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Topic: Insulin glargine

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	Insulin - Wikipedia, the free encyclopedia
		Insulin (from Latin insula, "island", as it is produced in the Islets of Langerhans in the pancreas) is a polypeptide hormone that regulates carbohydrate metabolism.
		Insulin is synthesized in humans, and other mammals, within the beta cells (β-cells) of the islets of Langerhans in the pancreas.
		In beta cells, insulin is synthesized from the proinsulin precursor molecule by the action of proteolytic enzymes known as prohormone convertases (PC1 and PC2), as well as the exoprotease carboxypeptidase E. These modifications of proinsulin remove the center portion of the molecule, or C-peptide, from the C- and N- terminal ends of the proinsulin.
	en.wikipedia.org /wiki/Insulin (5976 words)

	insulin glargine - General Practice Notebook (Site not responding. Last check: 2007-10-24)
		Insulin glargine (Lantus) is a long-acting human insulin analogue, which is prepared by modifying the chemical structure of insulin to allow more consistent release during the day, thereby mimicking natural basal insulin release.
		Insulin glargine is licensed for people with type 1 and type 2 diabetes where treatment with insulin is required.
		Insulin glargine, injected subcutaneously, maintains a basal concentration of insulin in the blood that can be raised by supplementary injections of a short-acting insulin as required.
	www.gpnotebook.co.uk /cache/x20030109071346665170.htm (215 words)

	Glargine (Lantus) insulin and feline diabetes remission
		Insulin glargine is a new human synthetic insulin analogue that is very long-acting.
		Insulin dose was then adjusted based on serial blood glucose curves and water intake.
		The relative euglycemia achieved with glargine was assumed responsible for rapid reversal of beta cell glucose toxicity and early diabetic remission.
	www.felinediabetes.com /glargine.htm (511 words)

	All About Insulin : Juvenile Diabetes Research Foundation International
		Insulin analogs are versions of insulin that have been altered to achieve improved effect.
		Insulin lispro, the first insulin analog, introduced in August 1996 by Eli Lilly and Company under the brand name Humalog, is a rapid-acting analog that works much more quickly than regular insulin and lasts only about two hours, making it ideal for mealtime insulin injections.
		Once injected, insulin glargine forms a precipitate, which is absorbed very slowly and evenly into the bloodstream.
	www.jdrf.org /index.cfm?page_id=103610 (370 words)

	Glargine Q&A (Site not responding. Last check: 2007-10-24)
		Insulin glargine is also available in a vial for use with syringes.
		Insulin glargine must not be mixed with any other insulins or solutions, and if it appears to have any sediment in it, it should not be used and must be discarded.
		Insulin glargine may be either on its own or in combination with other insulin or tablets for diabetes.
	www.diabetes.org.uk /infocentre/inform/glargine.htm (704 words)

	MedlinePlus Drug Information: Insulin Glargine (rDNA origin) Injection
		Insulin glargine is used to treat type 1 (insulin-dependent) diabetes (formerly called 'juvenile-onset').
		Insulin glargine is a long-acting, man-made version of human insulin.
		Your dose of insulin glargine may need to be changed when you are ill (especially with fever, vomiting, or diarrhea), have emotional changes or stress, gain or lose weight, or change the amount of food you eat or amount of exercise you do.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a600027.html (2014 words)

	Pharmaceutical Technology - Aventis Recombinant Insulin Plant, Frankfurt
		Insulin glargine is a long-acting single dose insulin injection that will last over a 24 hour period (24-hour basal insulin).
		The insulin is harvested by lysing the dead bacteria and then separating out the pre-insulin from the rest by centrifugation and filtration.
		The new inhalable insulin product requires the insulin to be put through a process called micronisation, where very small particles are produced suitable for blister capsules to be used in a normal inhaler.
	www.pharmaceutical-technology.com /projects/aventis (592 words)

	Study reveals benefits of using insulin earlier (Site not responding. Last check: 2007-10-24)
		When insulin glargine was added to their treatment, patients were able to achieve lower and steady blood glucose levels more quickly and more often.
		Insulin glargine is approved for once-daily administration in patients over the age of 17 with type 1 or type 2 diabetes who require basal insulin to control abnormally high blood sugar levels.
		Insulin glargine can be used with oral diabetes medications and/or short-acting insulin to help control diabetes.
	www.news-medical.net /?id=10998 (520 words)

	Glargine Insulin
		PZI insulin, currently the insulin of choice for cats, has a reliably long duration most of the time but is expensive since it became available only for the veterinary market or must be compounded with inconsistent quality control between batches.
		Studies are still on-going and even the glargine researchers in Australia still say that PZI insulin should remain “insulin of choice” at this time but have released some guidelines on how to use glargine insulin in the cat.
		Glargine is available in a Pen injector that measures one unit increments but it is expensive, expires in 1 month and cannot be refrigerated.
	www.marvistavet.com /html/body_glargine_insulin.html (607 words)

	Diabetes This Week 05/27/01: new insulin glargine, inhaled insulin successful, sepsis drug, new eye exam, diabetes ...
		Researchers found that there was little variation in insulin levels from day to day in the participants, and that glargine provides constant basal levels for 24 hours without peaking.
		Glargine takes about five days to reach its full effect so fine adjustments are not recommended before at least five to seven days of use, unless, of course, low blood sugars begin.
		The insulin is delivered by way of an aerosol pump designed by Inhale Therapeutic Systems Inc. At a recent meeting of the American Thoracic Society, results of a study of the 140 people who have taken the insulin for two years were presented.
	www.diabetesnet.com /news/news052701.php (2249 words)

	MedlinePlus Drug Information: INSULIN GLARGINE (Systemic) (Site not responding. Last check: 2007-10-24)
		Insulin is one of many hormones that help the body turn the food we eat into energy.
		Insulin glargine is a long-acting insulin that works slowly over about 24 hours.
		You may have to use insulin glargine in combination with another type of insulin or with a type of oral diabetes medicine to keep your blood sugar under control.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500147.html (1766 words)

	EASD: Insulin Glargine Produces Less Symptomatic Hypoglycemia Than NPH Insulin In Type-2 Diabetes (Site not responding. Last check: 2007-10-24)
		Insulin glargine is a human insulin analog that offers a smooth and steady rate of insulin release from the injection site.
		Also, the percentage of patients reporting a symptomatic hypoglycemic event confirmed by a blood glucose <2.8 mmol/L was markedly lower in the insulin glargine group than in the NPH group (17.3 percent vs. 31.3 percent, p=0.0017).
		The authors claim that their results show the bedtime insulin glargine is as effective as bedtime NPH insulin as far as improving blood glucose control is concerned and this is associated with fewer hypoglycemic symptoms and confirmed hypoglycemic events.
	www.pslgroup.com /dg/205ef2.htm (494 words)

	insulin - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Insulin is required by the cells of the body in order for them to remove and use glucose from the blood.
		Insulin aspart and insulin glargine are both human insulin that have had their chemical composition slightly altered.
		Human recombinant insulin, insulin lispro, insulin aspart, and insulin glargine are the commonly-used insulins.
	www.medicinenet.com /insulin/article.htm (978 words)

	Lantus (insulin glargine [rDNA] injection) Drug Brief / RxPalace.com
		However, when patients were transferred from twice-daily NPH human insulin to Lantus once daily at bedtime, to reduce the risk of hypoglycemia, the initial dose (IU) was usually reduced by approximately 20% (compared to total daily IU of NPH human insulin) within the first week of treatment and then adjusted based on patient response.
		This is particularly true for patients with acquired antibodies to human insulin needing high-insulin doses and occurs with all insulin analogs.
		Insulin and its analogs lower blood glucose levels by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production.
	www.rxpalace.com /DrugBriefs/Lantus.htm (515 words)

	EASD: Insulin Glargine, NPH Insulin Not Linked To Retinopathy Progression (Site not responding. Last check: 2007-10-24)
		The allocated treatments were as follows: Insulin glargine (LANTUS), 556 patients with type 1 diabetes, 548 with type 2 diabetes; NPH insulin, 563 patients with type 1 diabetes and 540 with type 2 diabetes.
		The incidence of adverse events was the same in the insulin glargine and NPH insulin groups (10 percent).
		In the case of development of macular edema, in studies 3001 and 3004 there was no difference in the number of people developing macular edema in the insulin glargine and NPH insulin groups, and this was also true for study 3006.
	www.pslgroup.com /dg/206456.htm (549 words)

	Lantus Online, Description, Chemistry, Ingredients - Insulin Glargine [rDNA origin] Inj - RxList Monographs
		(insulin glargine [rDNA origin] injection) is a sterile solution of insulin glargine for use as an injection.
		Insulin glargine is a recombinant human insulin analog that is a long-acting (up to 24-hour duration of action), parenteral blood-glucose-lowering agent.
		Insulin glargine differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the C-terminus of the B-chain.
	www.rxlist.com /cgi/generic2/lantus.htm (228 words)

	News - Insulin Glargine Improves Diabetes Control
		Available as a subcutaneous injection, glargine is indicated for adults and children over age six years with type 1 diabetes and in adults with type 2 diabetes.
		Insulin glargine is a recombinant human insulin analogue derived from a nonpathogenic strain of escherichia coli.
		Two modifications of human insulin result in a stable molecule which is soluble in slightly acidic conditions (pH 4.0) and precipitates in the neutral pH of subcutaneous tissue.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256B84004D15FD (477 words)

	BD Diabetes - Diabetes News - Long-acting insulin unaffected by exercise
		The investigators compared the effect of exercise on the absorption of injected insulin glargine in 13 patients with type 1 diabetes.
		The usual insulin dose was given in the thigh on the evening before the exercise study on two occasions 1 week apart.
		However, no significant difference was observed in the rate of insulin glargine decay on the 2 study days (exercise versus no exercise).
	www.bddiabetes.com /us/newsletter/landing/22Q2landing2.asp (368 words)

	children with DIABETES - Lantus (Insulin Glargine)
		Another study concluded that Lantus was a better basal insulin than NPH when used as part of a basal-bolus regimen for patients with Type 1 diabetes.
		Switch to multiple daily injections with insulin glargine and insulin lispro from continuous subcutaneous insulin infusion with insulin lispro: a randomized, open-label study using a continuous glucose monitoring system.
		Insulin glargine improves hemoglobin A1c in children and adolescents with poorly controlled type 1 diabetes.
	www.childrenwithdiabetes.com /d_0n_115.htm (635 words)

	INSULIN GLARGINE - INJECTABLE (Lantus) side effects, medical uses, and drug interactions.
		USES: Insulin glargine is used to treat diabetes mellitus.
		Like other insulin products, it works by helping sugar (glucose) get into cells but has a more long-acting (over 24 hours) effect.
		Insulin glargine is not recommended to be given into a vein (IV).
	www.medicinenet.com /insulin_glargine-injectable/article.htm (413 words)

	LANTUS® insulin glargine [rDNA origin] injection (Site not responding. Last check: 2007-10-24)
		It is the only insulin analog used once a day that is proven to lower basal glucose levels for a full 24 hours with no pronounced peak.
		Lantus is indicated for once-daily subcutaneous administration at bedtime in the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
		Lantus is a long-acting insulin analog that helps the body regulate the removal of glucose from the bloodstream.
	www.acofp.org /member_publications/newapril_02.htm (424 words)

	Insulin Glargine recombinant drug profile and news (Site not responding. Last check: 2007-10-24)
		The primary activity of insulin is the regulation of glucose metabolism.
		The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor.
		Four insulin injections are given throughout the day, three through a Novolog pen syringe and a bedtime dose of Lantus, which provides the base rate for her...
	emergency.mongabay.com /rx/Insulin_Glargine_recombinant.html (2052 words)

	WebMD Health Search
		Lantus Insulin Supplies From the most trusted source for Insulin Supplies.
		One study shows that insulin glargine (Lantus) is as effective as NPH insulin in controlling blood sugar in people with type 1 diabetes.
		Insulin pumps deliver a steady stream of insulin, which most closely mimics a natural state, experts say...Convenient Care: The Insulin Pump Insulin pumps deliver a steady stream of insulin, which most closely mimics a natural state, experts...
	www.webmd.com /search/search_results/?query=glargine&filter=mywebmd_all_filter&go.x=13&go.y=12 (381 words)

	RemedyFind: patient ratings of Insulin: Lantus (Insulin glargine) for Diabetes Type 1
		Insulin injections work in the same way as natural insulin, by binding to insulin receptors on cells in the body.
		Insulin causes cells in the liver, muscle and fat tissue to increase their uptake of glucose from the bloodstream.
		Insulin injections also decrease the production of glucose by the liver, and have various other effects that lower the amount of glucose in the blood.
	www.remedyfind.com /treatments/48/916 (1165 words)

	Insulin Glargine Ftir Portal \| Insulin Glargine Ftir News (Site not responding. Last check: 2007-10-24)
		Controversial, but it is generally accepted that insulin levels, which rise sharply is a significant association between insulin resistance and depression.
		Click here if you are looking for insulin glargine ftir insulin glargine ftir resource and news page all the insulin glargine ftir resources you need to know about are here.
		Insulin is best known for its role as a blood sugar lowering hormone, but it has many other important functions, some of which have potentially negative as well as positive ramifications these include the following, which are largely drawn from the work of Rosedale 1.
	www.mydiabetesguru.com /insulin-glargine-ftir.html (931 words)

	[No title] (Site not responding. Last check: 2007-10-24)
		The pre-meal insulin is usually given with an insulin pen (see Figure 1).
		This is an insulin pen used to administer insulin glargine (Lantus) and the...
		Insulin pens that are "in use" may be kept at room temperature,...
	members.lycos.co.uk /lolipoper/lantusinsulinpen.html (423 words)

	Effects of the Long-Acting Insulin Analog Insulin Glargine on Cultured Human Skeletal Muscle Cells: Comparisons to ...
		Cross-talk of insulin glargine for the IGF-I receptor was
		that insulin glargine was unable to overcome this insulin resistance.
		A and B, Effects of human insulin, insulin glargine, and IGF-I on Akt serine phosphorylation in human skeletal muscle cells from nondiabetic subjects and patients with type 2 diabetes.
	jcem.endojournals.org /cgi/content/full/86/12/5838 (5781 words)

	insulin glargine - General Practice Notebook
		insulin glargine and insulin detemir both seem to result in glycaemic control that is at least comparable to that with isophane insulin
		insulin glargine seems to reduce nocturnal hypoglycaemia in patients with type 1 or type 2 diabetes
		NICE guidance - the use of long-acting insulin analogues for the treatment of diabetes - insulin glargine
	www.gpnotebook.co.uk /simplepage.cfm?ID=x20030109071346665170 (1019 words)

	What is Lantus (insulin glargine)?
		Lantus (generic name insulin glargine) is a new type of long-acting insulin for treating children and adults with diabetes.
		Insulin is a hormone that plays an important role in regulating the amount of sugar (glucose) in the body.
		According to preliminary studies, Lantus is as effective as NPH insulin (another form of human insulin) in keeping blood glucose under control.
	www.drugstore.com /qxa1708_332828_sespider/what_is_lantus_insulin_glargine.htm (351 words)

	Diabetes Monitor - Lantus (insulin glargine) (Site not responding. Last check: 2007-10-24)
		For: once-daily subcutaneous administration in the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
		It's the first clear long-acting insulin; all the other medium and long-acting insulins are "cloudy" (i.e., suspensions).
		Insulin Glargine Mary Ross, R.Ph., M.B.A. At Virtual Hospital.
	www.diabetesmonitor.com /lantus.htm (346 words)

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