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Topic: Iodine-131


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In the News (Thu 23 May 19)

  
 Iodine - Wikipedia, the free encyclopedia
Iodine is primarily used in medicine, photography and in dyes.
Iodine compounds are important in the field of organic chemistry and are very useful in medicine.
Iodine pills are sometimes distributed to persons living close to nuclear establishments, for use in case of accidents that could lead to releases of radioactive Iodine.
en.wikipedia.org /wiki/Iodine   (1365 words)

  
 Iodine-131 - Wikipedia, the free encyclopedia
If Iodine-131 is present in high levels in the environment from radioactive fallout, it is absorbed by the body and may cause damage to the thyroid.
Case Studies in Environmental Medicine: Radiation Exposure from Iodine 131
Iodine-131 is also used as a radioactive label for radiopharmaceuticals that can be used for imaging and therapy e.g.
en.wikipedia.org /wiki/Iodine-131   (408 words)

  
 It's Elemental - The Element Iodine
A radioactive isotope of iodine, iodine-131, is used to treat some diseases of the thyroid gland.
Iodine is pronounced as EYE-eh-dine or as EYE-eh-din.
Iodine is part of thyroxin, a hormone produced by the thyroid gland that controls the body's rate of physical and mental development.
education.jlab.org /itselemental/ele053.html   (214 words)

  
 I-131 - What Do I Need To Know? (Iodine Basics)
I-131 is normally present at low levels in hospital nuclear medicine departments, patients administered radioactive iodine in the last 3 months, and in releases from nuclear power plants.
This web site focuses on iodine 131 (I-131) because large amounts of this isotope were released during the production and testing of nuclear weapons.
I-131 is produced during nuclear fission, which occurs during the operation of nuclear reactors or detonation of a nuclear bomb.
www.iodine131.org /q2.htm   (281 words)

  
 EPA - Iodine - Information Home (EPA's Radiation Protection Program: Information)
Since iodine is concentrated in the thyroid gland, a radioassay of the thyroid can determine the level of exposure to many of its isotopes.
Iodine (chemical symbol I) is a nonmetallic solid element.
Some isotopes of iodine, such as I-123 and I-124 are used in medical imaging and treatment, but are generally not a problem in the environment because they have very short half-lives.
www.epa.gov /radiation/radionuclides/iodine.htm   (1635 words)

  
 ORINS Mock Iodine Calibration Kit (1958-1959)
The cesium 137 in the mock iodine is used to match the high-energy peak of iodine 131.
The barium 133 is used in mock iodine to match the 360 kev peak in iodine 131.
however, there is less of the 360 keV and more of the 280 kev in mock iodine than there is in iodine 131.
www.orau.org /PTP/collection/nuclearmedicine/mockiodinekit.htm   (434 words)

  
 m4.txt
Because iodine is taken into thyroid cells, radioactive iodine, usually the isotope I-131, can be used in just such a manner to treat some types of thyroid cancers, or for treatment of thyroid hormone overproduction (hyperthyroidism).
The dose to cells containing the iodine is mostly due to the emitted beta particles and the dose at a distance is mostly due to the gamma rays.
Iodine can be absorbed into the body by the mouth, directly through the skin, or by inhaling vaporized iodine in the air.
www.iaea.org /ns/rasanet/training/m4.txt   (2775 words)

  
 I-131 Radioactive Iodine Therapy for Cats with Feline Hyperthyroidism
Radioactive Iodine (I-131) therapy is very effective, has few side effects, is a one-time treatment in over 95% of animals, and does not require administration of pills or anesthesia.
Treatment with Radioactive Iodine (I-131) is the preferred treatment for cat hyperthyroidism (and weel as in humans).
The cost of radioactive iodine therapy is similar to the other forms of therapy, and is often less expensive when compared to long term medical therapy or the higher probability of a required second surgery.
www.thyrocat.com /inside/radioactive-iodine.html   (556 words)

  
 CDC Radiation Emergencies Radioisotope Brief: Iodine-131 (I-131)
I-131 is used in medicine to diagnose and treat cancers of the thyroid gland.
I-131 in fallout from nuclear weapons or reactor accidents can occur in particle form, which can be ingested in food or water.
Liquid I-131 sodium iodide used to diagnose and treat thyroid disease is a clear liquid.
www.bt.cdc.gov /radiation/isotopes/iodine.asp   (524 words)

  
 Bexxar Online, Description, Chemistry, Ingredients - Tositumomab and Iodine 1131 Tositumomab - RxList Monographs
Iodine 1131 Tositumomab is supplied as a sterile, clear, preservative-free liquid for IV administration.
Iodine 1131 Tositumomab is a radio-iodinated derivative of Tositumomab tha t has been covalently linked to lodine-131.
The BEXXAR therapeutic regimen (Tositumomab and Iodine 1131 Tositumomab) contains a radioactive component and should be administered only by physicians and other health care professionals qualified by training in the safe use and handling of therapeutic radionuclides.
www.rxlist.com /cgi/generic3/bexxar.htm   (790 words)

  
 Patient Guide to Iodine-131 Therapy
Iodine will be transferred to anything that you handle or that your body touches, such as bed linens or eating utensils.
The radioactive iodine that is not taken up by your thyroid is rapidly eliminated through body fluids such as urine, feces, saliva, and perspiration.
When the amount of iodine in your body has reached the desired level, all that remains is to get the doctor’s release order, take a final shower, and change into clean clothes.
www.mcg.edu /services/ehs/radsafe/Clinical/i131.htm   (2306 words)

  
 Press Release N° 162
Exposure to radioactive iodine 131 (I-131) in childhood is associated with an increased risk of thyroid cancer, and both iodine deficiency and supplementation appear to modify this risk, according to a new study in the May 18 issue of the Journal of the National Cancer Institute.
Both iodine deficiency and iodine supplementation appear to be important and independent modifiers of the risk of thyroid cancer after exposure to I-131 in childhood.
Although this increase has been attributed to fallout from the accident, questions remained about the magnitude of the risk related to I-131 and to the potential modifying effect of iodine deficiency, which was common in most of the affected areas at the time of the Chernobyl accident."
www.iarc.fr /ENG/Press_Releases/pr162a.html   (461 words)

  
 MedlinePlus Drug Information: Tositumomab and Iodine I 131 Tositumomab (Systemic)
Tositumomab and iodine I 131 tositumomab is usually given by a doctor in the hospital or an outpatient clinic.
Tositumomab and iodine I 131 tositumomab may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent.
Although there is no specific information comparing use of tositumomab and iodine I 131 tositumomab in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
www.nlm.nih.gov /medlineplus/druginfo/uspdi/500535.html   (1074 words)

  
 AllThyroid.org: Thyroid Research Archive - Thyroid Cancer
The thyroid uptake of I-131 was higher in the low-iodine diet group before I-131 therapy, and they had more severe hypothyroidism and were more likely to have no detectable thyroid I-131 uptake and a low serum thyroglobulin concentration at the time of the second study.
In this study the ability of I-131 to destroy thyroid remnants was compared in patients who ate a low-iodine diet or their usual diet before treatment.
The effect of I-131 to destroy thyroid remnants may be increased by dietary iodine restriction.
www.tsh.org /research/summaries/archive/cancer/03_07_efficacy.html   (316 words)

  
 Iodine-131 Ablation of Thyroid Neoplasm
I-131 therapy has not been shown to reduce fertility of treated patients or increase the risk of congenital abnormalities in their offspring [JNM, Jan. 95, p.21-27].
In patients being considered for ablation therapy, a pre-treatment diagnostic I-131 scan is performed to assess for the presence of metastatic lesions.
It is important to note that I-131 given for this diagnostic scan can exert a negative effect on the uptake of the therapeutic dose by functioning mets- this is referred to as "Thyroid Stunning".
www.indyrad.iupui.edu /public/lectures/HTML/NM/thyroid/THY10.HTM   (2883 words)

  
 Nat' Academies Press, Exposure of the American People to Iodine-131 from Nevada Nuclear-Bomb Tests: Review of the National Cancer Institute Report and Public Health Implications (1999)
The major health risks associated with exposure to iodine-131 (I-131) involve the thyroid gland, which concentrates this radionuclide.
Second, the same amount or a higher fraction of internalized iodine is concentrated in the smaller thyroid glands of children; therefore the radiation dose to the thyroid in children is higher than it is in adults.
Once iodine has been incorporated into proteins by the thyroid, the biologic half-life of iodine within the thyroid is typically 80-120 days; non-protein-bound iodine has a biologic half-life of several hours in the body.
www.nap.edu /books/030906175X/html/45.html   (9184 words)

  
 Environmental Origins of Thyroid Disease Part 2
Iodine 131 is a radioisotope artificially produced from the fission of uranium.
The Iodine 131 is placed in molecules, cells and tissues where iodine is needed, just as if it were Iodine127.
Prior to the 1940’s, there was no biologically available Iodine 131.
www.ryandrum.com /thyroidpart2.htm   (2085 words)

  
 New Drugs - Lexi-Comp, Inc.
Following infusion of the iodine I 131 tositumomab dosimetric dose, the total body gamma camera counts and whole body images should be taken within 1 hour of the infusion and prior to urination, and 2-4 days after the infusion and following urination, and 6-7 days after the infusion and following urination.
Iodine I 131 tositumomab is a radio-iodinated derivative of tositumomab covalently linked to iodine 131.
Iodine I 131 tositumomab: Store frozen at less than or equal to -20°C in the original lead pots.
www.lexi.com /web/content/newdrugs/chapter/mono/newdrugsdisp.jsp?id=hf126410   (1219 words)

  
 Durable remissions with fludarabine followed by Tositumomab and Iodine I 131 tositumomab (BEXXAR® therapeutic regimen) for patients with previously untreated follicular non-Hodgkin’s lymphoma.
Tositumomab and Iodine I 131 tositumomab therapy has been evaluated as single-agent therapy in addition to combination chemotherapy in the treatment of follicular lymphoma, both of which have led to impressive results in treatment of this disease.
The most common non-hematologic toxicities associated with tositumomab and Iodine I 131 tositumomab treatment were asthenia (43%), cough (29%), fever (29%), nausea (26%), and somnolence (23%).
[2],[3],[4]Tositumomab and Iodine I 131 tositumomab is comprised of the monoclonal antibody tositumomab, which is directed against the CD20 antigen, plus a radio-labeled tositumomab, which has been linked to radioactive Iodine-131.
professional.cancerconsultants.com /jc_issue1_nhl.aspx?id=32613   (1334 words)

  
 MIBG (iodine-131-meta-iodobenzylguanidine) scintiscan Encyclopedia Search - Drug Price Search
Lugol's iodine solution may be given before the test as well as after administration of the radioisotope.
After injection of the radioisotope, you are given Lugol's iodine solution to block uptake into the thyroid.
The radioisotope contains iodine, so precautions (such as administration of Lugol's solution) are used to prevent excessive uptake by the thyroid.
www.drug-price-search.com /encyclopedia/?encyclopedia_name_url=203&level=2   (610 words)

  
 Chapter 12: The Iodine 131 Experiment in Alaska
Doses were officially reported to range from 9 to 65 microcuries of iodine 131, with most being approximately 50 microcuries.
In 1956 and 1957 the U.S. Air Force's Arctic Aeromedical Laboratory conducted a study of the role of the thyroid gland in acclimatizating humans to cold, using iodine 131.
As was common at the time, the principal investigator, Dr. Rodahl, took a one-week course on the proper handling and administration to humans of iodine 131.
www.eh.doe.gov /ohre/roadmap/achre/chap12_4.html   (2115 words)

  
 Bexxar (Tositumomab and iodine I 131 tositumomab) - Formulary
A multicenter, single-arm study was conducted in 40 individuals to evaluate the efficacy of the tositumomab and iodine I 131 tositumomab therapeutic regimen.
The tositumomab and iodine I 131 tositumomab therapeutic regimen is dosed in 2 steps: a dosimetric step, followed 7­14 days later by a therapeutic step.
The radiolabeled monoclonal antibody, iodine I 131 tositumomab, delivers a dose of radiation directly to the cancerous cells.
www.formularyjournal.com /formulary/article/articleDetail.jsp?id=66785   (472 words)

  
 New York Thyroid Center: Radioactive Iodine
Since the thyroid gland is the only area of the body that uses iodine, RAI does not travel to any other areas of the body, and the RAI that is not taken up by thyroid cells is eliminated from your body, primarily in urine.
Since iodine is a natural substance your thyroid uses to make thyroid hormone, radioactive iodine (RAI) is collected by your thyroid gland in the same way as non-radioactive iodine.
Because it may take a few weeks after the treatment dose of radioactive iodine before there is a decrease in the blood level of thyroid hormone, you are at risk for a worsening of hyperthyroidism during this period.
cpmcnet.columbia.edu /dept/thyroid/RAI.html   (1586 words)

  
 low_iodine_diet_research_edited.doc
For those who were able to state the recommended iodine intake restriction of their LIDs, 50 ug iodine daily was the most common restriction level and it was also similar to the restriction level recommended by various literature studies.
This included the effectiveness of the diet, the level of iodine restriction required, the procedures in which the diet is prescribed for, and the optimal length of time a patient should follow such a diet.
It should be noted, however, that as I-131 has a half life of 8 days, it might be appropriate to remain on the diet for at least 2 days after the I-131 treatment as suggested by OncoLink at the University of Pennsylvania Cancer Centre.
members.shaw.ca /emilykwan102/low_iodine_diet_research_edited.doc   (7016 words)

  
 Iodine - IRIN Asia Asia AFGHANISTAN AFGHANISTAN: National iodine
Iodine is an essential component required for a healthy functioning thyroid gland.
Iodine is a naturally occurring element that is required for good health.
Iodine was discovered by B. Courtois in 1811 in Paris, France.
www.globalinfoplus.com /?q=iodine   (231 words)

  
 NGC - NGC Summary
Iodine-131 (I-131) is a beta-emitting radionuclide with a physical half-life of 8.1 days, a principal gamma ray of 364 KeV and a principal beta particle with a maximum energy of 0.61 MeV, an average energy of 0.192 MeV and a range in tissue of 0.8 mm.
Patients with large, iodine-avid multinodular glands who are given larger amounts of iodine-131 (I-131) are more likely to experience radiation thyroiditis with release of stored thyroid hormone into the circulation resulting in occasional worsening of hyperthyroidism and rarely, precipitation of thyroid storm.
In patients with hyperthyroidism and non-toxic multinodular goiter, iodine 131 (I-131) therapy can cause radiation thyroiditis with release of stored thyroid hormone into the circulation resulting in occasional worsening of hyperthyroidism and rarely, precipitation of thyroid storm.
www.guideline.gov /summary/summary.aspx?ss=15&doc_id=3191&nbr=2417   (1562 words)

  
 National Cancer Institute Press Release on Iodine-131 Doses
Because I-131 accumulates in the thyroid gland, concerns have been raised that the fallout could cause thyroid cancer in people who were exposed to it as children.
The complete report includes estimates of average I-131 dose to the thyroid for representative persons in each county during 1951 to 1958, when the nuclear tests were carried out in Nevada.
The small number of studies on persons exposed to I-131 from NTS fallout have produced suggestive but not conclusive evidence that it is linked to cancer.
www.ieer.org /latest/ncipress.html   (961 words)

  
 Iodine 131 - Clinical Trial: A Study of Rituximab Versus Iodine I 131
Iodine 131 - Clinical Trial: A Study of Rituximab Versus Iodine I 131
Exposure of American People to I-131 (Radioactive Iodine) Radioactive Iodine (I-131) would be carried downwind for miles.
In Arm B, patients will receive Iodine I 131 Tositumomab therapy.
iodide.okeysearch.com /?q=iodide-iodine-131   (209 words)

  
 Draxis Receives FDA Approval For Diagnostic Iodine I-131 Capsules
The DRAXIMAGE sodium iodide I-131 diagnostic capsules will be supplied in several different strengths of radioactivity and DRAXIMAGE will employ a system of color-coding to allow each patient to be administered the precise dose of radioactive iodine prescribed by their physician.
These diagnostic sodium iodide I-131 capsules are intended to be used by physicians to perform the radioactive iodide (RAI) uptake test to evaluate thyroid function prior to treatment with stronger therapeutic doses of sodium iodide I-131.
The Sodium Iodide I-131 Capsules USP, Diagnostic - Oral are a further addition to the existing line of I-131 radiopharmaceutical products produced by DRAXIMAGE, including its widely used kit for the preparation of Sodium Iodide I-131 Capsules and Oral Solution for the treatment of thyroid cancer and hyperthyroidism.
www.medicalnewstoday.com /medicalnews.php?newsid=36238&nfid=rssfeeds   (714 words)

  
 Potassium Iodide Anti-Radiation Pill FAQ. Iodine pills, tablets, sources.
Iodine is normally used in doses of 8 PPM to treat clear water for a 10 minute contact time.
Ingesting elemental free iodine, such as 'tincture of iodine', in quantities sufficient to attempt thyroid-blocking in a nuclear emergency is not a safe, nor an effective, alternative.
Furthermore, elemental iodine supplied by iodine tablets and released by tincture of iodine dropped into water is not effective as a blocking agent to prevent thyroid damage.
www.ki4u.com   (12662 words)

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