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Topic: Ira Mellman


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In the News (Wed 30 Dec 09)

  
  Faculty: I. Mellman, Department of Cell Biology, Yale University
Mellman, I. Turley, and R.M. Steinman (1998) Antigen presentation for amateurs and professionals.
Mellman, and N.H. Ruddle (1997) Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-a deficient mice.
Mellman (1997) Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.
info.med.yale.edu /cellbio/Mellman.html   (3416 words)

  
 The Cell Biology of Dendritic Cell Function: a Metro-North Odyssey-The Rockefeller University
Ira Mellman, professor of Cell Biology and Immunobiology and chairman of Cell Biology at Yale University School of Medicine, concentrates on fundamental questions of understanding membrane transport and cell morphogenesis as they apply to two distinct but complimentary problems: cell polarity and antigen processing.
Mellman’s group has applied a unique cell biological approach to unraveling the mechanisms underlying DC function, work which has already begun to elucidate several long-standing questions in immunology and to provide surprising new insights into fundamental cell biology.
Mellman and his colleagues have concentrated on DC “maturation,” the terminal stage in a differentiation process that converts DCs from immature sentinels that accumulate foreign and self-antigens in peripheral tissue to mature antigen-presenting cells that stimulate T lymphocytes in lymphoid tissues.
www.rockefeller.edu /lectures/102403.php   (389 words)

  
 3M Distinguished Lectureship: 2000 Lecturer
Ira Mellman's research spans and combines the disciplines of cell biology and immunology in a fashion which is as unique as it is remarkable.
In addition to his academic pursuits, Mellman is a founder of two corporations: Athersys, Inc. and Cellular Genomics, Inc. The U.S. patent for idiotype and anti-idiotype antibodies used in the detection of viruses is held by Mellman.
Currently, Dr. Mellman is a member of the editorial boards for Cell and the Journal of Experimental Medicine and the editor-in-chief of the Journal of Cell Biology.
www.uwo.ca /mni/MNI/3M/Mellman.html   (660 words)

  
 ASCB Profile - Ira Mellman   (Site not responding. Last check: 2007-10-17)
Ira Mellman is as known for his eclectic interests as he is for his science.
Mellman grew up in a politically charged household, went to college determined to become a musician, became interested in science hoping to teach biology at a small liberal arts college, and finally became a researcher at Yale University.
Mellman notes gratefully that the environment at Yale has been "terrifically supportive" of their joint and unorthodox approach to work, which early on resulted in the definition of endosomes.
www.ascb.org /news/vol20no8/profile.html   (1009 words)

  
 Office of Public Affairs at Yale - News Release   (Site not responding. Last check: 2007-10-17)
Mellman is Sterling Professor of Cell Biology and Immunobiology, and Chair of the Department of Cell Biology at Yale University School of Medicine.
Mellman's research combines cell biology and immunology to understand fundamental mechanisms of antigen processing and presentation by cells.
Mellman received his undergraduate degree from Oberlin College, his Ph.D. in genetics from Yale University School of Medicine, and trained as a fellow at Rockefeller University before joining the faculty at Yale in 1981.
www.yale.edu /opa/newsr/04-07-08-01.all.html   (508 words)

  
 Cornell News: Cancer Biology Lecture   (Site not responding. Last check: 2007-10-17)
ITHACA, N.Y. -- Ira Mellman, the Sterling Professor of Cell Biology and Immunobiology, and chair of the Department of Cell Biology at Yale University's School of Medicine, will present a seminar, "Generation and Maintenance of Epithelial Cell Polarity," Friday, March 12, at 4 p.m.
Mellman and his colleagues were the first to characterize endosomes, a ubiquitous organelle crucial to controlling endocytosis in virtually all cell types.
Mellman also is the director-designate of the Ludwig Institute for Cancer Research and the editor-in-chief of the Journal of Cell Biology.
www.news.cornell.edu /releases/March04/cancer.lecture.bpf.html   (254 words)

  
 Ira S. Mellman - Yale Cell Biology
Winckler B, Forscher P, Mellman I. (1999) Polarity in neurons is maintained by a novel diffusion barrier at the axon initial segment.
Koivisto U-M, Hubbard AL, Mellman I. (2001) A novel cellular phenotype for familial hypercholesterolemia due to a defect in polarized targeting of LDL receptor.
Delamarre L, Holcombe H, Giodini A, Mellman I. (2003) Presentation of exogenous antigens on MHC class I and MHC class II molecules is differentially regulated during dendritic cell maturation.
www.cellbiology.yale.edu /cellbio/html/faculty/i_mellman.shtml   (718 words)

  
 LICR | News | Yale video technique: dendritic cells
Using an advanced filming method, a team led by Dr. Ira Mellman watched as activated dendritic cells rummaged through a type of cellular trash bin, known as the lysosome, to salvage unused major histocompatibility complex class II (MHC II) molecules.
The team went on to demonstrate that the tubules from stimulated dendritic cells fused with plasma membrane found on the surface of cells, evidence that MHC II molecules once destined for obscurity could be rescued and put to use.
Mellman points out that fully understanding this pathway has some very direct implications: His own son is currently undergoing successful treatment for Crohn’s disease that follows the same principle.
www.licr.org /C_news/020829_dendritic.php   (568 words)

  
 CGI Pharmaceuticals, Inc   (Site not responding. Last check: 2007-10-17)
Ira Mellman, Ph.D. Ira Mellman is Professor of Cell Biology and Immunobiology, and Chair of the Department of Cell Biology at Yale University School of Medicine.
Dr. Mellman is also a member of the Scientific Committee of the Ludwig Institute for Cancer Research.
The recipient of many awards, named lectureships, and also the current Editor in Chief of the prestigious Journal of Cell Biology, Dr. Mellman is the author of over 150 scientific publications.
www.cellulargenomics.com /comp_info/bio_imellman.shtml   (143 words)

  
 Ira Mellman
Steinman, R.M., S. Turley, I. Mellman, and K. Inaba (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells.
Turley, S., K. Inaba, W. Garrett, M. Ebersold, R.M. Steinman, and I. Mellman (2000) Selective transport of MHC class II-peptide complexes and co-stimulatory molecules to the surface of developing dendritic cells.
Chow, A., D. Toomre, W. Garrett, and I. Mellman (2002) Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.
www.cancerresearch.org /cvc2002/ira_mellman.html   (734 words)

  
 The Schmid Lab at TSRI
Marsh, M., Schmid, S.L., Kern, H., Harms, E., Male,P., Mellman, I. and Helenius, A. Rapid Analytical and Preparative Isolation of Functional Endosomes by Free Flow Electrophoresis J. Cell Biol.
and Mellman, I. (1989) Acidification of Endosome Subpopulations in Wild-type CHO cells and Temperature-sensitive Acidification-defective Mutants.
Mellman, I., Fuchs, R., Schmid, S.L., and Helenius, A. (1988) The control of intracellular membrane traffic: Implications for Ca and phosphate transport.
www.scripps.edu /cb/schmid/sandycv.html   (1943 words)

  
 Ira Mellman, His Story   (Site not responding. Last check: 2007-10-17)
The current Ira Mellman picture is from the WBIG server where Ira can be heard doing the news on their morning show.
An e-mail from Ira Mellman to Gerry Wilkinson....
Gee, until we saw this photo, we thought that when Ira said, "I like soft sax," we thought his spelling was just a little off.
members.aol.com /GmmZ504918/mellman.html   (240 words)

  
 Untitled Document
of the Yale Cancer CenterNew Haven, CT Richard L. Edelson, M.D., Director of Yale Cancer Center, has announced the appointment of Ira Mellman as Scientific Director of the Center.
Mellman's demonstrated leadership skills and intricate familiarity with the research community at Yale make him the ideal choice for this position.
He also serves on the editorial boards of Cell, Journal of Experimental Medicine, and the International Journal of Cancer as well as on the advisory boards of key research institutes and cancer research foundations worldwide.
info.med.yale.edu /cellbio/html/news/news_mellman_Jul6_04.shtml   (482 words)

  
 "A Way to Combat Viruses..."
Ira Mellman of the school's School of Medicine said the researchers spent three years developing an efficient way to develop antibody-AUtobodies, which zero in on common parts of two classes of viruses, alpha-class and flavi-type.
The common denominators should make it possible to develop tests, treatments, and vaccines that work against all the viruses in the two classes, Mellman said.
Med-Venture of Minneapolis has received a license for the process and is negotiating with a major pharmaceutical company to test and possibly market it, Mellman said.
www.aegis.com /news/ads/1988/ad880180.html   (427 words)

  
 Science -- Published E-Letter responses for Steinman and Mellman, 305 (5681) 197-200
In Dublin, currently, there is a research revolution that addresses some of the obstacles outlined by Steinman and Mellman.
Key partnerships between government and funding bodies have established The Science Foundation of Ireland and The Conway Institute/The Dublin Molecular Medicine Centre with close links to St. Vincent’s University Hospital, where a new genome resource unit is under construction.
This constellation of research resources espouses the principles of Steinman and Mellman and a major Immunotherapy initiative is underway.
www.sciencemag.org /cgi/eletters/305/5681/197   (607 words)

  
 Cancer Immunity 3 Suppl 1:21 (2003)
Steinman RM, Turley S, Mellman I, Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells.
Turley SJ, Inaba K, Garrett WS, Ebersold M, Unternaehrer J, Steinman RM, Mellman I. Selective transport of MHC class II-peptide complexes and co-stimulatory molecules to the surface of developing dendritic cells.
Rodriguez A, Regnault A, Kleijmeer M, Ricciardi-Castagnoli P, Amigorena S. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.
www.cancerimmunity.org /v3suppl1p21/021137_abs.htm   (715 words)

  
 Cellular Genomics Inc. Names Dr. Louis Matis President and Chief Scientific Officer
Matis is the author of over 120 scientific and clinical publications and is a co-inventor on multiple patents.
"We are delighted to have Lou Matis as President and Chief Scientific Officer of Cellular Genomics," commented Professor Ira Mellman, Cellular Genomics' Scientific Founder and Chair of the Scientific Advisory Board.
Lou possesses the knowledge and creativity of a first rate scientist and the critical insight into the industry of a seasoned executive that will benefit CGI greatly," said Dr. Mellman.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-04-2000/0001329574&EDATE=   (587 words)

  
 Yale Bulletin and Calendar
Ira Mellman, Sterling Professor of Cell Biology and Immunology and chair of the Department of Cell Biology at the School of Medicine, has been appointed as scientific director of the Yale Cancer Center.
"Ira Mellman brings all of the right ingredients to the critical leadership position of scientific director of the Yale Cancer Center," said Dr. Richard L. Edelson, director of the center.
In enhancing our cancer research programs, Dr. Mellman will be collaborating closely with two other senior leaders of the center: Dr. Jose Costa, deputy director, and Dr. Edward Chu, director of clinical research." (See related story.)
www.yale.edu /opa/v32.n33/story19.html   (526 words)

  
 Yale Medicine Fall/Winter 2004: Faculty
Ira Mellman, Ph.D. ’78, chair and Sterling Professor of Cell Biology and professor of immunobiology, has been named scientific director.
As scientific director Mellman will have a central role in the recruitment of cancer scientists and will collaborate closely with Chu and Jose Costa, M.D., the center’s deputy director.
His leadership skills and familiarity with the Yale research community make him an ideal choice for the new position, said Richard L. Edelson, M.D. ’70, director of the Yale Cancer Center, who announced the appointments.
www.yalemedicine.yale.edu /ym_fw04/faculty.html   (1469 words)

  
 Quo Vadis: Polarized Membrane Recycling in Motility and Phagocytosis -- Mellman 149 (3): 529 -- The Journal of Cell ...
Quo Vadis: Polarized Membrane Recycling in Motility and Phagocytosis -- Mellman 149 (3): 529 -- The Journal of Cell Biology
Articles by Mellman, I. © The Rockefeller University Press, 0021-9525/2000/5/529/ $5.00
Correspondence to: Ira Mellman, Department of Cell Biology, Ludwig Institute for Cancer Research, 333 Cedar Street, PO Box 208002, New Haven, CT 06520-8002.
www.jcb.org /cgi/content/abstract/149/3/529   (400 words)

  
 GL2A7 Antibody Database Information
This hybridoma was generated by B.L.G. in the laboratory of Ira Mellman and Ari Helenius, Dept. of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Granger, B.L., Green, S.A., Gabel, C.A., Howe, C.L., Mellman, I., and Helenius, A. Characterization and cloning of Igp100, a lysosomal membrane glycoprotein from mouse and rat cells.
Uthayakumar, S., and Granger, B.L. Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins.
www.uiowa.edu /~dshbwww/gl2a7.html   (852 words)

  
 Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane : Nature
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
Amy Chow, Derek Toomre, Wendy Garrett and Ira Mellman
Correspondence to: Ira Mellman Correspondence and requests for materials should be addressed to I.M. (e-mail: Email: ira.mellman@yale.edu).
www.nature.com /nature/journal/v418/n6901/abs/nature01006.html   (313 words)

  
 Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory ...
Articles by Anderson, E. Articles by Mellman, I. PubMed
Articles by Anderson, E. Articles by Mellman, I. Article
Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways
www.jcb.org /cgi/content/abstract/170/4/595   (279 words)

  
 Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells -- ...
Articles by Ang, A. Articles by Mellman, I. Articles citing this Article
Articles by Ang, A. Articles by Mellman, I. Article
Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells
www.jcb.org /cgi/content/abstract/167/3/531   (610 words)

  
 Science -- Published E-Letter responses for Mellman, 292 (5514) 51
Science -- Published E-Letter responses for Mellman, 292 (5514) 51
It is always disappointing to have my interest in a particular paper dampened by the Web unavailability or the need to spend money to have access to the paper.
I do agree with Ira Black (Science's Compass letter, 6 April, p.
www.sciencemag.org /cgi/eletters/292/5514/51b   (327 words)

  
 Research Workshop Series Speaker Biographies for the 1999 Women in Bioscience Conference
Sandra Schmidt received her Ph.D. in biochemistry from Stanford University in 1985.
Following a post-doctoral fellowship in Ira Mellman’s laboratory at Yale University, Sandra joined The Scripps Research Institute as an Assistant Member of the Department of Cell Biology in 1988.
Currently, she is a tenured Associate Member of that Department.
awis.npaci.edu /WIB/wib_1999/about/res_bios.html   (1807 words)

  
 Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is ...   (Site not responding. Last check: 2007-10-17)
Articles by Delamarre, L. Articles by Mellman, I. Rockefeller University Press, 0022-1007/2003/7/111 $5.00
Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520
Address correspondence to I. Mellman, Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar St., PO Box 208002, New Haven, CT 06520-8002.
www.jem.org /cgi/content/abstract/198/1/111   (1009 words)

  
 The Rockefeller University - Lectures 2003
A panel discussion on the nature of creativity
Moderated By: Ira Flatow, Host and Executive Producer of NPR's, Talk of the Nation: Science Friday
Doctor Nerve and the Sirius Sting Quartet perform Ereia - a gale force performance of rock, classical and jazz
www.rockefeller.edu /lectures.past2004.php   (266 words)

  
 Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells -- Pierre et al. 191 (6): 1057 -- ...   (Site not responding. Last check: 2007-10-17)
Articles by Pierre, P. Articles by Mellman, I. Articles citing this Article
Articles by Pierre, P. Articles by Mellman, I. © The Rockefeller University Press, 0022-1007/2000/3/1057/ $5.00
Correspondence to: Ira Mellman, Department of Cell Biology and Section of Immunobiology, Ludwig Institute for Cancer Research, Yale University School of Medicine, P.O. Box 208002, 333 Cedar St., New Haven, CT 06520-8002.
www.jem.org /cgi/content/abstract/191/6/1057   (532 words)

  
 Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Organizer(s): Ira Mellman, Richard Flavell and Ralph M. Steinman
The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
* Ira Mellman, Yale University School of Medicine
keystonesymposia.org /Meetings/viewPastMeetings.cfm?MeetingID=639&...   (1419 words)

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