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Topic: Interleukin 9


  
  NIH Backgrounder--Stress System Malfunction Could Lead to Serious, Life Threatening Disease--09/09/2002
In response to an infection, or an inflammatory disorder like rheumatoid arthritis, cells of the immune system produce three substances that cause inflammation: interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor (TNF).
When the HPA axis is continually running at a high level, however, that damping down can have a down side, leading to decreased ability to release the interleukins and fight infection.
In addition, the high cortisol levels resulting from prolonged stress could serve to make the body more susceptible to disease, by switching off disease-fighting white blood cells.
www.nih.gov /news/pr/sep2002/nichd-09.htm   (2705 words)

  
 Obesity-News.com
The second article provides details on a phase II interleukin 1-b inhibitor, also for diabetes.
Company presentations from the Bio Investor Forum October 9 - 11, 2007, the Lazard Health Conference November 27 - 28, 2007, and various other R&D day conferences.
Highlights include data a new 5HT2C agonist for weight loss which in early trials has been shown to have a better selectivity and side effect profile than lorcaserin.
www.obesity-news.com   (759 words)

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