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Topic: Interleukin 6

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	Interleukin - Wikipedia, the free encyclopedia
		Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-).
		The name is something of a relic though; it has since been found that interleukins are produced by a wide variety of bodily cells.
		The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency.
	en.wikipedia.org /wiki/Interleukin (242 words)

	Interleukin 6 - Wikipedia, the free encyclopedia
		IL-6 is probably the best studied of the cytokines that use gp130 in their signalling complexes.
		Other cytokines that signal through receptors containing gp130 are Interleukin 11 (IL-11), Interleukin 27 (IL-27), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF), oncostatin M (OSM), Kaposi's sarcoma associated herpes virus interleukin 6 like protein (KSHV-IL6).
		These cytokines are commonly referred to as the IL-6 like or gp130 utilising cytokines.
	en.wikipedia.org /wiki/Interleukin_6 (516 words)

	Interleukin-6: Catabolic Agent or Growth Factor? by Robert Ames
		Interleukins (abbreviated IL) are cytokines that are produced by leukocytes (white blood cells) and that function during inflammatory responses.
		Hinson RM, Williams JA, Shacter E. Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.
		Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells.
	www.mesomorphosis.com /articles/ames/interleukin-6.htm (6907 words)

	Interleukin-6, obstructive sleep apnea, and obesity - communications to the editor - Letter to the Editor CHEST - Find ... (Site not responding. Last check: 2007-10-13)
		Carpagnano and colleagues (1) recently reported in CHEST (October 2002) a significant increase in 8-iseprostane and interleukin (IL)-6 levels in the exhaled breath condensate of obstructive sleep apnea (OSA) patients compared with that of obese subjects.
		The obesity was concomitant with decreased glucose tolerance and increased circulatory triglyceride levels in females, as well as increased leptin levels and lepta insensitivity in older mice of both genders.
		Interleukin 6 is required for the development of collagen-induced arthritis.
	www.findarticles.com /p/articles/mi_m0984/is_4_124/ai_110218200 (730 words)

	Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in ...
		Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis.
		Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
		Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death.
	stemcells.alphamedpress.org /cgi/content/full/17/3/127 (6302 words)

	BioMed Central \| Full text \| Platelet count and Interleukin 6 Gene polymorphism in healthy subjects
		Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis.
		In fact, circadian interrelationships among levels of plasma fibrinogen, blood platelets and serum interleukin 6 have been recently reported [11].
		Although basal interleukin 6 levels were not statistically different between genotypes in this report (p = 0.07), the study of circadian IL-6 levels will shed light on differences of transcription rate attributed to IL-6 gene polymorphism.
	www.biomedcentral.com /1471-2350/2/6 (2216 words)

	Fever - Wikipedia, the free encyclopedia (via CobWeb/3.1 planetlab2.cs.unc.edu) (Site not responding. Last check: 2007-10-13)
		Body temperature normally fluctuates over the day, with the lowest levels at 4 A.M. and the highest at 6 P.M. Therefore, an oral temperature of 37.5°C would strictly be a fever in the morning, but not in the afternoon.
		The endogenous pyrogens (such as interleukin 1) are a part of the innate immune system, produced by phagocytic cells, and cause the increase in the thermoregulatory set-point in the hypothalamus.
		This binding results in the synthesis and release of various cytokine factors, such as interleukin 1 (IL-1), interleukin 6 (IL-6), and the tumor necrosis factor-alpha.
	en.wikipedia.org.cob-web.org:8888 /wiki/Fever (1660 words)

	bioWORLD - HUMAN INTERLEUKIN-6 (Site not responding. Last check: 2007-10-13)
		They have a compact, globular fold (similar to other interleukins), stabilised by the 2 disulphide bonds.
		One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist: the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet.
		Interleukin (IL)-6 is an important proinflammatory and immunoregulatory cytokine expressed by various cells.Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.
	www.bio-world.com /MoreInfo.asp?ItemCode=508810 (437 words)

	InterPro: IPR003573 Interleukin-6/G-CSF/MGF
		One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist [ 4 ]: the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet.
		Rose T.M. Bruce A.G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
		Somers W. Stahl M. Seehra J.S. 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR003573 (3359 words)

	Re: Maitake, Interleukin-6, arthritis, O's
		Interleukin 6 (IL 6) stimulates bone breakdown (osteoclasts) and thus is contraindicated during injury.
		For A's I recommend it taken with hypericum as hypericum inhibits the release of IL 6.
		IL 6 is considered an anti inflammatory cytokine because it stimulates the release of cortisone (NOT a good thing if your an A!!).
	www.dadamo.com /forum/archive6/config.pl?read=20710 (164 words)

	BioMed Central \| Full text \| Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming ...
		Elevated plasma EBV DNA load is regarded as an important marker for the presence of the disease and for the monitoring of disease progression.
		The knowledge on the expression and functions of certain cytokines in relation to NPC might be able to explain the lack of an effective tumour-specific immune response despite the induction of EBV-specific humoral and cytotoxic response in NPC patients.
		Although IL-10 was reported to be expressed in tissues of primary NPC [8,18], our data did not indicate any observable differences in the level of this interleukin in the plasma of NPC patients in comparison to controls.
	www.biomedcentral.com /1471-2407/6/227 (5165 words)

	Recombinant Porcine Interleukin-6 - CYT-399
		Recombinant Porcine IL-6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 21,113 Dalton.
		Soluble interleukin 6 receptor: A novel marker of moderate to severe sleep-related breathing disorder.
		Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer.
	www.prospec.co.il /~prospec/cart/catalog/rpIL6.html (502 words)

	Genomics\|HuGENet\|Fact sheets\|Kaposi's Sarcoma and Interleukin-6
		The etiology of KS is complex, but infection with human herpesvirus 8 (HHV-8) appears to be the primary and necessary event for development of the tumor (6).
		The virus encodes for several genes, incorporated from its human host, that are homologous to human oncoproteins, including a cyclin that regulates the G1-to-S phase of the cell cycle, and a Bcl-2 like protein that prevents apoptosis (6).
		Dourado I. Interleukin 6 and AIDS-associated Kaposi’s sarcoma: a nested case control study within the Multicenter AIDS Cohort Study.
	www.cdc.gov /genomics/hugenet/factsheets/FS_IL6.htm (1099 words)

	Interleukin 6 Dependence of Anti-DNA Antibody Production: Evidence for Two Pathways of Autoantibody Formation in ...
		Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.
		Interleukin 6 is essential for in vivo development of B lineage neoplasms.
		Age-associated increase in interleukin 6 in MRL/lpr mice.
	www.jem.org /cgi/content/full/188/5/985 (3483 words)

	Arthritis Research & Therapy \| Full text \| Interleukin-6 and rheumatic diseases
		Interleukin (IL)-6 is a pleiotropic cytokine that has actions on a host of biologic systems.
		IL-6 is also known to be an endogenous pyrogen [5] and is the major cytokine inducer of acute phase response genes [6].
		Lindmark E, Diderholm E, Wallentin L, Siegbahn A: Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease.
	arthritis-research.com /content/8/S2/S4 (3037 words)

	IL-6, insulin resistance and...
		Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-a or its receptors.
		Another important finding was that the authors, due to the size of the study, could use statistical analyses to show that the associations between IL-6 levels and markers of inflammation could not be accounted for by differences in BMI.
		C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.
	www.medforum.nl /idm/il-6,_insulin_resistance_and___.htm (1051 words)

	Interleukin-6-deficient mice develop mature-onset obesity - Nature Medicine
		Schobitz, B., de Kloet, E.R., Sutanto, W. and Holsboer, F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain.
		Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.
		Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia.
	www.nature.com /uidfinder/10.1038/nm0102-75 (3299 words)

	Targeted Anti-Interleukin-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence -- ...
		Badache A., Hynes N. Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.
		Novick D., Shulman L. M., Chen L., Revel M. Enhancement of interleukin 6 cytostatic effect on human breast carcinoma cells by soluble IL-6 receptor from urine and reversion by monoclonal antibody.
		Bataille R., Jourdan M., Zhang X. G., Klein B. Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.
	clincancerres.aacrjournals.org /cgi/content/full/9/13/4653 (8467 words)

	IL6 - Interleukin 6 (interferon, beta 2) - aka: IFNB2 - Cancer GeneticsWeb
		Clinical correlates of elevated serum levels of interleukin 6 in patients with untreated Hodgkin's disease.
		Serum evaluation of interleukin 6 in ovarian cancer patients.
		Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma.
	www.cancerindex.org /geneweb/IL6.htm (428 words)

	Recombinant Human Interleukin-6 - CYT-213
		Recombinant Human IL-6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 21000 Dalton.
		Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism.
		Two novel somatic mutations in the human interleukin 6 promoter region in a patient with sporadic breast cancer.
	www.prospec.co.il /~prospec/cart/catalog/rHuIL6.html (521 words)

	Is Interleukin-6 the 'holy grail' of exercise mediation?
		Call To Rename Class Of Muscle-Derived IL-6 As "Myokines" Austin, Texas (Oct. 6, 2004) — For the most of the past century, researchers have searched for a muscle-contraction-induced factor, which mediates some of the exercise effects in other tissues and organs such as the liver and adipose tissue.
		From Oct. 6 (2 p.m.) - Oct. 9, the onsite phone number in Austin is 512-482-8000, room 602, or 512-682-2950.
		The 2004 Intersociety Meeting on the Integrated Biology of Exercise is cosponsored by APS, the American College of Sports Medicine and the Canadian Society for Exercise Physiology.
	www.eurekalert.org /pub_releases/2004-10/aps-iit100604.php (656 words)

	Circulating interleukin 6 and interleukin 10 in community acquired pneumonia -- Glynn et al. 54 (1): 51 -- Thorax
		Circulating interleukin 6 and interleukin 10 in community acquired pneumonia
		Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
		Anti-inflammatory cytokine response during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10 and IL-13.
	thorax.bmjjournals.com /cgi/content/full/54/1/51 (3432 words)

	IL-6, Human or Mouse
		Human/mouse IL6, human and mouse interleukin-6 and interleukin 6
		If the product is going to be used for applications requiring absolute asepsis, it’s best to filter-sterilize the solution using a sterile and non-pyrogenic 0.2µm membrane before use.
		Human and mouse interleukin-6, IL-6, interleukin 6, IL6 or IL-6.
	www.biomyx.net /hmil6 (241 words)

	The Pathophysiologic Roles of Interleukin-6 in Human Disease -- Papanicolaou et al. 128 (2): 127 -- Annals of Internal ...
		B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
		The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
		Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow serum of patients with rheumatoid arthritis.
	www.annals.org /cgi/content/full/128/2/127 (7036 words)

	Interleukin Nomenclature (Site not responding. Last check: 2007-10-13)
		interleukin 6 signal transducer (gp130, oncostatin M receptor)
		interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene
		We work closely with the IUIS (International Union Of Immunological Societies) Interleukin Nomenclature Committee for all new interleukin designations.
	www.gene.ucl.ac.uk /nomenclature/genefamily/interleukins.html (151 words)

	Differential modulation of interleukin-6 and interleukin-10 by diclofenac in patients undergoing major surgery -- Mahdy ...
		and 2, 6, 12 and 24 h after skin incision.
		IL-5 and IL-10 and are associated with immunosuppressive responses.
		Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma.
	bja.oxfordjournals.org /cgi/content/full/88/6/797 (2847 words)

	Asthma cure research on the Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells ...
		Asthma cure research on the Production of basic fibroblast growth factor and interleukin 6 by human smooth muscle cells following infection with Chlamydia pneumoniae.
		In this study we demonstrated that C. pneumoniae infection of human smooth muscle cells in vitro increased production of interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) as shown by reverse transcription-PCR, immunoblotting, and enzyme-linked immunosorbent assay.
		These findings suggest that chlamydial infection of smooth muscle cells elicits a cytokine response that may contribute to structural remodeling of the airway wall in chronic asthma and to fibrous plaque formation in atherosclerosis.
	www.asthmastory.com /a23.asp (247 words)

	Reciprocal increase of circulating interleukin-10 and interleukin-6 in patients with acute myocardial infarction -- ...
		Reciprocal increase of circulating interleukin-10 and interleukin-6 in patients with acute myocardial infarction
		Increased circulating interleukin (IL)-10 is reported in patients with acute myocardial infarction (AMI)
		Figure 1 Time course of interleukin (IL)-10 (A), IL-6 (B), and IL-12 (C) in 20 patients with acute myocardial infarction.
	heart.bmjjournals.com /cgi/content/full/86/6/704 (885 words)

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