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Interleukin 3 - Wikipedia, the free encyclopedia Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF. This page was last modified 16:47, 3 July 2006. en.wikipedia.org /wiki/IL-3   (132 words)

Interleukin 3 Improves the Ex Vivo Expansion of Primitive Human Cord Blood Progenitor Cells and Maintains the ... Interleukin 3 Improves the Ex Vivo Expansion of Primitive Human Cord Blood Progenitor Cells and Maintains the Engraftment Potential of SCID Repopulating Cells -- Roßmanith et al. Interleukin 3 Improves the Ex Vivo Expansion of Primitive Human Cord Blood Progenitor Cells and Maintains the Engraftment Potential of SCID Repopulating Cells Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. stemcells.alphamedpress.org /cgi/content/full/19/4/313   (3713 words)

Cyclosporin A Promotes Translational Silencing of Autocrine Interleukin-3 via Ribosome-Associated Deadenylation -- Nair ... Lanes: 1 and 3, untreated cells; 2 and 4, cells treated with 1 mg of CsA per ml for 8 h; 1 and 2, cells transfected with full-length IL-3 construct; 3 and 4, cells transfected with ARE-deleted construct. Lanes: 1, 3, 5, and 7, RNA from untreated cells; 2, 4, 6, and 8, RNA from cells treated with 500 ng of CsA per ml for 12 h. Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions. mcb.asm.org /cgi/content/full/19/1/889   (6413 words)

The mechanism of IL-5 signal transduction -- Adachi and Alam 275 (3): 623 -- AJP - Cell Physiology Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras-GTP by herbimycin A, a specific inhibitor of tyrosine kinases. ajpcell.physiology.org /cgi/content/full/275/3/C623   (5525 words)

Prognostic Value of Serum Interleukin-6 in Diffuse Large-cell Lymphoma -- Preti et al. 127 (3): 186 -- Annals of ... Expression of an exogenous interleukin 6 in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity. Interleukin 6 gene expression in normal and neoplastic B cells. Serum level of interleukin 6 as a prognostic factor in metastatic renal cell carcinoma. www.annals.org /cgi/content/full/127/3/186   (4826 words)

Malignant Mesothelioma Treatment using Interleukin   (Site not responding. Last check: 2007-10-12) Interleukins stimulate the growth and activities of certain kinds of white blood cells. Interleukins are a group of cytokines that are expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. mesothelioma.stafi.net /2_interleukin_malignant_mesothelioma_treatment.htm   (987 words)

Recombinant Human Interleukin-3 (IL-3) | Imgenex Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Evidence for a lectin activity for human interleukin 3 and modeling of its carbohydrate recognition domain. www.imgenex.com /recomb_tds.php?id=1065   (447 words)

Interleukin 3 Prevents Delayed Neuronal Death in the Hippocampal CA1 Field -- Wen et al. 188 (4): 635 -- The Journal ...   (Site not responding. Last check: 2007-10-12) Interleukin 3 Prevents Delayed Neuronal Death in the Hippocampal CA1 Field -- Wen et al. Interleukin 3 Prevents Delayed Neuronal Death in the Hippocampal CA1 Field Interleukin (IL)-3, identified as a T cell-derived cytokine, affects the proliferation of hematopoietic progenitor cells at www.jem.org /cgi/content/full/188/4/635   (7605 words)

Interleukin-3-induced downregulation of the expression of interleukin-2 receptor beta chain in human T cells.   (Site not responding. Last check: 2007-10-12) IL-3-accelerating internalization of IL-2R beta chain appeared to be one of the mechanisms for IL-3-induced downregulation of surface IL-2R beta chain expression. The downregulation of the IL-2R beta chain began 3 hours after culture initiation, increased further thereafter, and was completely inhibited by anti- IL-3 antibodies. IL-3 alone increased the proliferation of T-cell clones but decreased the existing increment of their proliferation by IL-2. www.ihop-net.org /UniPub/iHOP/gp/7013557.html   (213 words)

Involvement of Interleukin-3 in Delayed-Type Hypersensitivity -- Mach et al. 91 (3): 778 -- Blood Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3 Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL www.bloodjournal.org /cgi/content/abstract/91/3/778   (360 words)

Medical Dictionary: Interleukin 3 - WrongDiagnosis.com Interleukin 3: Growth factors which promote the development of blood cells. Terms that may be interchangeable with Interleukin 3: The description of Interleukin 3 may also be used for the following terms: www.wrongdiagnosis.com /medical/interleukin_3.htm   (162 words)

[Frontiers in Bioscience 1, d340-357, December 1, 1996]   (Site not responding. Last check: 2007-10-12) The importance of this region is underscored by the observation that the proximal 300 bp of the human and murine IL-6 gene 5'-flanking region share approximately 80% homology (98). Marinkovic and H. Baumann: Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene. Siegsmund, H. Yamazki and I. Pastan: Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia. www.bioscience.org /1996/v1/d/keller2/htmls/340-357.htm   (9437 words)

Interleukin 3-dependent survival by the Akt protein kinase -- Songyang et al. 94 (21): 11345 -- Proceedings of the ... Interleukin 3-dependent survival by the Akt protein kinase -- Songyang et al. Interleukin 3 (IL-3)-dependent survival of hematopoietic cells is known to rely on the activity of multiple signaling pathways, The improved survival of hematopoietic cells cultured with a fusion protein of insulin-like growth factor II (IGF-II) and interleukin 3 (IL-3) is associated with increases in Bcl-xL and phosphatidylinositol-3 kinase activity www.pnas.org /cgi/content/full/94/21/11345   (5109 words)

A Diphtheria Toxin-Interleukin 3 Fusion Protein Is Cytotoxic to Primitive Acute Myeloid Leukemia Progenitors But Spares ... A Diphtheria Toxin-Interleukin 3 Fusion Protein Is Cytotoxic to Primitive Acute Myeloid Leukemia Progenitors But Spares Normal Progenitors -- Feuring-Buske et al. A Diphtheria Toxin-Interleukin 3 Fusion Protein Is Cytotoxic to Primitive Acute Myeloid Leukemia Progenitors But Spares Normal Progenitors related gene products (3, 4, 5, 6, 7). cancerres.aacrjournals.org /cgi/content/full/62/6/1730   (6693 words)

Ras Is Not Required for the Interleukin 3-induced Proliferation of a Mouse Pro-B Cell Line, BaF3 -- Terada et al. 270 ... It has been demonstrated that Ras is involved in interleukin 3 (IL-3)-stimulated signal transduction in various hematopoietic cultured cells (Satoh, T., Nakafuku, M., Miyajima, A., and Kaziro, Y.(1991) Proc. During the last 3 h, the cells were starved in RPMI 1640 containing bovine serum albumin (1 mg/ml). V2 or N6 cells were cultivated for 48 h, in the culture medium in the presence or absence of mouse IL-3 and IPTG (5 mM). www.jbc.org /cgi/content/full/270/46/27880   (6645 words)

Efficacy of an Insulin-Like Growth Factor-Interleukin-3 Fusion Protein in Reversing the Hematopoietic Toxicity ... insulin-like growth factor II and mouse interleukin 3 was investigated 406, a chimera between BOMIGF and mouse interleukin 3 was isolated by a three-step HPLC procedure from culture supernatants Figure 2 shows the effects of 406 in AZT-treated mice on white cell counts and the hemoglobin content of peripheral blood. jpet.aspetjournals.org /cgi/content/full/284/2/449   (4016 words)

Role of Nitric Oxide in Hematosuppression and Benzene-induced Toxicity Taken together, these data demonstrate that nitric oxide produced by the bone marrow cells is formed from l-arginine via nitric oxide synthase. As observed with cells from control animals, in the absence of stimulation, bone marrow cells from benzene-treated mice produced negligible quantities of nitric oxide. In further studies, we found that increased production of nitric oxide was due to benzene-induced alterations in expression of inducible nitric oxide synthase in the bone marrow cells (3). www.ehponline.org /docs/1996/Suppl-6/laskin.html   (3915 words)

Interleukin-3, -5, and Granulocyte Macrophage Colony-Stimulating Factor-Induced Adhesion Molecule Expression on ... to be involved in the release of ECP (3), chemotaxis, and transendothelial B activity (Figure 3); therefore, the activation of p38 MAPK (3 µm) coated with 20 ng/ml human fibronectin and adhesion ajrcmb.atsjournals.org /cgi/content/full/29/1/133   (4380 words)

IL3RA (Interleukin-3 Receptor alpha) The gene encoding interleukin-3 receptor is located in the pseudoautosomal region (PAR) at the end of the short arm of the X and Y chromosomes. IL3RA 3563 interleukin 3 receptor, alpha (low affinity) Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor. www.infobiogen.fr /services/chromcancer/Genes/IL3RAID40959chXp22Yp13.html   (1188 words)

I1646 Interleukin 3 human recombinant, expressed in Escherichia coli, ≥98% (SDS-PAGE and HPLC), cell ... I1646 Interleukin 3 human recombinant, expressed in Escherichia coli, ≥98% (SDS-PAGE and HPLC), cell culture tested Cerny, J., et al., Stimulation of bone marrow haemopoietic stem cells by a factor from activated T cells. Cytokines and Growth Factors > Interleukins (IL) and Receptors www.sigmaaldrich.com /catalog/search/ProductDetail?ProdNo=I1646&Brand=SIGMA   (283 words)

DSMZ III - Cancer Cell Lines Part 3: Leukemias and Lymphomas (ed Masters JRW, Palsson BO), Kluwer Academic Pub, Dordrecht (2000), pp. Drexler HG, Quentmeier H, MacLeod RAF, Uphoff CC, Hu ZB: Leukemia cell lines: In vitro models for the study of acute promyelocytic leukemia. PubMed ID Hassan HT, Drexler HG: Interleukins and colony stimulating factors in human myeloid leukemia cell lines. www.dsmz.de /human_and_animal_cell_lines/main.php?contentleft_id=7   (7669 words)

Autoantibodies against granulocyte-macrophage colony stimulating factor and interleukin-3 are rare in patients with ... of 3 standard deviations above the mean of normal control absorbance In contrast, serum from patient 3, serum from one were not found in serum of patient 3. ard.bmjjournals.com /cgi/content/full/63/7/862   (3178 words)

Patent 6,361,976 The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants. The present invention encompasses recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins) These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at either/or both the N- and C-termini. at least one factor selected from the group consisting of a cytokine, an interleukin, a lymphokine, a colony stimulating factor, and a hematopoietic growth factor. www.pharmcast.com /Patents/Yr2002/Mar2002/032602/6361976_Interleukin032602.htm   (2170 words)

IL3 (interleukin-3) The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression. Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. www.infobiogen.fr /services/chromcancer/Genes/IL3ID60.html   (306 words)

Characterization of diphtheria fusion proteins targeted to the human interleukin-3 receptor -- Frankel et al. 13 (8): ... 25% of D. The final yields were 3 mg/l for P1, 6 mg/l for D, 3 mg/l for P5 and 4 mg/l for M. The final purities based on Molecular weight standards were run on each gel and replaced by arrows at the left of each gel. EGF (Seragen, Hopkinton, MA) or DT IL3s in varying concentrations was mixed in DTEB buffer (0.2% bovine serum albumin, 40 mM dithiothreitol, 1 mM EDTA, 50 mM Tris, pH 8.0, in a total volume of 450 µl. peds.oxfordjournals.org /cgi/content/full/13/8/575   (3874 words)

IngentaConnect In vitro expansion of human basophils by interleukin-3 from granu...   (Site not responding. Last check: 2007-10-12) cells were cultured, 20.0–83.3% of the cells, mostly with a yield of >10%, were metachromatic cells after 3 weeks of culture. These cells resembled mature peripheral blood basophils morphologically when examined by light and electron microscopy. 3: Department of Internal Medicine, National Minami-Okayama Hospital, Okayama, Japan www.ingentaconnect.com /content/bsc/cea/2003/00000033/00000011/art00015   (387 words)

Two Distinct Interleukin-3-Mediated Signal Pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, Regulate the Survival of Murine ... Alvarez, J. V., Febbo, P. G., Ramaswamy, S., Loda, M., Richardson, A., Frank, D. Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors. Doi, M., Nakajima, Y., Okano, T., Fukada, Y. Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene. Nishimura, Y., Tanaka, T. Calcium-dependent Activation of Nuclear Factor Regulated by Interleukin 3/Adenovirus E4 Promoter-binding Protein Gene Expression by Calcineurin/Nuclear Factor of Activated T Cells and Calcium/Calmodulin-dependent Protein Kinase Signaling. mcb.asm.org /cgi/content/abstract/19/4/2754   (780 words)

[Frontiers in Bioscience 3, d313-324, March 15, 1998]   (Site not responding. Last check: 2007-10-12) Robb, L., Drinkwater, C.C., Metcalf, D., Li, R., Kontgen, F., Nicola, N.A., Begley, C.G. Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukin 3 and 5. Mui, A., Kay, R., Humphries, R., Krystal, G. Purification of the murine interleukin 3 receptor. An B., Dou Q.P. Cleavage of retinoblastoma protein during apoptosis: An interleukin 1beta-converting enzyme-like protease as candidate. www.bioscience.org /1998/V3/d/johnson/10.htm   (3866 words)

Granulocyte/Macrophage Colony-Stimulating Factor and Interleukin-3 Correct Osteopetrosis in Mice with Osteopetrosis ... Miyashita M, Sugimoto K, Suzuki J, Taniguchi S, Aramaki K, Mori KJ: Hierarchical regulation of interleukin production: induction of interleukin 6 (IL-6) production from bone marrow cells and bone marrow stromal cells by interleukin 3 (IL-3). Tsuji T, Sugimoto K, Yanai T, Takashita E, Mori KJ: Induction of granulocyte-macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) expression in bone marrow and fractionated marrow cell populations by interleukin 3 (IL-3): IL-3-mediated positive feedback mechanisms of granulopoiesis. Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1{beta} and tumour necrosis factor {alpha} ajp.amjpathol.org /cgi/content/full/154/2/553   (7194 words)

Distinct Methylation of the Interferon gamma  (IFN-gamma ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary ...   (Site not responding. Last check: 2007-10-12) Distinct Methylation of the Interferon gamma  (IFN-gamma) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-gamma Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells -- Fitzpatrick et al. Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals. The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymoma. www.jem.org /cgi/content/full/188/1/103   (6359 words)

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