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Topic: Indazole


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In the News (Fri 19 Jul 19)

  
  Indazoles - LoveToKnow 1911
The parent substance N/N N indazole, C7H6N2, was obtained by E. Fischer (Ann.
Nitrous acid converts it into nitrosoindazole; whilst on heating with the alkyl iodides it is converted into alkyl indazoles.
A series of compounds isomeric with these alkyl derivatives is known, and can be considered as derived from the ring system / NH N. N/NCH7 be prepared by the reduction of the nitroso-ortho-alkylaminoacetophenones with zinc dust and water or acetic acid.
www.1911encyclopedia.org /Indazoles   (197 words)

  
 Patents in Class 514/403
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described.
The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflamm...
www.freepatentsonline.com /CCL514-403.html   (1844 words)

  
 33-Methyl-4,5,6,7-tetrafluoro-1H-indazole: Synthesis, Structure, Spectroscopy and ab Initio Computational Study.
There have been only relatively few quantum-mechanical studies of indazoles at the semi-empirical level [29, 30] or at the ab initio level [31, 32, 33] and the ab initio studies that were reported have been limited to Hartree-Fock level theory with small to modest basis sets.
The structure of the parent indazole is shown in Figure 3.
The fluorination of the indazole polarizes the C(3a)-C(3) bond, resulting in a larger positive charge on C(3) and a build-up of negative charge on C(3a), while the charges on C(7a) and N(1) are virtually unaffected.
www.ch.ic.ac.uk /ectoc/echet98/pub/076   (3616 words)

  
  3-Methyl-4,5,6,7-tetrafluoro-1H-indazole
The MP2(fc)/6-311G** optimized structures of the parent indazole and of ecl-4 are shown in Figure 3 and Figure 5, respectively.
The structure of the parent indazole is shown in Figure 3.
The fluorination of the indazole polarizes the C(3a)-C(3) bond, resulting in a larger positive charge on C(3) and a build-up of negative charge on C(3a), while the charges on C(7a) and N(1) are virtually unaffected.
www.missouri.edu /~chemrg/echet98   (3579 words)

  
 INDAZOLE
This operation is carried out in an open flask in the hood and at a point remote from flames; the indazole is dried by the steam distillation of the water with the benzene.
The procedure for the conversion of indazolone to indazole is a modification of that of Fischer and Seuffert.
Indazole has been obtained in a variety of ways which are of no preparative value.
www.orgsyn.org /orgsyn/orgsyn/prepContent.asp?prep=cv3p0475   (1269 words)

  
 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described.
The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
www.patentalert.com /docs/000/z00063439.shtml   (189 words)

  
 Heterocyclic Chemistry: Synthesis of Indazole nucleus
I was looking for a straigthforward synthesis of indazole nucleus, I found a paper from Abbot lab.
They have depicted the synthesis of indazole starting from benzaldehyde with fluorine as leaving group and hydrazine, we can hope in that case to have formation of the hydrazone and subsequent intramolecular cyclization, but the reaction is very low yielding, because the cyclization is very slow and there is a competitive Wolf-Kishner reduction.
With some experiments they have confirmed that the reaction did not proceed via intramolecular cyclization of the hydrazone, but through a transient aminal (obtained by a previous nucleophilic subsitution of hydrazine on fluorine) which give the indazole core after elimination of hydrazine.
hetchem.blogspot.com /2007/06/synthesis-of-indazole-nucleus.html   (175 words)

  
 Contrasting effects of circulating nitric oxide and nitrergic transmission on exocrine pancreatic secretion in rats -- ...
Amylase output was measured in rats in response to caerulein (0.1-50 µg/kg) alone or with indazole.
Inhibition of nNOS by indazole (fig 2) or capsaicin
Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinocioceptives and cardiovascular effects.
gut.bmj.com /cgi/content/full/43/5/684   (4258 words)

  
 [No title]
The indazole core of the dyes is not photoreactive under the conditions used in cleavage of compounds from the solid support and detection of binding events to target molecules, respectively.
Functionalized 1,3-diarylsubstituted indazoles can also be synthesised on solid support starting with immobilised arylhydrazones of appropriate benzophenone derivatives.
Compound 6a is synthesised from benzoyl benzoic acid methylester and 4-hydrazino benzoic acid according to the general procedure.
www.mdpi.net /ecsoc-5/b0008/b0008.htm   (1657 words)

  
 Recording sheets containing pyrrole, pyrrolidine, pyridine, piperidine, homopiperidine, quinoline, isoquinoline, ...
A recording sheet according to claim 1 wherein the additive is selected from the group consisting of (1) indazole; (2) 5-aminoindazole; (3) 6-aminoindazole; (4) 3-indazolinone; (5) N'-(6-indazolyl) sulfanilamide; (6)4,5-dihydro-3-(4-pyridinyl)-2H-benz(g) indazole methane sulfonate; and mixtures thereof.
The pyrrole compound, pyrrolidine compound, pyridine compound, piperidine compound, homopiperidine compound, quinoline compound, isoquinoline compound, quinuclidine compound, indole compound, indazole compound, or mixture thereof is present inany effective amount relative to the substrate.
The coating containing the pyrrole compound, pyrrolidine compound, pyridine compound, piperidine compound, homopiperidine compound, quinoline compound, isoquinoline compound, quinuclidine compound, indole compound, indazole compound, or mixturethereof is present on the substrate of the recording sheet of the present invention in any effective thickness.
www.patentgenius.com /patent/7105214.html   (7008 words)

  
 NOS inhibitors exhibit antinociceptive properties in the rat formalin test: [Les inhibiteurs de NOS affichent des ...
7-nitro indazole and aminoguanidine in phase 1 and phase 2.
Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects.
Effect of 7-nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase.
www.cja-jca.org /cgi/content/full/50/9/909   (3161 words)

  
 Chapter 5 Comparative study of normotensive and hypertensive nitric oxide synthase inhibitors on morphine withdrawal ...
Abstract - The effects of the normotensive, mainly centrally active nitric oxide synthase (NOS) inhibitor, 7-nitro indazole and the hypertensive compound N g-nitro-L-arginine, which blocks both the endothelial and central NOS, have been examined for their effects on naloxone-precipitated withdrawal syndrome in morphine-dependent rats.
However, recently 7-nitro indazole (7-NI), which is a selective inhibitor for brain NOS, lacking effects on endothelial NOS and blood pressure (Moore et al., 1993a,b), has become available.
Moore PK, Wallace P, Gaffen ZA, Hart SL and Babbedge RC, Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects, Br J Pharmacol 110: 219-224, 1993b.
www.drugtext.org /library/books/cappendijk/chapter05.htm   (2447 words)

  
 BSP :: Mini Reviews in Medicinal Chemistry Home Page
Indazole derivatives were extensively studied as bioactive compounds, such as anti-aggregatory and vasorelaxant activity by NO release and increase of cGMP levels and anticancer effects, antimicrobial and antiparasitic properties, among others.
Recently, the research and development in the medicinal chemistry of these systems have produced compounds with contraceptive activities for men, for the treatment of osteoporosis, inflammatory disorders and neurodegenerative diseases.
On the other hand, indazole N-oxide derivatives were poorly studied as bioactive compounds, but recently compounds with antiparasitic properties were produced.
www.bentham.org /mrmc/contabs/mrmc5-10.htm   (947 words)

  
 YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid ...
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9 -- Liu et al.
Articles by Liu, Y.-N. Articles by Teng, C.-M. YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9
indazole (YC-1), a benzyl indazole compound, on MMP-2 and MMP-9
jpet.aspetjournals.org /cgi/content/short/316/1/35?ck=nck   (336 words)

  
 Indole indazole and benzazole derivative patent invention
[0001] The present invention relates to a novel indole, indazole, and benzazole derivative, or a pharmaceutically acceptable salt thereof, which are useful as a medicament.
[0010] The present inventors have intensively studied in order to solve the above problems, and have found that indole, indazole and benzazole derivatives of the following formula (I) and a pharmaceutically acceptable salt thereof may exhibit an excellent.beta.3-adrenoceptor-stimulating activity, and they have finally accomplished the present invention.
FreshPatents.com SupportThank you for viewing the Indole indazole and benzazole derivative patent info.
www.freshpatents.com /Indole-indazole-and-benzazole-derivative-dt20060323ptan20060063762.php   (822 words)

  
 The Temps Group - Guest Book
He successfully measured the excitation and dispersed fluorescence spectra of indazole monomer and indazole-water complexes and managed to analyze the spectra with the help of ab initio calculations.
Erko has recently carried out hole-burning experiments on the dimers and trimers of indazole and various complexes of indazole with water and now wants to measure REMPI spectra.
We also hope to do SEP and femtosecond measurements on indazole and the indazole-water complexes in the future to look at the tautomerization dynamics.
www.uni-kiel.de /phc/ags/temps/temps_guestbook.htm   (865 words)

  
 ExactAntigen angpt2 -- reagents, researchers, and patents   (Site not responding. Last check: 2007-10-20)
8: US 6534524 2005 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use
9: US 6884890 2005 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use
7: US 6534524 2005 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases and methods for their use
www.exactantigen.com /gene/apoe/angpt2.html   (447 words)

  
 Neuronal nitric oxide synthase modulates rat renal microvascular function -- Ichihara et al. 274 (3): 516 -- AJP - ...
In several previous studies, 7-nitro indazole has been used to cause specific nNOS inhibition (4, 22, 27).
Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles.
Kunau, R. The influence of the carbonic anhydrase inhibitor, benzolamide (CL-11,366), on the reabsorption of chloride, sodium, and bicarbonate in the proximal tubule of the rat.
ajprenal.physiology.org /cgi/content/full/274/3/F516   (5067 words)

  
 Learning & Memory, Volume 2, Issue 5 Abstracts
Nitric oxide (NO) is an intercellular messenger that has been suggested to have a role in learning and memory formation.
A novel NO synthase inhibitor, 7-nitro indazole (7-NI), as a dose (30 mg/kg i.p.) shown previously to inhibit neuronal NO synthase by 85% without affecting blood pressure, produced amnesic effects both in a water maze and in an 8-arm radial maze.
Latency as well as distance was greater in the 7-NI group in the water maze while swim speed was not affected.
www.cshl.edu /lm/2/c5l206a.html   (986 words)

  
 Indazole Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channels in Rat Epididymal Epithelial ...
Indazole Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channels in Rat Epididymal Epithelial Cells -- Gong et al.
Indazole Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Cl Channels in Rat Epididymal Epithelial Cells
Copyright © 2002 by the Society for the Study of Reproduction.
www.biolreprod.org /cgi/content/abstract/67/6/1888   (364 words)

  
 Search Results for- Indazole: Indazole - Cole-Parmer Catalog
We have access to suppliers full lines— for products beyond what you see here.
Indazole and other Ia to Iodine products are now available to order from the Cole Parmer Instrument Catalog.
Click any Indazole category to view all models and products.
www.coleparmer.com /catalog/product_index.asp?cls=35776   (62 words)

  
 Increased Blood Pressure in Rats after Long-Term Inhibition of the Neuronal Isoform of Nitric Oxide Synthase -- ...
A new experimental model for studying systemic hypertension in rats has been developed in recent years.
indazole (7-NI) was as potent as unselective NOS inhibition in
Wallace, Z.A. Gaffen, and S.L. Hart (1993) 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure.
www.jci.org /cgi/content/full/99/9/2212   (5606 words)

  
 Dalton Transactions Articles
(Hind = indazole) with an excess of dimethyl sulfoxide (dmso) in acetone afforded the complex trans,trans,trans-[Ru Cl
N group in the N1—H bond of the N2-coordinated indazole ligand in the nomenclature used for 1H-indazole.
These are the first examples of the metal-assisted iminoacylation of indazole.
www.rsc.org /Publishing/Journals/DT/article.asp?doi=b503650j   (169 words)

  
 Crystal Structure of Nitric Oxide Synthase Bound to Nitro Indazole Reveals a Novel Inactivation Mechanism   (Site not responding. Last check: 2007-10-20)
Crystal Structure of Nitric Oxide Synthase Bound to Nitro Indazole Reveals a Novel Inactivation Mechanism
Departments of Molecular Biology and Biochemistry and Physiology and Biophysics and the Program in Macromolecular Structure, University of California, Irvine, California 92697, Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229, Department of Pediatrics, First Medical Faculty, Charles University, Prague, Czech Republic, and Inotek Corp., Beverly, Massachusetts 01915
We also present three crystal structures that reveal how alterations at the substrate site facilitate 7-NIBr and structurally dissimilar ligands to occupy the cofactor site.
pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2001/40/i45/abs/bi010957u.html   (229 words)

  
 Journal of Cerebral Blood Flow & Metabolism - Table 2 for article: Cerebroprotective Effect of the Nitric Oxide ...   (Site not responding. Last check: 2007-10-20)
Journal of Cerebral Blood Flow and Metabolism - Table 2 for article: Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, After Transient Focal Cerebral Ischemia in the Rat
Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, After Transient Focal Cerebral Ischemia in the Rat
Katherine J Escott, John S Beech, Kristin K Haga, Steve C R Williams, Brian S Meldrum and Philip M W Bath
www.nature.com /jcbfm/journal/v18/n3/fig_tab/9590361t2.html?url=/jcbfm/journal/v18/n3/full/9590361a.html   (124 words)

  
 Soluble Guanylyl Cyclase Activator YC-1 Inhibits Human Neutrophil Functions through a cGMP-Independent but ...
This article has been cited by other articles:
Molecular Mechanisms Underlying Rat Mesenteric Artery Vasorelaxation Induced by the Nitric Oxide-Independent Soluble Guanylyl Cyclase Stimulators BAY 41-2272 [5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole]
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G0-G1 in Human Hepatocellular Carcinoma Cells
molpharm.aspetjournals.org /cgi/content/abstract/64/6/1419   (351 words)

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