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	Humalog (Insulin Lispro (Human Analog)) drug description - prescription drugs and medications at RxList
		Humalog® (insulin lispro, rDNA origin) is a human insulin analog that is a rapid-acting, parenteral blood glucose-lowering agent.
		Chemically, it is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B -chain are reversed.
		Humalog is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for insulin lispro.
	www.rxlist.com /cgi/generic/insulinlispro.htm (228 words)

	children with DIABETES - Lantus (Insulin Glargine)
		Other insulin analogs, such as Humalog, are engineered to provide a very rapid effect.
		Insulin glargine in the treatment of type 1 and type 2 diabetes.
		Insulin glargine improves hemoglobin A1c in children and adolescents with poorly controlled type 1 diabetes.
	www.childrenwithdiabetes.com /d_0n_115.htm (779 words)

	Diabetes Monitor - lispro insulin (Humalog)
		Insulin lispro (Humalog) was the first insulin analog.
		Analogs are modifications of natural insulin, where changes are made in the amino acid sequence of the insulin molecule that affect the duration of action.
		The total daily dose of rapid-acting insulin (insulin lispro or regular human insulin) and the total daily dose of basal insulin were similar during clinical trials with insulin lispro and regular human insulin.
	www.diabetesmonitor.com /lispro.htm (1176 words)

	Treatments: Human Insulin Analog (Lispro) - WrongDiagnosis.com
		Insulin lysine-proline or "lispro" is a synthesized human insulin analog, where "analog" means it is not exactly identical to human insulin.
		Insulin lispro's rapid action also makes it better for counteracting the effects of any simple sugars eaten, although it's still not so effective against sugars, and eating sugars is still a bad dietary choice for diabetics.
		Insulin analogs have been available for some time and are available for numerous injection devices.
	www.wrongdiagnosis.com /treat/human_insulin_analog_lispro_.htm (487 words)

	All About Insulin : Juvenile Diabetes Research Foundation International (Site not responding. Last check: )
		Insulin analogs are versions of insulin that have been altered to achieve improved effect.
		Insulin lispro, the first insulin analog, introduced in August 1996 by Eli Lilly and Company under the brand name Humalog, is a rapid-acting analog that works much more quickly than regular insulin and lasts only about two hours, making it ideal for mealtime insulin injections.
		Whereas regular insulin is supposed to be taken 30 to 45 minutes before meals, Humalog is taken within 15 minutes of eating, which adds flexibility and convenience to meal planning.
	www.jdrf.org /index.cfm?page_id=103610 (370 words)

	Insulin Analogs
		While insulin lispro is the only insulin analog sold anywhere today, this is likely to change soon as insulin manufacturers rush other insulin analogs to the market.
		Insulin glargine differs from human insulin in three amino acids, slowing down its release and reducing its solubility in the blood.
		When insulin glargine and perhaps other long-acting insulin analogs become available, people with diabetes will be able to combine a true basal insulin with a rapid-acting insulin like lispro or aspart with their meals.
	www.mendosa.com /analogs.htm (0 words)

	Aventis Pharmaceuticals -Apidra - April 2004
		Insulin glulisine differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid.
		The distribution and elimination of insulin glulisine and regular human insulin after intravenous administration are similar with volumes of distribution of 13 L and 21 L and half-lives of 13 and 17 minutes, respectively.
		The effects of insulin glulisine did not differ from those observed with subcutaneous regular human insulin at the same doses and were attributed to secondary effects of maternal hypoglycemia.
	www.insulin-pumpers.org /faq/apidra_TXT.html (4981 words)

	Howstuffworks "Insuline Glargine: A Profile of a Diabetes Drug"
		Insulin is a hormone that is normally produced by the pancreas; it functions in the regulation of blood sugar levels.
		Insulin glargine is more slowly absorbed into the bloodstream, resulting in a more constant level of insulin in the blood.
		Insulin glargine is used to treat diabetes mellitus (sugar diabetes), a disorder that results from an inability of the pancreas to produce enough insulin.
	health.howstuffworks.com /define-insulin-glargine.htm (1355 words)

	InsulinDevice.com - Novo Nordisk®
		Innovo® is a state-of-the-art insulin doser that takes a whole new approach to insulin delivery.
		Designed to make injecting insulin as easy as possible, NovoPen® 3 has a number of features, including an easy-to-read dosing window, easy-dial dosing mechanism, and easy administration of 2 to 70 units of insulin, in 1-unit increments.
		Your insulin needs may change due to a number of factors, such as illness, stress, medicines, or changes in diet or exercise routines.
	www.insulindevice.com /which_prod.asp (0 words)

	Diabetes Self Management
		Insulin is a hormone, or chemical messenger that is released into the bloodstream to be transported throughout the body.
		The structure of the insulin lispro molecule is identical to that of human insulin except that the amino acids at two positions on the B chain, B28 and B29, are reversed.
		In insulin glargine, two molecules of the amino acid arginine are added to one end of the B chain, and one molecule of glycine is substituted for asparagine at position A21.
	www.diabetesselfmanagement.com /article.cfm?aid=1982 (959 words)

	Insulin Detemir—A New Basal Insulin Analog
		Only human studies were used for pharmacokinetic, drug interaction, efficacy, and safety data.
		DATA SYNTHESIS: Insulin detemir is a basal insulin analog that has been shown to improve glycemic control in patients with type 1 and type 2 diabetes.
		CONCLUSIONS: Insulin detemir offers some benefits over NPH for use as basal insulin in patients with type 1 and type 2 diabetes.
	www.pharmace.com /abstracts/detemir.html (0 words)

	Insulin definition - Diabetes Mellitus, Type 2, Type 1, and Metabolic Disorders treatment and medications
		Insulin is made specifically by the beta cells in the islets of Langerhans in the pancreas.
		Insulin was the first hormone to be synthesized completely in the laboratory, a feat accomplished in 1966 by the American worker Michael Katsoyannis and scientists in China.
		Insulin Resistance - Insulin resistance is associated with obesity, fatty liver, type 2 diabetes, heart disease, skin tags, polycystic ovary disease, and growth abnormalities.
	www.medterms.com /script/main/art.asp?articlekey=3989 (701 words)

	Insulin analog Information
		Insulin in the form of a hexamer will not bind to its receptors, so the hexamer has to slowly equilibrate back into its monomers to be biologically useful.
		Non hexameric insulins were developed to be faster acting and replace the injection of normal unmodified insulin that comes after a meal.
		These insulin analogues are used to replace the basal level of insulin, and are effective over a period of 24 hours.
	www.bookrags.com /wiki/Insulin_analog (964 words)

	Insulin Glargine Drug Information, Professional
		Analog of human insulin created by replacing the amino acid at position 21 of the A-chain (asparagine) with glycine and by adding two arginines to the C-terminus of the B-chain.
		Insulin glargine was not mutagenic in tests for detection of gene mutations in bacteria and mammalian cells (Ames- and HGPRT-test) and in tests for detection of chromosomal aberrations (cytogenetics in vitro in V79 cells and in vivo in Chinese hamsters).
		Insulin glargine should not be given intravenously because the prolonged duration of effect is dependent on injection into subcutaneous tissue.
	www.drugs.com /MMX/Insulin_Glargine.html (2519 words)

	PRESS RELEASE New Long-Acting Insulin Analog Levemir(R) Now Available in United States (Site not responding. Last check: )
		Levemir is the first basal insulin analog to have a treat-to-target study in its label.
		Levemir (insulin detemir [rDNA origin] injection) is a long-acting basal insulin analog indicated for once- or twice-daily subcutaneous administration for the treatment of adults and children with type 1 diabetes mellitus and adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
		Levemir is contraindicated in patients hypersensitive to insulin detemir or its excipients.
	www.marketwire.com /mw/release_html_b1?release_id=114901 (1210 words)

	Insulin
		Insulin is a natural protein made by the pancreas that helps the body use sugar.
		In such cases, the amount of insulin may need to be reduced in order to avoid a hypoglycemic reaction.
		Insulin has been shown to decrease the levels of DHEA and DHEA-sulfate in the blood.
	www.gianteagle.com /healthnotes/Drug/Insulin.htm (712 words)

	Insulin
		Insulin is a natural protein made by the pancreas that helps the body use sugar.
		Insulin is injected by all people with type 1 (insulin-dependent) diabetes mellitus and by some people with type 2 (non-insulin-dependent) diabetes mellitus to help control blood sugar levels.
		In such cases, the amount of insulin may need to be reduced in order to avoid a hypoglycemic reaction.
	www.publix.com /wellness/notes/Display.do?id=Drug&childId=Insulin (873 words)

	Howstuffworks "Insulin Aspart: A Profile of an Antidiabetic Drug"
		Insulin aspart is a short-acting human insulin that has undergone small changes in its chemical structure.
		These changes affect the way the insulin is absorbed after it is injected under the skin, making it enter the bloodstream faster than regular human insulin.
		Insulin aspart is used to treat diabetes mellitus (sugar diabetes), a disorder resulting from an inability of the pancreas to produce enough insulin.
	health.howstuffworks.com /define-insulin-aspart.htm (1210 words)

	Insulin
		Insulin fördert den Transport von Glukose zu allen Zellen des Körpers.
		Insulin aktiviert in der Leber und in den Muskelzellen Enzyme, die für die Verbrennung von Glukose und die Verarbeitung von Glukose in Glykogen verantwortlich sind.
		Insulin sorgt in den Fettzellen für die Aktivierung von Enzymen, die zur Umwandlung von Glukose in Fett notwendig sind.
	www.medizinfo.de /diabetes/diasto3.htm (829 words)

	Patent 6,051,551
		The invention relates to a method of administering a fatty acid-acylated insulin or insulin analog by inhalation, a method for treating diabetes by administering a fatty acid-acylated insulin or insulin analog by inhalation, and a method for treating hyperglycemia by administering a fatty acid-acylated insulin or insulin analog by inhalation.
		Second, presently known soluble, long-acting insulins and insulin derivatives are delivered by subcutaneous injection, which involves the inconvenience of preparing a sample for injection, and the pain of a needle-stick.
		A method of treating diabetes or hyperglycemia, comprising administering to a patient in need thereof an effective amount of a fatty acid-acylated human insulin or a fatty acid-acylated human insulin analog by inhalation, such that the fatty-acid acylated human insulin or fatty acid-acylated insulin analog is deposited in the lungs of the patient.
	www.pharmcast.com /Patents/041800OG/6051551_Insulin041800.htm (482 words)

	Insulin lispro: a fast-acting insulin analog - includes patient information directions for use American Family ...
		Insulin is necessary for the normal metabolism of carbohydrates, protein and fat.
		In persons who do not have diabetes, insulin is very sensitive to the rise in blood glucose concentration that occurs in response to meals.
		Insulin lispro is available only by prescription and is indicated for the management of hyperglycemia in patients with diabetes mellitus.
	www.findarticles.com /p/articles/mi_m3225/is_n2_v57/ai_20309420 (551 words)

	German Article Link
		R-DNA insulin is a genetically manufacturer material which is an exact match to the human body's own insulin.
		The analog, which had already been tested in humans, had to be withdrawn from the market.
		In order to be able to judge potential cancer-causing effects if insulin analogs, data and bioassays would need to be accessible from the pharmaceutical firms.
	members.tripod.com /diabetics_world/insulin_analog_eng.htm (742 words)

	Insulin glargine: a long acting insulin analog.
		Most insulin preparations and insulin delivery systems, do not mimic the physiological insulin secretion in the body, leading to impaired metabolic control and increased hypoglycemic attacks.
		Insulin glargine is newer, long acting insulin analog with duration of action of 24 hr.
		In the current scenario, though it is difficult to achieve an ideal replacement therapy, insulin glargine is definitely a positive step in that direction.
	www.galenicom.com /medline/article/15793346/jo:0022-3859 (175 words)

	Long-Acting Insulin Analog Levemir
		FDA-approved Levemir® (insulin detemir) is a new long-acting insulin analog* now available in the U.S. Levemir® is approved for use by adults and children with Type 1 diabetes, and by adults with Type 2 diabetes who require long-acting (basal) insulin to control hyperglycemia.
		Like insulin glargine (trade name Lantus), a long-lasting insulin introduced in 2001, Levemir® is designed to have a relatively steady level of activity, which means it doesn’t “peak” the way other insulins do.
		Levemir® should not be diluted or mixed with any other insulin, and should not be used if the patient is hypersensitive to insulin detemir or any of its excipients.
	www.focuspharmacy.com /acatalog/Long-Acting_Insulin_Analog_Levemir.html (497 words)

	NovoLog® is a rapid-acting insulin analog
		Mean free serum insulin concentrations collected up to 6 hours following a single dose of NovoLog injected before a meal versus regular human insulin injected immediately before a meal in 22 patients with type 1 diabetes.
		Levels of antibodies that cross-react with human insulin and insulin aspart were transiently increased in type 1 patients treated with NovoLog compared with regular human insulin and no longer evident at 12 months of treatment.
		This is especially pertinent for rapid-acting insulin analogs that are more rapidly absorbed and have shorter durations of action.
	www.novolog.com /professional/clinical-information-analog.asp (437 words)

	Hyperglycemia Management With LANTUS® Basal Insulin
		Apidra® (insulin glulisine [rDNA origin] injection) should normally be used in regimens that include a longer-acting insulin or basal insulin analog.
		Apidra® (insulin glulisine [rDNA origin] injection) is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Apidra® (insulin glulisine [rDNA origin] injection) or one of its excipients.
		As with all insulin preparations, the time course of Apidra® (insulin glulisine [rDNA origin] injection) action may vary in different individuals or at different times in the same individual and is dependent on site of injection, blood supply, temperature, and physical activity.
	www.lantus.com /hcp/hyperglycemia.aspx (903 words)

	Apidra(R) - a New Rapid-Acting Insulin Analog - Is Now Available in the United States for Hyperglycemia in Adults with ...
		As with all insulin preparations, the time course of Apidra(R) action may vary in different individuals or at different times in the same individual and is dependent on site of injection, blood supply, temperature, and physical activity.
		About LANTUS(R) (insulin glargine [rDNA origin] injection) Lantus(R) is indicated for once-daily subcutaneous administration, at the same time each day, for the treatment of adult and pediatric patients (6 years and older) with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
		LANTUS(R) is contraindicated in patients hypersensitive to insulin glargine or the excipients.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/02-28-2006/0004308541&EDATE= (1190 words)

	Metabolically Inactive Insulin Analog Prevents Type I Diabetes in Prediabetic NOD Mice -- Karounos et al. 100 (6): 1344 ...
		Administration of insulin or an inactive insulin analog, altered by a single amino acid at position 25 of the B chain, was
		to 0.05% for the insulin receptor, and to < 0.005% for the IGF-I
		the stomach, and subsequent absorption of insulin peptides (8).
	www.jci.org /cgi/content/full/100/6/1344 (2977 words)

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