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Topic: Insulin sensitivity

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	Assessing Insulin Sensitivity
		Normal insulin sensitivity varies widely and is influenced by age, ethnicity, and obesity.
		The gold standard for evaluating insulin sensitivity, this "clamp" technique requires a steady IV infusion of insulin to be administered in one arm.
		Remember that insulin sensitivity is the ability of the hormone to reduce serum glucose.
	www.musc.edu /dfm/RCMAR/InsulinSens.html (1826 words)

	Insulin resistance -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-18)
		Insulin resistance denotes decreased sensitivity of target ((biology) the basic structural and functional unit of all organisms; cells may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) cells (muscle, fat cells) to insulin.
		In order to compensate for the insulin (A solution obtained by steeping or soaking a substance (usually in water)) infusion, (A monosaccharide sugar that has several forms; an important source of physiological energy) glucose 20% is infused to maintain blood sugar levels between 5 and 5.5 mmol/l.
		The concept that insulin resistance may be the underlying cause of (Diabetes caused by a relative or absolute deficiency of insulin and characterized by polyuria) diabetes mellitus type 2 was first advanced by Sir (additional info and facts about Harold Percival Himsworth) Harold Percival Himsworth in 1936.
	www.absoluteastronomy.com /encyclopedia/i/in/insulin_resistance.htm (933 words)

	Insulin Sensitivity Decreases with Obesity, and Lean Cats with Low Insulin Sensitivity Are At Greatest Risk of Glucose ...
		The measurements of insulin sensitivity based on computer modeling of insulin concentrations and glucose disappearance from the plasma indicated that, after weight gain, cats had altered distribution and binding kinetics of insulin and decreased receptor binding and post-receptor activation of intracellular effects.
		The authors concluded that insulin resistance and glucose intolerance occurs in obese cats and that lean cats with low insulin sensitivity are at increased risk for developing glucose intolerance when obese.
		Male cats have been shown to have an increased risk for diabetes mellitus, and possible explanations include an increased incidence of obesity and the lower insulin sensitivity in male cats that was suggested by this study.
	www.vspn.org /Library/Journals/VSPN_AbstractOWeek032103.htm (1060 words)

	Clinical Trial: Effects of Dark Chocolate on Insulin Sensitivity in People with High Blood Pressure
		Blood glucose and insulin levels are measured frequently during the test and the rate of the glucose infusion is adjusted to keep blood glucose at the baseline (fasting) level.
		Blood pressure, insulin sensitivity, and insulin-mediated capillary recruitment will be assessed in each subject after the run-in period, after 15 days of treatment, and after completion of the cross-over.
		Insulin sensitivity will be measured using the hyperinsulinemic euglycemic glucose clamp technique.
	www.clinicaltrials.gov /show/NCT00099476 (1402 words)

	Obesity and diet affect glucose dynamics and insulin sensitivity in Thoroughbred geldings -- Hoffman et al. 81 (9): ...
		CV of <1% for glucose, and 5% for insulin.
		CV was 2% for glucose and 5.5% for insulin.
		Glucose tolerance and insulin sensitivity in ponies and Standardbred horses.
	jas.fass.org /cgi/content/full/81/9/2333 (5160 words)

	[No title]
		Insulin is found in even single-celled organisms and has been around for several billion years.
		Insulin resistance is the basis of all of the chronic diseases of aging, because the disease itself is actually aging.
		Insulin's evolutionary purpose as is known right now, we are looking at other possibilities, is to store excess nutrients.
	www.mercola.com /2001/jul/14/insulin.htm# (3587 words)

	Diabetes Forecast May 2003 - Research Profile - American Diabetes Association (Site not responding. Last check: 2007-10-18)
		Insulin sensitivity and the menstrual cycle; the role of the autonomic nervous system in the regulation of blood sugar
		Therefore, her team will compare insulin sensitivity at different times of the month in women who have PMS to insulin sensitivity in women who don't have PMS.
		Teff's team will then compare the women's insulin sensitivity while they are taking Zoloft during the luteal phase with their insulin sensitivity during the luteal phase when they weren't taking Zoloft.
	www.diabetes.org /diabetes-forecast/may2003/research.jsp (992 words)

	Clinical Trial: Methods for Measuring Insulin Sensitivity
		We hypothesize that the majority of the information needed to accurately estimate insulin sensitivity is contained in the fasting insulin and glucose levels as well as the insulin and glucose levels obtained shortly after an intravenous glucose load.
		Data from these studies will be used obtain estimates of insulin sensitivity by the glucose clamp method, minimal model method, and a novel analysis that utilizes only fasting and peak levels of glucose and insulin.
		We hope to devise a simpler method for determining insulin sensitivity in vivo that is suitable for testing large populations.
	clinicaltrials.gov /show/NCT00001625 (731 words)

	B AHRÉN and G PACINI: Insulin secretion versus insulin sensitivity (European Journal of Endocrinology) (Site not responding. Last check: 2007-10-18)
		Insulin sensitivity and insulin secretion are mutually related such that insulin resistance is compensated by increased insulin secretion.
		Mathematical analyses of the relation between insulin sensitivity and insulin secretion have revealed a hyperbolic function, such that the product of the two variables is constant.
		Using these techniques the compensation of beta cell function to insulin resistance has been verified in obesity, in pregnancy and after glucocorticoid administration as has the defective beta cell function as the underlying cause to impaired glucose tolerance and type 2 diabetes.
	www.eje.org /eje/150/eje1500097.htm (278 words)

	Medical Research News for Parents - Significant Weight Loss Improves Insulin Sensitivity in Obese Kids and Teens (Site not responding. Last check: 2007-10-18)
		Excess body weight can decrease the body's response (or sensitivity) to insulin, a condition known as insulin resistance, which can be associated with the development of several health problems.
		At the beginning of the study and 1 year later, the children's insulin sensitivity levels were measured and height and weight measurements were taken.
		The overweight children who gained weight over the 1-year study period had decreases in their body's sensitivity to insulin (normal-weight children who gained weight did not have decreases in insulin sensitivity).
	kidshealth.org /research/weight_loss_insulin.html (453 words)

	QUICKI is a useful index of insulin sensitivity in subjects with hypertension -- Chen et al. 284 (4): 804 -- AJP - ... (Site not responding. Last check: 2007-10-18)
		QUICKI is a useful index of insulin sensitivity in subjects with hypertension -- Chen et al.
		QUICKI is a useful index of insulin sensitivity in subjects with hypertension
		Insulin resistance may link disorders of metabolic homeostasis such as diabetes and obesity with disorders of hemodynamic
	ajpendo.physiology.org /cgi/content/abstract/284/4/E804 (447 words)

	Obesity, Body Fat Distribution, Insulin Sensitivity and Islet {{beta}}-Cell Function as Explanations for Metabolic ... (Site not responding. Last check: 2007-10-18)
		) had a broad range of insulin sensitivity so that some of the leanest subjects were as insulin resistant as the most obese individuals.
		-cell function; some lean individuals were as insulin resistant as obese subjects, whereas no obese subjects were insulin sensitive.
		Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.
	nutrition.org /cgi/content/full/131/2/354S (5147 words)

	Mathematical Modeling of Insulin Action and in Vivo Estimates of Insulin Sensitivity by Michael J. Quon
		Diabetes, obesity, and hypertension are major inter-related public health problems that are all characterized, in part, by insulin resistance (decreased sensitivity or responsiveness to metabolic actions of insulin).
		A well-accepted alternative for estimating insulin sensitivity in vivo is to analyze insulin and glucose data from a frequently sampled intravenous glucose tolerance test (FSIVGTT) using Bergman*s minimal model of glucose metabolism.
		We conclude that QUICKI is a simple, accurate, and reliable insulin sensitivity index obtained from a single fasting blood sample that may be useful for clinical research and epidemiological studies related to diabetes and other insulin resistant states.
	www.ima.umn.edu /biology/wkshp_abstracts/quon1.html (355 words)

	B AHRÉN and G PACINI: Insulin secretion versus insulin sensitivity (European Journal of Endocrinology) (Site not responding. Last check: 2007-10-18)
		Excessive insulin response to glucose in obese subjects as measured by immunochemical assay.
		Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
		The relative contributions of insulin resistance and beta cell dysfunction to the pathophysiology of type 2 diabetes.
	www.eje.org /eje/150/0097/eje1500097.htm (1311 words)

	Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study -- Liese et al. 78 (5): 965 -- ...
		Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study -- Liese et al.
		A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance.
		Consumption of whole grain and legume powder reduces insulin demand, lipid peroxidation, and plasma homocysteine concentrations in patients with coronary artery disease: randomized controlled clinical trial.
	www.ajcn.org /cgi/content/full/78/5/965 (3976 words)

	Sensitin: Insulin Sensitivity
		Your pancreas secretes insulin, a hormone responsible for your cells' ability to uptake, store, and use glucose for energy.
		Without insulin, glucose (the energy your body converts from food), cannot get inside your cells where it is used for energy or stored for energy use later on.
		That's why it's important for you to understand how insulin works in your body and what you can do to be sure you have the right levels of insulin.
	www.sensitin.com /sensitivity.htm (215 words)

	Reversing diabetes means making tough choices in foods, nutrition and exercise
		The other problem is that type 2 diabetics have decreased insulin sensitivity in the cells of their body.
		That means that even though insulin is being produced and circulating through the bloodstream, the cells in the body aren't responding to it.
		That's why reduced insulin sensitivity is a physiological marker that indicates a person is about to become diabetic.
	www.newstarget.com /002035.html (1417 words)

	Direct Measure of Insulin Sensitivity with the Hyperinsulinemic-Euglycemic Clamp and Surrogate Measures of Insulin ...
		Mean values for the direct measure of insulin sensitivity, as assessed by the GIR during the last 20 min of a 2-h hyperinsulinemic-euglycemic clamp, in the LF, IF, and HF diet groups.
		Correlation between multiplicity of ACF (number of aberrant crypts/ACF) and direct measures of insulin sensitivity, as assessed by the GIR during the hyperinsulinemic-euglycemic clamp.
		was associated with a reversal of insulin resistance (50).
	cebp.aacrjournals.org /cgi/content/full/12/1/47 (6860 words)

	Cinnamon Extracts Boost Insulin Sensitivity
		Agricultural Research Service scientists are seeking a patent on compounds extracted from cinnamon that make cells much more sensitive to insulin in test tube studies.
		It is characterized by the failure of body cells to recognize and respond to insulin as well as they once did.
		This leads to elevated blood sugar because insulin's job is to prompt cells to take in glucose.
	www.ars.usda.gov /is/AR/archive/jul00/cinn0700.htm (591 words)

	Does Exercise Without Weight Loss Improve Insulin Sensitivity? -- Ross 26 (3): 944 -- Diabetes Care (Site not responding. Last check: 2007-10-18)
		with a marked and rapid decrease in insulin sensitivity (4).
		Wojtaszewski JFP, Nielsen JN, Richter EA: Exercise effects on muscle insulin signaling and action: effect of acute exercise on insulin action in humans insulin sensitivity in human skeletal muscle.
		Segal KR, Edano A, Abalos A: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men.
	care.diabetesjournals.org /cgi/content/full/26/3/944 (1455 words)

	Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study. ...
		Low Insulin Sensitivity (Si = 0) in Diabetic and Nondiabetic Subjects in the Insulin Resistance Atherosclerosis Study.
		Insulin Secretion and Insulin Sensitivity in Relation to Glucose Tolerance: Lessons From the Botnia Study
		Insulin Sensitivity in Subjects With Type 2 Diabetes Relationship to Cardiovascular Risk Factors: The Insulin Resistance Atherosclerosis Study
	www.ndei.org /v2/website/litalerts/article.cfm?article_id=757 (542 words)

	Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies -- Hanson et ...
		Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies -- Hanson et al.
		Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies
		the estimate of insulin sensitivity derived from the
	aje.oxfordjournals.org /cgi/content/abstract/151/2/190 (2115 words)

	Hormone Replacement Therapy, Insulin Sensitivity, and Abdominal Obesity in Postmenopausal Women -- Ryan et al. 25 (1): ...
		venipuncture for the infusion of glucose and insulin.
		and is associated with body fat and insulin resistance (22,25,48,49).
		Campbell PJ, Gerich JE: Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity.
	care.diabetesjournals.org /cgi/content/full/25/1/127 (4584 words)

	Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke -- Kernan et al. 60 (9): ...
		Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke -- Kernan et al.
		Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke
		insulin sensitivity was defined by a value of
	www.neurology.org /cgi/content/abstract/60/9/1447 (335 words)

	Improvement of Insulin Sensitivity by Short-term Exercise Training in Hypertensive African American Women -- Brown et ... (Site not responding. Last check: 2007-10-18)
		all insulin measurements were performed at the end of the study.
		Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after a single bout of exercise.
		The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest.
	hyper.ahajournals.org /cgi/content/full/30/6/1549 (3718 words)

	Insulin Sensitivity, Cardiorespiratory Fitness, and Physical Activity in Overweight Hispanic Youth -- Ball et al. 12 ...
		Insulin Sensitivity, Cardiorespiratory Fitness, and Physical Activity in Overweight Hispanic Youth -- Ball et al.
		Insulin Sensitivity, Cardiorespiratory Fitness, and Physical Activity in Overweight Hispanic Youth
		PA was not related to any measure of insulin sensitivity and
	www.obesityresearch.org /cgi/content/abstract/12/1/77 (439 words)

	Effect of Rosiglitazone on Insulin Sensitivity and Body Composition in Type 2 Diabetic Patients -- Carey et al. 10 ...
		Effect of Rosiglitazone on Insulin Sensitivity and Body Composition in Type 2 Diabetic Patients -- Carey et al.
		sensitivity and body composition in 33 type 2 diabetic patients.
		The RSG treatment-related increase from baseline in the glucose
	www.obesityresearch.org /cgi/content/full/10/10/1008 (3926 words)

	Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents ...
		Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents -- Yeckel et al.
		Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
		insulin sensitivity index (WBISI) and the insulin sensitivity
	jcem.endojournals.org /cgi/content/abstract/89/3/1096 (664 words)

	Endothelial Nitric Oxide Production and Insulin Sensitivity : A Physiological Link With Implications for Pathogenesis ...
		Insulin sensitivity has been shown to be related to age, BMI,
		Cardiovascular actions of insulin in humans: implications for insulin sensitivity and vascular tone.
		Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation?
	circ.ahajournals.org /cgi/content/full/93/7/1331 (3099 words)

	Impaired Glucose Tolerance News
		Insulin Resistance - update from the 6th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV
		Hypertension Among HIV Patients Is Associated with Insulin Resistance and Metabolic Syndrome
		Insulin Resistance and Diabetes Update from the 5th Workshop on Adverse Drug Reactions and Lipodystrophy in HIV
	www.hivandhepatitis.com /recent/metabolic/glucose/1.html (421 words)

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