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Topic: Indomethacin

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	MedlinePlus Drug Information: Indomethacin
		Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine).
		Indomethacin is also used to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone).
		Indomethacin is also sometimes used to relieve fever, pain, and inflammation caused by many types of conditions or injuries, to reduce the amount of calcium in the blood, and to treat a certain type of low blood pressure Talk to your doctor about the risks of using this medication for your condition.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a681027.html (1615 words)

	Indomethacin for slowing preterm labor
		Indomethacin is given through a vein (intravenously), by mouth as capsules or liquid (orally), or in the rectum (anal suppository).
		Indomethacin is used with caution, particularly for pregnant women with heart disease, asthma, a history of intestinal bleeding or ulcers, kidney disease, problems with blood clotting, or a decreased amount of amniotic fluid (oligohydramnios).
		When indomethacin is used for more than 3 to 7 days, fetal monitoring with an echocardiogram and regular ultrasound testing on the mother are used to check the amount of amniotic fluid.
	www.webmd.com /baby/indomethacin-for-slowing-preterm-labor (640 words)

	Indomethacin for slowing preterm labor - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: )
		Indomethacin is sometimes used as a tocolytic medication to prolong pregnancy by slowing preterm uterine contractions.
		Indomethacin is given through a vein (intravenously), by mouth as capsules or liquid (orally), or in the rectum (anal suppository).
		Indomethacin is used with caution, particularly for pregnant women with heart disease, asthma, a history of intestinal bleeding or ulcers, kidney disease, problems with blood clotting, or a decreased amount of amniotic fluid (oligohydramnios).
	www.questdiagnostics.com /kbase/topic/detail/drug/hw222014/detail.htm (490 words)

	Indomethacin [www.sopharma.com]
		Indomethacin belongs to the group of indol derivatives and is a highly effective non-steroid antiphlogistic preparation, with strongly manifested antipyretic and analgesic properties.
		The advantage of Indomethacin over corticosteroids and phenylbutazon is that its application does not cause retention of water in organism, which does not lead to increased edema and body weight.
		Indomethacin is quickly absorbed, the maximum serum level is reached within 1-2 h; its biological half-life is 90 min.
	www.bpg.bg /sopharma/categories/421/42109indomethacin.html (566 words)

	Indomethacin
		Indomethacin is used to reduce pain/swelling involved in osteoarthritis,
		Indomethacin has been reported to decrease absorption of folic acid and vitamin C.
		Under certain circumstances, indomethacin may interfere with the actions of vitamin C. Calcium and phosphate levels may also be reduced with indomethacin therapy.
	www.puritan.com /vf/healthnotes/HN75_english/Drug/Indomethacin.htm (671 words)

	Prophylactic Indomethacin Prevents Intraventricular Hemorrhage
		The impact was most pronounced for Grade 2 IVH but the indomethacin group did also have fewer Grade 3-4 hemorrhages (in terms of absolute numbers).
		15% of the indomethacin group weighing 900-1300 had ROP >or =to stage 3 as opposed to 3% of the placebo group (P<.07).
		Indomethacin is thought to exert its protective effect by attenuating the prostaglandin mediated cerebral vasodilatation in response to hypoxia, hypercarbia, and blood pressure fluctuations.
	www.med.umich.edu /pediatrics/ebm/cats/ivh.htm (447 words)

	Indomethacin Drug Information, Professional
		Fenoprofen, ibuprofen, indomethacin, mefenamic acid, and naproxen may also be taken prior to and during menstruation to prevent migraine associated with menstruation.
		Indomethacin is chemically related to the pyrroleacetic acid derivatives sulindac and tolmetin and to the pyranoindoleacetic acid derivative etodolac.
		This medication is chemically related to the indoleacetic acid derivative indomethacin and to the pyrroleacetic acid derivatives sulindac and tolmetin.
	www.drugs.com /MMX/Indomethacin.html (3922 words)

	[No title]
		As a formulation, indomethacin has been commercially available in the form of a capsule since 1966 and has found wide use for the medical treatment of rheumatoid arthritis and arthritis deformans as well as various inflammatory diseases and postoperative inflammations.
		Indomethacin reduces sulphate uptake in the articular cartilage of experimental animals.3 The sulphate uptake of chondrocytes reflected their protein-polysaccharide synthesis, an important constituent of cartilage matrix.
		Seven patients (three indomethacin, four ibuprofen) required a second treatment with indomethacin and in five (three in the indomethacin group and two in the ibuprofen group) the duct was ultimately ligated.
	www.lycos.com /info/indomethacin--effects.html?page=2 (628 words)

	Centre for Integrated Healing \| Foundations \| Indomethacin (Site not responding. Last check: )
		Although generally well tolerated, indomethacin, like aspirin, can be irritating to the stomach and thus, indomethacin should not be used by people with a history of ulcers or other stomach problems.
		Indomethacin should also not be used by people who are allergic to aspirin or other non-steroidal anti-inflammatory agents.
		Indomethacin should not be taken while undergoing chemotherapy with cyclosporin or methotrexate since indomethacin increases the toxicity associated with these two drugs.
	www.healing.bc.ca /therapy_indomethacin.shtml (355 words)

	Indomethacin
		The hyperkalaemia, which was reversed by discontinuing indomethacin, is attributed to a drug-induced defect in the cellular uptake of potassium.
		Results obtained by varying the concentrations of indomethacin and arachidonic acid and measuring inhibition of the conversion of Fe++ to Fe+++ by the indomethacin are consistent with a one to one complex forming between indomethacin and Fe++.
		Abstract: The role of oxygen-derived free radicals in the pathogenesis of acute gastric ulceration induced by indomethacin (Indo) was investigated in rats.
	home.caregroup.org /clinical/altmed/interactions/Drugs/Indomethacin.htm (1531 words)

	The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from ...
		Indomethacin conventional tablets were produced by mixing the drug with microcrystalline cellulose-silica (ratio of microcrystalline cellulose: silica was 20:1) for a period of 10 min in a cubic mixer (Erweka, Type UG, Germany).
		Indomethacin was dispersed in propylene glycol (this vehicle was used as the liquid vehicle to prepare the liquid medication of the different drug concentrations) with different ratios ranging from 1:1 to 1:4 (drug: propylene glycol).
		In each dissolution test, a standard solution of indomethacin (in the medium used) that had a concentration equal to the one expected to be obtained at the 100% dissolution level, was placed in the seventh dissolution vessel of set.
	www.ualberta.ca /~csps/JPPS8(1)/A.Nokhodchi/indomethacin.htm (3692 words)

	[No title]
		Four hours after administration of indomethacin, the animals were killed under deep anesthesia and their stomachs were removed and opened along the greater curvature.
		In the experiments carried out to determine the effect of indomethacin on SR Ca2+ loading, the SR of the fiber was first depleted of all releasable Ca2+ by exposure to a "depletion" solution (Table 1) and then partly reloaded with Ca2+ in a weakly buffered Ca2+ load solution for a fixed period.
		Depletion measurements made after loading in the presence of 200 µM indomethacin were compared with control measurements made before and after loading with the drug to minimize errors associated with any deterioration in the size of the control responses.
	www.lycos.com /info/indomethacin.html (736 words)

	Indomethacin (Site not responding. Last check: )
		Indomethacin relieves the inflammation and painassociated with rheumatoid arthritis, osteoarthritis, ankylosingspondylitis, and gout.
		Indomethacin works byreducing hormones that cause inflammation and pain in the body.
		Indomethacin capsules, liquid, and suppositoriesusually are taken two to four times a day extended-release capsulesare taken one or two times a day.
	pharmacycom.net /product_indomethacin-p13934.html (569 words)

	indomethacin (Indocin, Indocin-SR) - drug class, medical uses, medication side effects, and drug interactions by ...
		PRESCRIBED FOR: Indomethacin is used for the treatment of inflammation and pain caused by rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, osteoarthritis, and soft tissue injuries such as tendinitis and bursitis.
		Indomethacin and other NSAIDs may decrease the elimination of lithium by the kidneys and, therefore, increase the blood level of lithium, which could lead to lithium toxicity.
		NURSING MOTHERS: Indomethacin is excreted in breast milk and therefore should be avoided by nursing mothers.
	www.medicinenet.com /indomethacin/article.htm (655 words)

	Indocin (Indomethacin) drug description - prescription drugs and medications at RxList
		Suspension INDOCIN for oral use contains 25 mg of indomethacin per 5 mL, alcohol 1%, and sorbic acid 0.1% added as a preservative and the following inactive ingredients: antifoam AF emulsion, flavors, purified water, sodium hydroxide or hydrochloric acid to adjust pH, sorbitol solution, and tragacanth.
		Suppositories INDOCIN for rectal use contain 50 mg of indomethacin and the following inactive ingredients: butylated hydroxyanisole, butylated hydroxytoluene, edetic acid, glycerin, polyethylene glycol 3350, polyethylene glycol 8000 and sodium chloride.
		Indomethacin is practically insoluble in water and sparingly soluble in alcohol.
	www.rxlist.com /cgi/generic/indometh.htm (368 words)

	TopSearch10 - Search Results - indomethacin suppository
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	indomethacin-suppository.tbl.sytes.net (37 words)

	eMJA: Indomethacin and long-term outcome for tiny babies
		Indomethacin is often successful in closing the ductus when used therapeutically, but is associated with many short-term side effects.
		Therefore, whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in cerebral blood flow, as well as reduced blood flow to other organs, is not certain.
		However, this should be undertaken in the full knowledge that indomethacin prophylaxis does not impart any other important short-term benefits, such as a reduction in oxygen requirements, and that there remains the unknown issue of potential longer-term harm.
	www.mja.com.au /public/issues/179_02_210703/doy10003_fm.html (1169 words)

	INDOMETHACIN FOR TREATMENT OF FETOFETAL TRANSFUSION SYNDROME: 15(3)
		However, we planned to continue indomethacin until 34 weeks or to stop it earlier if the maximal depth of a pool in any sac was reduced to 2 cm, which would denote severe oligohydramnios.
		The physiological reason for the different responses shown by the fetuses to indomethacin may have been due to the circulatory volume changes induced by twin transfusion.5 Circulatory volume changes are powerful regulators of ADH secretion.6 The hypervolemia in the recipient inhibits fetal ADH secretion, causing increased urine output and polyhydramnios in its sac.
		The indomethacin responses are dose-related.3 The diversion of a greater portion of the drug to the recipient via transplacental shunts would also have contributed to the differential response.
	www.kfshrc.edu.sa /annals/153/94087.html (983 words)

	National Headache Foundation: INDOCIN (INDOMETHACIN
		Unlike steroids, the side effects with indomethacin are not as likely to be common or severe.
		Indomethacin may also be helpful in headache related to physical stress or exertional headache.
		Indomethacin is available in immediate or sustained-release (SR) pill form and can be compounded by certain pharmacies as a rectal suppository.
	www.headaches.org /consumer/topicsheets/indocin.html (164 words)

	indomethacin Consumer Drug Information
		Indomethacin is used to treat pain or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis.
		If you take indomethacin for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects.
		If you are taking indomethacin as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.
	www.drugs.com /MTM/indomethacin.html (1777 words)

	Indomethacin, Indocin
		Under certain circumstances, indomethacin may interfere with the actions of vitamin C. Calcium and phosphate levels may also be reduced with indomethacin therapy.
		Indomethacin should be taken with food to prevent stomach irritation.
		Use of alcohol during indomethacin therapy increases the risk of stomach irritation and bleeding.
	www.truestarhealth.com /Notes/1147006.html (733 words)

	Prolonged versus short course of indomethacin for the treatment of patent ductus arteriosus in preterm infants (Site not responding. Last check: )
		Indomethacin is a prostaglandin inhibitor used to treat patent ductus arteriosus (PDA) in preterm infants.
		Although indomethacin does result in ductal closure in the majority of cases, it is ineffective in up to 40% of patients (Siassi 1976).
		Furthermore, in preterm infants, the half-life of indomethacin is longer in infants of lowest extrauterine age and levels are cumulative with repeated dosing (Yaffe 1980).
	www.nichd.nih.gov /cochrane/Herrera/herrera.HTM (5805 words)

	Indomethacin for Recurrent PDA
		This study demonstrates that if the ductus fails to completely close after the first course of indomethacin, and then the ductus becomes hemodynamically significant again, more indomethacin probably won’t help.
		We are not told how many infants who had persistent ductal flow after the first course of indomethacin never went on to develop further problems from their PDA.
		This information would be important to know before making a recommendation that all infants who receive indomethacin for PDA get a follow up Doppler-echocardiogram to document ductal closure.
	www.fsneo.org /JourClub/4-041.htm (376 words)

	Indomethacin and other NSAIDs for gout
		Since indomethacin has for many years been one of the mainstay treatments for acute gout, Bandolier sought to review studies on its efficacy.
		Indomethacin and control treatments were effective in treating pain and inflammation from acute gouty arthritis.
		Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
	www.jr2.ox.ac.uk /bandolier/booth/gout/indo.html (1067 words)

	ACS :: Cancer Drug Guide: indomethacin
		Indomethacin is a nonopioid analgesic that belongs to the general class of drugs called nonsteroidal anti–inflammatory drugs (NSAIDs).
		Indomethacin can be taken by mouth or as a rectal suppository.
		Do not take indomethacin if you are allergic to aspirin or have severe kidney or liver disease.
	www.cancer.org /docroot/CDG/content/CDG_indomethacin.asp (737 words)

	Indomethacin Tocolysis Increases Postnatal Patent Ductus Arteriosus Severity -- Hammerman et al. 102 (5): e56 -- ...
		Indomethacin tocolysis has been reported to increase the incidence of persistent PDA in premature infants.
		18 (24%) of the 76 infants not exposed to antenatal indomethacin
		Moise KJ Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use.
	pediatrics.aappublications.org /cgi/content/full/102/5/e56 (2097 words)

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