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Topic: Interleukin 13

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	Recombinant Rat Interleukin-13 (IL-13) <br> - CYT-447
		It is recommended to reconstitute the lyophilized Interleukin 13 in sterile 18MΩ-cm H
		O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
		The early growth response factor-1 is involved in stem cell factor (SCF)-induced interleukin 13 production by mast cells, but is dispensable for SCF-dependent mast cell growth.
	www.prospec.co.il /~prospec/cart/customer/product.php?productid=825 (452 words)

	The Interleukin 13 Receptor Complex -- Jensen 18 (1): 61 -- Stem Cells
		Interleukin 13 (IL-13) is closely related to IL-4.
		Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
		Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
	stemcells.alphamedpress.org /cgi/content/full/18/1/61 (691 words)

	e-Prints Soton - Kinetic analysis of the interleukin-13 receptor complex
		Detailed kinetic analyses of the binding properties of the heteromeric complexes suggested a sequential mechanism for the binding of IL-13 to its signaling receptor, in which IL-13 first binds to IL-13Rα1 and this then recruits IL-4α to stabilize a high affinity interaction.
		Interleukin (IL)-13 is a key cytokine associated with the asthmatic phenotype.
		Abbreviations: IL, interleukin; shIL-13Rα1, soluble human IL-13 receptor α chain 1; shIL-13Rα2, soluble human IL-13 receptor α chain 2; sIL-4Rα, soluble human IL-4 receptor; SPR, surface plasmon resonance, RU resonance units; STAT, signal transducers and activators of transcription; SA chip, streptavidin-coated sensor chip.
	eprints.soton.ac.uk /26907 (459 words)

	Interleukin 13 receptor, alpha 1, Mus musculus - UniGene Mm.24208
		Interleukin 13 receptor, alpha 1, Mus musculus - UniGene Mm.24208
		ref:NP_446097.1 - interleukin 5 receptor, alpha [Rattus norvegicus]
		Mus musculus interleukin 13 receptor, alpha 1 (Il13ra1), mRNA
	www.ncbi.nlm.nih.gov /UniGene/clust.cgi?ORG=Mm&CID=24208 (354 words)

	Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in ... (Site not responding. Last check: 2007-10-21)
		Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells.
		A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4.
		Intratumoral administration of interleukin 13 receptor-targeted cytotoxin induces apoptotic cell death in human malignant glioma tumor xenografts.
	mct.aacrjournals.org /cgi/content/full/3/2/137 (5420 words)

	Mutants of Interleukin 13 with Altered Reactivity toward Interleukin 13 Receptors -- Thompson and Debinski 274 (42): ...
		Interleukin 13 (IL13) belongs to a family of cytokines whose members exhibit structural homology, despite amino acid sequence
		The italicized and underlined codon denotes the new mutation.
		Cultured cells were incubated with buffer alone, shown in all panels by closed diamonds, or 1 µg/ml of hIL13 or its mutants for 1 h at 37 °C, prior to the addition of increasing concentrations of hIL13-CTX.
	www.jbc.org /cgi/content/full/274/42/29944 (4616 words)

	Respiratory Research \| Full text \| The gene encoding interleukin-13: a susceptibility locus for asthma and related ... (Site not responding. Last check: 2007-10-21)
		Although the exact genes controlling susceptibility to asthma have not been identified, several genome-wide searches have provided evidence for the linkage of asthma or asthma-related traits (serum IgE levels, skin test reactivity, bronchial hyper-responsiveness, blood eosinophils) to loci on multiple autosomal chromosomes [1,2,3,4,5,6].
		Of particular interest is the 5q31-33 region, which contains the T helper type 2 (Th2) cytokine gene cluster [interleukin (IL)-4, IL-13, IL-5 and IL-9] and has been linked to asthma or related phenotypes in many studies [2,3,4,5,6,7,8].
		To test for a genetic association with clinical asthma and IgE they conducted case control studies in a British population (150 young adults with asthma and atopy, and 150 controls) and a Japanese population (100 young adults with asthma and atopy, 100 subjects with non-atopic asthma, and 100 controls).
	respiratory-research.com /content/1/1/019 (3777 words)

	Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells -- Danahay et al. ...
		Interleukin (IL)-13 has been associated with asthma, allergic rhinitis, and chronic sinusitis, all conditions where an imbalance
		of the intact epithelium (1, 7, 13, 25).
		on the ion transport function of the human airway epithelium (13).
	ajplung.physiology.org /cgi/content/full/282/2/L226 (6034 words)

	Receptor for Interleukin 13 -- Obiri et al. 270 (15): 8797 -- Journal of Biological Chemistry
		Receptor for Interleukin 13 -- Obiri et al.
		Interleukin 13 (IL-13) shares many biological properties with IL-4, and although the receptor for IL-4 (IL-4R) has been characterized, the expression and structure of IL-13 receptor are unknown.
		Chem., September 13, 1996; 271(37): 22428 - 22433.
	www.jbc.org /cgi/content/abstract/270/15/8797 (2525 words)

	Correspondence re: B. H. Joshi et al., Interleukin-13 Receptor {alpha} Chain: A Novel Tumor-associated Transmembrane ...
		Debinski W., Gibo D. M., Hulet S. W., Connor J. R., Gillespie G. Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.
		Debinski W., Thompson J. Retargeting interleukin 13 for radioimmunodetection and radioimmunotherapy of human high-grade gliomas.
		Thompson J. P., Debinski W. Mutants of interleukin 13 with altered reactivity toward interleukin 13 receptors.
	cancerres.aacrjournals.org /cgi/content/full/61/14/5660 (2888 words)

	Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis : comparison with asthma CHEST - Find ... (Site not responding. Last check: 2007-10-21)
		Study objectives: Experimental studies on asthma have indicated that interleukin (IL)-13 induces airway hyperreactivity (AHR).
		Abbreviations: AHR = airway hyperresponsiveness; EB = eosinophilic bronchitis; IL = interleukin; IQR = interquartile range; PBMC = peripheral blood mononuclear cell; [PC.sub.20] = provocative concentration of a substance causing a 20% fall in [FEV.sub.1]; PMA = phorbol myristate acetate; Th2 = T helper type 2
		(1) The excessive production of interleukin (IL)-4, IL-5, and IL-13 by T-helper type 2 (Th2) cells is implicated in the development of asthma, (2,3) IL-5 mobilizes eosinophils from the bone marrow pool, and chemokines, such as eotaxin-1, induce the recruitment of eosinophils into the airway of experimental asthma models.
	www.findarticles.com /p/articles/mi_m0984/is_4_128/ai_n15779038 (869 words)

	Interleukin-13 Upregulates Eotaxin Expression in Airway Epithelial Cells by a STAT6-Dependent Mechanism -- Matsukura et ...
		Interleukin (IL)-13 is a T helper 2-derived cytokine that has recently been implicated in allergic airway responses.
		Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human STAT6.
		Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.
	ajrcmb.atsjournals.org /cgi/content/full/24/6/755 (5326 words)

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