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Topic: Islets of Langerhans

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	Islets of Langerhans - Wikipedia, the free encyclopedia
		Discovered in 1869 by the German pathological anatomist Paul Langerhans (1847-1888), the Islets of Langerhans constitute 1-2% of the mass of the pancreas.
		65-80% of the islet cells are insulin-producing beta cells.
		Islet cells can influence each other through paracrine and autocrine communication, and beta-cells are coupled electrically to beta-cells (but not to other cell-types!).
	en.wikipedia.org /wiki/Islets_of_Langerhans (230 words)

	pancreatic islets (islets of langerhans)
		A dual population of islets of Langerhans in bovine pancreas.
		Insulin release in aging: dynamic response of isolated islets of Langerhans of the rat to D-glucose and D-glyceraldehyde.
		Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets.
	www.arclab.org /node_pages/257.html (925 words)

	Diabetes: Human islets of Langerhans express Fas ligand a... @ HighBeam Research (Site not responding. Last check: 2007-11-07)
		Batches of islets were routinely tested for insulin secretory activity and, in all cases, exhibited a three- to sixfold increase in insulin secretion when the glucose concentration was raised from 4 to 20 mmol/l.
		Islets were harvested from the tissue culture plates and dispersed by trypsin digestion followed by brief centrifugation (500g/3 min).
		In rodent islets, the effects of HAP are mediated principally by induction of nitric oxide synthase, with the subsequent generation of nitric oxide from arginine within the islet cells (10,27-29).
	www.highbeam.com /library/doc0.asp?DOCID=1G1:20755166&refid=ip_encyclopedia_hf (4275 words)

	Islets of Langerhans (Site not responding. Last check: 2007-11-07)
		Discovered in 1869 by the German pathological anatomist Paul Langerhans (1847 - 1888), the Islets of Langerhans constitute 1-2% of the mass of the pancreas.
		Ninth International Workshop on Langerhans Cells, Funchal, Madeira, The scope of the Workshop will be the biology of Langerhans cells under physiological and, even more importantly, pathological conditions.
		Langerhans cell-histiocytos Fakta om sjukdomen LCH och dess sjukdomsförlopp.
	www.serebella.com /encyclopedia/article-Islets_of_Langerhans.html (421 words)

	islets of Langerhans on Encyclopedia.com (Site not responding. Last check: 2007-11-07)
		Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.
		Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in [alpha]TC6 cells, mouse clonal [alpha]-cells, and [alpha]-cells of islets of Langerhans.
		Islets of Langerhans generate wavelike electric activity modulated by glucose concentration.
	www.encyclopedia.com /html/X/X-isletsL1a.asp (544 words)

	Search Tuna Report for islets of langerhans (Site not responding. Last check: 2007-11-07)
		Islets of Langerhans contain beta cells and are located within the pancreas.
		Islets are made up of two types of cells: alpha cells, which make glucagon, a hormone that raises the level of glucose sugar in the blood, and beta cells, which make insulin....
		Islets Of Langerhans - Islands Of Langerhans -...
	searchtuna.com /ftlive2/502.html (1510 words)

	[No title]
		Langerhans is notable for his studies of human and animal histology.
		The islets of Langerhans were first given that name in 1893 by the French histologist G. Laguesse.
		Langerhans also studied the anatomy of the skin and its innervation.
	www2.merriam-webster.com /cgi-bin/mwmednlm?book=Medical&va=islet+of+langerhans (129 words)

	Islets of Langerhans (Site not responding. Last check: 2007-11-07)
		Discovered in 1869 by the German pathological anatomist Paul (1847 - 1888) the Islets of Langerhans constitute 1-2% the mass of the pancreas.
		65-80% of the islet cells are insulin -producing beta cells.
		Electrical activity of pancreatic islet-cells has been using the patch-clamp technique and it has out that the behaviour of cells in islets differs significantly from the behaviour of cells.
	www.freeglossary.com /Islet_of_Langerhans (339 words)

	Insulin release in aging: dynamic response of isolated islets of Langerhans of the rat to D-glucose and ...
		Glucose-stimulated insulin release is diminished in islets of Langerhans from older rats compared to that in islets from young controls.
		Insulin release was reduced by 36% from islets of older rats incubated in the presence of 16.7 mM D-glucose, and the first phase of insulin release was largely blunted compared with that in islets from young controls.
		The differences in the insulin secretory responses to D-glucose and D-glyceraldehyde in islets from older rats support the hypothesis that the major rate-limiting step in stimulus-secretion coupling in aging is before the metabolism of the trioses.
	www.arclab.org /medlineupdates/abstract_3881248.html (295 words)

	islets of Langerhans cell
		Letter N Such cells may comprise a peripheral endocrine gland (eg, the insulin-secreting beta cells of the islets of Langerhans in the pancreas and the adrenaline...
		Letter G A protein hormone that is produced especially by the islets of Langerhans and that...
		In the pancreas, nuclear and cytoplasmic staining for DENTT was present in the islets of Langerhans.
	www.cancer-help.org /cancer/0604/islets_of_Langerhans_cell.html (350 words)

	Diabetes: Islets of Langerhans generate wavelike electric... @ HighBeam Research (Site not responding. Last check: 2007-11-07)
		Islets of Langerhans were isolated from pancreases of mice (ICR strain), hamsters (Mesociretus auratus), rats (Wistar and Sprague-Dawley), and gerbus (Psamnomys obesus).
		The islets were isolated from the pancreases by a 4- to 5-min incubation at 37.5[degrees]C in 2 mg/ml type P collagenase (Boehringer Mannheim, Mannheim, Germany).
		However, because the islets are spherical and there is no way to determine the location of the proposed pacemaker relative to the recording electrodes, the shape of the EIG is unpredictable.
	www.highbeam.com /library/doc0.asp?docid=1G1:18308124&refid=ink_tptd_g1 (3943 words)

	NDI Terminology - pancreas (Site not responding. Last check: 2007-11-07)
		Most of the pancreas consists of exocrine tissue, embedded in which are "nests" of endocrine cells (the islets of Langerhans).
		The islets of Langerhans are surrounded by many blood vessels into which they secrete hormones.
		The endocrine cells in the islets of Langerhans secrete the hormones insulin and glucagon, which regulate the level of glucose in the blood.
	www.ndif.org /Terms/pancreas.html (222 words)

	Renal (Site not responding. Last check: 2007-11-07)
		The islets of Langerhans are normal in number or somewhat reduced with type II diabetes mellitus.
		ENDO039.jpg [184k] Normal islets of Langerhans, on the right with immunoperoxidase staining for insulin to identify beta cells and on the left with immunoperoxidase staining for glucagon to identify alpha cells, microscopic.
		ENDO033.jpg [192k] Islet of Langerhans demonstrating amorphous pink deposition of amyloid in a patient with type II diabetes mellitus, microscopic.
	www.md.huji.ac.il /mirror/webpath/DIABETES.html (523 words)

	Langerhans, islets of -- Encyclopædia Britannica (Site not responding. Last check: 2007-11-07)
		The islets consist of four distinct cell types, of which three (alpha, beta, and delta cells) produce important hormones; the fourth component…
		The islets consist of four distinct cell types, of which three (alpha, beta, and delta cells) produce important hormones; the...
		Alpha cells in the islets produce glucagon, a hormone that raises blood sugar levels by converting stored carbohydrates into the sugar glucagon, which is the primary fuel of cells.
	www.britannica.com /eb/article-9047095?tocId=9047095 (793 words)

	"Genetic Engineering & Xenotransplantation" by Shane T. Grey, Ph.D.
		In the early 1970's it was demonstrated that islets of Langerhans (the tissue that produces insulin) isolated from one animal could be transplanted to another and cure diabetes.
		Of 270 islet transplants performed world wide by 1995, in only 5% (~14) of cases were the transplanted individuals still cured one year later.
		Additionally, it is believed that transplanted islets are quite sensitive to their new environment, and in the time that it takes them to adjust to their new body, many of the islets die.
	www.actionbioscience.org /biotech/grey.html (2140 words)

	Islets Of Langerhans - Encyclopedia.WorldSearch (Site not responding. Last check: 2007-11-07)
		High-glucose stimulation of 64,000-Mr islet cell autoantigen expression.
		Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation.(IMMUNOLOGY...
		Cellular infiltrates in rejecting and surviving murine pancreatic islet allografts
	encyclopedia.worldsearch.com /islets_of_langerhans.htm (118 words)

	Images with Islets of Langerhans (Site not responding. Last check: 2007-11-07)
		An island (geographic) is a body of land surrounded by water.
		Islets (small islands) are one tissue type (endocrine) surrounded by another (exocrine).
		The islets produce polypeptide hormones, notably insulin and glucagon.
	www.med.uiuc.edu /histo/small/atlas/objects/862.htm (32 words)

	islets of Langerhans (Site not responding. Last check: 2007-11-07)
		Three-dimensional imaging of intact isolated islets of langerhans with confocal microscopy.
		Identification in islets of Langerhans of a new rat alpha-2-adrenergic receptor.
		The role of histocompatibility antigens in transplantation of isolated islets of Langerhans in the rat.
	www.infoplease.com /id/A0914761 (180 words)

	Islets of Langerhans - Uncyclopedia
		The Isles of Langerhans are a small group of islands that are part of the Pan Creas Archipelago, and home to strange creatures simply not found anywhere else in the world.
		The population of the Isles of Langerhan, though varied, are divided primarily into two tribes, the Exocrine and the Endocrine.
		Occassionally, though, Endocrine chefs leave the islets, and are put to work in some of the finest eating establishments in the world.
	uncyclopedia.org /wiki/Islets_of_Langerhans (582 words)

	Quadrupole Magnetic Separation (Qms) of Porcine Islets of Langerhans (Site not responding. Last check: 2007-11-07)
		Recent advances in islet transplantation and immunosuppression reversed diabetes in up to 90% of cases with relatively minor complications.
		Studies are underway to optimize Dynabead® uptake by islets as well as to increase the purity of recovered islets.
		Islets of significant purity from the QMS will be transplanted into diabetic mice for direct comparison with density gradient-purified islets.
	aiche.confex.com /aiche/2005/techprogram/P17656.HTM (430 words)

	children with DIABETES - Diabetes Dictionary: I
		A tumor of the beta cells in areas of the pancreas called the islets of Langerhans.
		Most people with Type 1 diabetes have antibodies to a variety of islet cell proteins that are apparently released as a consequence of damage to the beta cells of the pancreas.
		The islet cells appear under low-power magnification to be islands (islets) within the pancreas.
	www.childrenwithdiabetes.com /dictionary/i.htm (1763 words)

	A Science Odyssey: People and Discoveries: Banting and Best isolate insulin
		The connection was further narrowed down to the islets of Langerhans, a part of the pancreas.
		He realized that the pancreas' digestive juice was destroying the islets of Langerhans hormone before it could be isolated.
		By August they had the first conclusive results: when they gave the material extracted from the islets of Langerhans (called "insulin," from the Latin for "island") to diabetic dogs, their abnormally high blood sugars were lowered.
	www.pbs.org /wgbh/aso/databank/entries/dm22in.html (584 words)

	Anyone know how Dr. Ulrichs' xeno research is progressing? (Site not responding. Last check: 2007-11-07)
		To avoid the life-long immunosuppression of young diabetics, immunoisolation of isolated porcine islets of Langerhans using biocompatible alginates will be pursued and evaluated.
		In this funding period, we aim for the reliable, long-term reversion of a chemically-induced (Streptozotozin) diabetes in rats using barium-alginate-microencapsulated islets of Langerhans from the pig: we will try to achieve long-term islet graft function for more than 365 days in over 70% of the animal recipients, without immunosuppression.
		In the process of optimizing the graft function, we plan to improve the isolation process, the microencapsulation (material and technology), the in vitro culture and function of porcine islets of Langerhans, as well as the analysis of the specific and unspecific immune reactions of the recipient to the graft.
	www.islet.org /forum/messages/37282.htm (304 words)

	Excitation Wave Propagation as a Possible Mechanism for Signal Transmission in Pancreatic Islets of Langerhans -- ...
		In this section the experimental results concerning wave-like activity in the islets of Langerhans are described.
		Islets of Langerhans are known to be heterogeneous in sense of the
		to a decrease in insulin release by islets of Langerhans (Pipeleers
	www.biophysj.org /cgi/content/full/80/3/1195 (6766 words)

	Defining the cell lineages of the islets of Langerhans using transgenic mice (Site not responding. Last check: 2007-11-07)
		Defining the cell lineages of the islets of Langerhans using transgenic mice
		Considerable knowledge concerning the ontogeny of the endocrine pancreas has been gained in recent years, mainly through the use of two complementary genetic approaches in mice: gene inactivation and genetic labelling of precursor cells.
		However, neither gene inactivation in KO mice nor co-localisation of hormones in single cells during development can be taken as evidence for cell lineage relationships among different cell types.
	www.ijdb.ehu.es /abstract.0201/a97.html (296 words)

	Harlan Ellison / Islets of Langerhans
		Published in paper and cloth by The Ohio State University Press (ironically, the college that Ellison got kicked out of).
		Islets of Langerhans is a noncommercial Web site, not associated (except by fond good wishes) with Harlan Ellison.
		If you've found the information here useful and would like to support this project, please consider making a donation.
	www.islets.net (252 words)

	The islets of Langerhans, (from pancreas) -- Britannica Student Encyclopedia (Site not responding. Last check: 2007-11-07)
		More results on "The islets of Langerhans, (from pancreas)" when you join.
		Although the final form of the cells that compose a tissue may not be evident until the organ itself is well along in development, distinctive biochemical reactions, which are the...
		hormone that regulates the level of sugar (glucose) in the blood and is produced by the beta cells of the islets of Langerhans in the pancreas.
	www.britannica.com /ebi/article-206119?tocId=206119&ct= (905 words)

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