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Topic: Interleukin 5

	interleukins - multiple sclerosis encyclopaedia
		Interleukins (also called lymphokines) are a sub-group of small soluable proteins called cytokines which function as chemical messengers between cells.
		The role of interleukins is to mediate and control the immunologic and inflamatory response.
		Interleukins are largely secreted by white blood cells (leukocytes) and received by receptors in others.
	www.mult-sclerosis.org /interleukins.html (393 words)

	IL5 - interleukin 5 (colony-stimulating factor, eosinophil)
		Interleukin 5 (IL-5) has an enhancing effect on IL-4 induced immunoglobulin E (IgE) synthesis.
		Soluble interleukin 5 (IL-5), but no interleukin 3 (IL-3) and granulocyte-macrophage colony- stimulating factor (GM-CSF), was detected in sera from all patients.
		Interleukin 4 (IL 4)- induced IgE production by peripheral blood lymphocytes and tonsil cells from normal donors was enhanced in a dose-dependent fashion by IL 5.
	www.ihop-net.org /UniPub/iHOP/gg/89450.html (4975 words)

	Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions -- Büttner et al. 21 (5): ... (Site not responding. Last check: 2007-10-03)
		Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity and lung damage in a mouse asthma model.
		Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin 5.
		Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
	erj.ersjournals.com /cgi/content/full/21/5/799 (2540 words)

	Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent CHEST - Find ... (Site not responding. Last check: 2007-10-03)
		Study objectives: To establish a murine model of pneumothorax-associated pleural eosinophilia and to examine the role of interleukin (IL)-5 and IL-13 in the pathogenesis of this reaction.
		Since eotaxin (10) and vascular cell adhesion molecule-1 (5) levels have been reported to be higher in EPEs than in the non-EPEs, it is reasonable to hypothesize that IL-13 plays a role in pneumothorax-associated pleural eosinophilia.
		The purpose of the present study was to establish a routine model of pneumothorax-associated pleural eosinophilia.
	www.findarticles.com /p/articles/mi_m0984/is_4_128/ai_n15795186 (820 words)

	In Vitro and In Vivo Inhibition of Interleukin (IL)-5-Mediated Eosinopoiesis by Murine IL-5R{alpha} Antisense ... (Site not responding. Last check: 2007-10-03)
		In Vitro and In Vivo Inhibition of Interleukin (IL)-5-Mediated Eosinopoiesis by Murine IL-5R
		Serum interleukin 5 concentrations in atopic and non-atopic patients with glucocorticoid-dependent chronic severe asthma.
		Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival: IL-5 as an eosinophil chemotactic factor.
	ajrcmb.atsjournals.org /cgi/content/full/24/2/116 (4240 words)

	Medical Dictionary: Interleukin 5 - WrongDiagnosis.com
		Interleukin 5: lymphokine produced by antigen or mitogen activated T lymphocytes that acts as a differentiation factor for B lymphocytes and eosinophils and increases the production of IgA by B lymphocytes.
		Interleukin 5 : lymphokine produced by antigen or mitogen activated T lymphocytes that acts as a differentiation factor for B lymphocytes and eosinophils and increases the production of IgA by B lymphocytes.
		The description of Interleukin 5 may also be used for the following terms:
	www.wrongdiagnosis.com /medical/interleukin_5.htm (247 words)

	Bioline International Official Site (site up-dated regularly)
		Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate in the lungs during asthma.
		We have studied anti IL-5 antibodies on allergic responses in mice, guinea pigs and monkeys and are extending this experiment into humans with a humanized antibody.
		Figure 5: inhibition by Sch 55700 of the total cells and eosinophils in the BAL of allergic mice.
	www.bioline.org.br /request?oc97171 (2588 words)

	Induction of Interleukin-4 and Interleukin-5 Expression in Mast Cells Is Inhibited by Glucocorticoids -- Sewell et al. ... (Site not responding. Last check: 2007-10-03)
		Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4.
		Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.
		Phenotype of cells expressing mRNA for Th2-Type (interleukin 4 and interleukin 5) and Th1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.
	cdli.asm.org /cgi/content/full/5/1/18 (4228 words)

	Relationship between Interleukin-5 and Eotaxin in Regulating Blood and Tissue Eosinophilia in Mice -- Mould et al. 99 ... (Site not responding. Last check: 2007-10-03)
		Leder(1995)Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.
		Suda(1988)Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival.
		Hamid(1991)Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony stimulating factor, in allergen-induced late-phase cutaneous reaction in atopic subjects.
	www.jci.org /cgi/content/full/99/5/1064 (5948 words)

	An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils -- McKinnon et al. 186 ... (Site not responding. Last check: 2007-10-03)
		Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines.
		Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival.
		Molecular cloning and expression of the human interleukin 5 receptor.
	www.jem.org /cgi/content/full/186/1/121 (4884 words)

	Interleukin 5 - Wikipedia, the free encyclopedia
		Its functions are to stimulate B cell growth and increase immunoglobulin secretion.
		The IL-5 gene is located on chromosome 11 (in the mouse, chromosome 5 in humans) in close proximity to the genes encoding IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF)
		Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5.
	en.wikipedia.org /wiki/Interleukin_5 (1061 words)

	Interleukin-5 Transgene Expression and Eosinophilia Are Associated with Retarded Mammary Gland Development in Mice -- ... (Site not responding. Last check: 2007-10-03)
		5 and 7 wk of age and in the uterus and ovary at 7 wk of age.
		Epithelial proliferation was assessed by BrdU incorporation in sections of uterus (A) and ovary (B) taken from Wt and IL-5Tg mice in metestrus at 7 wk of age and of mammary glands (C) retrieved at 5 and 7 wk of age.
		Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma.
	www.biolreprod.org /cgi/content/full/69/1/224 (6756 words)

	Recombinant Rat IL-5 - CYT-387
		Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo.
		Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells.
		Differential regulation of interleukin 5-stimulated signaling pathways by dynamin.
	www.prospec.co.il /~prospec/cart/catalog/rrIL5.html (485 words)

	An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils -- McKinnon et al. 186 ... (Site not responding. Last check: 2007-10-03)
		An Interleukin 5 Mutant Distinguishes between Two Functional Responses in Human Eosinophils
		Interleukin 5 (IL-5) is the key cytokine involved in regulating the production and many of the specialized functions of mature
		Kips, J.C., Tournoy, K.G., Pauwels, R.A. New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5.
	www.jem.org /cgi/content/abstract/186/1/121 (427 words)

	Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function -- Li et al. ... (Site not responding. Last check: 2007-10-03)
		Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function
		Human interleukin 5 (hIL-5) is a hematopoietic growth factor protein implicated in the development of eosinophil-dependent
		GM-CSF, granulocyte-macrophage colony-stimulating factor; hIL-5, human interleukin 5; DABC-IL-5 (or DABC for short), the protein engineered derivative of IL-5 in which the order of helical segments from the amino to carboxyl terimus is D to
	www.pnas.org /cgi/content/full/94/13/6694 (4276 words)

	Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis : comparison with asthma CHEST - Find ... (Site not responding. Last check: 2007-10-03)
		Study objectives: Experimental studies on asthma have indicated that interleukin (IL)-13 induces airway hyperreactivity (AHR).
		Abbreviations: AHR = airway hyperresponsiveness; EB = eosinophilic bronchitis; IL = interleukin; IQR = interquartile range; PBMC = peripheral blood mononuclear cell; [PC.sub.20] = provocative concentration of a substance causing a 20% fall in [FEV.sub.1]; PMA = phorbol myristate acetate; Th2 = T helper type 2
		(1) The excessive production of interleukin (IL)-4, IL-5, and IL-13 by T-helper type 2 (Th2) cells is implicated in the development of asthma, (2,3) IL-5 mobilizes eosinophils from the bone marrow pool, and chemokines, such as eotaxin-1, induce the recruitment of eosinophils into the airway of experimental asthma models.
	www.findarticles.com /p/articles/mi_m0984/is_4_128/ai_n15779038 (871 words)

	Interleukin 5 regulates the isoform expression of its own receptor alpha -subunit -- Tavernier et al. 95 (5): 1600 -- ... (Site not responding. Last check: 2007-10-03)
		Interleukin 5 regulates the isoform expression of its own receptor alpha -subunit -- Tavernier et al.
		Interleukin 5 regulates the isoform expression of its own receptor
		The receptor for interleukin 5 (IL-5) consists of a cytokine-specific
	www.bloodjournal.org /cgi/content/abstract/95/5/1600 (821 words)

	Secreted Respiratory Syncytial Virus G Glycoprotein Induces Interleukin-5 (IL-5), IL-13, and Eosinophilia by an ... (Site not responding. Last check: 2007-10-03)
		A panel of recombinant vaccinia viruses that express various RSV proteins was constructed (5, 59).
		Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.
		Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice.
	jvi.asm.org /cgi/content/full/73/10/8485 (7316 words)

	Role for Neurokinin-2 Receptor in Interleukin-5-induced Airway Hyperresponsiveness but not Eosinophilia in Guinea Pigs ... (Site not responding. Last check: 2007-10-03)
		The nonselective neurokinin receptor antagonist, FK224, and the neurokinin-1 receptor antagonist, FK888, were dissolved in
		P (n = 5, hatched bars) or vehicle (n = 5, open bars).
		All examined NK receptor antagonists did not affect the IL-5-induced eosinophil accumulation into the BAL fluid (Figure 5).
	ajrccm.atsjournals.org /cgi/content/full/156/2/367 (4004 words)

	Transcription of the Murine Interleukin 5 Gene Is Regulated by Multiple Promoter Elements -- Stranick et al. 270 (35): ... (Site not responding. Last check: 2007-10-03)
		Transcription of the Murine Interleukin 5 Gene Is Regulated by Multiple Promoter Elements -- Stranick et al.
		Cis-acting regions in the 5`-flank of the mouse interleukin 5 (IL-5) gene involved in the specific and inducible regulation of IL-5 transcription in an untransformed mouse T cell clone, D10.G4.1, have been identified.
		Transient transfection assays with a series of deletion IL-5 promoter reporter constructs indicate that multiple regulatory elements in the 5`-flanking region of the IL-5 promoter play a role in regulating IL-5 transcription in Th2 cells.
	www.jbc.org /cgi/content/abstract/270/35/20575 (501 words)

	Pulmonary eosinophilia in mice devoid of interleukin-5 -- Domachowske et al. 71 (6): 966 -- Journal of Leukocyte Biology (Site not responding. Last check: 2007-10-03)
		5, 10, 8, 8, and 10 pg/ml, respectively).
		limits on day 5 in response to this inoculum.
		is observed in both IL-5 +/+ and IL-5 -/- strains (Table 5).
	www.jleukbio.org /cgi/content/full/71/6/966 (3378 words)

	Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle -- Whelan et al. 24 ... (Site not responding. Last check: 2007-10-03)
		5.— Protein expression of stimulatory interleukin (IL)-1 axis molecules in human airway smooth muscle (HASM) cells.
		Autocrine role of interleukin 1beta in altered responsiveness of atopic asthmatic sensitised airway smooth muscle.
		Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.
	erj.ersjournals.com /cgi/content/full/24/4/559 (5628 words)

	Synergism of Gamma Interferon and Interleukin-5 in the Control of Murine Filariasis -- Saeftel et al. 71 (12): 6978 -- ...
		Germany) in RPMI 1640-5% FCS at 37°C and 5% CO for 2 h.
		Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis.
		Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different developmental stages.
	iai.asm.org /cgi/content/full/71/12/6978 (4780 words)

	Interleukin-5 inhibition of biliary cell chloride currents and bile flow -- McGill et al. 280 (4): 738 -- AJP - ... (Site not responding. Last check: 2007-10-03)
		Cells were prepared for immunohistochemistry by cytospinning (100 g for 5 min) smears of small and large cholangiocytes from
		Desreumaux, P, Bloget F, Seguy D, Capron M, Cortot A, Colombel JF, and Janin A. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis.
		Activated eosinophils and interleukin 5 expression in early recurrence of Crohn's disease.
	ajpgi.physiology.org /cgi/content/full/280/4/G738 (4627 words)

	Expression of Interleukin-5 and Granulocyte-Macrophage Colony-stimulating Factor in Aspirin-sensitive and ... (Site not responding. Last check: 2007-10-03)
		human interleukin 5 is a selective activator of human eosinophil
		5 messenger RNA expression by eosinophils in the intestinal mucosa
		5 synthesis by eosinophils: associations with granules and immunoglobulin-dependent
	ajrccm.atsjournals.org /cgi/content/full/156/5/1384 (2904 words)

	Interleukin Nomenclature (Site not responding. Last check: 2007-10-03)
		interleukin 6 signal transducer (gp130, oncostatin M receptor)
		interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene
		We work closely with the IUIS (International Union Of Immunological Societies) Interleukin Nomenclature Committee for all new interleukin designations.
	www.gene.ucl.ac.uk /nomenclature/genefamily/interleukins.html (151 words)

	InterPro: IPR000186 Interleukin-5 (Site not responding. Last check: 2007-10-03)
		Campbell H.D. Tucker W.Q. Hort Y. Martinson M.E. Mayo G. Clutterbuck E.J. Sanderson C.J. Young I.G. Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).
		The Additional Reading field provides a list of publications derived from the references provided by the member databases for the methods associated with each InterPro entry which are not referenced in the abstract.
		Additionally, a maximum of 5 references per entry are taken from the PDB where one or more of the proteins in the entry has had its structure determined.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000186 (3009 words)

	INTERLEUKIN 5 (IL-5) antibodies available from Research Diagnostics Inc
		INTERLEUKIN 5 (IL-5) antibodies available from Research Diagnostics Inc
		(request Interleukin and Growth Factor Receptor Data Pack for more antibodies and spec sheets)
		We are not responsible for any patent infringements that might result with the use of or derivation of this product.
	www.researchd.com /cytokines/il5ab.htm (601 words)

	Cyclosporin A and FK506 Reduce Interleukin-5 mRNA Abundance by Inhibiting Gene Transcription -- Rolfe et al. 17 (2): ... (Site not responding. Last check: 2007-10-03)
		Cells were harvested by centrifugation at 400 × g for 5 min at 4°C, washed three times with ice-cold phosphate-buffered saline
		Abbreviations CsA, cyclosporin A; IL, interleukin; PBMC, peripheral blood mononuclear cells; PHA, phytohemagglutinin; RT-PCR, reverse transcriptase- polymerase chain reaction.
		(interleukin 2 and interferon gamma) cytokines in bronchoalveolar
	ajrcmb.atsjournals.org /cgi/content/full/17/2/243 (4413 words)

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