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Topic: Indole

Related Topics

Skatole

Fischer indole synthesis

Pyrrole

Benzofuran

Ergotamine

Isoquinoline

Ergine

Quinoline

Alkaloid

Pyridine

Benzene

Indigo plant

Diethyltryptamine

Indigo dye

Anthracene

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	Effect of Indole and some Indolic Compounds on Muscle Sensitivity to Acetylcholine and Potassium
		AMONG the indolic compounds formed from tryptophane in animal intestine, indole, skatole and indolethylamine are those reported to have the strongest pharmacological action.
		have examined the effect of indole, skatole, indole-3-acetate and tryptophane on the sensitivity of frog striated muscle to acetylcholine and potassium, finding that only indole increases the response to acetylcholine, while indole, skatole and indoleacetate increase the potassium effect.
		, and presumably other indole compounds as well, it seemed interesting to study their effect on the intestinal smooth muscle, as it might have implications in regard to the alterations of intestine motility.
	www.nature.com /nature/journal/v166/n4226/abs/166734a0.html (218 words)

	INDOLE TEST (Site not responding. Last check: )
		Indole is a component of the amino acid tryptophan.
		When tryptophan is broken down, the presence of indole can be detected through the use of Kovacs' reagent.
		Kovac's reagent, which is yellow, reacts with indole and produces a red color on the surface of the test tube.
	medic.med.uth.tmc.edu /path/indole.htm (63 words)

	SpaTherapy.com \| Indole
		Indole (also known as indole-3-carbinol) is a chemical found in leafy green vegetables that belong to the cabbage family.
		In animal studies, indole appears to be especially effective against breast and cervical cancers because of its ability to increase the body's breakdown of estrogen.
		The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole.
	www.spatherapy.com /herbcentral/indole.php (393 words)

	"Indole 3 Carbinol : by Ray Sahelian, M.D., benefits research
		We recently found that indole 3 carbinol functions as an inhibitor of Akt and nuclear factor kappaB (NF-kappaB), which play important roles in cell survival and which are believed to be potential targets in cancer therapy.
		The mechanism of action was linked primarily to the ability of indole 3 carbinol and derived substances to induce mixed-function oxidases and phase II antioxidant enzymes by binding and activating the aryl hydrocarbon receptor.
		It does not appear that indole 3 carbinol per se is the primary active compound in chemoprotection or chemoprevention.
	www.raysahelian.com /indole3carbinol.html (1395 words)

	J2. Pyrolysis of Indole, Quinoline and Isoquinoline
		Indole, quinoline and isoquinoline are bicyclic compounds, embedded in the structure of coal of many sources and origins and are known to be its major nitrogenous constituents.
		The study of the thermal reactions of these compounds in a pyrolytic, non oxidative environment, is a prerequisite for the understanding the combustion of coal and its nitrogenous constituents.
		The thermal reactions of Indole, quinoline and isoquinoline were studied behind reflected shock waves in a pressurized driver single pulse shock tube at overall densities behind the reflected shocks of ~3
	www.cstl.nist.gov /div838/kinet_conf/agenda/j_session/j2/j2.html (473 words)

	Indole Butyric Acid
		Indole Butyric Acid is the leading plant hormone used to promote the formation of roots in plants and to generate new roots in the cloning of plants through cuttings.
		Indole Butyric Acid is an auxin and the leading plant hormone used to promote the formation of roots in plants and to generate new roots in the cloning of plants through cuttings.
		Indole Butyric acid (IBA) is the most used compound for rooting plant cuttings.
	www.super-grow.biz /IndoleButiricAcidPlantRootingHormone.jsp (915 words)

	D (Site not responding. Last check: )
		The indole ring is found in a range of compounds from LSD (A) psycho-actives to antibiotics such as mitomycin (B).
		Indole compounds play an important role in fundamental metabolism since it is found in the essential amino acid tryptophan.
		The reaction cannot be used to prepare indole rings unfunctionalized in the 2 position, which is unfortunate since these derivatives are in very high demand in the pharmaceutical industry as starting materials in selected syntheses.
	www.pitt.edu /~soriano/models/indoles/indole.html (514 words)

	Learn More About Indole 3 Carbinol -- iSnare.com Articles
		Oral ingestion of Indole 3 Carbinol has been shown to alter the metabolism of estrogen in a beneficial manner.
		Indole 3 Carbinol mimics the weakest forms of estrogen.
		Therefore, the more Indole 3 Carbinol that is absorbed by the body and used to plug the estrogen receptors, less receptors will be available to the stronger estrogens.
	www.isnare.com /?aid=20060&ca=Wellness%2C+Fitness+and+Diet (1406 words)

	Indole Test Reagents
		The indole test is a qualitative procedure for determining the ability of bacteria to produce indole by deamination of tryptophan.
		Indole tests may be used as an aid in the identification and differentiation of gram-positive and gram-negative organisms.
		Since peptones have been shown to vary with regard to their suitability for use with indole testing, media selected for indole determination should be tested with known positive and negative organisms to insure suitability.
	www.hardydiagnostics.com /catalog/hugo/IndoleTestRgnts.htm (766 words)

	BD - Diagnostic Systems: BBL DrySlide Indole
		BBL™ DrySlide™ Indole is used for determining the indole reaction of bacteria.
		The indole test is a qualitative procedure for determining the ability of bacteria to produce indole by reductive deamination of tryptophan.
		BBL DrySlide Indole is a disposable slide with four filter paper reaction areas containing 5% p-dimethylaminobenzaldehyde (DMABA).
	www.bd.com /ds/productCenter/231748.asp (369 words)

	Indole Alkaloids
		The indole system can be considered to consist of a pyrrole ring and a benzene ring fused together to form two isomeric benzopyrroles, INDOLE and ISOINDOLE.
		The indole itself appears to be an essential constituent of the perfumes of flowers such as jasminium and of the citrus species.
		The indole alkaloids derived from tryptamine and secologanin can be classified into eight types, according to the structural characteristics of their skeletons.
	www.friedli.com /herbs/phytochem/alkaloids/alkaloid5.html (312 words)

	The Individualist: Indole
		The indole structure can be found in many organic compounds like the amino acid tryptophan and in tryptophan-containing protein, in alkaloids, and in pigments.
		Substituted indoles are structural elements of (and for some compounds the synthetic precursors for) the tryptophan-derived tryptamine alkaloids like the neurotransmitter serotonin, melatonin, the hallucinogens psilocybin, DMT, 5-MeO-DMT, or the ergolines like LSD.
		The name indole is derived from a combination of the words indigo and oleum, since indole was first isolated by treatment of the indigo dye with oleum.
	www.dadamo.com /wiki/wiki.pl/Indole (332 words)

	Indole-3-Butyric Acid (IBA)
		Indole-3-Butyric Acid (IBA) is used in the same manner as IAA and is accepted around the world as a propagating and rooting hormone for ornamental and fruit graftings and cuttings.
		Indone-3-Butyric Acid appears to be the most practical of the indole Alkonic Acid Series and is especially effective for initiating roots of both stems and leaves.
		IBA is a white or tan powder or crystalline solid which exhibits the reactions characteristic of an organic acid.
	www.interchemtechnologies.com /ic/IBA.htm (170 words)

	Indole Molecule Files (Site not responding. Last check: )
		Class I indole alkaloids are derivatives which arise from the alpha or beta condensation products of tryptamine with an unrearranged secologanin skeleton.
		Class II indole alkaloids are similar to class I, in being derived generally from the condensation of tryptamine with the secologanin skeleton.
		Class III indole alkaloids are actually a "mongrel mix" of iboga type alkaloids which are similar to class II alkaloids in the cleavage of the secologanin skeleton at the C-2 position, but with new bond formation between C-2,6 and C-5.
	users.lycaeum.org /~desoxy/indolemols.html (432 words)

	The Fischer Indole Synthesis: A Semiempirical Study.
		Fischer indole synthesis is a well established procedure for the synthesis of substituted indoles.
		Several members of the indole alkaloid familiy, flavopereirin and sempervirin among them, have shown antitumor activity.[1] Since our drug-development efforts focus on the indoloquinolizinium moiety, recently we have become interested in synthesizing substituted tryptamines as intermediates for the synthesis of indoloquinolizinium analogues with enhanced antitumor activity.
		So it may well be that, in the resulting indole structures, the lone pair on the nitrogen fails to extend the aromatic system to the five-membered ring, and ring strain produces the increased energy.
	www.ch.ic.ac.uk /ectoc/echet98/pub/051/index.htm (1252 words)

	NTP: INDOLE-3-CARBINOL-References (Site not responding. Last check: )
		Jellinck, P.H., Forkert, P.G., Riddick, D.S., Okey, A.B., Michnovicz, J.J., Bradlow, H.L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
		Jongen, W.M.F., Topp, R.J., Wienk, K.J.H. and Homan, E.C. (1989) Modulating effects of naturally occurring indoles on SCE induction depend largely on the type of mutagen.
		carcinogenesis in rainbow trout by flavone and indole compounds.
	ntp-server.niehs.nih.gov /index.cfm?objectid=03DF4362-CF9B-2A91-C2DA6B2A3B011862 (1762 words)

	Cytochrome P450 CYP79B2 from Arabidopsis Catalyzes the Conversion of Tryptophan to Indole-3-acetaldoxime, a Precursor ...
		Cytochrome P450 CYP79B2 from Arabidopsis Catalyzes the Conversion of Tryptophan to Indole-3-acetaldoxime, a Precursor of Indole Glucosinolates and Indole-3-acetic Acid -- Mikkelsen et al.
		of indole glucosinolates and that indole glucosinolates have evolved
		Jasmonate-Dependent Induction of Indole Glucosinolates in Arabidopsis by Culture Filtrates of the Nonspecific Pathogen Erwinia carotovora
	www.jbc.org /cgi/content/full/275/43/33712 (5127 words)

	Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in ...
		are sulfur-containing indole alkaloids (1) and the synthesis
		the biosynthetic pathway of indole glucosinolates (14, 15).
		The absence of indole glucosinolates and camalexin in Arabidopsis
	www.pnas.org /cgi/content/full/101/21/8245 (4145 words)

	Proton Transfer and Carbon-Carbon Bond Cleavage in the Elimination of Indole Catalyzed by Escherichia coli Tryptophan ...
		In addition, the rate constant for indole elimination shows a linear Eyring plot between 5 and 35
		-aminoacrylate intermediate with indole to form a quinonoid intermediate also exhibits a kinetic isotope effect for 3-
		In contrast to our expectations, the results suggest that the proton transfer and carbon-carbon bond cleavage in the elimination reaction are very nearly simultaneous and that the indolenine structure is a transient intermediate which occupies a very shallow well on the reaction coordinate, or a transition state, in the reaction of Trpase.
	pubs.acs.org /cgi-bin/jtext?jacsat/122/i06/abs/ja991647q (315 words)

	Applied Health Indole 3 Carbinol
		For the eight indoles tested, there was a strong relationship between instability in acidic solution, as indicated by the generation of insoluble products, and capacity to induce hepatic EROD.
		The results presented strongly support the hypothesis that dietary indoles influence the levels of monooxygenase activities via a series of acid-condensation products generated upon introduction of the indole into the acidic environment of the stomach.
		Bradfield CA Bjeldanes LF Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism.
	www.appliedhealth.com /nutri/page7071.php (10091 words)

	BD - Diagnostic Systems: Indole
		BBL™ Indole Reagent Droppers (modified Kovacs' reagent) are used in determining the ability of bacteria to produce indole by the deamination of tryptophan.
		The production of indole has been widely used as an aid in differentiating certain genera and species within the same genus.
		Indole Reagent may be used for tube or extraction procedures or with a variety of biochemical kits requiring Kovacs' or Ehrlich's reagents.
	www.bd.com /ds/productCenter/261185.asp (466 words)

	Indole-3-Carbinol (I3C) and Diindolylmethane (DIM) Abstracts
		In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3- disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
		A dose dependent increase in ICZ in both liver and feces as well as relatively high levels of DIM in feces (0.05-1.0 mg/gram) was observed over the dose range of 3IC examined.
		All four indoles slightly induced glutathione S-transferase in cultured hepatocytes.
	www.integratedhealth.com /infoabstract/i3cab.html (8717 words)

	indole - OneLook Dictionary Search
		indole : Encarta® World English Dictionary, North American Edition [home, info]
		INDOLE : 1911 edition of the Encyclopedia Britannica [home, info]
		Phrases that include indole: indole test, indole acetic acid, 2-methyl indole, 2 methyl indole, 5-methyl indole, more...
	www.onelook.com /?w=indole (153 words)

	Utilization of the Plant Hormone Indole-3-Acetic Acid for Growth by Pseudomonas putida Strain 1290 -- Leveau and Lindow ...
		Cloning and characterization of a locus encoding an indole pyruvate decarboxylase involved in indole-3-acetic acid synthesis in Erwinia herbicola.
		Microbial synthesis and degradation of indole 3-acetic acid.
		Proctor, M. Bacterial dissimilation of indoleacetic acid: a new route of breakdown of the indole nucleus.
	aem.asm.org /cgi/content/full/71/5/2365 (4597 words)

	indole’s Profile – Users at Last.fm (Site not responding. Last check: )
		Type in some bands or artists you like, separated by commas.
		Want to know how similar your music taste is to indole’s?
		It’s easy, create your own musical profile and share your taste with your friends.
	www.last.fm /user/indole (197 words)

	The auxin conjugate 1-O-indole-3-acetyl-{beta}-D-glucose is synthesized in immature legume seeds by IAGlc synthase and ...
		Indole compounds were detected using the Ehmann reagent.
		determined) has also been observed toward indole butyric acid
		The Van Urk-The Ehmann reagent—a sensitive and specific chromogenic reagent for silica gel thin-layer chromatographic detection and identification of indole derivatives.
	jxb.oxfordjournals.org /cgi/content/full/55/398/791 (5766 words)

	Indole 3 Carbinol
		Categories A-Z > Anti-Oxidants > Indole 3 Carbinol
		Life Extension, Dual-Action Cruciferous Vegetable Extract with Cat's Claw, 60 Veggie Caps
		They are not intended to diagnose, treat, cure, or prevent any disease.
	www.iherb.com /store/ProductsList.aspx?c=Herbs&cid=indole_3_carbinol (127 words)

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