| | DETECTION OF SIMILAR PROTEINS BY THE INVERSE-FOLDING PROTOCOL (Site not responding. Last check: ) |
 | | The protocol in which a sequence recognizes its compatible structure in the structural library, i.e., the fold recognition or the forward-folding search, is available for the structure prediction of new proteins. |
 | | However, the reverse protocol in which a structure recognizes its homologues in a sequence database, called the inverse-folding protocol, is known difficult in practice. |
 | | Also noticed was that the procedure in which a query sequence is re-mounted onto a structure according to the 3D-1D alignment determined by the dynamic programming method is only effective in the forward-folding protocol, but not in the inverse-folding protocol. |
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