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Topic: Integral membrane protein

Related Topics

Transmembrane protein

Peripheral membrane protein

Membrane protein

Plasma membrane

Transmembrane receptor

Lipid anchored protein

Cell membrane

G protein

Bacteriorhodopsin

Endoplasmic reticulum

ATPase

Cell wall

Phospholipid

Phosphorylation

Cyclic AMP

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	Protein - Open Encyclopedia (Site not responding. Last check: 2007-10-19)
		Proteins are essential to the structure and function of all living cells and viruses.
		Proteins are generally large molecules, having molecular masses of up to 3,000,000 (the muscle protein titin has a single amino acid chain 27,000 subunits long).
		Protein deficiency can lead to symptoms such as fatigue, insulin resistance, hair loss, loss of hair pigment (hair that should be fl becomes reddish), loss of muscle mass (proteins repair muscle tissue), low body temperature, and hormonal irregularities.
	open-encyclopedia.com /Protein (1833 words)

	W0008: Integral Membrane Protein Studied With Static Light Scattering (Site not responding. Last check: 2007-10-19)
		Integral Membrane Protein Studied With Static Light Scattering.
		We are using static light scattering to characterize the phase behavior of solutions containing pure detergent and detergent-protein complexes, with the goal of extending the observation that crystals of membrane protein-detergent complexes form near the detergent cloud point.
		We are using solutions of both protein-detergent complexes and pure detergents in order to assess the relative contributions of the detergent and protein moieties to the overall behavior of the complexes.
	www.hwi.buffalo.edu /ACA/ACA99/abstracts/text/W0008.html (162 words)

	At2g26350 - zinc-binding peroxisomal integral membrane protein (PEX10) (Site not responding. Last check: 2007-10-19)
		These synonyms are used for gene At2g26350 (zinc-binding peroxisomal integral membrane protein (PEX10)): T9J22.2, T9J22.2 T1D16.1.
		At2g26350 is a homologue of PEX10 (Peroxisome assembly protein 10) from Homo sapiens.
		At2g26350 is a homologue of PEX10 (Peroxisome assembly protein PEX10) from Saccharomyces cerevisiae.
	www.ihop-net.org /UniPub/iHOP/gg/2556.html (82 words)

	annual report 97 (Site not responding. Last check: 2007-10-19)
		The Protein Transport Group has found that a short region in the cytoplasmic tail of a viral membrane protein is both necessary and sufficient to localize membrane proteins to the Golgi complex.
		The group is focusing on various aspects of the exocytic protein transport route by studying the ER to Golgi transport, with an emphasis on the role of the intermediate compartment, as well as the mechanism of retention of membrane proteins in the Golgi complex.
		In yeast cells lacking SHR3, an integral membrane component of the endoplasmic reticulum (ER), all seventeen members of the amino acid permease (aap) gene family are unable to enter into ER derived COPII-coated transport vesicles and accumulate in the ER membrane.
	www.licr.ki.se /annrep97.html (7721 words)

	An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport
		This is the profile expected for an integral membrane protein and is similar to that observed for the known nuclear envelope integral membrane protein Pom152p (Figure 4B).
		In the absence of trypsin, a protein of
		Greber UF and Gerace L (1992) Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.
	www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v20/n15/full/7593915a.html (7655 words)

	Cellular Genomics Awarded U.S. Patent for Integral Membrane Protein-Protein Interaction/Pathway Mapping Technology
		This technology has significance for genomics-based drug discovery as membrane proteins have proven to be a rich source of drug targets that are highly amenable to the development of both small molecule and protein-based therapeutics.
		The Membrane 1-Hybrid Platform(TM) will enable us to identify a wealth of potential drug targets in the context of biologically relevant cellular pathways." Cellular Genomics is implementing the Membrane 1-Hybrid(TM) Platform both to map the signaling pathways of individual protein drug targets, as well as on a genome-wide basis as a high-throughput protein-protein interaction screen.
		While traditional yeast-based two-hybrid methods are being widely applied by industry for the mapping of the human proteome, these methods rely on the interaction of two proteins in the nucleus of the cell, and are therefore not useful for the study of most integral membrane proteins.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-11-2001/0001511292&EDATE= (715 words)

	Articles - Membrane protein (Site not responding. Last check: 2007-10-19)
		A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle.
		Integral membrane proteins are firmly attached to the membrane.
		In most cases, the protein spans the entire membrane (a transmembrane protein) but in all cases, the protein is anchored in the membrane's hydrophobic region, by a covalently attached lipid or glycolipid.
	www.gaple.com /articles/Membrane_protein (278 words)

	7TM receptor
		In cell biology and biochemistry, a 7TM receptor (or seven transmembrane receptor) is an integral membrane protein belonging to a large and ancient superfamily of transmembrane receptors.
		G protein-coupled receptor), such as the receptors of the olfactory epithelium that bind odorants and the receptors of the neurotransmitter serotonin in the mammalian brain.
		The name derives from the proteins' structure or membrane topology, which exhibits seven membrane-spanning elements or transmembrane helices.
	encycl.opentopia.com /term/7TM_receptor (134 words)

	NMR structural studies of the integral membrane protein Vpu from HIV-1.
		NMR structural studies of the integral membrane protein Vpu from HIV-1.
		Vpu is an 81-residue membrane protein that enhances the release of new virus particles from cells infected with HIV-1 and induces the degradation of the CD4 receptor protein.
		Methodology developments toward structure determination of membrane proteins are also discussed.
	repository.upenn.edu /dissertations/AAI9976449 (232 words)

	An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region -- ...
		An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region -- Hallberg et al.
		An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region
		Integral Membrane Proteins of the Nuclear Envelope Are Dispersed throughout the Endoplasmic Reticulum during Mitosis
	www.jcb.org /cgi/ijlink?linkType=ABST&journalCode=jcb&resid=122/3/513 (1011 words)

	The Integral Membrane Protein Snl1p Is Genetically Linked to Yeast Nuclear Pore Complex Function -- Ho et al. 9 (2): ...
		Integral membrane proteins are predicted to play key roles in the biogenesis and function of nuclear pore complexes (NPCs).
		Snl1p is an integral membrane protein, oriented with the C-terminal region accessible to the cytoplasm.
		the Snl1p membrane span is exposed to the cytosol, the Snl1p-Suc2p
	www.molbiolcell.org /cgi/content/full/9/2/355 (7382 words)

	The Localization of the Integral Membrane Protein Cps1p to the Cell Division Site is Dependent on the Actomyosin Ring ...
		Chang, F., Drubin, D., and Nurse, P. cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.
		Eng, K., Naqvi, N.I., Wong, K.C., and Balasubramanian, M.K. Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.
		Fankhauser, C., and Simanis, V. The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.
	www.molbiolcell.org /cgi/content/full/13/3/989 (6967 words)

	Access of Antibody or Trypsin to an Integral Outer Membrane Protein (P66) of Borrelia burgdorferi Is Hindered by Osp ...
		Access of Antibody or Trypsin to an Integral Outer Membrane Protein (P66) of Borrelia burgdorferi Is Hindered by Osp Lipoproteins -- Bunikis and Barbour 67 (6): 2874 -- Infection and Immunity
		Coburn, J., Cugini, C. Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin {alpha}v{beta}3.
		Carroll, J. A., El-Hage, N., Miller, J. C., Babb, K., Stevenson, B. Borrelia burgdorferi RevA Antigen Is a Surface-Exposed Outer Membrane Protein Whose Expression Is Regulated in Response to Environmental Temperature and pH.
	iai.asm.org /cgi/content/abstract/67/6/2874 (1020 words)

	ETH Zurich: Publications
		NMR characterization of the full-length recombinant murine prion protein, mPrP(23231).
		NMR structure of the integral membrane protein OmpX.
		Membrane protein – lipid interactions in mixed micelles studied by NMR with the use of paramagnetic reagents.
	www.mol.biol.ethz.ch /groups/wider_group/publications (2471 words)

	Integral membrane protein biosynthesis: why topology is hard to predict -- Ott and Lingappa 115 (10): 2003 -- Journal ...
		Shown here are a type I integral membrane protein, a type II integral membrane protein, a C-terminally anchored integral membrane protein, a type II signal-anchored protein and a multi-spanning membrane protein.
		to the translocon, an aqueous pore in the ER membrane responsible
		Kelleher, D. J., Kreibich, G. and Gilmore, R. Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein.
	jcs.biologists.org /cgi/content/full/115/10/2003 (4650 words)

	Pex3 (Site not responding. Last check: 2007-10-19)
		It is anchored in the peroxisome membrane with its amino-terminal end, while the remainder of the protein is exposed to the cytosol.
		One possibility for the role of PEX3 in membrane biogenesis is as a docking factor for PEX19, the peroxisome membrane protein receptor.
		The topology of PEX3 is consistent with this theory, as it is anchored in its membrane by its N terminus, with the majority of the protein exposed to the cytoplasm.
	www.peroxisome.org /Scientist/Biogenesis/peroxins/PEX3text.html (1581 words)

	Size Comparisons among Integral Membrane Transport Protein Homologues in Bacteria, Archaea, and Eucarya -- Chung et al. ... (Site not responding. Last check: 2007-10-19)
		eucaryotic homologues; loops 2 and 3 in the procaryotic proteins
		From membrane to molecule to the third amino acid from the left with a membrane transport protein.
		Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya, p.
	jb.asm.org /cgi/content/full/183/3/1012 (3337 words)

	Structural details of an interaction between cardiolipin and an integral membrane protein -- McAuley et al. 96 (26): ...
		integral membrane proteins that catalyze photosynthetic and respiratory
		in the intramembrane surface of the protein, in regions that are
		intramembrane and cytoplasmic regions of the protein (12, 13).
	www.pnas.org /cgi/content/full/96/26/14706 (4905 words)

	Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al. 78 ...
		of P16 is embedded in the membrane as a transmembrane helix.
		is that the release of the infection vertex proteins from the
		Subregions of a conserved party of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals.
	jvi.asm.org /cgi/content/full/78/18/9790 (4563 words)

	An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport -- Kops and Guthrie 20 ... (Site not responding. Last check: 2007-10-19)
		An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport -- Kops and Guthrie 20 (15): 4183 -- The EMBO Journal
		An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport
		Three proteins required for early steps in the protein secretory pathway also affect nuclear envelope structure and cell cycle progression in fission yeast
	embojournal.npgjournals.com /cgi/content/abstract/20/15/4183 (284 words)

	BCH 4053 Biochemistry I (Site not responding. Last check: 2007-10-19)
		A pore in the inner cell membrane of gram-negative cells, or in the cell membrane of gram-positive or animal cells is a potentially lethal situation - it can allow the free-flow of ions across the membrane and prevent the formation of ion gradients essential to cell function.
		Colicin protein will pass through the outer membrane of a target bacteria and insert into the inner membrane where it folds up into a porin molecule.
		These helices are believed to be able to insert into membranes and form a complex assemly that positions the hydrophobic face of the helices towards the apolar lipid environment, and the hydrophilic region towards the center.
	wine1.sb.fsu.edu /BCH4053/Lecture17/Lecture17.htm (1623 words)

	Membrane Protein Folding
		We are pushing the envelope of what is currently possible for the structure determination of membrane proteins by NMR spectroscopy.
		To this end, we are working to increase expression levels of membrane proteins and we are developing protocols to refold membrane proteins in lipid and detergent environments.
		Secondary and tertiary structure formation of the beta-barrel membrane protein OmpA is synchronized and depends on membrane thickness.
	www.faculty.virginia.edu /tamm/pages/project_folding.html (405 words)

	Biological Membranes (Site not responding. Last check: 2007-10-19)
		Bacteriorhodopsin embedded in a bilayer membrane (156K): a Chime page showing an integral membrane protein.
		Largely contained in the membrane (requires disruption of the membrane by detergents for solubilization).
		Stability energetics are similar to water soluble proteins, except that non-polar groups interact with acyl chains in the membrane.
	www.nitorig.net /lec25.html (288 words)

	Home Page
		The native form of BR is the purple membrane, a crystalline lattice consisting of BR trimers assembled with unique membrane lipids in an extensive hexagonal array.
		This system is therefore ideal for exploring the structural features of an integral membrane protein that are critical for its biogenesis, as well as the cellular factors that mediate this process.
		By focusing on an integral membrane protein of known structure, we hope to provide a basic understanding of the structural features and cellular factors that determine integral membrane protein biogenesis.
	www.bio.ilstu.edu /Krebs (600 words)

	Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al. 78 ...
		Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al.
		Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure
		the viral membrane and is necessary for spike stability.
	jvi.asm.org /cgi/content/abstract/78/18/9790 (231 words)

	Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein -- Broos et al. ...
		Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein -- Broos et al.
		Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein
		Protein Sci., October 1, 2005; 14(10): 2638 - 2653.
	www.proteinscience.org /cgi/content/abstract/12/9/1991 (359 words)

	Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR ...
		Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy -- Fernández et al.
		A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis
		Protein Sci., May 1, 2003; 12(5): 1087 - 1096.
	www.pnas.org /cgi/content/abstract/99/21/13533 (330 words)

	CHEST: HTI56, An Integral Apical Membrane Protein of the Human Alveolar Type I Cell, Is a Biochemical Marker of Acute ... (Site not responding. Last check: 2007-10-19)
		We hypothesized that cell-specific alveolar epithelial apical plasma membrane proteins might be useful biochemical markers for lung injury.
		This hypothesis has been validated in various models of rodent lung injury, in which the airspace liquid content of RT140, a rat type I cell integral membrane protein, correlated directly with the extent of epithelial injury assessed by morphologic criteria (Am J Physiol 1995; 268:L181-186, and 1997., 272:L631-638).
		HTI56 in pulmonary edema fluid from 14 patients with acute lung injury (edema fluid protein/plasma protein [is greater than] 0.75) was 4.5X that (p [is less than] 0.0001) of 12 patients with hydrostatic pulmonary edema (clinical history compatible with congestive heart failure, edema fluid protein/plasma protein [is less than] 0.65).
	www.findarticles.com /p/articles/mi_m0984/is_1_116/ai_55332554 (495 words)

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