specific Polysaccharide-Protein Conjugate Vaccines in Adults in Israel ...
		The immunogenicity of polysaccharide-based vaccines, including conjugates, is age dependent ( 46-48).
		Immunogens consisting of oligosaccharides from the capsule of Haemophilus influenzae type b coupled to diphtheria toxoid or the toxin protein CRM197.
		Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O-specific polysaccharide conjugates in children.
	iai.asm.org /cgi/content/full/69/3/1351 (4200 words)

	Immunology, Biology 328
		Immunogens For the induction of humoral immunity (antibody response), the most potent immunogens are macromolecular proteins or glycoproteins, but polysaccharides, synthetic peptides, and other synthetic polymers such as polyvinylpyrrolidone are immunogenic under appropriate conditions.
		Pure nucleic acids or lipids are not immunogenic but antibodies which react with them can be induced by immunization with nucleoproteins or lipoproteins.
		When the hapten is conjugated to a carrier (a large immunogenic molecule such as a protein) the animal responds by producing antibodies to both the hapten and the carrier.
	bioweb.wku.edu /faculty/Davis/Biol328/Lecture5.html (1148 words)

	Peptides, NIAID Division of AIDS, HIV Vaccine Site (Site not responding. Last check: 2007-11-05)
		In addition to the need for inclusion of helper epitopes, the intrinsically low immunogenicity of peptides requires that they be administered with strong adjuvants to enhance and/or modulate the nature of the response generated.
		Limited studies in humans (including HIV seropositive volunteers) have confirmed such immunogenicity: antibody responses, proliferative and CTL responses were generated after 3 doses of the vaccine; adoptive transfer of cells from vaccinees have been shown to protect SCID mice from challenge with HIV-1.
		Safety and immunogenicity of a V3 loop synthetic peptide conjugated to purified protein derivative in HIV-seronegative volunteers.
	www.niaid.nih.gov /daids/vaccine/peptides.htm (2185 words)

	Safety and immunogenicity of a paediatric presentation of an influenza vaccine -- Gonzalez et al. 83 (6): 488 -- ...
		Safety and immunogenicity of a paediatric presentation of an influenza vaccine -- Gonzalez et al.
		Table 3 summarises the immunogenicity results for each strain of vaccine virus, 30 days after the second injection.
		Reactogenicity and immunogenicity of bivalent influenza A and monovalent influenza B virus vaccine in high-risk children.
	adc.bmjjournals.com /cgi/content/full/archdischild%3b83/6/488 (2722 words)

	Increased Immunogenicity and Induction of Class Switching by Conjugation of Complement C3d to Pneumococcal Serotype 14 ...
		immunogenicity with that of a conjugate of PPS14 and ovalbumin
		conjugation on the immunogenicity of PPS14 in BALB/c mice.
		Immunogenicity of a Streptococcus pneumoniae type 4 polysaccharide-protein conjugate vaccine is decreased by admixture of high doses of free saccharide.
	iai.asm.org /cgi/content/full/69/5/3031 (6531 words)

	IMMUNOGENICITY AND SAFETY OF A VARICELLA VACCINE (OKAVAXTM) AND A TRIVALENT MEASLES, MUMPS, AND RUBELLA VACCINE ...
		Immunogenicity and safety of a live attenuated varicella vaccine (Oka/SB Bio) in healthy children.
		The immunogenicity and reactogenicity of the trivalent vaccine, Trimovax
		Measles, mumps, rubella, and varicella combination vaccine: safety and immunogenicity alone and in combination with other vaccines given to children.
	www.ajtmh.org /cgi/content/full/70/3/273 (2975 words)

	BioMed Central \| Full text \| Enhanced immunogenicity of a functional enzyme by T cell epitope modification
		We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation of recombinant protein-based vaccines.
		Consistent with this general understanding of the induction of antibody responses to protein immunogens, good antibody responses to synthetic peptide-epitope constructs have been shown to depend on the presence, orientation, and multiplicity of the T cell epitope in the construct [ 7-11 ].
		The improved immunogenicity of the variant was not related to changes in the proteolytic capacity of the enzyme, because the variant exhibited 80% of the activity of the parent enzyme.
	www.biomedcentral.com /1471-2172/3/2 (7486 words)

	: The AMEDEO Literature Guide
		Immunogenicity and reactogenicity of four doses of diphtheria-tetanus-three-component acellular pertussis-hepatitis B-inactivated polio virus-Haemophilus influenzae type b vaccine coadministered with 7-valent pneumococcal conjugate Vaccine.
		Immunogenicity of the seven valent pneumococcal conjugate vaccine in patients with ataxia-telangiectasia.
		Tolerability and immunogenicity of an eleven valent mixed carrier Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid or tetanus protein conjugate vaccine in Finnish and Israeli infants.
	www.amedeo.com /medicine/vac/pedinf.htm (2490 words)

	Enhanced In Vitro Potency and In Vivo Immunogenicity of a CTL Epitope from Hepatitis C Virus Core Protein following ...
		In vivo immunogenicity of C7A2-derived peptides in HLA-A2.1 transgenic mice.
		Immunogenicity of C7A2-substituted peptides in AAD transgenic mice.
		Takeshita, C.D. Pendleton, and J.A. Berzofsky (1997) Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence.
	www.jci.org /cgi/content/full/102/6/1239 (8220 words)

	An Endoplasmic Reticulum-Targeting Signal Sequence Enhances the Immunogenicity of an Immunorecessive Simian Virus ...
		ER targeting contributed to enhanced antigenicity and immunogenicity of determinant V in TAP-expressing cells.
		Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes.
		Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability.
	jvi.asm.org /cgi/content/full/72/2/1469 (8538 words)

	Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon -- ...
		All of the constructs were immunogenic, with the exception
		the immunogenicity of the constructs, as the immunogenicity between
		Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon.
	jap.physiology.org /cgi/content/full/91/5/2213 (6520 words)

	Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with ...
		Potent immunogenicity of the B subunits of Escherichia coli heat labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.
		Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.
		Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli.
	www.jem.org /cgi/content/full/187/7/1123 (6894 words)

	Full Text: Immunogenicity of Hylan G-F 20 in Guinea Pigs and Mice
		Immunogenicity of Hylan G-F 20 in Guinea Pigs and Mice
		To determine the product-specific immunogenicity of a chemically-modified sodium hyaluronate derivative, hylan G-F 20, that is used in the treatment of osteoarthritis of the knee.
		Hylan G-F 20 exhibited immunogenicity in guinea pigs and mice.
	www.jrheum.com /abstracts/abstracts04/943.html (340 words)

	ACIP: Use of Haemophilus b Conjugate Vaccines
		Specific characteristics of the four conjugate vaccines available for infants and children vary (e.g., the type of protein carrier, the size of the polysaccharide, and the chemical linkage between the polysaccharide and carrier) ( Table 1).
		One study reported comparative immunogenicity with PRP-OMP, HbOC, and PRP-T (12), and two other studies compared immunogenicity with all four conjugate vaccines (11,13) ( Table 2).
		The infants who received the combination vaccine, however, experienced a higher likelihood of restless sleep following the second dose and greater than or equal to 1 inch of swelling at the injection site after administration of the first dose of the combination vaccine ( Table 5).
	wonder.cdc.gov /wonder/prevguid/p0000326/P0000326.asp (5282 words)

	Fusion to C3d Enhances the Immunogenicity of the E2 Glycoprotein of Type 2 Bovine Viral Diarrhea Virus -- Wang et al. ...
		Fusion to C3d Enhances the Immunogenicity of the E2 Glycoprotein of Type 2 Bovine Viral Diarrhea Virus -- Wang et al.
		The immunogenicity of the E2s-C3d construct was assessed by
		Increased immunogenicity and induction of class switching by conjugation of complement C3d to pneumococcal serotype 14 capsular polysaccharide.
	jvi.asm.org /cgi/content/full/78/4/1616 (5414 words)

	Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence -- Ahlers et al. 94 ...
		Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence -- Ahlers et al.
		Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence
		Sequence modification increases immunogenicity for CTL induction in vivo.
	www.pnas.org /cgi/content/full/94/20/10856 (5486 words)

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