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| | Patent 6,897,238 (Site not responding. Last check: 2007-11-05) |
 | | Since both plugging of the infundibulum and high sebaceous gland activity are necessary for an acne lesion to develop, it is likely that two of the predisposing factors for the follicles which become infected are (1) an infundibulum shape which is easily plugged, and/or (2) a hyperactive sebaceous gland. |
 | | A sufficient amount of the ALA infiltrates spaces about the infundibulum and the infundibulum is exposed to sufficient energy to cause the converted ALA to become photodynamically activated, thereby modifying the opening to the infundibulum. |
 | | In one embodiment, the opening to the infundibulum is altered such that pore pluggage will not occur, e.g., the infundibulum is reshaped such that excess sebum, oils, dirt and bacteria will not cause pore pluggage to occur, resulting in a flhead (comedon) or white head (milium). |
| pharmcast.com /Patents100/Yr2005/May2005/052405/6897238_Acne052405.htm (5788 words) |
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