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Topic: Intrinsic factor

Related Topics

Parietal cell

Pernicious anemia

Megaloblastic anemia

Anemia

Malabsorption

Hemolytic anemia

Digestive fluid

Stomach

Sickle cell anaemia

Vitamin B12

Mast cell

Genetic disorder

Epithelium

Histamine

Pepsinogen

	- Northwestern Memorial Hospital - Chicago
		Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract.
		Intrinsic factor is a protein the body uses to absorb vitamin B12.
		In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of surgery to remove the stomach.
	www.nmh.org /nmh/adam/adamencyclopedia/HIEArticles/000569.htm (938 words)

	Press Release Detail
		The Intrinsic Factor Ab assay gives mid- to large-volume hospitals and reference laboratories the ability to produce rapid, accurate results for the differential diagnosis of pernicious anemia, which is characterized by megaloblastic anemia, neuropathy and gastritis with intrinsic factor autoantibodies.
		Intrinsic factor is a natural substance present in the stomach and is essential to the digestion of vitamin B
		Pernicious anemia and the presence of intrinsic factor antibodies are associated with a number of autoimmune disease states, such as Hashimoto’s thyroiditis, insulin-dependent diabetes mellitus, Grave’s disease, rheumatoid arthritis, myasthenia gravis, hypoparathyroidism and Lambert-Eaton syndrome.
	www.beckman.com /hr/pressroom/oc_pressReleases_detail.asp?Key=5744 (362 words)

	Intrinsic factor - B12 deficiency and unsteadiness
		Intrinsic factor is a substance produced by glands in the stomach lining.
		Intrinsic factor is a glycoprotein produced and secreted by the parietal Hence, a deficiency of intrinsic factor can lead to vitamin B12 deficiency.
		Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to Intrinsic factor is a protein the body uses to absorb vitamin B12.
	factor.allinfosites.com /q/factor-intrinsic-factor.htm (593 words)

	Dorlands Medical Dictionary (Site not responding. Last check: 2007-10-09)
		Often, use of the term “factor” indicates that the chemical nature of the substance or its mechanism of action is unknown, as in endocrinology, where “factors” are renamed as “hormones” when their chemical nature is determined.
		VI a factor (accelerin) previously thought to be an activated form of factor V. It no longer is considered in the scheme of hemostasis, and hence it is currently assigned neither a name nor a function.
		VIII antihemophilic factor (AHF): a relatively storage-labile factor participating in the intrinsic pathway of blood coagulation, acting (in concert with von Willebrand factor) as a cofactor in the activation of factor X. Deficiency, an X-linked recessive trait, causes hemophilia A (classical hemophilia).
	www.mercksource.com /pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_f_02zPzhtm (4948 words)

	Lack of intrinsic factor (Site not responding. Last check: 2007-10-09)
		Intrinsic factor is a natural substance normally present in the stomach.
		Lack of intrinsic factor leads to pernicious anemia and vitamin B-12 deficiency.
		The juvenile type of lack of intrinsic factor tends to manifest itself after the age of ten.
	www.umm.edu /ency/article/001155.htm (230 words)

	[No title] (Site not responding. Last check: 2007-10-09)
		Arabidopsis thaliana plants expressing recombinant human intrinsic factor were harvested and homogenized in 0.2 M phosphate buffer before centrifugation and analysis of the supernatant.
		Intrinsic factor was isolated from transgenic plants, human gastric juice and hog stomach.
		Purification of the recombinant intrinsic factor from plants 1 kg of the crude plant material was chopped and homogenized in 2 L of 0.2 M Sodium Phosphate buffer, pH 7.5.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=03/06661.030123&ELEMENT_SET=DECL (7650 words)

	Test for Anemia
		Intrinsic factor enables the body to absorb vitamin B12; in its absence, the resulting malabsorption of vitamin B12 leads to B12 deficiency or megaloblastic anemia.
		Intrinsic factor blocking antibody, which prevents the binding of vitamin B12 to the intrinsic factor molecule, is present in more than half of all patients with pernicious anemia.
		A qualitative assay for intrinsic factor blocking antibody contributes to the differential diagnosis of B12 deficiency.
	www.dpcweb.com /medical/anemia/anemia_tests.html (982 words)

	Expression of Intrinsic Factor in Rat and Murine Gastric Mucosal Cell Lineages Is Modified by Inflammation -- Shao et ...
		Expression of Intrinsic Factor in Rat and Murine Gastric Mucosal Cell Lineages Is Modified by Inflammation -- Shao et al.
		Expression of Intrinsic Factor in Rat and Murine Gastric Mucosal Cell Lineages Is Modified by Inflammation
		Intrinsic factor is produced primarily by chief cells in rat
	ajp.amjpathol.org /cgi/content/abstract/157/4/1197 (380 words)

	Dr. Murray's Natural Facts
		Intrinsic factor is secreted by the parietal cells of the stomach.
		The B12-intrinsic factor complex is absorbed in the small intestine with the aid of the pancreatic enzyme trypsin.
		In order for vitamin B12 to be absorbed, an individual must secrete enough hydrochloric acid and intrinsic factor and adequate pancreatic enzymes, including trypsin, and have a healthy and intact ileum (the end portion of the small intestine, where the vitamin B12-intrinsic factor complex is absorbed).
	www.doctormurray.com /newsletter/1-11-2003.htm (1097 words)

	Intrinsic Factor blocking Antibodies, Serum
		Antibodies to intrinsic factor are found in very high percentage of children with juvenile pernicious anemia (PA).
		A proportion of patients have IgA intrinsic factor antibody in gastric juice (serum antibody is IgG).
		Intrinsic factor antibody may be especially useful as an adjunct to serum vitamin B
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sr002700.htm (493 words)

	Vitamin B12 (Site not responding. Last check: 2007-10-09)
		Intrinsic factor is a type of protein manufactured in the stomach.
		A lack of intrinsic factor is usually caused by a defect in the gene associated with the factor, or if part of the stomach is removed during surgery.
		Deficiency of vitamin B12 caused by lack of intrinsic factor is termed ‘pernicious anaemia’.
	www.ivu.org /nzvs/nutri/vb12.htm (721 words)

	Pernicious Anemia
		Intrinsic Factor has a two fold function, to protect the Vitamin B12 from destruction in the gastrointestinal tract and to bind to the receptor sites, facilitating vitamin B12 absorption in the intestinal mucosa.
		Intrinsic factor antibodies act by blocking the combination with B12 by combining with the intrinsic factor at various receptor cites.
		An improvement with the dose of Vitamin B12 with intrinsic factor is indicative of Pernicious Anemia.
	www.musc.edu /BCMB/onlinepubs/molecularmedicinejournal/vol1999/pernicious_anemia/pernicious_anemia.htm (1323 words)

	Schilling test (Site not responding. Last check: 2007-10-09)
		Intrinsic factor is produced in the stomach and binds to Vitamin B12.
		Intrinsic factor is produced in the stomach and is required for Vitamin B12 absorption.
		Low Vitamin B12 levels can occur from the lack of intrinsic factor because of pernicious anemia, gastrectomy (partial removal of stomach), inadequate absorption due to bowel disease, bacterial overgrowth in the intestine, pancreatic insufficiency or certain medications.
	www.shands.org /health/information/article/003572.htm (844 words)

	Final Diagnosis -- Case 428
		Intrinsic factor is a 60-kd glycoprotein produced by gastric parietal cells that binds vitamin B12.
		The vitamin B12-intrinsic factor complex is absorbed in the terminal ileum, after binding to intrinsic-factor receptors on the luminal membranes of ileal cells (Figure 2) [3].
		In patients with pernicious anemia, malabsorption of vitamin B12 is caused by intrinsic factor deficiency.
	path.upmc.edu /cases/case428/dx.html (1447 words)

	The Dynamics of Thrombin Formation -- Mann et al. 23 (1): 17 -- Arteriosclerosis, Thrombosis, and Vascular Biology
		factor and factor Xa-membrane and the reaction is principally
		In the absence of factor VIII or factor IX, the intrinsic factor
		The zymogen factor XI is a symmetrical two-chain serine protease
	atvb.ahajournals.org /cgi/content/full/23/1/17 (5742 words)

	ARUP: Intrinsic Factor Blocking Antibody (Site not responding. Last check: 2007-10-09)
		It is a disease in which gastric secretion of intrinsic factor is severely reduced or absent, resulting in malabsorption of B
		In view of its association with a variety of antibodies, including parietal cell antibody and at least two types of intrinsic factor antibodies, PA is an autoimmune process.
		to the intrinsic factor molecule, is present in more than 50 percent of all patients with PA and only rarely encountered in other conditions.
	www.aruplab.com /guides/clt/tests/clt_a23b.jsp (356 words)

	MIR Teaching file case st001
		The 48 hour excretion of the Co- 57 cyanocobalamin- intrinsic factor complex is 0.75% of the administered dose.
		In patients with intrinsic factor deficiency, there is discordance in the urinary excretion of vitamin B12 without and with intrinsic factor.
		The Schilling test is useful in determining the cause of impaired absorption of vitamin B12; specifically whether it is related to intrinsic factor deficiency or secondary to intestinal disease.
	gamma.wustl.edu /st001te175.html (630 words)

	Intrinsic Factor (Site not responding. Last check: 2007-10-09)
		Intrinsic factor is a glycoprotein secreted by parietal (humans) or chief (rodents) cells of the gastric mucosa.
		(cobalamin) in the intestine, and failure to produce or utilize intrinsic factor results in the condition pernicious anemia.
		Finally, there are receptors for intrinsic factor on the ileal mucosa which bind the complex, allowing vitamin B
	arbl.cvmbs.colostate.edu /hbooks/pathphys/digestion/stomach/intrinsic_factor.html (228 words)

	Gale Encyclopedia of Medicine: Pernicious anemia (Site not responding. Last check: 2007-10-09)
		Intrinsic factor is produced by parietal cells which line the stomach.
		-intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream.
		Intrinsic factor is produced by specialized cells within the stomach called parietal cells.
	www.findarticles.com /p/articles/mi_g2601/is_0010/ai_2601001048 (607 words)

	Bartell Drugs \| Health Encyclopedia
		A form of anemia caused by a lack of intrinsic factor, a substance needed to absorb Vitamin B12 (cobalamin) from the gastrointestinal tract.
		Intrinsic factor is a binding protein required for the absorption of Vitamin B12.
		Other causes of reductions in the level of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.
	www.bartelldrugs.com /ency/document.jsp?ID=000569 (802 words)

	Healthopedia.com - Congenital Lack of Intrinsic Factor (Congenital Pernicious Anemia)
		Intrinsic factor is a protein made by the stomach that helps the body take in B1\
		When this occurs, it is called a congenital lack of intrinsic factor.
		A congenital lack of intrinsic factor is thought to be inherited in most cases.
	www.healthopedia.com /congenital-lack-of-intrinsic-factor (350 words)

	Pernicious Anemia \| AHealthyMe.com
		is given along with intrinsic factor, the intestine is able to absorb the vitamin.
		In order to be absorbed by the intestine, vitamin B must form a complex with intrinsic factor.
		These cells are responsible for producing intrinsic factor, acid, and pepsin.
	www.ahealthyme.com /topic/pernicious (1308 words)

	The Intrinsic Bayes Factor for Model Comparison E. Moreno, F. Bertolino and W. Ragcuno University of Valencia, Spain (Site not responding. Last check: 2007-10-09)
		The most important theoretical justification of the IBF is that it is asymptotically equivalent to an actual Bayes Factor associated with the so-called Intrinsic Prior Distributions.
		For the particular case where the models are nested the solution to the intrinsic equation is typically not unique and hence the robustness of the IBF arises (see Sanso, Pericchi and Moreno, 1996).
		The idea of choosing as prior for the simple model the restriction of the noninformative prior on a compact set, to compute the associated IBF and then to make the compact set tends to the whole space, is explored.
	web.uct.ac.za /depts/maths/isba96/abstracts/node32.html (325 words)

	Natural MD - Vitamin B12 Deficiency (Site not responding. Last check: 2007-10-09)
		Moreover, if true vitamin B12 deficiency exists, the cause—lack of intrinsic factor, general malabsorption conditions, lack of stomach acidity, or dietary deficiency—must also be properly diagnosed by examination and blood tests before the appropriate treatment can be determined.
		People who lack intrinsic factor or have a malabsorption condition need to depend on high amounts of vitamin B12 from supplements and not the lower amounts found in food.
		In a person lacking intrinsic factor, only about 1% of this oral amount (10–20 mcg) will be absorbed, but that amount is more than sufficient to prevent future vitamin B12 deficiency.
	www.naturalmd.com /NaturalMD/content/Concern/Vitamin_B12_Deficiency.html (1403 words)

	Better Nutrition (1989-90): The intrinsic factor is vital for B12 absorption (Site not responding. Last check: 2007-10-09)
		A good supply of what is called the intrinsic factor is necessary for this vitamin to become available to the body.
		The intrinsic factor, despite its rather cryptic name, is nothing mysterious.
		Without intrinsic factor, most B12 could never reach its destination, because bacteria which line the intestine are hungry for this nutrient and would intercept it.
	www.findarticles.com /p/articles/mi_m0860/is_n2_v52/ai_8540075 (481 words)

	[No title] (Site not responding. Last check: 2007-10-09)
		In the Schillings test (part 2), intrinsic factor is given orally, along with the tracer dose, to see if absorption is improved.
		In this patient, the marked improved with intrinsic factor is diagnostic of intrinsic factor deficiency (Pernicious Anemia).
		Coboloamin deficiency may be due to inadequate intake (e.g., vegetarians), malabsorption (intrinsic factor deficiency, terminal ileum disorders, bacterial overgrowth), some medications.
	gamma.wustl.edu /tf/temp/st002te478.html (491 words)

	Intrinsic Life Factor
		One of the main concerns of many who are not feeling well is the question, "Am I in trouble or am I going through a cleanse?" One of the first things we check on is what we refer to as the intrinsic life factor and intrinsic death factor.
		It is important to note if these factors have been increasing or decreasing for a period of time and to what degree that has been occurring.
		The intrinsic life factor (ILF) is a measurement that can be used to determine the integrity of life at the cell level plus the overall flow and amplitude of life-force energy throughout the body.
	harmonicsinternational.com /newnews_intrinsic.html (761 words)

	The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless -- Fyfe ...
		The intrinsic factor vitamin B-12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
		The intrinsic factor-vitamin B-12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.
		The human intrinsic factor vitamin B-12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.
	www.bloodjournal.org /cgi/content/full/103/5/1573 (4899 words)

	Expression of intrinsic factor and pepsinogen in the rat stomach identifies a subset of parietal cells -- Shao et al. ...
		Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11.
		Human gastric intrinsic factor expression is not restricted to parietal cells.
		The rat intrinsic factor gene: its 5'-upstream region and chief cell-specific transcription.
	ajpgi.physiology.org /cgi/content/full/274/1/G62 (3895 words)

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