Wolf SF, Sieburth D, Sypek J. Interleukin12: a key modulator of immune function.
B7 and interleukin12 cooperates for proliferation and interferon-
Interleukin12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for the antitumor activity of interleukin12 and/or interleukin 2.
Interleukin 12 Signaling in Th1 Cells Involves(Site not responding. Last check: 2007-10-17)
Interleukin12 Signaling in Th1 Cells Involves Tyrosine Phosphorylation of Stat3 and Stat4.
Interleukin12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.
Interleukin (IL)-12 is a heterodimeric cytokine produced by APCs, phagocytes, and granulocytes ( 1).
Interleukin12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for the antitumor activity of interleukin12 and/or interleukin 2.
Inhibition of angiogenesis in vivo by interleukin12.
Finally, mRNA coding for InterLeukin (IL)-12p40 was only detected in a very few number of MS and Inflammatory cases.
The objective of this study was to determine whether AutoReactive T-Cells in patients with Multiple Sclerosis (MS) are polarized and committed in their differentiation to a stable Cytokine phenotype or whether the Cytokine secretion can be altered.
We examined the Cytokines secreted by Myelin Basic Protein (MBP) as compared to Tetanus Toxoid-reactive (TT) T-Cells in 12 patients with Relapsing/Remitting MS (RR-MS), 9 patients with Chronic/Progressive MS (CP-MS), and 14 normal individuals.
Interleukin12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
Interleukin12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activation of transcription (Stat) 3 and Stat4.
Interleukin12 promotes the proliferation and cytolytic activity of immune effectors: implications for the immunotherapy of cancer.
Cells were cultured with interleukin (IL) 12 (100 pg/ml final concentration) or anti-CD28 (1 µ g/ml final concentration) or anti-CD2 (1:1000 final dilution) antibody in the presence or absence of IL-7 (10 ng/ml final concentration) or IL-15 (10 ng/ml final concentration).
Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.
Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa.
An interleukin12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo -- Stallmach et al.
An interleukin12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo
Interleukin12 is expressed and actively released by Crohn’s disease intestinal lamina propria mononuclear cells.
Interleukin12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse.
This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.
Overall, these results point to several mediators and effector mechanisms that contribute to T1D (ref. 12), and it is likely that the genetic absence of IL-12 or IFN-
Arch Otolaryngol Head Neck Surg -- Abstract: Cure of an Established Nonimmunogenic Tumor, SCC VII, With a Novel ...(Site not responding. Last check: 2007-10-17)
VII cells in C3H mice was established for 7 to 12 days.
12 were successfully cured, and all cured mice resisted subsequent
interleukin12 leads to complete regression in 75% of mice.
