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Topic: Integral protein


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In the News (Mon 17 Jun 19)

  
 Cellular Genomics Awarded U.S. Patent for Integral Membrane Protein-Protein Interaction/Pathway Mapping Technology
This technology has significance for genomics-based drug discovery as membrane proteins have proven to be a rich source of drug targets that are highly amenable to the development of both small molecule and protein-based therapeutics.
While traditional yeast-based two-hybrid methods are being widely applied by industry for the mapping of the human proteome, these methods rely on the interaction of two proteins in the nucleus of the cell, and are therefore not useful for the study of most integral membrane proteins.
This is significant, because a considerable percentage of all proteins -- including many important drug receptors -- are anchored in the cell membrane, and are thus unlikely to enter the nucleus.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-11-2001/0001511292&EDATE=   (715 words)

  
 Cytochrome b6f Page
Energy transducing proteins are prominent in the list of hetero-oligomeric integral membrane proteins, for which only about a dozen structures have been solved to a resolution of 3.0 Å (www.blanco.biomol.uci.edu/Membrane_Proteins_xtal.html).
The explanation of the fact that the majority of the high resolution structures of hetero-oligomeric integral membrane proteins are derived from energy-transducing (photosynthetic or respiratory) membranes is that almost all of these complexes contain chromophores that allow simple quantitative assay of redox activity.
The flexible hinge region of the Rieske protein that connects the soluble and membrane-bound domains serves as the pivot of the rotation-translation.
www.biology.purdue.edu /people/faculty/cramer/Cramer/html/cytbf.html   (1593 words)

  
 An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport
This is the profile expected for an integral membrane protein and is similar to that observed for the known nuclear envelope integral membrane protein Pom152p (Figure 4B).
In the absence of trypsin, a protein of
Greber UF and Gerace L (1992) Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.
www.nature.com /emboj/journal/v20/n15/full/7593915a.html   (7655 words)

  
 Proteins: Biogenesis to Degradation - BioChemWeb.org
Protein Folding - in vivo and in vitro
MIT Biology Hypertextbook: Proteins - Tutorial on the biochemistry of proteins.
MIT Biology Hypertextbook: Membrane Proteins - Tutorial on membrane proteins.
www.biochemweb.org /proteins.shtml   (731 words)

  
 Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al. 78 ...
Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al.
is that the release of the infection vertex proteins from the
Subregions of a conserved party of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals.
jvi.asm.org /cgi/content/full/78/18/9790   (4564 words)

  
 Integral membrane protein 2A, Homo sapiens - UniGene Hs.17109
Integral membrane protein 2A, Homo sapiens - UniGene Hs.17109
ref:NP_004858.1 - integral membrane protein 2A [Homo sapiens]
Homo sapiens integral membrane protein 2A (ITM2A), mRNA
www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=17109   (358 words)

  
 Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane -- Wu et al. 115 (7): ...
Domains of proteins are represented as follows: yellow, FLAG-tag; white, nucleoplasmic, luminal and C-terminal domains of MAN1; red, LEM domain; orange, the first transmembrane segment of MAN1; dark green, the second transmembrane segment of MAN1; pink, transmembrane segment of CHL; light blue, luminal domain of CHL.
integral membrane protein, it was attached to the transmembrane
Domains of proteins are represented by: yellow, FLAG-tag; white, nucleoplasmic, luminal and C-terminal domains of MAN1; red, LEM domain; orange, the first transmembrane segment of MAN1; dark green, the second transmembrane segment of MAN1; pink, transmembrane segment of CHL; light blue, luminal domain of CHL.
jcs.biologists.org /cgi/content/full/115/7/1361   (7466 words)

  
 Secretion of Surfactant Protein C, an Integral Membrane Protein, Requires the N-terminal Propeptide -- Conkright et al. ...
SP-C is a type II integral membrane protein and that sorting to
SP-C is an integral membrane protein that is sorted to the lamellar body and subsequently secreted with surfactant lipids
Integral membrane proteins are sorted to specific subcellular compartments based on information encoded in the cytosolic domain
www.jbc.org /cgi/content/full/276/18/14658   (5273 words)

  
 Phtf1 Is an Integral Membrane Protein Localized in an Endoplasmic Reticulum Domain in Maturing Male Germ Cells -- ...
indicate that phtf1 is a membrane-spanning protein [1].
Protein extracts (20 µg) of the various samples were separated on a 10% SDS-PAGE and transferred onto a PVDF membrane and then detected using mp71 antibody.
that phtf1 partitioned as a hydrophobic integral membrane protein.
www.biolreprod.org /cgi/content/full/68/3/1044   (5628 words)

  
 The Integral Membrane Protein Snl1p Is Genetically Linked to Yeast Nuclear Pore Complex Function -- Ho et al. 9 (2): ...
Integral membrane proteins are predicted to play key roles in the biogenesis and function of nuclear pore complexes (NPCs).
Protein samples were separated by electrophoresis in SDS-polyacrylamide gels and transferred to nitrocellulose membranes.
Snl1p is an integral membrane protein, oriented with the C-terminal region accessible to the cytoplasm.
www.molbiolcell.org /cgi/content/full/9/2/355   (7288 words)

  
 Characterization of an Integral Protein of the Brush Border Membrane Mediating the Transport of Divalent Metal Ions -- ...
Characterization of an Integral Protein of the Brush Border Membrane Mediating the Transport of Divalent Metal Ions -- Knöpfel et al.
Characterization of an Integral Protein of the Brush Border Membrane Mediating the Transport of Divalent Metal Ions
the protein encoded by the mutated Nramp2 gene in anemic mice
www.biophysj.org /cgi/content/full/79/2/874   (6502 words)

  
 Membrane Protein Folding
To this end, we are working to increase expression levels of membrane proteins and we are developing protocols to refold membrane proteins in lipid and detergent environments.
These methods may now be applied to G-protein-coupled receptors or other integral membrane proteins that have been indentified as potential drug targets.
Secondary and tertiary structure formation of the beta-barrel membrane protein OmpA is synchronized and depends on membrane thickness.
www.faculty.virginia.edu /tamm/pages/project_folding.html   (447 words)

  
 A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis - Nature Genetics
A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis
Eleven different mutations, all predicted to cause loss of function of the protein, were found to segregate with the disorder.
A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis.
www.nature.com /doifinder/10.1038/ng0498-319   (691 words)

  
 InterPro: IPR001899 Surface protein from Gram-positive cocci, anchor region
Novick R.P. Sortase: the surface protein anchoring transpeptidase and the LPXTG motif.
Both the protein accession number and the protein overview match are clickable and return the detailed matches view for the protein.
The protein entries in the examples, have a match status of TRUE, and illustrate as far as possible the diversity in taxonomy, structure and function of the proteins in the InterPro entry.
www.ebi.ac.uk /interpro/IEntry?ac=IPR001899   (3051 words)

  
 Thermodynamics of unfolding of an integral membrane protein in mixed micelles -- Sehgal and Otzen 15 (4): 890 -- ...
Thermodynamics of unfolding of an integral membrane protein in mixed micelles -- Sehgal and Otzen 15 (4): 890 -- Protein Science
helix protein DsbB from the inner membrane of Escherichia coli
proteins, the heat capacity increases upon unfolding, and this
www.proteinscience.org /cgi/content/short/15/4/890?rss=1   (304 words)

  
 The Localization of the Integral Membrane Protein Cps1p to the Cell Division Site is Dependent on the Actomyosin Ring ...
Chang, F., Drubin, D., and Nurse, P. cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin.
Eng, K., Naqvi, N.I., Wong, K.C., and Balasubramanian, M.K. Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.
Fankhauser, C., and Simanis, V. The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.
www.molbiolcell.org /cgi/content/full/13/3/989   (6989 words)

  
 Integral Membrane Protein Sorting to Vacuoles in Plant Cells: Evidence for Two Pathways -- Jiang and Rogers 143 (5): ...
Notice that the lower 32-kD band (single asterisk, lanes 3 and 6) derived from the reporter protein is identical in size to mature aleurain (single asterisk, lane 8) processed from wild-type proaleurain (solid circle, lane 8) in tobacco cells.
and the soluble protein phytohemagglutinin (PHA) in transgenic
Positions of the 80- and 72-kD tobacco VSR proteins and the 78 kD ER proteins are indicated.
www.jcb.org /cgi/content/full/143/5/1183   (9153 words)

  
 The Integral Membrane Protein Pom34p Functionally Links Nucleoporin Subcomplexes -- Miao et al. 172 (3): 1441 -- ...
1.— Pom34p is a double-pass integral membrane protein with the N- and the C-terminal regions exposed to the cytosol/pore.
to the integral membrane proteins or the nuclear membrane (A
in the genes encoding the NE/ER membrane proteins Brr6p, Spo7p,
www.genetics.org /cgi/content/full/172/3/1441   (6378 words)

  
 Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane -- Schuler ...
Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane -- Schuler et al.
Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane
vertebrate gene encoding an integral membrane protein of the nuclear
www.jbc.org /cgi/lookup?vol=269&fp=11312&view=abstract   (812 words)

  
 Integral membrane protein 2C, Homo sapiens - UniGene Hs.111577
Integral membrane protein 2C, Homo sapiens - UniGene Hs.111577
Comparison of sequences in UniGene with proteins supported by a complete genome.
ref:NP_071862.1 - integral membrane protein 3 [Mus musculus]
www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Hs&CID=111577   (460 words)

  
 Structural details of an interaction between cardiolipin and an integral membrane protein -- McAuley et al. 96 (26): ...
integral membrane proteins that catalyze photosynthetic and respiratory
grooves in the irregular surface of the protein.
Structure of the H subunit of the photosynthetic reaction center from the thermophilic purple sulfur bacterium, Thermochromatium tepidum: Implications for the specific binding of the lipid molecule to the membrane protein complex
www.pnas.org /cgi/content/abstract/96/26/14706   (1006 words)

  
 P13, an Integral Membrane Protein of Borrelia burgdorferi, Is C-Terminally Processed and Contains Surface-Exposed ...
P13, an Integral Membrane Protein of Borrelia burgdorferi, Is C-Terminally Processed and Contains Surface-Exposed Domains -- Noppa et al.
The protein was immunogenic and was expressed in large
Pinne, M., Denker, K., Nilsson, E., Benz, R., Bergstrom, S. The BBA01 Protein, a Member of Paralog Family 48 from Borrelia burgdorferi, Is Potentially Interchangeable with the Channel-Forming Protein P13.
iai.asm.org /cgi/content/abstract/69/5/3323   (461 words)

  
 A Critical Residue in the Folding Pathway of an Integral Membrane Protein   (Site not responding. Last check: 2007-11-02)
Although a number of common diseases are a direct consequence of membrane protein misfolding, studies of membrane protein folding and misfolding lag well behind those of soluble proteins.
Here it is shown that an interfacial residue, Tyr16, of the integral membrane protein diacylglycerol kinase (DAGK) plays a critical role in the folding pathway of this protein.
The Y16C mutant represents a class of mutations which may be commonly found in disease-related membrane proteins.
pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2002/41/i29/abs/bi020318z.html   (171 words)

  
 CRASP: a program for analysis of coordinated substitutions in multiple alignments of protein sequences -- Afonnikov and ...
of the integral physicochemical characteristics of a protein.
The three main modules for analysis of coordinated substitutions accept multiple sequence alignments and enable the estimation of (A) pairwise covariation between the physicochemical property values at protein positions, (B) analysis of dependencies at specific position pairs and (C) the contribution of covarying substitutions to the invariance or variability in integral physicochemical characteristics.
Benner,S.A. and Gerloff,D. ((1991)) Patterns of divergence in homologous proteins as indicators of secondary and tertiary structures: the catalytic domain of protein kinases.
nar.oxfordjournals.org /cgi/content/full/32/suppl_2/W64   (2408 words)

  
 A Biophysical Study of Integral Membrane Protein Folding
In order to characterize the thermodynamic constraints on the process of integral membrane protein folding and assembly, we have conducted a biophysical dissection of the structure of bacteriorhodopsin (BR), a prototypical
However, the preference for a non-native conformation exhibited by two of the polypeptides suggests that the formation of some transmembrane substructures could require external constraints such as the links between the helices, interactions with the rest of the protein, or the involvement of cellular chaperones or translocases.
-helical integral membrane proteins, a goal that could facilitate attempts to overexpress and/or refold them.
pubs.acs.org /cgi-bin/abstract.cgi/bichaw/1997/36/i49/abs/bi970146j.html   (322 words)

  
 Movement Protein of a Closterovirus Is a Type III Integral Transmembrane Protein Localized to the Endoplasmic Reticulum ...
Movement Protein of a Closterovirus Is a Type III Integral Transmembrane Protein Localized to the Endoplasmic Reticulum -- Peremyslov et al.
Movement Protein of a Closterovirus Is a Type III Integral Transmembrane Protein Localized to the Endoplasmic Reticulum
Sauri, A., Saksena, S., Salgado, J., Johnson, A. E., Mingarro, I. Double-spanning Plant Viral Movement Protein Integration into the Endoplasmic Reticulum Membrane Is Signal Recognition Particle-dependent, Translocon-mediated, and Concerted.
jvi.asm.org /cgi/content/abstract/78/7/3704   (279 words)

  
 SDHD (succinate dehydrogenase complex II, subunit D, integral membrane protein)
Complex II (succinate-ubiquinone oxidoreductase) of the respiratory chain is involved in the oxidation of succinate, carries electrons from FADH to CoQ.
The subunit D protein or small subunit (cybS) is one of two integral membrane proteins anchoring the complex to membrane.
The complex II includes SDHC (cybL) and SDHB (iron-sulfur protein) which are also implicated in paragangliomas and pheochromocytomas.
atlasgeneticsoncology.org /Genes/SDHDID390.html   (643 words)

  
 HT Membrane Protein Structural Biology
The mission of the recently proposed Joint Center for Innovative Membrane Protein Technologies (JCIMPT) is to develop and disseminate methods and technologies for structure-grade
are major components in the systematic investigation of membrane proteins and in the development of novel genetically engineered expression systems and sample preparation technologies.
The structure of the JCIMPT includes three primary projects: IMPEE - Integral Membrane Protein Expression Engineering; IMPSP - Integral Membrane Protein Sample Preparation; and IMPBC - Integral Membrane Protein Biophysical Characterization.
stevens.scripps.edu /webpage/htsb/htmembr.html   (144 words)

  
 Large-scale identification of yeast integral membrane protein interactions -- Miller et al. 102 (34): 12123 -- ...
Large-scale identification of yeast integral membrane protein interactions -- Miller et al.
of proteins that have been difficult to analyze on a high-throughput
roles for integral membrane proteins of ascribed functions.
www.pnas.org /cgi/content/abstract/102/34/12123   (567 words)

  
 Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin ...
Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain -- Hamann et al.
Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain
suggests that it is a type II membrane protein.
www.jimmunol.org /cgi/lookup?vol=150&fp=4920&view=abstract   (952 words)

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