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Topic: Isotretinoin

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	Isotretinoin (marketed as Accutane) Information
		Patients should stop isotretinoin and they or their caregiver should contact their healthcare professional right away if the patient has any of the previously mentioned symptoms.
		Isotretinoin is a potentially dangerous prescription medicine that should only be taken under the close supervision of your healthcare professional and pharmacist.
		You should NEVER take Accutane (isotretinoin) or any of the generic versions of Accutane if you are pregnant or trying to get pregnant or could accidentally become pregnant.
	www.fda.gov /cder/drug/infopage/accutane (391 words)

	MedlinePlus Drug Information: Isotretinoin
		There is a high risk that isotretinoin will cause loss of the pregnancy, or will cause the baby to be born too early, to die shortly after birth, or to be born with birth defects (physical problems that are present at birth).
		Isotretinoin is used to treat severe recalcitrant nodular acne (a certain type of severe acne) that has not been helped by other treatments, such as antibiotics.
		Isotretinoin may cause the bones to weaken or thicken abnormally and may increase the risk of certain bone injuries in people who perform some types of physical activity.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a681043.html (2427 words)

	Accutane
		Four to five months of isotretinoin treatment usually leads to clearing of acne for one year or more after the medicine is stopped.
		Isotretinoin may increase the level of blood fats, sometimes to risky levels.
		A woman who does get pregnant while on isotretinoin must be prepared to have an abortion and must state this in writing before many physicians will prescribe isotretinoin for her.
	www.skinsite.com /info_accutane.htm (642 words)

	BEST ONLINE PHARMACY
		Isotretinoin is a form of vitamin A. It decreases the amount of sebum (oil) that is released by the sebaceous (oil) glands, and it increases that rate at which the skin renews itself.
		Isotretinoin is used to treat severe nodular acne that has not responded to other treatments, including antibiotics.
		Isotretinoin is in the FDA pregnancy category X. This means that isotretinoin is known to cause severe birth defects in an unborn baby.
	drugsale.org /?product=accutane (1063 words)

	Isotretinoin Information on Healthline
		Isotretinoin is a medication taken to treat severe nodular acne that has not been helped by other treatments, including antibiotics.
		Isotretinoin is in the FDA pregnancy category X. This means that isotretinoin is known to cause severe birth defects in an unborn baby.
		Isotretinoin may increase the sensitivity of the skin to sunlight and a severe sunburn could result.
	www.healthline.com /multumcontent/isotretinoin (875 words)

	Isotretinoin - Wikipedia, the free encyclopedia
		Prior to the development of isotretinoin, the mainstay treatment of severe acne was oral antibiotics such as the tetracyclines and erythromycin.
		Isotretinoin, when administered orally, is best absorbed when taken after a high fat meal, as it has a high level of lipophilicity.
		Isotretinoin is indicated for the treatment of severe cystic acne vulgaris.
	en.wikipedia.org /wiki/Isotretinoin (1778 words)

	Isotretinoin (Site not responding. Last check: )
		Isotretinoin (Accutane®) is given orally in the treatment of cystic acne and other dermatological diseases.
		Typical malformations occurred in children born to women who took various dosages of isotretinoin (0.2-1.5 mg/kg), even within the usual therapeutic range and in women who were treated for less than one week in the first trimester of pregnancy.
		Isotretinoin (Accutane®) is the most potent human teratogen (a teratogen interferes with the development of a fetus and causes birth defects).
	www.genetics.missouri.edu /motis/isotretinoin.htm (646 words)

	PharmGKB: isotretinoin
		Isotretinoin is indicated in the treatment of severe, recalcitrant nodular acne, where severe is defined as numerous lesions of at least 5 millimeters in diameter that may be suppurative or hemorrhagic.
		Although isotretinoin is produced naturally in the body and is a retinoid, it does not bind directly to any of the two classes of nuclear retinoic acid receptors (RARs or RXRs) or their subclasses of receptors (alpha, beta, and gamma receptors).
		Studies in animals have shown that prolonged isotretinoin therapy increased the incidence of focal calcification; fibrosis and inflammation of the myocardium; calcification of coronary, pulmonary, and mesenteric arteries; and metastatic calcification of the gastric mucosa.
	www.pharmgkb.org /do/serve?objId=368&objCls=DrugProperties (1764 words)

	Isotretinoin 20mg capsules (Beacon Pharmaceuticals Ltd) , SPC from the eMC
		Isotretinoin capsules are indicated for the treatment of severe forms of acne (such as nodular or conglobate acne or acne at risk of permanent scarring), resistant to adequate courses of standard therapy with systemic antibacterials and topical therapy.
		Isotretinoin should only be prescribed by or under the supervision of physicians with expertise in the use of systemic retinoids for the treatment of severe acne and a full understanding of the risks of isotretinoin therapy and monitoring requirements.
		Isotretinoin is not indicated for the treatment of prepubertal acne and is not recommended in patients less than 12 years of age.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=15655 (3623 words)

	Acne, Isotretinoin and Depression
		Isotretinoin (13-cis retinoic acid) is a derivative of vitamin A. Following oral administration, it is converted to all-trans retinoic acid within target cells (sebocytes) and this metabolite suppresses sebaceous gland activity.
		In 2 of these people, depression was thought not to be related to isotretinoin use because there were other psychosocial stressors present that could account for the symptoms, and these patients were continued on, or retreated with, isotretinoin without a recurrence of their depressed mood.
		In keeping with this, a recent overview of the use of isotretinoin in the USA reported that isotretinoin is being used there for mild to moderate acne, increasing the population exposed to the drug and potentially to its unwanted effects.
	www.medsafe.govt.nz /profs/PUarticles/isotretDTB.htm (2511 words)

	Isotretinoin - Patient UK
		Isotretinoin is used to treat severe acne especially in patients whose acne has not responded to other types of treatment.
		Isotretinoin is not used to treat acne that occurs before the onset of puberty.
		Isotretinoin may cause some people's skin to become more sensitive to sunlight than it usually is. Avoid bright sunlight and sunbeds and use a sun cream higher than factor 15 until you know how your skin reacts.
	www.patient.co.uk /showdoc/30003722 (983 words)

	Chemical Name: Isotretinoin (Site not responding. Last check: )
		Isotretinoin is used to treat severe nodular (cystic) acne.
		The closest naturally occurring substance to Isotretinoin is vitamin A. Vitamin A is used by the body to maintain healthy mucus membranes in the nose, mouth, and ears.
		Isotretinoin can be considered a hardcore version of vitamin A, with the benefits but also the potential for hugely negative side effects.
	academic.evergreen.edu /curricular/anatomyphysiology/Accutane.htm (735 words)

	Should I take isotretinoin for severe acne? (Site not responding. Last check: )
		Isotretinoin is a powerful and effective medication used to treat severe acne that cannot be cleared up with other medications, including antibiotics.
		Isotretinoin may not be appropriate if you have a history of depression or a family history of depression.
		Isotretinoin causes temporary side effects, including dry skin, eyes, and mouth; increased cholesterol and triglyceride levels; and headaches and muscle and joint pain.
	www.webmd.com /a-to-z-guides/Should-I-take-isotretinoin-for-severe-acne (1032 words)

	Isotretinoin. DermNet NZ
		Isotretinoin or 13-cis retinoic acid is a very effective medication for the treatment of acne.
		Isotretinoin has a very high chance of resulting in a spontaneous miscarriage or a severe birth deformity if a fetus is exposed to it during the first half of pregnancy.
		Isotretinoin has no effect on sperm or male fertility and has not been shown to cause birth defects in children fathered by men taking it.
	www.dermnetnz.org /treatments/isotretinoin.html (2469 words)

	Acne Treatments: Accutane (Isotretinoin)
		Isotretinoin is one of the strongest and most successful medicines available for the treatment of acne.
		Isotretinoin has received a lot of negative press and several issues are part of the hot topics section.
		Isotretinoin is a complete medication in that it is the only medication that tackles all of the key factors in acne production.
	www.everythingacne.com /accutane.htm (497 words)

	Acne and Isotretinoin: Using Isotretinoin the Right Way -- familydoctor.org (Site not responding. Last check: )
		Isotretinoin (brand name: Accutane) is a medicine used to treat very bad acne.
		Isotretinoin is like vitamin A, so while you are taking isotretinoin, you should not take vitamin A pills or multivitamins that contain vitamin A. You should also not take any antibiotics without talking to your doctor first
		Isotretinoin causes severe birth defects, including malformation of the head and face, mental retardation and severe internal defects of the brain, heart, glands and nervous system.
	familydoctor.org /631.xml (891 words)

	Isotretinoin for acne vulgaris - [Medication]
		Isotretinoin is a powerful and effective medication derived from vitamin A. Doctors prescribe it to treat severe acne only after other treatments have failed.
		If acne returns after you stop using isotretinoin, it usually is not as bad as it once was.
		In Canada, isotretinoin is strictly regulated for use in women because of the danger of miscarriage and of serious birth defects in babies whose mothers took the medication during pregnancy.
	www.bchealthguide.org /kbase/topic/detail/drug/hw199463/detail.htm (623 words)

	Isotretinoin and Rhabdomyolysis
		Isotretinoin, a mainstay of therapy for recalcitrant nodulocystic acne, has been reported to successfully treat dissecting cellulitis of the scalp (DCS).[1,2] Although the common side effects of isotretinoin are well recognized, its association with elevated creatine kinase (CK) levels and its potential to cause rhabdomyolysis is not well established or understood.
		Mildly elevated CK levels during isotretinoin therapy are not uncommon and may frequently be associated with exercise.
		Moreover, elevated CK levels in the range for rhabdomyolysis are associated with an increased risk of acute renal failure and death.[8] The expanding body of literature regarding the association of elevated CK levels with isotretinoin should alert physicians to consider routine evaluation of CK levels in all patients being treated with isotretinoin.
	dermatology.cdlib.org /DOJvol5num2/case_reports/trauner.html (913 words)

	Isotretinoin (Site not responding. Last check: )
		Oral isotretinoin, since its introduction more than 20 years ago, has been and still is the “ gold standard” in the treatment of acne and its variants.
		The role of isotretinoin has evolved with higher dosage schedules and use earlier in the course of the disease.
		Isotretinoin (Accutane®) is a retinoid or vitamin A analog, which means that its molecular structure is similar to Vitamin A. It was first approved in the US in 1982.
	www.isotretinoin.ca (171 words)

	isotretinoin (Accutane) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		The exact mechanism of action of isotretinoin is not known; however, it may reduce acne by reducing the secretion of sebum.
		DRUG INTERACTIONS: Isotretinoin is closely related to vitamin A. Therefore, the use of both vitamin A and isotretinoin at the same time may lead to vitamin A side effects.
		Treatment with tetracycline and isotretinoin should not be given at the same time since the combination has been associated with brain swelling.
	www.medicinenet.com /isotretinoin/article.htm (655 words)

	Accutane and Other Retinoids - March of Dimes
		Accutane (isotretinoin) is a prescription medication used to treat a severe form of acne (nodular or cystic acne) that has not been helped by other treatments, including oral antibiotics.
		Isotretinoin is a member of a family of drugs called retinoids, which are related to vitamin A. When taken during pregnancy, isotretinoin and other retinoids can cause miscarriage or very serious birth defects.
		Isotretinoin can cause these birth defects in the early weeks after conception when a woman often does not know she is pregnant.
	www.marchofdimes.com /professionals/14332_1168.asp (2171 words)

	Accutane (Isotretinoin) drug description - FDA approved labeling for prescription drugs and medications at RxList
		Isotretinoin, a retinoid, is available as Accutane in 10-mg, 20-mg and 40-mg soft gelatin capsules for oral administration.
		Chemically, isotretinoin is 13-cis-retinoic acid and is related to both retinoic acid and retinol (vitamin A).
		It is a yellow to orange crystalline powder with a molecular weight of 300.44.
	www.rxlist.com /cgi/generic/isotret.htm (521 words)

	Isotretinoin - Accutane
		Made under the brand name "Accutane", isotretinoin is a derivative of vitamin A taken in pill form for 15-20 weeks.
		"Isotretinoin Causing Acute Aseptic Arthropathy." Clinical and Experimental Dermatology 20.3 (1995): 279-281.
		McLane, J. "Analysis of Common Side Effects of Isotretinoin." Journal of the American Academy of Dermatology 45.5 (2001): 188-94.
	www.acne.org /prescription.php?view=Isotretinoin (352 words)

	Acne Oral Treatments: Isotretinoin (Accutane)
		Isotretinoin (Accutane®) is a retinoid or vitamin A analog, which means that its molecular structure is similar to Vitamin A. It was first approved in the US in 1982.
		Most dermatologists believe it is a remarkable acne medication, some people’s acne clears quickly while in others improvement is gradual, multiple courses can be taken.
		Isotretinoin basically helps the sebaceous gland to mature, it does so in several ways.
	www.acneguide.ca /acne_med_treatments/isotretinoin/isotretinoin_accutane.html (500 words)

	isotretinoin (oral) - [Medication]
		Isotretinoin is a form of vitamin A. It decreases the amount of sebum (oil) that is released by the sebaceous (oil) glands, and it increases that rate at which the skin renews itself.
		Isotretinoin is used to treat severe nodular acne that has not responded to other treatments, including antibiotics.
		You may not be able to take isotretinoin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
	www.peacehealth.org /kbase/multum/d01245a1.htm (2119 words)

	RedOrbit - Health - FDA Approves Isotretinoin Pregnancy Risk Management Program
		Isotretinoin, which is marketed under the trade names Accutane(R), Amnesteem(R), Claravis(TM) and Sotret(R), is used to treat severe recalcitrant nodular acne that has not responded to other therapies.
		Isotretinoin has a high risk of birth defects if taken during pregnancy, and an evolving risk management program has been in place since 1988.
		Isotretinoin must not be used by female patients who are or may become pregnant.
	www.redorbit.com /news/display?id=205892&source=r_health (869 words)

	Accutane (Isotretinoin) Information for Acne
		Isotretinoin is an oral drug and is usually taken once or twice a day for 16 to 20 weeks.
		Isotretinoin also reduces cell shedding and the stickiness of cells in the follicles, which helps prevent the development of comedones.
		To make sure isotretinoin is stopped if these side effects occur, the doctor usually monitors a patient’s complete blood count, blood chemistries, cholesterol, triglycerides, and liver enzymes before therapy is started and periodically during treatment.
	www.ultimate-cosmetics.com /beauty/skin_disorders/accutane.htm (714 words)

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