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Topic: Integrin

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	Integrin Advanced Biosystems (Site not responding. Last check: 2007-10-11)
		Integrin was founded in September 1999 and was the first marine biotechnology company in the UK.
		There is, however, still a poor coupling between academic research and industry compared with that in the wider biotechnology sector.
		Integrin aims to stimulate the commercialisation of Marine Biotechnology through improving technology transfer.
	www.integrin.co.uk /over.html (251 words)

	The Scientist : Integrin Signaling at a Crossroads
		Integrins serve as the cell's conduit to the outside world, sensing the external environment and passing on instructions: differentiate or not, adhere or move on, live or die.
		Integrins are the major adhesion receptors in cells, linking the extracellular matrix with internal cytoskeletal elements and signaling pathways.
		In cancer, integrins are involved in loss of anchorage-dependent growth, tumor angiogenesis, and tumor-cell migration during tissue invasion and metastasis.
	www.the-scientist.com /article/display/15706 (1610 words)

	BioCarta - Charting Pathways of Life
		Integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals in response to the extracellular matrix including cellular shape, mobility, and progression through the cell cycle.
		Integrins do not themselves possess a kinase domain or enzymatic activity but rely on association with other signaling molecules to transmit signals.
		Talin forms a direct interaction with the integrin cytoplasmic domain, and interacts with cytoskeletal elements (actin) and signaling factors.
	www.biocarta.com /pathfiles/h_integrinPathway.asp (176 words)

	The Laboratory of Tom Walz
		That is the essence of anchorage dependence of cell survival and proliferation and integrins lie at the basis of these phenomena.
		Inside-out signals are thought to activate integrins by breaking a clasp between the α and β subunit cytoplasmic or transmembrane domains.
		The rotation in the plane of the figure is such as to maximize comparison between the conformers, and is not uniform with regard to expected orientation relative to the cell membrane, especially in (D).
	walz.med.harvard.edu /Research/Cell_Adhesion/Integrins.php (1691 words)

	InterPro: IPR012896 Integrin beta tail (Site not responding. Last check: 2007-10-11)
		Integrins are a large family of cell surface adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions.
		Structurally, integrins are membrane glycoprotein heterodimers, each consisting of non-covalently associated alpha and beta subunits.
		P07228 Integrin beta-1 precursor (CSAT antigen) (JG22 antigen) (RGD- receptor)
	www.ebi.ac.uk /interpro/IEntry?ac=IPR012896 (3175 words)

	BioMed Central \| Full text \| Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor ...
		Integrins function in cell-to-cell and cell-to-extracellular matrix (ECM) adhesive interactions and transduce signals from the ECM to the cell interior and vice versa.
		The distribution pattern of those integrins which were predominantly expressed on the respective tumor cell line was further explored by confocal microscopy (figure 4).
		Based on a murine spleen injection-liver metastasis protocol, the alpha3beta1 integrin subtype was identified to predominantly facilitate the metastatic activity of colon cancer cells [17].
	www.biomedcentral.com /1471-2407/5/4 (4200 words)

	Chemicon - Product #ECM400 - AlphaVbeta3 Integrin Investigator Kit
		Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins.
		Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain.
		Integrins are thought to play critical roles in cell migration, differentiation, and survival.
	www.chemicon.com /browse/productdetail.asp?ProductID=ECM400 (419 words)

	[No title]
		Integrins are transmembrane proteins that serve as receptors for extracellular matrix (ECM) proteins.
		In the human prostate gland, α3β1 and α6β4 integrins bind to the ECM protein laminin 5 in the basement membrane.
		In tumor cells, however, the α3 and α4 integrin subunits disappear—as does laminin 5—and the tumor cells express primarily α6β1 and adhere to a basement membrane containing laminin 10.
	www.vai.org /Research/Labs/IntegrinSignalingAndTumorigenesis.aspx (1307 words)

	Walking the integrin activation road - Cell Signaling Update - Signaling Gateway
		The GTPase Rap1 mediates protein kinase C activity to induce the formation of an 'integrin activation complex' that binds to and activates integrin receptors.
		Many signalling molecules have been shown to regulate integrin activation, yet the molecular links that connect agonist stimulation with the final steps that lead to integrin activation are not known.
		Binding of the adaptor protein, talin, is a final step in integrin activation, and platelets express abundant talin compared with most nucleated cells.
	www.signaling-gateway.org /update/updates/200611/nrm2048.html (430 words)

	Breast Cancer Research \| Full text \| beta3 Integrin and Src facilitate transforming growth factor-beta mediated ...
		Integrins are heterodimeric transmembrane receptors that bind ECM ligands and couple cells to their microenvironments [19].
		Integrins also interact with and couple to receptor tyrosine kinases (RTKs) to promote cell survival, proliferation, and migration in response to soluble growth factors and cytokines [23,24].
		Although integrins lack intrinsic protein tyrosine kinase (PTK) activity, they facilitate tyrosine phosphorylation of target proteins via their recruitment of FAK and Src PTKs to focal adhesions [22].
	breast-cancer-research.com /content/8/4/R42 (7699 words)

	A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling -- Wei et al. 144 (6): 1285 ...
		In this case integrin (green) and caveolin (red) fluorescent signals emerge and colocalize (E-G) with clustering in comparison with that of nonclustered cells (H) or clustered cells stained without primary caveolin antibodies (I).
		1 integrins sequentially immunoblotted for caveolin, Src, and cortactin as in Fig.
		1 integrin antibodies and the precipitates immunoblotted sequentially for Src kinases and
	www.jcb.org /cgi/content/full/144/6/1285 (6581 words)

	Integrin indecision - Nature Medicine
		Integrins are cell-surface receptors that anchor cells to the ECM and transduce signals from the extracellular environment to the cell's interior
		integrins using integrin antagonists inhibits angiogenesis in cancer, arthritis and ischemic retinopathy and is currently being evaluated in clinical trials
		Integrins could enhance angiogenesis by cooperating with sister integrins and amplifying the response of Flk-1 to VEGF (upregulated in tumors and ischemia).
	www.nature.com /uidfinder/10.1038/nm0102-14 (1434 words)

	Integrin Expression in Developing Smooth Muscle Cells -- Wang et al. 46 (1): 119 -- Journal of Histochemistry and ...
		integrin, a laminin-collagen receptor, during myogenesis and neurogenesis in the avian embryo.
		Elices MJ, Hemler ME (1989) The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others.
		7 integrin and desmin define the primary and secondary myogenic lineages.
	www.jhc.org /cgi/content/full/46/1/119 (2983 words)

	The integrin[ndash]actin connection, an eternal love affair (Site not responding. Last check: 2007-10-11)
		The integrin family of cell adhesion molecules mediates cellular contacts to the extracellular matrix (ECM) or cell counter receptors, thereby regulating cell motility, cell polarity, cell growth and survival (Brakebusch et al., 2002).
		Ligand binding to integrins leads to integrin clustering and recruitment of actin filaments and signalling proteins to the cytoplasmic domain of integrins (Hynes, 2002).
		At the rear of the cell, integrins detach from the ECM, dissolve the link to the cytoskeleton and are, at least partially, recycled to the front of the cell (Ballestrem et al., 2001; Laukaitis et al., 2001).
	www.nature.com /emboj/journal/v22/n10/full/7590656a.html (7036 words)

	Integrin activation takes shape -- Liddington and Ginsberg 158 (5): 833 -- The Journal of Cell Biology
		Identification of Shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling.
		Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.
		A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.
	www.jcb.org /cgi/content/full/158/5/833 (5693 words)

	In the world of Integrin and cytoskeleton
		In the case of b2 integrin, its ligand-binding activity on the extracellular surface of the plasma membrane is tightly regulated by a number of intracellular signals originating from other membrane receptors such as T cell receptors or chemokine receptors.
		Our laboratory and others have demonstrated that the b2 integrin molecules are maintained in an inactive form in resting leukocytes; the molecules are immobilized on the cell membrane in a diffused distribution by constraints from cytoskeletal complex.
		Relaxation of the cytoskeletal constraint puts integrin in a free diffusion mode and facilitates the formation of clusters and conformational change that provide high avidity and affinity binding to the ligands.
	www.uic.edu /dent/oralbio/jxlilab.html (1163 words)

	Identification of Heat Shock Protein 60 as a Molecular Mediator of {alpha}3{beta}1 Integrin Activation -- Barazi et al. ... (Site not responding. Last check: 2007-10-11)
		the integrin with one of its ligands, TSP1
		integrin, and its induced expression on the cell surface is
		-actinin and the ß1 integrin subunit in vitro.
	cancerres.aacrjournals.org /cgi/content/full/62/5/1541 (5719 words)

	Hypoxia-inducible Factor Regulates {alpha}v{beta}3 Integrin Cell Surface Expression -- Cowden Dahl et al. 16 (4): 1901 ...
		1 integrin from the basal surface to the apical surface of
		V integrins in hepatocellular carcinoma: an in vivo and in vitro study.
		Suzuma, K., Takagi, H., Otani, A., and Honda, Y. Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells.
	www.molbiolcell.org /cgi/content/full/16/4/1901 (5273 words)

	Genetic compensation for sarcoglycan loss by integrin {alpha}7{beta}1 in muscle -- Allikian et al. 117 (17): 3821 -- ...
		Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.
		Mutations in the integrin alpha7 gene cause congenital myopathy.
		McDonald, K. A., Lakonishok, M. and Horwitz, A. Alpha v and alpha 3 integrin subunits are associated with myofibrils during myofibrillogenesis.
	jcs.biologists.org /cgi/content/full/117/17/3821 (5202 words)

	{beta}3A-Integrin Downregulates the Urokinase-Type Plasminogen Activator Receptor (u-PAR) through a PEA3/ets ...
		The cytoplasmic domain of integrins is fundamental for gene expression, cell proliferation, and cell cycle regulation (9,
		A-integrin downregulates the receptor for urokinase at the
		Chapman, H. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration.
	mcb.asm.org /cgi/content/full/21/6/2118 (5872 words)

	InterPro: IPR012012 Integrin, beta subunit (Site not responding. Last check: 2007-10-11)
		Weljie A.M. Hwang P.M. Vogel H.J. Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
		Beglova N. Blacklow S.C. Takagi J. Springer T.A. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
		Vinogradova O. Velyvis A. Velyviene A. Hu B. Haas T. Plow E. Qin J. A structural mechanism of integrin alpha(IIb)beta(3) andquot;inside-outandquot; activation as regulated by its cytoplasmic face.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR012012 (3180 words)

	Blocking the {alpha}4 integrin{alpha}paxillin interaction selectively impairs mononuclear leukocyte recruitment to an ...
		4 integrin by a fragment of paxillin (12) or a small-molecule
		Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (Integrin alpha L beta 2)-dependent T Cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.
		The cytoplasmic domain of the integrin alpha 9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner.
	www.jci.org /cgi/content/full/116/3/715 (4228 words)

	Beta1 integrin (Site not responding. Last check: 2007-10-11)
		Consequences of lack of beta 1 integrin gene expression in mice.
		Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.
		Two targeting vectors were made for the disruption of the beta-1 integrin locus.
	www.bioscience.org /knockout/int.htm (136 words)

	Ligation of Integrin alpha 5beta 1 Is Required for Internalization of Vitronectin by Integrin alpha vbeta 3 -- ...
		Ligation of Integrin alpha 5beta 1 Is Required for Internalization of Vitronectin by Integrin alpha vbeta 3 -- Pijuan-Thompson and Gladson 272 (5): 2736 -- Journal of Biological Chemistry
		To determine the integrin receptor(s) mediating U-251MG cell adhesion to fibronectin, cell adhesion assays were performed
		Integrins mediating astrocytoma cell adhesion to fibronectin, collagen, or laminin.
	www.jbc.org /cgi/content/full/272/5/2736 (4038 words)

	Potentiation of the ligand-binding activity of integrin {alpha}3{beta}1 via association with tetraspanin CD151 -- ...
		Potentiation of the ligand-binding activity of integrin {alpha}3{beta}1 via association with tetraspanin CD151 -- Nishiuchi et al.
		integrin ubiquitously expressed in many cell types (3–5).
		with integrins (8), there is no reason to assume that exogenous
	www.pnas.org /cgi/content/full/102/6/1939 (3853 words)

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