
	Where results make sense

Topic: Janus kinase

Related Topics

Insulin receptor

Tyrosine kinase

	Janus kinase
		Janus kinase (short JAK) is a family of intracellular tyrosine kinases, ranging from 120-140 kDa, that are involved in the signalling cascade of cytokines by associating with one of the cytokine receptors[?], for example, the interferon receptor.
		The kinase was named after Janus, the Roman[?] gatekeeper of heaven.
		He is described as having two faces, as the kinase has two phosphate-transferring domains.
	www.ebroadcast.com.au /lookup/encyclopedia/ja/Janus_kinase.html (72 words)

	JAK2 - Janus kinase 2 (a protein tyrosine kinase)
		Briefly, binding of GH to GH receptor induces receptor dimerization and activation of the tyrosine kinase JAK2.
		Pituitary GH triggered the tyrosine phosphorylation of Janus kinase 2 (Jak2) and STAT3 in neutrophils.
		Dissociation of Janus kinase 2 and signal transducer and activator of transcription 5 activation after treatment of Nb2 cells with a molecular mimic of phosphorylated prolactin.
	www.ihop-net.org /UniPub/iHOP/gg/89592.html (4462 words)

	Interactive Fly, Drosophila
		Jak 1 is the prototype of Jak (Janus kinase) subfamily of non-receptor tyrosine kinases.
		Janus kinases (JAKs) associate with cytokine receptors and are essential for transmitting downstream cytokine signals.
		In murine pre-B lymphocytes transformed with A-MuLV, the Janus kinases (Jaks) Jak1 and Jak3 exhibit constitutive tyrosine kinase activity, and the STAT proteins (signal transducers and activators of transcription) normally activated by interleukin-4 and interleukin-7 are tyrosine-phosphorylated in the absence of these cytokines.
	www.sdbonline.org /fly/gene/hopscot2.htm (4086 words)

	Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages -- Okugawa et al. 285 (2): C399 -- ...
		Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages -- Okugawa et al.
		receptor-associated kinase (IRAK) to the receptor (35, 54).
		Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.
	ajpcell.physiology.org /cgi/content/full/285/2/C399 (5999 words)

	Janus kinase - Wikipedia, the free encyclopedia
		Janus kinase (JAK) is a family of intracellular non-receptor tyrosine kinases, ranging from 120-140 kDa, that transduce cytokine-mediated signals via the JAK-STAT pathway.
		Janus kinase was initially named JAK after "just another kinase." Later, it was said to be named after Janus, the Thessalian gatekeeper of heaven worshipped by Romans.
		Since members of the type I and type II cytokine receptor families possess no catalytic kinase activity, they rely on the JAK family of tyrosine kinases to phosphorylate and activate downstream proteins involved in their signal transduction pathways.
	en.wikipedia.org /wiki/Janus_kinase (1049 words)

	Human protein: P23458 - Tyrosine-protein kinase JAK1 (EC ) (Janus kinase 1) (JAK-1). EMBL Bioinformatics Harvester
		Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain.
		These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
		Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).
	harvester.embl.de /harvester/P234/P23458.htm (938 words)

	Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem ... (Site not responding. Last check: 2007-10-03)
		Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation -- Roberts et al.
		Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation
		Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
	www.bloodjournal.org /cgi/content/full/103/6/2009 (6079 words)

	Faculty Information: Roy J. Duhé, Ph.D.
		Janus protein tyrosine kinases are essential early mediators of cytokine-initiated signal transduction.
		Kiranam Chatti, William L. Farrar and Roy J. Duhé, "Tyrosine phosphorylation of the Janus Kinase 2 activation loop is essential for a high-activity catalytic state but dispensable for a basal catalytic state", (2004) Biochemistry 43: 4272-4283.
		Viktoria Lukashova, Zhangguo, Chen, Roy J. Duhé, Marek Rola-Pleszcynski, and Jana Stankova "Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus ", (2003) Journal of Immunology 14: 175-222.
	pharmacology.umc.edu /research/duhe.html (513 words)

	RedOrbit - Science - Chronic Myelocytic Leukemia - Part I: History, Clinical Presentation, and Molecular Biology
		The continuous activation of tyrosine kinase, together with the altered binding affinity of the fusion protein for membranes and DNA, and the activation of signal transduction pathways involving oncogenes like RAS, are sufficient to produce full transforming capabilities.
		The constitutive tyrosine kinase activity produced by the fusion protein results in an increased activation of RAS, a known oncogene, creating proliferation that is independent of cytokine control.
		Phosphatidylinositol-3 kinase activity is regulated by BCR-ABL and is required for the growth of Philadelphia chromosome-positive cells.
	www.redorbit.com /news/display?id=125082 (6155 words)

	Medical Policy GENE.00004 \| Janus Kinase 2 (JAK2) Gene Mutation Assay
		The Janus Kinase 2 V617F point mutation (phenylalanine substituted for valine at amino acid position 617) results in unregulated JAK2 tyrosine kinase activity and JAK2 STAT signaling.
		JAK2 is a member of the Janus kinase family of genes coding for tyrosine kinases which mediate signaling functions between cell membrane receptors and STAT (signal transducers and activators of transcription) factors within the cytoplasm. JAK cell-surface receptors respond to various cytokines and growth factors including interferons, interleukins, EPO, GMCSF, and thrombopoietin.
		Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
	medpolicy.unicare.com /policies/GENE/JAK2.html (917 words)

	Hypertonicity Activates Na+/H+ Exchange through Janus Kinase 2 and Calmodulin -- Garnovskaya et al. 278 (19): 16908 -- ...
		KN-93 and KT-5926 are inhibitors of CaM kinase, K-252a and ML-9 inhibit myosin light chain kinase, vinpocetine and 8-methoxy-isobutylmethylxanthine are inhibitors of CaM-dependent cyclic nucleotide phosphodiesterase, and cyclosporin A inhibits calcineurin.
		Role for Janus Kinase 2 in Hypertonicity-induced Activation of NHE-1-- Because the Jak/STAT pathway is activated by hypertonicity (15), and Jak2 is an indirect regulator of bradykinin-stimulated
		Involvement of Janus kinase 2 in hypertonicity-induced NHE-1 activation.
	www.jbc.org /cgi/content/full/278/19/16908 (6453 words)

	BLAST Search Results
		1023 0.0 gbAF001362.1AF001362 Homo sapiens Jak2 kinase (JAK2) mRNA...
		1023 0.0 gbAF058925.1AF058925 Homo sapiens Jak2 kinase mRNA, compl...
		Homo sapiens tyrosine kinase 2 (TYK2), mRNA 672 0.0 gbL24895.1CYIFJAK Cyprinus carpio tyrosine kinase (f-JAK1...
	www.chickest.udel.edu /orthohuman/h37.html (2936 words)

	CYP1A-Mediated Metabolism of the Janus Kinase-3 Inhibitor 4-(4'-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: ... (Site not responding. Last check: 2007-10-03)
		IRK (insuline receptor kinase), or Janus kinases JAK1 and JAK2
		Goodman PA, Niehoff LB and Uckun FM (1998) Role of tyrosine kinases in induction of c-jun proto-oncogene in irradiated B-lineage lymphoid cells.
		Malaviya R and Uckun FM (1999) Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions.
	dmd.aspetjournals.org /cgi/content/full/30/1/74 (6622 words)

	BLAST Search Results
		Mus musculus Janus kinase 2 (Jak2), mRNA 1118 0.0 gbAF001362.1AF001362 Homo sapiens Jak2 kinase (JAK2) mRNA...
		1118 0.0 gbAF058925.1AF058925 Homo sapiens Jak2 kinase mRNA, compl...
		Homo sapiens TXK tyrosine kinase (TXK), mRNA 164 5e-38 gbL27071.1HUMTYRKINA Human tyrosine kinase (TXK) mRNA, co...
	www.chickest.udel.edu /orthochick/c37.html (2904 words)

	IngentaConnect JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transduce... (Site not responding. Last check: 2007-10-03)
		IngentaConnect JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transduce...
		JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
		In addition to its role as a tyrosine kinase inhibitor, JSI-124 appears to be involved in regulating proteosome degradation for proteins such as JAK3 and NPM-ALK.
	www.ingentaconnect.com /content/bsc/bjh/2006/00000135/00000001/art00006 (341 words)

	Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents ...
		Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis.
		We have used tyrphostin B42 (AG490), a Jak-2 inhibitor, to determine the role of Jak-2 kinase in IL-12 signaling and IL-12-induced T cell functions.
		Treatment of activated T cells with tyrphostin B42 inhibited the IL-12-induced tyrosine phosphorylation and activation of Jak-2 without affecting Tyk-2 kinase.
	www.aegis.com /aidsline/1999/aug/A9980323.html (507 words)

	Localization of Janus Kinase 2 to the Nuclei of Mature Oocytes and Early Cleavage Stage Mouse Embryos -- Ito et al. 71 ...
		Localization of Janus Kinase 2 to the Nuclei of Mature Oocytes and Early Cleavage Stage Mouse Embryos -- Ito et al.
		Protein tyrosine kinase activity during egg activation is important for morphogenesis at gastrulation in the sea urchin embryo.
		Insulin induces rapid accumulation of insulin receptors and increases tyrosine kinase activity in the nucleus of cultured adipocytes.
	www.biolreprod.org /cgi/content/full/71/1/89 (4424 words)

	Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with ... (Site not responding. Last check: 2007-10-03)
		Janus kinase 3 (Jak3) is a cytoplasmic tyrosine (Tyr) kinase associated with the interleukin-2 (IL-2) receptor common gamma
		Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
		Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation.
	www.bloodjournal.org /cgi/content/full/99/2/680 (6238 words)

	Interactive Fly, Drosophila
		Despite a lack of catalytic kinase domains, these receptors combine ligand binding with the induction of tyrosine phosphorylation.
		This means that members of the Janus kinase (JAK) family of cytoplasmic protein tyrosine kinases physically associate with ligand-bound receptors.
		Because Hunchback and Knirps set the anterior and posterior borders of eve stripe 3, the JAK-STAT pathwy is not needed to spatially activate eve.
	www.sdbonline.org /fly/gene/hopscotc.htm (622 words)

	Induction of Endothelial NO Synthase by Hydrogen Peroxide via a Ca2+/Calmodulin-Dependent Protein Kinase II/Janus ...
		CaM kinase II was detected in the cytoplasm.
		Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells.
		Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans.
	atvb.ahajournals.org /cgi/content/full/21/10/1571 (4055 words)

	Identification of an Acquired Mutation in Jak2 Provides Molecular Insights into the Pathogenesis of Myeloproliferative ...
		Saharinen, P., Vihinen, M., and Silvennoinen, O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain.
		Giordanetto, F. and Kroemer, R.T. Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.
		Huang, L.J., Constantinescu, S.N., and Lodish, H.F. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.
	molinterv.aspetjournals.org /cgi/content/full/5/4/211 (3229 words)

	Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by ...
		A, MAPK activity in cell lysates was assayed by an in-gel kinase assay.
		A, The kinase activity of the cell lysates was assayed by an in-gel kinase assay.
		Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR 1995 PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
	endo.endojournals.org /cgi/content/full/138/9/3666 (7402 words)

	Genome Biology \| Abstract \| The Janus kinases (Jaks)
		The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases.
		Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors through amino-terminal FERM (Band-4.1, ezrin, radixin, moesin) domains.
		Upon binding of cytokines to their receptors, Jaks are activated and phosphorylate the receptors, creating docking sites for signaling molecules, especially members of the signal transducer and activator of transcription (Stat) family.
	genomebiology.com /2004/5/12/253/abstract (227 words)

	Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to ...
		Janus kinase/STAT and PI 3-kinase regulation of Mcl-1 contributed
		Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways.
		C-fps/fes protein-tyrosine kinase is implicated in a signalling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.
	www.jimmunol.org /cgi/content/full/166/12/7486 (6419 words)

	Rigel's Janus Kinase 3 (JAK3) Inhibitors Show Benefit In Organ Transplant Model And Potential Use In Immunosuppression
		Current anti-rejection therapy suppresses the immune system with a cocktail of drugs including cyclosporin and steroids, the long-term use of which has been shown to cause kidney damage, hypertension, atherosclerosis, and diabetes.
		JAK3 is a cytoplasmic tyrosine kinase with expression limited to T cells, B cells, natural killer (NK) cells, mast cells, and macrophages.
		JAK3 acts in the signal transduction cascade of numerous growth factors critical for lymphocyte (white blood cell) activation, and plays an important role in lymphocyte differentiation and proliferation.
	www.medicalnewstoday.com /medicalnews.php?newsid=47707 (613 words)

	In Vivo Toxicity and Pharmacokinetic Features of the Janus Kinase 3 Inhibitor WHI-P131 ...
		Nakamura N., Chin H., Miyasaka N., Miura O. An epidermal growth factor receptor/JAK2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells.
		Ihle J. The Janus protein tyrosine kinase family and its role in cytokine signaling.
		Witthuhn B. A., Williams M. D., Kerawalla H., Uckun F. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
	clincancerres.aacrjournals.org /cgi/content/full/5/10/2954 (4203 words)

	Janus Kinase 2 Determinants for Growth Hormone Receptor Association, Surface Assembly, and Signaling -- He et al. 17 ...
		Janus Kinase 2 Determinants for Growth Hormone Receptor Association, Surface Assembly, and Signaling -- He et al.
		Janus Kinase 2 Determinants for Growth Hormone Receptor Association, Surface Assembly, and Signaling
		Janus Kinase 2 Enhances the Stability of the Mature Growth Hormone Receptor
	mend.endojournals.org /cgi/content/abstract/17/11/2211 (766 words)

	Bovine Interferon-{{tau}} Stimulates the Janus Kinase-Signal Transducer and Activator of Transcription Pathway in ...
		Bovine Interferon-{{tau}} Stimulates the Janus Kinase-Signal Transducer and Activator of Transcription Pathway in Bovine Endometrial Epithelial Cells -- Binelli et al.
		Stimulates the Janus Kinase-Signal Transducer and Activator of Transcription Pathway in Bovine Endometrial Epithelial Cells
		kinase in a microfuge tube (500 µl) and incubated for
	www.biolreprod.org /cgi/content/full/64/2/654 (6730 words)

	Protein kinase - Wikipedia, the free encyclopedia
		A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
		Orientations of C1 domains of protein kinases in membranes
		Orientations of C2 domains of protein kinases and other proteins in membranes
	en.wikipedia.org /wiki/Protein_kinase (968 words)

Try your search on: Qwika (all wikis)