
	Where results make sense

Topic: Iproniazid

In the News (Sat 6 Sep 08)

Gordon Brown

Derby County

Mike Huckabee

Lute Olson

Pearl Harbor

Sonia Gandhi

Ricky Hatton

Narendra Modi

Jesus Christ

Rudy Giuliani

	Iproniazid - Health Encyclopedia (via CobWeb/3.1 planetlab2.cs.unc.edu) (Site not responding. Last check: 2007-11-06)
		When iproniazid is administered daily to rats for 4 days and the animals are examined on the fifth day brain noradrenaline and serotonin levels are elevated similarly to those seen after acute administration but dopamine concentration is near normal while serum prolactin is significantly elevated.
		Iproniazid is no longer used as an antidepressant because of toxic side effects, but the effectiveness of this drug led to further interest in the idea that drugs might cure depression.
		Although iproniazid is no longer used as an antidepressant because of toxic side-effects, the effectiveness of this drug led to further interest in the idea that depression might be alleviated by appropriate drugs.
	www.steadyhealth.com.cob-web.org:8888 /encyclopedia/Iproniazid (164 words)

	Home (Site not responding. Last check: 2007-11-06)
		Iproniazid (the first MAO inhibitor) itself was originally developed to fight tuberculosis.
		Although Iproniazid is no longer used as an antidepressant, the effectiveness of the drug led to further interest in the idea that depression might be alleviated by appropriate drugs.
		Around the same time Iproniazid and the early tricyclic antidepressants were being studied, an antipsychotic drug known as Resperine was observed to induce depression in a small number of patients.
	www.macalester.edu /~agerber/depression/maois_history.html (532 words)

	Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine -- Nelson et al. 206 (3): 574 -- Journal of ...
		Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine -- Nelson et al.
		identical to that in the administered iproniazid or isopropylhydrazine and
		is the metabolite of iproniazid that is oxidized by a microsomal P-450
	jpet.aspetjournals.org /cgi/content/abstract/206/3/574 (360 words)

	202. WHEN
		In the same year, iproniazid was introduced as a treatment for tuberculosis, and this is also where part of the story begins.
		Iproniazid was found by chance to have a marked effect on depressive symptoms in TB patients, so much so that it was soon superseded by another less stimulating drug, (and finally withdrawn by the manufacturers in 1961, when found to cause liver damage):
		Iproniazid had been found to somewhat inhibit the effects of monoamine oxidase and the MAOIs were developed as compounds with a more potent inhibiting effect than iproniazid itself.
	www.socialaudit.org.uk /22when.htm (894 words)

	RemedyFind news, site changes
		Iproniazid, an MAOI that is considered to be the first modern antidepressant, was originally developed to treat tuberculosis.
		Researchers found that Iproniazid was able to block the activity of monoamine oxidase, the enzyme that destroys the monoamine neurotransmitters (norepinephrine, serotonin and dopamine).
		Iproniazid was approved for the treatment of major depression in 1957.
	www.remedyfind.com /news.aspx?lNewsID=33 (1784 words)

	Psychopharmacologic Discovery: The Relative Contributions of Clinical and Laboratory Studies
		Iproniazid's "psychic energizing effect" could not be evaluated with animal experiments because subtle psychic phenomena can only be studied in humans.
		These observations are highlighted by the fact that almost every significant advance in antidepressant drug treatment from the discovery of iproniazid and imipramine to the recently introduced "second generation" class of antidepressants has resulted either from astute clinical observations or serendipity; a far cry from a planned, predictive, screening test.
		Iproniazid [which caused euphoria] in tuberculosis patients leading to the new class of [antidepressant] monoamine oxidase inhibitors is an outstanding example, as are the tricyclic antidepressants originally developed as antipsychotics.
	www.curedisease.com /Perspectives/vol_2_1990/PsycholDisc.html (3621 words)

	Michael Morea Hauck 's Home Page (Site not responding. Last check: 2007-11-06)
		The first modern antidepressant, iproniazid, was originally developed as an anti-tubercular drug in the early 1950's.
		Besides its ability to treat tuberculosis, iproniazid was observed to heighten mood and stimulate activity in many patients.
		After preliminary findings in 1957, iproniazid was prescribed widely to patients with major depression.
	users.wfu.edu /haucmm2/index.html (565 words)

	Iproniazid (via CobWeb/3.1 planetlab2.cs.unc.edu) (Site not responding. Last check: 2007-11-06)
		It was employed as an antidepressant until it was found to cause liver damage.
		Prior to its introduction as an antidepressant, iproniazid was studied as a drug similar in function to the antituberculotic drug isoniazid, which it resembles in chemical structure.
		Iproniazid has been replaced in antidepressant therapy by other members of the monoamine-oxidase inhibitor series (e.g., isocarboxazid, phenelzine, and tranylcypromine) and the tricyclic antidepressant drugs (e.g., imipramine, amitriptyline, and nortriptyline), which have less severe side effects.
	www.landborgen.net.cob-web.org:8888 /EOL/html/Iproniazid.htm (114 words)

	History (Site not responding. Last check: 2007-11-06)
		It in addition to effectively treating tuberculosis, Iproniazid was observed to elevate mood and stimulate activity in many patients.
		These effects led researchers to investigate the ability of Iproniazid to treat the symptoms of depression.
		Around the same time Iproniazid and the early tricyclic antidepressants were being studied.
	www.macalester.edu /~agerber/depression/history.html (456 words)

	Untitled Document
		Iproniazid was termed a "psychic energizer" by Nathan Kline, who first investigated its psychological effects and proposed that this property might prove useful in treating depression.
		Meanwhile, the 1952 introduction of chlorpromazine, the first modern psychotherapeutic medication, which was effective in treating schizophrenia, inspired the search for antidepressant agents among similar compounds, a familiar class of drugs found in many cough syrups known as the antihistamines.
		Several analogues to iproniazid and imipramine were synthesized in hopes of producing an effective compound free of the undesirable side-effects that accompanied these drugs.
	web.grinnell.edu /courses/sst/f01/SST395-01/PublicPages/PerfectDrugs/Chris/history/index2.html (654 words)

	AN INTEGRAL VIEW OF ANTIDEPRESSANTS
		Iproniazid was originally developed as an anti-tubercular drug but turned out to be the first monoamine oxidase inhibitor (MAO inhibitor).
		Using the Freudian terminology dominant at the time, he proposed that there were drugs, Iproniazid among them, that actually functioned as “psychic energizers.” These drugs would increase the id energy available to the ego and this would result in a sense of joy and optimism (Kramer, 1993).
		Iproniazid fell into disfavor due to heptotoxcity – it caused a type of cell death in the liver called hepatic necrosis.
	www.csuohio.edu /casal/NOAD.htm (8650 words)

	All About Antidepressants
		At the time, iproniazid was unmatched as a weapon in the ongoing fight against this deadly respiratory illness, decreasing the number of tubercule bacilli and suppressing their proliferation.
		But while it was designed to treat tuberculosis, as a side benefit iproniazid also seemed to be a sort of "happy drug," pepping up patients, improving their appetites, and restoring their feelings of well-being.
		With the publication of research in 1957 illustrating the success of iproniazid in the treatment of depression, a flurry of prescriptions were written almost immediately.
	www.webmd.com /content/article/87/99350.htm (1343 words)

	Drugs and the Brain: Antidepressants
		Iproniazid, the first modern antidepressant, was originally developed as an antitubercular drug in the early 1950's.
		In addition to its ability to treat tuberculosis, iproniazid was observed to elevate mood and stimulate activity in many patients.
		Within the first year it was available as an antidepressant, four hundred thousand depressed people were treated with iproniazid.
	www.csusm.edu /DandB/AD.html (2007 words)

	The Journal of the College of Physicians and Surgeons of Columbia University
		The first of the monoamine oxidase inhibitors to be used clinically, a drug called iproniazid, was initially given a trial as an agent for the treatment of tuberculosis.
		Although iproniazid was not as good against tuberculosis as its relative, isoniazid, the clinical investigators who were studying iproniazid unexpectedly observed that many of the sick and depressed patients who received the drug were no longer depressed, even if iproniazid failed to cure their tuberculosis.
		Iproniazid passed that test, and although the risk of giving iproniazid (it occasionally, and for no obvious reason, destroyed the livers of unlucky patients) eventually caused it to vanish from the market (to be replaced by the antidepressant monoamine oxidase inhibitors Marplan, Nardil, and Parnate), iproniazid left behind two great legacies.
	cpmcnet.columbia.edu /news/journal/journal-o/archives/jour_v19no2/second.html (2763 words)

	TIME.com: "Psychic Energizer" -- Apr. 15, 1957 -- Page 1
		It is no new chemical, but iproniazid (trade name: Marsilid), first cousin of isoniazid and a veteran of the 1951 campaign against tuberculosis.
		Iproniazid was soon retired from widespread use because it produced undesirable side effects, such as dizziness, constipation, difficulty in urination, and neuritis.
		But use of iproniazid for such patients is tricky: the drug is powerful and potentially dangerous.
	www.time.com /time/magazine/article/0,9171,862555,00.html (548 words)

	UNIVERSITY OF CAMBRIDGE PROPOSED PRIMATE RESEARCH FACILITY PROOF OF EVIDENCE
		Iproniazid (derived from surplus hydrazine) was originally given to TB patients after World War 11 in hopes that it would help them clear their secretions.
		After iproniazid's properties had been demonstrated in humans, it was tested on animals.
		It was the very failure of these animal models in screening out ineffective compounds that ushered in the next stage of psychopharmacologic research.
	www.curedisease.com /Cambridge/psychiatricmedications.html (2324 words)

	TIME.com: Drug of the Year? -- Dec. 16, 1957 -- Page 1
		Dropped like a hot potato after 1951 trials against tuberculosis because of admittedly unpleasant and possibly serious side effects, iproniazid was shunned until about a year ago, when psychiatrists decided that it might be useful against deep, unshakable states of depression.
		In psychiatry, Dr. Nathan S. Kline of New York's Rockland State Hospital reported, the drug is equally effective as a "psychic energizer" for long-term hospital patients and the at-large depressed whom he sees in private practice.
		Equally striking is the case of a professor of medicine who suffers from occasional dizziness and constipation on heavy iproniazid dosage, but refuses to cut down because he would rather suffer these than risk a recurrence of the depression that has handicapped him for twelve years and sometimes crippled him.
	www.time.com /time/magazine/article/0,9171,893796,00.html (705 words)

	Antidepressant - Wikipedia, the free encyclopedia
		It is also the case that placebos tend to have a significant antidepressant effect, so that establishing a drug as an antidepressant in a clinical trial involves demonstrating a significant additional effect.
		The chemical from which it was derived, isoniazid was independently recognized as having clinically significant effects on depression, in 1952 by Jean-Francois Buisson in France and Max Lurie in the United States, after it had come into widespread use as a treatment for tuberculosis.
		Iproniazid was then observed to have a greater "psychostimulant" effect and to inhibit the enzyme Monoamine Oxidase.
	en.wikipedia.org /wiki/Antidepressant (4704 words)

	Serendipity Homepage (Site not responding. Last check: 2007-11-06)
		Studies showed its ability to block the activity of monoamine oxidase, the enzyme that destroys the monoamine neurotransmitters (norepinephrine, serotonin and dopamine).
		The doctors who noticed the beneficial side effect of iproniazid had very prepared minds and were able to pick up on that slight difference.
		Their keen observation not only helped the patients of their own time but also inspired many others to pursue this path of research and so help many more.
	users.wfu.edu /haucmm2/serendipity.html (1394 words)

	The Lasker Foundation \| 1964 Winners
		Dr. Kline more than any other single psychiatrist has been responsible for one of the greatest revolutions ever to occur in the care and treatment of the mentally ill. Literally hundreds of thousands of people are leading productive normal lives, who-but for Dr. Kline's work-would be leading lives of fruitless despair and frustration.
		Having pioneered the introduction and use of the Rauwolfia and other tranquilizing drugs for the treatment of schizophrenia, in 1954, Dr. Kline first reported in 1957 the beneficial effects of iproniazid, a monamine oxidase inhibitor, in the treatment of severe depression.
		His experiments confirmed the euphoric effect of iproniazid first reported in the treatment of tuberculosis.
	www.laskerfoundation.org /awards/library/1964c_cit.shtml (317 words)

	MEDLINE Search on Medscape.com
		Medscape's search is configured to first deliver exact matches, then matches that contain all of your words, followed by matches that contain some of your words.
		Fast-flow EPR spectroscopic observation of the isoniazid, iproniazid, and phenylhydrazine hydrazyl radicals.
		Should iproniazid still be sold in France?]We report a new case of subfulminant hepatitis due to iproniazid, a MAO-inhibitor antidepressant, in a 27-year-old man. An auxiliary liver...
	search.medscape.com /uslclient/searchMedline.do?queryText=Iproniazid (312 words)

	Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat -- Nelson et al. 193 (4256): ...
		Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat -- Nelson et al.
		Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat
		Acetylhydrazine, a metabolite of isoniazid, a widely used antituberculosis drug, and isopropylhydrazine, a metabolite of iproniazid, an antidepressant removed from clinical use because of high incidence of liver injury, were oxidized by cytochrome P-450 enzymes in human and rat liver microsomes to highly reactive acylating and alkylating agents.
	www.sciencemag.org /cgi/content/abstract/193/4256/901 (329 words)

	Antidepressants: Table of Contents \| Drugs and Controlled Substances Information for Students
		One such accident occurred in the 1950s, when scientists searching for a tuberculosis treatment observed that the drug iproniazid caused mood elevation.
		The depletion of the neurotransmitters—as observed with reserpine—came under study as the possible cause of depression and became known as the "amine hypothesis of depression." The drug iproniazid reversed some of these negative side effects, confirming the usefulness of drugs in the treatment of depression.
		When used with psychiatric patients, iproniazid showed mood elevation and heralded the first class of antidepressants—the monoamine oxidase inhibitors (MAOIs)—into psychiatric practice.
	www.bookrags.com /research/antidepressants-dcsi-01 (298 words)

	Free Radicals Produced during the Oxidation of Hydrazines by Hypochlorous Acid (Site not responding. Last check: 2007-11-06)
		We investigated the oxidation of the hydrazine derivatives isoniazid, iproniazid, and hydralazine by HOCl.
		Moreover, reduction of nitroblue tetrazolium (NBT) was observed only during the reaction between HOCl and isoniazid, suggesting that different radical species may be produced from HOCl reaction with each hydrazine.
		The oxidation of iproniazid by HOCl in the presence of the radical trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) resulted in the formation of a carbon-centered radical adduct.
	pubs.acs.org /cgi-bin/abstract.cgi/crtoec/1996/9/i08/abs/tx960108l.html (293 words)

	Medical Dictionary: Iproniazid - WrongDiagnosis.com - WrongDiagnosis.com
		Iproniazid: An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent.
		It has also been used as an antitubercular agent, but its use is limited by its toxicity.
		The following terms can be used for Iproniazid
	www.wrongdiagnosis.com /medical/iproniazid_printer.htm (89 words)

	[No title]
		In the late 1950s the New York Times ran a picture of patients whose tuberculosis was controlled with iproniazid (an antitubercular drug with MAOI activity) dancing in their ward.
		A number of psychiatrists viewing that picture considered the possibility that the patients were dancing, not because of their joy about having their tuberculosis controlled, but rather because hypomania had been induced by the iproniazid.
		After a brief spurt of interest in MAOIs as antidepressants, they fell into a period of relative disuse.
	www.angelfire.com /me/CYBERMONKEY2/moi.html (993 words)

	THE INFLUENCE OF DRUG-TISSUE INTERACTIONS ON THE INHIBITION OF MONOAMINE OXIDASE BY PHENIPRAZINE AND IPRONIAZID -- ... (Site not responding. Last check: 2007-11-06)
		THE INFLUENCE OF DRUG-TISSUE INTERACTIONS ON THE INHIBITION OF MONOAMINE OXIDASE BY PHENIPRAZINE AND IPRONIAZID
		(PIH) and iproniazid in the supernatant fractions of homogenates
		The rate of disappearance of PIH and iproniazid
	jpet.aspetjournals.org.cob-web.org:8888 /cgi/content/abstract/142/2/141 (259 words)

	The catecholamine theory of depression (Site not responding. Last check: 2007-11-06)
		The next set of cumulative records shows the protective effects of iproniazid - a monoamine oxidase inhibitor (MAOI) - against tetrabenazine.
		Note how response rate is actually increased following pretreatment with iproniazid and tetrabenazine.
		This effect is outlined in red on the diagram.
	salmon.psy.plym.ac.uk /year1/DEPRESsion.HTM (4592 words)

	DIFFERENTIAL ACTION OF IPRONIAZID (MARSILID) AND BETA-PHENYLISOPROPYLHYDRAZINE (CATRON) ON ISOLATED ATRIA -- Pepeu et ...
		DIFFERENTIAL ACTION OF IPRONIAZID (MARSILID) AND BETA-PHENYLISOPROPYLHYDRAZINE (CATRON) ON ISOLATED ATRIA -- Pepeu et al.
		Both PIH and iproniazid completely inhibited MAO activity in
		PIH and iproniazid were shown to reduce the action of nicotine
	jpet.aspetjournals.org /cgi/content/abstract/132/2/131 (239 words)

Try your search on: Qwika (all wikis)