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Topic: Immunoglobulin D

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Immunoglobulin D

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	Prevention of D Isoimmunization - New Treatments, May 2, 2006
		If D antibody is present, D immunoglobulin will not be beneficial, and specialized management of the D isoimmunized pregnancy is undertaken to manage hemolytic disease of the fetus and hydrops fetalis.
		The dosage of D immunoglobulin is determined by the stage of gestation.
		D immunoglobulin is given to the D negative mother as soon after delivery as cord blood findings indicate that the baby is Rh positive.
	www.ccspublishing.com /journals2a/d_isoimmunization.htm (603 words)

	Results of the search (Site not responding. Last check: 2007-10-24)
		Sequence analysis of homogeneous peptides of shark immunoglobulin light chains by tandem mass spectrometry: correlation with gene sequence and homologies among variable and constant region peptides of sharks and mammals.
		Characterization of horse (Equus caballus) immunoglobulin mu chain-encoding genes.
		Immunoglobulin epitopes defined by synthetic peptides corresponding to joining region sequence: conservation of determinants and dependence upon the presence of an arginyl or lysyl residue for cross-reaction between light chains and T-cell receptor chains.
	invention.swmed.edu /trite/abstracts/user-1016148091/results.shtml (4925 words)

	Data Sheet
		Rh(D) Immunoglobulin is prepared by Cohn cold-ethanol fractionation of human plasma obtained from voluntary donors who have been immunised to the Rh antigen "D".
		Immunoglobulins for intramuscular injection, prepared by this process from plasma screened by current methods, have not been implicated in the transmission of viral infectious diseases including human immunodeficiency virus (HIV).
		Immunoglobulins are excreted in breast milk, however, it is not known whether this applies to passively administered Rh(D) Immunoglobulin.
	www.medsafe.govt.nz /Profs/Datasheet/r/RhDimmunoglobulininj.htm (1786 words)

	Results of the search
		Immunoglobulin gamma chains of a monotreme mammal, the echidna (Tachyglossus aculeatus): amino acid composition and partial amino acid sequence.
		Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II).
		Kappa and lambda immunoglobulin expression associated with abnormalities of chromosomes #2 and #22 in lymphoma and leukemia.
	invention.swmed.edu /trite/abstracts/user-1015690064/results.shtml (4190 words)

	Immunoglobulin D: Properties, Measurement, and Clinical Relevance -- Vladutiu 7 (2): 131 -- Clinical and Vaccine ...
		Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome.
		Oligoclonal immunoglobulin D in the cerebrospinal fluid of neurologic patients.
		Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.
	cdli.asm.org /cgi/content/full/7/2/131 (7276 words)

	[Clinical Preventive Services] Screening for D (Rh) Incompatibility (Site not responding. Last check: 2007-10-24)
		D (formerly Rh) blood typing and antibody screening is recommended for all pregnant women at their first prenatal visit.
		D blood typing and antibody testing is recommended for all pregnant women at their first prenatal visit, including visits for elective abortion ("A" recommendation).
		There is currently insufficient evidence to recommend for or against the routine administration of D immunoglobulin after other obstetric procedures or complications such as chorionic villus sampling, ectopic pregnancy termination, cordocentesis, fetal surgery or manipulation (including external version), antepartum placental hemorrhage, antepartum fetal death, and stillbirth ("C" recommendation).
	cpmcnet.columbia.edu /texts/gcps/gcps0048.html (1461 words)

	Labs- immunoglobulins
		Immunoglobulin A (IgA) is a type of antibody that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract.
		IgD, immunoglobulin D is mainly found on the surface of B-cells and may help regulate B-cell function.
		Detects the presence or absence of Immunoglobulins in the urine and assesses the qualitative character (polyclonal vs. monoclonal) of the immunoglobulins [1]
	www.lymphomation.org /tests-immunoglobulins.htm (490 words)

	Immunoglobulin Transmits Hepatitis C
		Subcutaneous injections of a drug containing human immunoglobulins 1974 and early 1975, several cases of viral hepatitis were reported in Italy among subjects who had received subcutaneous injections of a drug containing human immunoglobulins that was prescribed for the treatment of allergies.
		Anti-D immunoglobulin is prepared from the plasma of donors with high concentrations of anti-rhesus D antibody.
		Intravenous anti-D immunoglobulin was first reported to be involved in the transmission of HCV in an outbreak of NANBH that occurred in East Germany between 1978 and 1979 (Dittmann et al 1991).
	www.hcvets.com /data/transmission_methods/published_articles/immunoglobulin_transmits_hepatit.htm (3682 words)

	[No title] (Site not responding. Last check: 2007-10-24)
		In the Southern Blot shown below, a probe for the immunoglobulin D gene segment was used to detect rearrangement in DNA samples extracted from sperm and an antibody-producing myeloma.
		(D) The virus used to inject Group A is a better immunogen than the virus used to inject Group B. In a radial immunodiffusion assay, agar is impregnated with anti-lambda antisera.
		(D) The process by which antigens and receptors coalesce into a single aggregate at the pole of the B lymphocyte is termed "capping".
	www.usuhs.mil /mic/1994-1.txt (2023 words)

	eMedicine - Immunoglobulin D Deficiency : Article by Donald A Dibbern Jr, Jr
		Immunoglobulin D (IgD) deficiency is a defect of humoral immunity that is characterized by abnormally low serum levels of IgD immunoglobulins.
		Longitudinal follow-up examinations with periodic quantitative immunoglobulin measurements and surveillance for immune, infectious, or rheumatologic disease are advised.
		Specifically, intravenous or subcutaneous immunoglobulin replacement therapy is not indicated.
	www.emedicine.com /med/topic1160.htm (1490 words)

	Canadian Task Force on Preventive Health Care
		Unless the father is known to be D negative, unsensitized D negative women should receive D immunoglobulin (D Ig) at 28-29 weeks’ gestation, within 72 hours after delivery of a D positive infant, and after induced abortion or amniocentesis.
		This phenomenon is not dangerous to the fetus unless there is incompatibility between the mother and her fetus with respect to the D antigen of the red blood cells.
		Early detection of D negative blood type in the pregnant woman is of substantial benefit if the patient is not yet isoimmunized and the father is not known to be D negative.
	www.ctfphc.org /Full_Text_printable/Ch11full.htm (2772 words)

	MedlinePlus Drug Information: Rh O(D) Immune Globulin (Systemic) (Site not responding. Last check: 2007-10-24)
		(D) immune globulin is used to prevent your body from interacting with any of your baby's blood that may get into your blood system while you are pregnant or during the delivery of your baby.
		(D) immune globulin is to be administered only by or under the supervision of your doctor or other health care professional.
		The medicine may be used during your pregnancy, within 72 hours after your baby is born, at the end of an incomplete pregnancy (abortion, miscarriage), or after a transfusion.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202720.html (815 words)

	Anti-D immunoglobulin
		People whose blood type is rhesus positive (RhD positive) have a substance called D antigen on the surface of their red blood cells.
		Anti-D immunoglobulin may also be used if a rhesus negative individual is given a blood transfusion of rhesus positive blood, to prevent the individual forming antibodies against the transfused blood.
		If you need to be given anti-D immunoglobulin within two to four weeks of receiving a live vaccine, such as yellow fever, rubella, BCG or oral polio, the anti-D immunoglobulin may reduce the efficacy of these vaccines.
	www2.netdoctor.co.uk /medicines/100003104.html (1064 words)

	Chemicon - Product #MAB3435F - Anti-Com-DF (Rh-D PE/HbF-FITC) Reagent, Ready to Use
		To determine the appropriate dose, it is necessary to quantitate the magnitude of a suspected FMH and administer Rh D immunoglobulin according to the extent of the fetal bleed.
		The test should be carried out soon after the precipitating event or delivery in order to permit the timely administration of the appropriate amount of Rh D immunoglobulin to prevent alloimmunization occurring in the mother.
		This reagent is designed for the detection and quantitation of Rh D positive and HbF positive RBC arising in the circulation of mothers as a consequence of fetomaternal hemorrhage (FMH).
	www.chemicon.com /browse/productdetail.asp?ProductID=MAB3435F (1206 words)

	Data Sheet
		When only 600 IU of drug is administered to pregnant women, passive anti- Rho (D) antibodies are not detectable in the circulation for more than six weeks and therefore a dose of 1,500 IU should be used for antenatal administration.
		Immunoglobulins are excreted into breast milk and may contribute to the transfer of protective antibodies to the neonate within the first few days of birth.
		However, it is not known whether passively administered anti-D (Rho) immunoglobulin is excreted into the milk.
	www.medsafe.govt.nz /profs/datasheet/w/Winrhosdfinj.htm (1990 words)

	Loyola Univ. Health Univ. Health Sys- Microbiology & Immunology: Knight Lab Publications
		Lanning, D., Osbourne, B.A., and Knight, K.L., (2004) Immunoglobulin Genes and Generation of Antibody Repertoires in Higher Vertebrates: A Key Role for GALT, in Molecular Biology of B Cells, edited by F.W. Alt, T. Honjo, and M.S. Neuberger, Elsevier Science Ltd., 433-448.
		Lanning, D., Sethupathi, P., Rhee, K.J., Zhai, S-K., and Knight, K.L., (2000) Intestinal microflora and diversification of the rabbit antibody repertoire.
		Eskinazi, D.P., Bessinger, B.A., McNicholas, J.M., Leary, A.L. and Knight, K.L. Expression of an unidentified immunoglobulin isotype on rabbit Ig-bearing lymphocytes.
	www.meddean.luc.edu /lumen/DeptWebs/Microbio/KNIGHT/publicat.htm (2873 words)

	Albert C. Shaw, M.D., Ph.D., Internal Medicine
		Finally, we are engaged in ongoing studies in humans that seek to elucidate age-related changes in the innate immune system (such as the Toll-like receptors), and to correlate such changes with responsiveness to vaccines (which decreases substantially in older adults) and susceptibility to infectious diseases, using influenza as a model.
		Shaw, A.C., Swat, W., Davidson, L., Alt, F.W. Induction of immunoglobulin light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.
		A human immunoglobulin gene reduces the incidence of lymphomas in c-myc bearing transgenic mice.
	info.med.yale.edu /intmed/infdis/pages/shaw.html (447 words)

	Use of anti-D immunoglobulin in the treatment of threatened miscarriage in the accident and emergency department -- ...
		Use of anti-D immunoglobulin in the treatment of threatened miscarriage in the accident and emergency department -- Weinberg 18 (6): 444 -- Emergency Medicine Journal
		Use of anti-D immunoglobulin in the treatment of threatened miscarriage in the accident and emergency department
		Figure 2 Rhesus D negative patients and administration of anti-D immunoglobulin.
	emj.bmjjournals.com /cgi/content/full/18/6/444 (2128 words)

	NGC - NGC Summary
		Administration of a full (300 micrograms) dose of Rh(D) immunoglobulin is recommended for all unsensitized Rh(D)-negative women after repeated antibody testing at 24 to 28 weeks' gestation.
		Unless the biological father is known to be Rh(D)-negative, a full dose of Rh(D) immunoglobulin is recommended for all unsensitized Rh(D)-negative women after amniocentesis and after induced or spontaneous abortion; however, if the pregnancy is less than 13 weeks, a 50 microgram dose is sufficient.
		The benefit of routine administration of Rh(D) immunoglobulin after other obstetric procedures or complications such as chorionic villus sampling, ectopic pregnancy termination, cordocentesis, fetal surgery or manipulation (including external version), antepartum placental hemorrhage, abdominal trauma, antepartum fetal death, or stillbirth is uncertain due to inadequate evidence.
	www.guideline.gov /summary/summary.aspx?view_id=1&doc_id=4776 (1726 words)

	ARCBS > PG > Guidelines for the use of Rh (D) Immunoglobulin
		Visit our Stage 3 Rh (D) immunoglobulin Routine Prophylaxis Program Resource Area for more information and a range of support materials available to download or order on the latest guidelines for the use of Rh (D) immunoglobulin (Anti-D).
		• Rh (D) Immunoglobulin should not be given to women with preformed anti-D antibodies, except where the preformed anti-D is due to the antenatal administration of Rh (D) Immunoglobulin.
		The batch number of every vial of human immunoglobulin administered must be recorded in the patient’s medical history and in accordance with other legal statutory requirements.
	www.transfusion.com.au /TRANSFUSIONPOCKETGUIDES/Pocket_AntiD.asp (591 words)

	Intravenous anti-D immunoglobulin in the management of immune thrombocytopenic purpura.
		Anti-D immunoglobulin is well tolerated, with occasional adverse reactions similar to those seen in treatment with polyclonal intravenous immunoglobulin, but anemia requiring blood transfusion can occur.
		Inhibition of Fc receptor-mediated platelet destruction by anti-D immunoglobulin-opsonized erythrocytes is the most likely mechanism of action, although the relative ineffectiveness of a monoclonal anti-D immunoglobulin preparation in treatment of immune thrombocytopenic purpura suggests that other mechanisms may exist.
		Hepatitis C has been transmitted by intravenous anti-D immunoglobulin preparations when used in the prevention of Rh immunization, prior to the introduction of screening donor plasma for hepatitis C virus antibodies.
	www.aegis.com /aidsline/1998/feb/M9820504.html (401 words)

	Clinical Practice Guidelines : Rh D Immunoglobulin in Obstetrics
		For successful immunoprophylaxis, Rh D Immunoglobulin should always be administered as soon as possible after the sensitising event, but always within 72 hours.
		Rh D Immunoglobulin for Rh D Negative women with no preformed Anti-D
		All Rh D negative women with an Rh D positive infant should have an estimate of feto-maternal haemorrhage (FMH test) to determine the need for additional doses of anti-D. Advice regarding administration of additional doses for women with a greater than 6 ml FMH can be obtained from the Haematologist on-call.
	www.rwh.org.au /rwhcpg/maternity.cfm?doc_id=8660 (838 words)

	Screening for Rh (D) Incompatibility: Recommendation Statement
		Administration of a full (300µg) dose of Rh (D) immunoglobulin is recommended for all unsensitized Rh (D)-negative women after repeated antibody testing at 24-28 weeks' gestation.
		Unless the biological father is known to be Rh (D)-negative, a full dose of Rh (D) immunoglobulin is recommended for all unsensitized Rh (D)-negative women after amniocentesis and after induced or spontaneous abortion; however, if the pregnancy is less than 13 weeks, a 50 µg dose is sufficient.
		The benefit of routine administration of Rh (D) immunoglobulin after other obstetric procedures or complications such as chorionic villus sampling, ectopic pregnancy termination, cordocentesis, fetal surgery or manipulation (including external version), antepartum placental hemorrhage, abdominal trauma, antepartum fetal death, or stillbirth is uncertain due to inadequate evidence.
	www.ahrq.gov /clinic/3rduspstf/rh/rhrs.htm (818 words)

	Use of Anti-D Immunoglobulin for Rh Prophylaxis (22) - Revised May 2002
		Post-delivery immunoprophylaxis using anti-D Immunoglobulin (anti-D Ig) began in the UK in 1969.
		Hughes RG, Craig JI, Murphy WG, Greer IA. Causes and clinical consequences of Rhesus (D) haemolytic disease of the newborn: a study of a Scottish population, 1985-1990.
		Murphy MF, Lee D. Dose of anti-D immunoglobulin for the prevention of RhD immunisation after RhD-incompatible platelet transfusions (letter).
	www.rcog.org.uk /index.asp?PageID=512 (2636 words)

	Sensitive ELISA for Human Immunoglobulin D Measurement in Neonate, Infant, and Adult Sera -- Levan-Petit et al. 46 (6): ...
		Sensitive ELISA for Human Immunoglobulin D Measurement in Neonate, Infant, and Adult Sera -- Levan-Petit et al.
		Sensitive ELISA for Human Immunoglobulin D Measurement in Neonate, Infant, and Adult Sera
		Roes J, Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.
	www.clinchem.org /cgi/content/full/46/6/876 (1607 words)

	Preventing RhD haemolytic disease of the newborn -- Lee et al. 316 (7144): 1611 -- BMJ
		Guidelines for the use of anti-D immunoglobulin for Rh prophylaxis.
		To accompany the introduction of an antenatal prophylaxis programme with anti-D immunoglobulin we advocate the centralisation
		D. Kleindorfer, C. Lindsell, J. Broderick, M. Flaherty, D. Woo, I. Ewing, P. Schmit, C. Moomaw, K. Alwell, A. Pancioli, E. Jauch, J. Khoury, R. Miller, A. Schneider, and B. Kissela
	bmj.bmjjournals.com /cgi/content/full/316/7144/1611 (868 words)

	Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics
		Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics
		Summary of guideline recommendations for the use of Rh D immunoglobulin (Anti-D) in obstetrics
		Rh D immunoglobulin (anti-D) is used to prevent the effects of Rh blood group incompatibility between a woman and her baby.
	www.nhmrc.gov.au /publications/synopses/wh27syn.htm (388 words)

	Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics
		Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics - 2003 (PDF, 850kb)
		This 2003 document, produced by the National Blood Authority and approved by the National Health and Medical Research Council, updates the previous now rescinded guidelines on the use of Rh D immunoglobulin (anti-D) released in 1999.
		NOTE: Guidelines on the prophylactic use of Rh D immunoglobulin (anti-D) in obstetrics is on the National Blood Authority website, hard copies may be obtained from http://www.nba.gov.au
	www.nhmrc.gov.au /publications/synopses/wh33syn.htm (297 words)

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