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Topic: Interleukin 4

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	Interleukin-4 receptors (US6548655) (Site not responding. Last check: 2007-10-11)
		Galizzi et al., "Internalization of human interleukin 4 and transient down-regulation of its receptor in the C23-inducible Jijoye cells," J. Biol.
		Garrone et al., "A recombinant extracellular domain of the human interleukin 4 receptor inhibits the biological effects of interleukin 4 on T and B lymphocytes," Eur.
		Jabaari et al., "Elevated expression of the interleukin 4 receptor in carcinoma: a target for immunotherapy?" British J. Cancer 59(6):910-914, 1989.
	www.delphion.com /details?pn=US06548655__ (1291 words)

	Interleukin-4 Enhances Pulmonary Clearance of Pseudomonas aeruginosa -- Jain-Vora et al. 66 (9): 4229 -- Infection and ... (Site not responding. Last check: 2007-10-11)
		sterile PBS and resuspended in 4 to 8 ml of sterile PBS.
		and interleukin 4 stimulate expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.
		Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunology macrophage activation.
	iai.asm.org /cgi/content/full/66/9/4229 (4272 words)

	Recombinant Herpes Simplex Virus Type 1 Expressing Murine Interleukin-4 Is Less Virulent than Wild-Type Virus in Mice ...
		Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.
		Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.
		Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.
	jvi.asm.org /cgi/content/full/75/19/9029 (4648 words)

	Interleukin-4 Suppresses IL-1–Induced Expression of Matrix Metalloproteinase-3 in Human Gingival Fibroblasts (Site not responding. Last check: 2007-10-11)
		Background: In periodontitis, matrix metalloproteinase-3 (MMP-3, stromelysin 1) is present at increased levels in active disease sites compared to inactive or healthy sites, and the levels are correlated with clinical parameters and associated with progression of the disease.
		Interleukin (IL)-4 has been shown in human skin and synovial fibroblasts and articular chondrocytes to suppress IL-1–induced expression of MMP-3, but this has not been shown in human gingival fibroblasts.
		The objective of this study is to determine the effects of IL-4 on the IL-1–induced expression of MMP-3 in human gingival fibroblasts isolated from patients with periodontitis.
	www.electronicipc.com /JournalEZ/detail.cfm?code=02250010750213&cfid=&cftoken= (390 words)

	Targeting Interleukin-4 Receptors for Effective Pancreatic Cancer Therapy -- Kawakami et al. 62 (13): 3575 -- Cancer ...
		Kreitman R. J., Puri R. K., Pastan I. A circularly permuted recombinant interleukin 4 toxin with increased activity.
		Debinski W., Obiri N. I., Pastan I., Puri R. A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4.
		Kreitman R. J., Puri R. K., Pastan I. Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.
	cancerres.aacrjournals.org /cgi/content/full/62/13/3575 (2976 words)

	Interleukin-4 inhibits interleukin-11 production by rheumatoid synovial cells -- Taki et al. 39 (7): 728 -- Rheumatology
		In contrast, IL-4 was hardly detected in RA synovium [3, 4].
		Interleukin 10 cooperates with interleukin 4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells.
		Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.
	rheumatology.oxfordjournals.org /cgi/content/full/39/7/728 (1730 words)

	Expression Cloning of a cDNA Encoding the Murine Interleukin 4 Receptor Based on Ligand Binding -- Harad et al. 87 (3): ...
		Expression Cloning of a cDNA Encoding the Murine Interleukin 4 Receptor Based on Ligand Binding -- Harad et al.
		Interleukin 4 (IL-4) is a potent mediator of growth and differentiation for various lymphoid and myeloid cells.
		To isolate a cDNA encoding the murine IL-4 receptor, we have developed an expression cloning method that uses biotinylated ligand as a probe and that may be generally applicable to cloning of receptor genes.
	www.pnas.org /cgi/lookup?vol=87&fp=857&view=abstract (668 words)

	New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5 -- Kips et al. 17 (3): 499 -- ...
		An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or Il-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B Cell proliferation: support fora common component shared by Il-4 and Il-13 receptors.
		Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
		Characterization of potential antagonists of human interleukin 5 demonstrates their cross-reactivity withreceptors for interleukin 3 and granulocyte-macrophage colony-stimulating factor.
	erj.ersjournals.com /cgi/content/full/17/3/499 (4619 words)

	Impaired mucosal immune responses in interleukin 4-targeted mice. (Site not responding. Last check: 2007-10-11)
		Interleukin 4-targeted (IL-4-/-) mice are defective in T helper (Th)2 cytokine production as determined after nematode infection.
		As Th2 cells appear to be selectively induced by oral immunization we investigated the ability of IL-4-/- mice to respond to perorally administered antigen.
		Our findings demonstrate that IL-4 and probably functional Th2 cells are required for induction of gut mucosal antibody responses.
	www.bioscience.org /knockout/ref/vajdy.htm (351 words)

	Characterization of the Interleukin-4 Receptor Complex in Human Corneal Fibroblasts -- Fukuda et al. 43 (1): 183 -- ...
		Hilton, DJ, Zhang, JG, Metcalf, D, et al (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor Proc Natl Acad Sci USA 93,497-501
		Lowenthal, JW, Castle, BE, Christiansen, J, et al (1988) Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells J Immunol 140,456-464
		Obiri, NI, Debinski, W, Leonard, WJ, Puri, RK (1995) Receptor for interleukin 13: interaction with interleukin 4 by a mechanism that does not involve the common
	www.iovs.org /cgi/content/full/43/1/183 (4154 words)

	Helicobacter pylori cag Pathogenicity Island Is Associated with Reduced Expression of Interleukin-4 (IL-4) mRNA and ...
		Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.
		Expression of two interleukin 4 mRNA isoforms in B lymphoid cells.
		Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.
	iai.asm.org /cgi/content/full/71/11/6664 (1914 words)

	Human Cytokine Data Sheets (Interleukin 4) available through Research Diagnostics Inc (Site not responding. Last check: 2007-10-11)
		Reconstitution: The lyophilized IL-4 should be reconstituted in water to a maximum concentration of 1mg/ml.
		Allow to set at least 30 minutes at 4 DEG C, rotate, mix well.
		This solution can be diluted into other buffered solutions or stored at 4 DEG C for up to 1 week or at -20 DEG C for future use.
	www.researchd.com /cytokines/rdi204.htm (316 words)

	Interleukin-4 deficiency promotes gallstone formation -- King et al. 43 (5): 768 -- Journal of Lipid Research
		For the initial 4 weeks, both groups looked healthy.
		Lipoprotein cholesterol distribution was determined in serum from five individual mice per group.
		(closed shapes) mice were fed a normal (circles) or modified (triangles) diet for 4 weeks.
	www.jlr.org /cgi/content/full/43/5/768 (1943 words)

	Multiple Signaling Pathways Mediate Interleukin-4-Induced 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 ...
		Studies of the signal transduction of the interleukin signals
		4) serine phosphorylation of nonhistone chromosomal protein HMG-I(Y) in B lymphocytes (49, 50, 51).
		were resolved in a 4% polyacrylamide gel in 0.25
	mend.endojournals.org /cgi/content/full/14/2/229 (7017 words)

	AfCS signaling gateway - data center - ligand description
		Description of ligand: Interleukin 4 (IL-4; AfCS ID A001262) is a pleiotropic type I cytokine expressed by Th2 T lymphocytes (T cells), basophils, and mast cells.
		IL-4 may also be secreted by NK T cells, gamma/delta T cells, and eosinophils under some circumstances.
		Like other type I cytokines, its tertiary structure is defined by a hydrophobic core consisting of 4 alpha helices.
	www.signaling-gateway.org /data/cgi-bin/ligand_desc_display.cgi?ligandabbr=I04 (726 words)

	Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida ... (Site not responding. Last check: 2007-10-11)
		Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida albicans -- Mencacci et al.
		Endogenous Interleukin 4 Is Required for Development of Protective CD4
		Interleukin (IL)-4-deficient mice were used to assess susceptibility to systemic or gastrointestinal Candida albicans infections,
	www.jem.org /cgi/content/abstract/187/3/307 (1668 words)

	Increased Levels of Alternatively Spliced Interleukin 4 (IL-4delta 2) Transcripts in Peripheral Blood Mononuclear Cells ...
		Increased Levels of Alternatively Spliced Interleukin 4 (IL-4delta 2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis -- Sakkas et al.
		Recent in vitro studies have shown that interleukin 4 (IL-4) induces and gamma interferon (IFN-
		Atamas, S. P., White, B. Interleukin 4 in Systemic Sclerosis: Not Just an Increase.
	cdli.asm.org /cgi/content/abstract/6/5/660 (372 words)

	Interleukin-4- and Interleukin-13-Enhanced Transforming Growth Factor-beta 2 Production in Cultured Human Bronchial ...
		Interleukin-4- and Interleukin-13-Enhanced Transforming Growth Factor-beta 2 Production in Cultured Human Bronchial Epithelial Cells Is Attenuated by Interferon-gamma -- Wen et al.
		Biol., Volume 26, Number 4, April, 2002 484-490
		that cytokines derived from Th2 cells, interleukin (IL)-4 and
	ajrcmb.atsjournals.org /cgi/content/abstract/26/4/484 (496 words)

	New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5 -- Kips et al. 17 (3): 499 -- ...
		New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5 -- Kips et al.
		New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5
		which has been developed, is to inhibit the effect of interleukin
	erj.ersjournals.com /cgi/content/abstract/17/3/499 (290 words)

	Medical Dictionary: Interleukin 4 - WrongDiagnosis.com
		Terms that may be interchangeable with Interleukin 4:
		The term Interleukin 4 can be used for:
		The description of Interleukin 4 may also be used for the following terms:
	www.wrongdiagnosis.com /medical/interleukin_4.htm (115 words)

	GeneCard for IL4
		10810222 (4), 8250351 (3), 8534490 (3), 9314350 (3) (see all 66)
		8809430 (4), 10453034 (2), 10605015 (2), 10830775 (2) (see all 99)
		Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B- cell- and T-cell-stimulating activities.
	www.genecards.org /cgi-bin/carddisp.pl?gene=IL4 (972 words)

	Induction of 3{beta}-Hydroxysteroid Dehydrogenase/ Isomerase Type 1 Expression by Interleukin-4 in Human Normal ...
		4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
		Zurawski G, de Vries JE 1994 Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells.
		Zurawski G, de Vries JE 1994 Interleukin 13 elicits a subset of the activities of its close relative interleukin 4.
	endo.endojournals.org /cgi/content/full/140/10/4573 (7334 words)

	The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor -- ...
		Interleukin (IL)-13 elicits a subset of the biological activities of the related IL-4.
		Homodimerization of the human interleukin 4 receptor alpha chain induces Cvarepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain
		Modulation of Interleukin (IL)-13 Binding and Signaling by the gamma c Chain of the IL-2 Receptor
	www.jbc.org /cgi/content/abstract/270/23/13869 (2216 words)

	Interleukin-4 (IL-4) and IL-13 Enhance the Effect of IL-1beta on Production of IL-1 Receptor Antagonist by Human ...
		B probe; lane 4, preincubation with antibodies against p50; lane 5, preincubation with control IgG; lanes 6 to 8 contain the NF-
		Zurawski G, De Vries JE: Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells.
		Hasegawa M, Fujimoto M, Kikuchi K, Takehara K: Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis.
	www.bloodjournal.org /cgi/content/full/93/4/1299 (5591 words)

	Use of interleukin-4 receptors to inhibit biological responses mediated by interleukin-4 (US5767065) (Site not responding. Last check: 2007-10-11)
		Cabrillat et al., "High Affinity Binding of Human Interleukin 4 to Cell Lines", Biochem.
		Lowenthal et al., "Expression of High Affinity Receptors for Murin Interleukin 4 (BSF1)", J. Immunol.
		Finkelman et al., "T Help Requirements for the Generation of an In Vivo IgE Response: A Late Acting Form of T Cell Help Other Than IL-4 Is Required for IgE but not for IgG1 Production", J. Immunol.
	www.delphion.com /details?pn=US05767065__ (1311 words)

	Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for ...
		Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis -- Wurster et al.
		Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis
		with the cytoplasmic tail of the interleukin 4 (IL-4) receptor.
	mcb.asm.org /cgi/content/abstract/22/1/117 (858 words)

	Interleukin-4-Induced Apoptosis Entails Caspase Activation and Suppression of Extracellular Signal-Regulated Kinase ...
		in the presence of LPS and IL-4 (Figure 4).
		Human freshly isolated human monocytes (Fresh), monocytes undergoing spontaneous apoptosis or monocytes treated with either LPS, IL-4 (10 ng/ml) alone, or IL-4 in combination with LPS for 4 h were labeled using PE-TLR4 and analyzed by flow cytometry.
		Human toll-like receptor 2 and 4 are targets for deactivation of mononuclear phagocytes by interleukin-4.
	ajrcmb.atsjournals.org /cgi/content/full/29/3/367 (4335 words)

	Mechanisms of Interleukin-4 Effects on Calcium Signaling in Airway Smooth Muscle Cells -- Ethier et al. 313 (1): 127 -- ...
		Right, after establishing responsiveness in each cell (S1), cells were exposed to CPA alone (5 µM) or to CPA plus IL-4 (50 ng/ml) for 4 min.
		Corry DB, Folkesson HG, Warnoci ML, Erle DJ, Matthay MA, Wiener-Kronish JP, and Locksley RM (1996) Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
		Rankin JA, Picarella DE, Geba GP, Temann U-A, Prasad B, DiCosmo B, Tarallo A, Stripp B, Whitsett J, and Flavell RA (1996) Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
	jpet.aspetjournals.org /cgi/content/full/313/1/127 (4802 words)

	Genetic Polymorphisms of the Interleukin-4 Receptor{alpha} Gene Are Associated with an Increasing Risk and a Poor ...
		X174-HaeIII marker, Lane 4, Gln/Gln; Lane 5, Arg/Gln; Lane 6, Arg/Arg.
		The Arg576Gln polymorphism was genotyped by a mismatch PCR-RFLP
		Interaction with interleukin 4 by a mechanism that does not involve the common
	clincancerres.aacrjournals.org /cgi/content/full/8/8/2620 (3226 words)

	Interleukin (IL) 4 and IL-13 Act on Human Lung Fibroblasts . Implication in Asthma -- Doucet et al. 101 (10): 2129 -- ...
		Interleukin (IL) 4 and IL-13 Act on Human Lung Fibroblasts.
		Interleukin (IL) 4 and IL-13 Act on Human Lung Fibroblasts
		Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
	www.jci.org /cgi/content/abstract/101/10/2129 (2096 words)

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