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Topic: Interleukin-1

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Interleukin - Wikipedia, the free encyclopedia Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The name is sort of a relic though; it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. en.wikipedia.org /wiki/Interleukin   (221 words)

Interleukin 7 - Wikipedia, the free encyclopedia Interleukin 7 (IL7) is a hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. en.wikipedia.org /wiki/Interleukin_7   (74 words)

Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage -- Sivakumar et al. 50 (6): 812 -- Gut Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage -- Sivakumar et al. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process gut.bmjjournals.com /cgi/content/abstract/50/6/812   (455 words)

Interleukin 3 - Wikipedia, the free encyclopedia Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. en.wikipedia.org /wiki/Interleukin_3   (136 words)

Interleukin, Immunology Bookcase, Dalhousie University Interleukin 1 has many functions on many different cells and is secreted by a number of cells including macrophages, monocytes and dendritic cells. Here IL-1, and some other cytokines (including IL-6, the IFNs and TNFs), bind to receptors on the endothelial cells within the hypothalamus and appear to 'reset' the thermoregulatory centre increasing the core body temperature causing fever. pim.medicine.dal.ca /il1.htm   (165 words)

Interleukin 1: Facts and details from Encyclopedia Topic (which is a human recombinant form of interleukin 1 receptor antagonist. Interleukin-1 (IL-1) is secreted by the macrophage[Click link for more facts about this topic]s, EHandler: no quick summary. It is commercially produced as anakinra[For more facts and a topic of this subject, click this link], EHandler: no quick summary. www.absoluteastronomy.com /encyclopedia/i/in/interleukin_1.htm   (343 words)

Interleukin Interleukin 10, Recombinant, Murine (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) Interleukin 10, Recombinant, Rat (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) Interleukin 10, Recombinant, Porcine (IL-10, Cytokine Synthesis Inhibitory Factor, CSIF) www.usbio.net /Category.aspx?catName=Growth+Factors-Interleukin   (502 words)

Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury -- Gadient and Patterson 17 (3): 127 -- Stem Cells Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice. Recombinant human interleukin 11 decreases arthritis in HLA-B27 transgenic rats. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. stemcells.alphamedpress.org /cgi/content/full/17/3/127   (6319 words)

Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis -- Chen et al. 45 (6): 895 -- Gut Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis Interleukin 10 (IL-10) is a recently characterised potent anti-inflammatory cytokine. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis -- Chen et al. gut.bmjjournals.com /cgi/content/full/45/6/895   (2575 words)

Interleukin-1 Inhibition at Treatment for Rheumatoid Arthritis on Johns Hopkins Arthritis The interleukin gene family is comprised of IL-1a, IL-1b, and IL–1 receptor antagonist (IL–1ra). Interleukin 1 signaling occurs exclusively via the type I receptor. The third member of the interleukin gene family is IL-1ra. www.hopkins-arthritis.som.jhmi.edu /rheumatoid/il1.html   (3951 words)

Melanoma Center - Types of Treatment - Biological Therapy - Immunotherapy - Interleukin-2 High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. Like interferons, interleukins are cytokines, naturally produced proteins of the immune system. One type, interleukin-2, causes the immune system's T-cells to multiply and perform a variety of functions, including killing cancer cells. www.melanomacenter.org /treatment/interleukin.html   (319 words)

Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis -- Crawley et al. 40 (5): 574 -- Rheumatology Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. rheumatology.oxfordjournals.org /cgi/content/full/40/5/574   (2601 words)

Role of Tumor Necrosis Factor Alpha, Interleukin-1beta , and Interleukin-6 in a Mouse Model of Group B Streptococcal Arthritis -- Tissi et al. 67 (9): 4545 -- Infection and Immunity Interleukin 1 induced leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci. Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage. iai.asm.org /cgi/content/full/67/9/4545   (3689 words)

Prognostic Value of Serum Interleukin-6 in Diffuse Large-cell Lymphoma -- Preti et al. 127 (3): 186 -- Annals of Internal Medicine Constitutive production of the interleukins IL-5 and IL-6 by the lymphoma cell line OCI-Ly 17 derived from a patients with malignant lympoma and hypereosinophilia. Interleukin 6 gene expression in normal and neoplastic B cells. Expression of an exogenous interleukin 6 in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity. www.annals.org /cgi/content/full/127/3/186   (4826 words)

Polymorphisms Within the Interleukin-1{beta} Gene Cluster and Preeclampsia -- HEFLER et al. 97 (5): 664 -- Obstetrics & Gynecology Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: Evolution of a cytokine control mechanism. Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. A new member of the interleukin 1 family. www.greenjournal.org /cgi/content/full/97/5/664   (2221 words)

IL6 - Interleukin 6 (interferon, beta 2) - aka: IFNB2 - Cancer GeneticsWeb Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma. Clinical correlates of elevated serum levels of interleukin 6 in patients with untreated Hodgkin's disease. Serum evaluation of interleukin 6 in ovarian cancer patients. www.cancerindex.org /geneweb/IL6.htm   (428 words)

Interleukin Interleukin Genetics CEO to present at Korean Conference on Aging (5/16/06) Interleukin Genetics is among the world leaders in understanding and applying the genetics of inflammation, one of the body's most important defense mechanisms, to improve health. Our core mission is: (1) to develop genetic tests to inform people about increased risk for disease; and (2) to develop preventive and therapeutic products to reduce the risk of those diseases. www.ilgenetics.com   (96 words)

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production -- Zhu et al. 103 (6): 779 -- Journal of Clinical Investigation Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. Recombinant human interleukin 5 is a selective activator of human eosinophil function. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. www.jci.org /cgi/content/full/103/6/779   (6301 words)

Interleukin Th1 (interleukin (IL)-2) and Th2 (IL-6) cytokines and monokines (IL-1 =DF, IL-1 receptor antagonist (RA)) were studied during IFN therapy. The aim of this study was determine the immunoregulatory functions of Interleukin 12 (IL-12) with regard to local cytokine production in human liver. Materials and Methods: Sixty-one CHC patients who were treated by fixed protocol of IFN therapy (IFN [alpha] 9-10 mega U/day for 2 weeks followed by 3 times/week for 22 weeks) and showed similar clinical activities were carefully chosen from 542 IFN-treated CHC and enrolled in this study. www.hepatitis-c.de /interleu.htm   (1158 words)

interleukin.html To study the role of this domain in adhesion, we have expressed in NIH 3T3 cells a cDNA consisting of the interleukin 2 receptor alpha subunit extracellular and transmembrane domains, connected to the integrin beta 1 cytoplasmic domain (IL2R-beta 1). Because of their broad potential for modulation we examined the effect of a cytokine growth factor which is present constitutively in the marrow, interleukin 3 (IL3), on integrin-mediated adherence of hemopoietic progenitor cells to the matrix component fibronectin (FN). TI: Fibronectin modulates interleukin 6 and fibronectin synthesis of human glomerular mesangial cells in culture. www.indiana.edu /~pietsch/interleukin.html   (14766 words)

Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases -- Mukaida 284 (4): 566 -- AJP - Lung Cellular and Molecular Physiology Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: the effect of antiinflammatory agents. ajplung.physiology.org /cgi/content/full/284/4/L566   (7077 words)

Accelerated Prion Disease in the Absence of Interleukin-10 -- Thackray et al. 78 (24): 13697 -- The Journal of Virology Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy. Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. jvi.asm.org /cgi/content/full/78/24/13697   (6289 words)

Recombinant Human Interleukin-3 - CYT-210 Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression. Evidence for a lectin activity for human interleukin 3 and modeling of its carbohydrate recognition domain. Recombinant human interleukin-3 administered concomitantly with chemotherapy in patients with relapsed small cell lung cancer. www.prospec.co.il /~prospec/cart/catalog/rHuIL3.html   (463 words)

CancerGuide: Nutritional Supplements and Interleukin-2 Effects of interleukin 2 therapy on lymphocyte magnesium levels. Marcus SL, Dutcher JP, Paietta E, Ciobanu N, Strauman J, Wiernik PH, Hutner SH, Frank O, Baker H. Severe hypovitaminosis C occurring as the result of adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. Marcus SL, Petrylak DP, Dutcher JP, Paietta E, Ciobanu N, Strauman J, Wiernik PH, Hutner SH, Frank O, Baker H. Hypovitaminosis C in patients treated with high-dose interleukin 2 and lymphokine-activated killer cells. www.cancerguide.org /rcc_il2supplements.html   (1470 words)

Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene -- Nicklin et al. 191 (2): 303 -- The Journal of Experimental Medicine Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene -- Nicklin et al. Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene www.jem.org /cgi/content/abstract/191/2/303   (1470 words)

Inhibition of endotoxin-induced lung inflammation by interleukin-10 gene transfer in mice -- Dokka et al. 279 (5): 872 -- AJP - Lung Cellular and Molecular Physiology Interleukin (IL)-10 is an anti-inflammatory cytokine that has great potential for use in the treatment of inflammatory and Effect of pretreatment of mice with indicated amounts of recombinant interleukin (IL)-10 2 h before instillation of LPS (0.03 mg/mouse). Ghivizzani, SC, Lechman ER, Kang R, Tio C, Kolls J, Evans CH, and Robbins PD. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. ajplung.physiology.org /cgi/content/full/279/5/L872   (3677 words)

The Body: Interleukin Interleukin 2 Treatment for HIV Infection (July 12, 2000) Immunologic and Virologic Effects of Subcutaneous Interleukin 2 in Combination With Antiretroviral Therapy: A Randomized Controlled Trial (July 12, 2000) Study: Interleukin 2 Boosts Immunity of AIDS Patients (October 1996) www.thebody.com /treat/interleu.html   (962 words)

NEJM -- The Role of Interleukin-1 in Disease Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians. Increased rectal mucosal expression of interleukin 1{beta} in recently acquired post-infectious irritable bowel syndrome. Five genetic markers in the interleukin 1 family in relation to inflammatory bowel disease. content.nejm.org /cgi/content/extract/328/2/106   (2287 words)

The soluble interleukin 6 receptor: mechanisms of production and implications in disease -- JONES et al. 15 (1): 43 -- The FASEB Journal INTERLEUKIN 6 (IL-6) IS produced by a variety of cell types Interleukin 6 has been proposed to act as both a pro- and anti-inflammatory Interleukin 6 signaling is facilitated through the homodimerization www.fasebj.org /cgi/content/full/15/1/43   (6829 words)

Interleukin-5 Induces CD34+ Eosinophil Progenitor Mobilization and Eosinophil CCR3 Expression in Asthma -- STIRLING et al. 164 (8): 1403 -- American Journal of Respiratory and Critical Care Medicine Serum interleukin 5 concentrations in atopic and non-atopic patients with glucocorticoid-dependent chronic severe asthma. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. ajrccm.atsjournals.org /cgi/content/full/164/8/1403   (4567 words)

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