| |
| |
NIH Backgrounder--Stress System Malfunction Could Lead to Serious, Life Threatening Disease--09/09/2002 |
 | | In response to an infection, or an inflammatory disorder like rheumatoid arthritis, cells of the immune system produce three substances that cause inflammation: interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor (TNF). |
 | | When the HPA axis is continually running at a high level, however, that damping down can have a down side, leading to decreased ability to release the interleukins and fight infection. |
 | | In addition, the high cortisol levels resulting from prolonged stress could serve to make the body more susceptible to disease, by switching off disease-fighting white blood cells. |
| www.nih.gov /news/pr/sep2002/nichd-09.htm (2705 words) |
|