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	Joseph L. Goldstein Biography (1940-)
		Joseph Leonard Goldstein, the only son of Isadore E. and Fannie (Albert) Goldstein, was born on April 18, 1940, in Sumter, South Carolina.
		During this process, Goldstein and Brown were able to follow the manner inwhich the cells obtained cholesterol, and identify the process of cholesterolextraction from the lipoproteins in the serum of the culture medium, specifically LDLs.
		Goldstein's and Brown's research illuminating the activity of LDL receptors and their function in the management of cholesterol levels has had far-reaching effects.
	www.faqs.org /health/bios/46/Joseph-L-Goldstein.html (1472 words)

	Joseph L. Goldstein - Biography
		Joseph L. Goldstein was born on April 18, 1940, in Sumter, South Carolina, the only son of Isadore E. and Fannie Alpert Goldstein.
		After receiving the M.D. degree in 1966, Goldstein moved to Boston where he was an Intern and Resident in Medicine at the Massachusetts General Hospital (1966-68).It was at the Massachusetts General Hospital that Goldstein first met and developed a friendship with Michael S. Brown, his long-term scientific collaborator.
		In Seattle, Goldstein initiated and completed a population genetic study to determine the frequency of the various hereditary lipid disorders in an unselected population of heart attack survivors.
	nobelprize.org /nobel_prizes/medicine/laureates/1985/goldstein-bio.html (1027 words)

	The New York Academy of Medicine: News & Publications: Nobel Laureates Goldstein and Brown Receive Glorney-Raisbeck ...
		Goldstein in his lecture talked about the alarming prevalence of obese and overweight adults in America, and explained that being overweight can lead to diabetes and to “Syndrome X,” the most common cause of heart attacks in people under age 70.
		Goldstein explained that a molecule known as SREBP (“sterol-regulatory element-binding protein”) is the key to this dysfunction.
		The Academy is a non-profit institution founded in 1847 that is dedicated to enhancing the health of the public through research, education and advocacy, with a particular focus on disadvantaged urban populations.
	www.nyam.org /news/2176.html (663 words)

	Goldstein, Joseph L.
		Goldstein received his B.S. degree from Washington and Lee University, Lexington, Va., in 1962 and obtained his medical degree from the Southwestern Medical School of the University of Texas at Dallas in 1966.
		Goldstein then conducted research under the auspices of the National Institutes of Health from 1968 to 1972, studying genetically predisposing factors that caused the accumulation of blood cholesterol in people prone to heart attacks.
		From 1976 Goldstein was professor of medicine and from 1977 chairman of the department of molecular genetics at the University of Texas Health Science Center in Dallas.
	www.britannica.com /nobel/micro/239_22.html (316 words)

	HHMI News: Joseph L. Goldstein Is Elected HHMI Trustee (Site not responding. Last check: 2007-11-04)
		Goldstein, 62, received his medical degree from UT Southwestern in 1966, where he became first interested in genetics and in a research career.
		Goldstein is Trustee of The Rockefeller University, chair of the awards jury for the Albert Lasker Medical Research Awards, and a scientific adviser to numerous academic institutions.
		Goldstein is a member of the National Academy of Sciences, and a foreign member of the Royal Society (London).
	www.practicingsafescience.org /news/090502.html (836 words)

	Joseph L. Goldstein, PhD
		Joseph L. Goldstein is the recipient of this year’s
		Goldstein is a member of the U.S. National Academy of Sciences (elected 1980),
		Goldstein was a Harvey Society Lecturer in 1977.
	www.aacc.org /AACC/about/awards/hall_of_fame/JosephGoldstein1988L.htm (377 words)

	Board News (Site not responding. Last check: 2007-11-04)
		Brown and Goldstein were awarded the Nobel Prize in Medicine for their work in the regulation of cholesterol metabolism, and in 1988 they received the National Medal of Science.
		Joseph L. Goldstein, M.D. is Professor and Chairman of the Department of Molecular Genetics at University of Texas Southwestern Medical Center at Dallas.
		Goldstein, along with Dr. Brown, pioneered a multidisciplinary approach to the study of hypercholesterolemia by using a combination of biochemistry, somatic cell genetics, molecular biology and, most recently, gene regulation and cell biology.
	www.cumbre.net /board_news.htm (788 words)

	Washingtonpost.com: Politics
		Goldstein, who died at 85 at his Calvert County home over the weekend, was the unbeatable "Mr.
		Goldstein may be best remembered for his robust handshake and drawled signature greeting, "God bless y'all real good," behind this folksy manner was a keen financial acumen.
		Goldstein also was one of three members of the powerful Board of Public Works, which approves most state contracts and major purchases.
	www.washingtonpost.com /wp-srv/politics/campaigns/junkie/links/goldstein3.htm (349 words)

	Goldstein, Joseph L.
		Goldstein, Joseph L. Goldstein, Joseph L. Joseph L. Goldstein was born on April 18, 1940, in Sumter, South Carolina, the only son of Isadore E. and Fannie Alpert Goldstein.
		In Seattle, Goldstein initiated and completed a population genetic study to determine the frequency of the various hereditary lipid disorders in an unselected population of heart attack survivors.
		Goldstein was elected to membership in the National Academy of Sciences in 1980.
	www.cartage.org.lb /en/themes/Biographies/MainBiographies/G/Goldstein1/Goldstein.htm (954 words)

	AllRefer.com - Joseph Leonard Goldstein (Biochemistry, Biography) - Encyclopedia
		Joseph Leonard Goldstein[gOld´stIn] Pronunciation Key, 1940–, American molecular geneticist, b.
		Goldstein and colleague Michael S. Brown researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream.
		In 1985, Goldstein and Brown were jointly awarded the Nobel Prize in Physiology or Medicine.
	reference.allrefer.com /encyclopedia/G/Goldstei.html (217 words)

	UT Southwestern researchers, Nobel Prize winners share 2003 Albany Medical Center Prize
		Brown and Goldstein shared the 1985 Nobel Prize in physiology or medicine for their discovery of the mechanism by which cholesterol accumulates in the bloodstream, leading to a condition known as atherosclerosis, which is responsible for more than half the deaths in the United States by heart attack or stroke.
		In other areas of research, Brown and Goldstein pioneered the development of a new class of drugs, called farnesyl transferase inhibitors, that are currently being tested in patients with cancer.
		Goldstein received his bachelor's degree from Washington and Lee University in 1962 and his medical degree from UT Southwestern Medical School in 1966.
	www.eurekalert.org /pub_releases/2003-04/uots-usr043003.php (893 words)

	Joseph L Goldstein Information (Site not responding. Last check: 2007-11-04)
		He was a HebrewsHebrew who was known for receiving a multi-colored cloak from his father and later interpreted dreams, as well as a commodities trader for the Ancient Egyptian state.
		**''Joseph and the Amazing Technicolor Dreamcoat'' is a work of musical theater about the same character, by Andrew Lloyd Webber and Tim Rice.
		* Saint JosephJoseph of Nazareth, or '''Saint Joseph''' is a figure prominent in Christianity, from the New Testament who was husband of Mary and thus foster-father of Jesus.
	www.echostatic.com /Joseph_L_Goldstein.html (329 words)

	\|\| DukeMedNews \|\| Email (Site not responding. Last check: 2007-11-04)
		DURHAM, N.C. – Joseph L. Goldstein, M.D., winner of the 1985 Nobel Prize in physiology/medicine, will be the keynote speaker for the Medical Scientist Training Program's annual lecture on Friday, May, 3 at Duke University Medical Center.
		Goldstein is chairman of the department of molecular genetics at the University of Texas Southwestern Medical Center.
		Goldstein also serves as chairman of the Medical Advisory Board of the Howard Hughes Medical Institute, is a member of the Board of Trustees of The Rockefeller University and is a member of the U.S. National Academy of Sciences.
	www.dukemednews.org /global/email.php?context=/news/article.php&id=5494 (217 words)

	[No title]
		Two researchers currently dominate the field of cholesterol metabolism, Dr. Michael S. Brown and Dr. Joseph L. Goldstein, who in 1985 won the Nobel Prize in Physiology and Medicine for their innovations regarding the regulatory methods of cholesterol metabolism.
		Dr. Goldstein is an alumnus of Washington and Lee and currently works with Dr. Brown at the Southwestern School of Biomedical Science in Dallas, where they are continuing research on their discovery of LDL-receptor mediated endocytosis.
		Goldstein and Brown are presently conducting research on sterol regulatory element binding proteins (SREBP’s) to determine the mechanism by which the proteins regulate cholesterol metabolism at the molecular, cellular, and bodily level, in conjunction with the LDL-receptor and de novo cholesterol synthesis.
	journalofscience.wlu.edu /archive/Spring2000/05Cholesterol(SarahPollan).doc (979 words)

	Nobel laureates to open ASBMB annual meeting in San Diego
		Both Dr. Michael S. Brown and Dr. Joseph L. Goldstein, who were awarded the 1985 Nobel Prize in Physiology or Medicine for their discoveries concerning the regulation of cholesterol metabolism, will be on stage to open the Society's Annual Meeting on April 2 at 6:00 p.m.
		The Goldstein and Brown laboratory uncovered RIP through study of SREBPs, transcription factors that regulate the synthesis and uptake of cholesterol and fatty acids in animal cells.
		Goldstein and Dr. Brown have worked together for the last 30 years on the genetics and regulation of cholesterol metabolism.
	www.medicalnewstoday.com /medicalnews.php?newsid=21130&nfid=rssfeeds (543 words)

	Goldstein Delivers 3rd Annual Lerner Lecture
		Goldstein's recent research interests focus on Sterol Regulatory Element Binding Proteins (SREBPs) and the mechanism by which they regulate cholesterol metabolism at the molecular, cellular and whole body levels.
		Goldstein and Brown developed a model for integrating multi-disciplinary approaches to unravel the mysteries of human biology, pathologies and molecular medicine.
		Goldstein is Professor of Molecular Genetics and Internal Medicine and Regental Professor at the University of Texas Southwestern Medical Center at Dallas.
	www.lerner.ccf.org /news/2002/0726.php (360 words)

	15041 Private Joseph L. Vince, Royal Canadian Regiment (Site not responding. Last check: 2007-11-04)
		Joseph Vince was born in Ballarat, Victoria, Australia, in 1871, the 9th of 10 children, all born in Ballarat like their parents.
		When Joseph Vince enlisted in 1900, 1st Battalion Oxfordshire Light Infantry (the old 43rd Light Infantry of the Peninsular War fame) had been in South Africa since December 1899, The 2nd Battalion (the old 52nd Light Infantry also of the Famous Light Division in the Peninsular) were then in India (posted there in 1894).
		Joseph Vince obtained a 2nd class certificate of education on the 26th January 1903; he got his first promotion on the 22nd August 1904 as Unpaid Lance Corporal.
	www.victorianweb.org /history/empire/vince1.html (1173 words)

	Search Results for Goldstein - Encyclopædia Britannica
		Goldstein, Joseph L. American molecular geneticist who, along with Michael S. Brown, was awarded the 1985 Nobel Prize for Physiology or Medicine for their elucidation of the process of cholesterol metabolism in the human...
		Brown, Michael S. American molecular geneticist who, along with Joseph L. Goldstein, was awarded the 1985 Nobel Prize for Physiology or Medicine for their elucidation of a key link in the metabolism of cholesterol in...
		Biographies of Michael S. Brown and Joseph L. Goldstein of the U.S. Features a press release on the occasion of their jointly winning the medicine prize "for their discoveries concerning the regulation of cholesterol metabolism".
	www.britannica.com /search?query=Goldstein&submit=Find&source=MWTAB (412 words)

	Joseph L. Goldstein -- Encyclopædia Britannica
		in full Joseph Leonard Goldstein American molecular geneticist who, along with Michael S. Brown, was awarded the 1985 Nobel Prize for Physiology or Medicine for their elucidation of the process of cholesterol metabolism in the human body.
		Brown, Michael S. American molecular geneticist who, along with Joseph L. Goldstein, was awarded the 1985 Nobel Prize for Physiology or Medicine for their elucidation of a key link in the metabolism of cholesterol in the human body.
		Mankiewicz, Joseph L. motion-picture director, screenwriter, and producer Joseph Mankiewicz became one of Hollywood's most celebrated writers for creating screenplays with fascinating story lines as well as witty, often biting dialogue.
	www.britannica.com /eb/article-9037283 (752 words)

	HHMI Bulletin: Ace of Hearts
		Nobel Prize laureates Michael S. Brown and Joseph L. Goldstein still remember their reactions when they heard that Helen H. Hobbs was coming to work in their lab some 20 years ago.
		For more than a decade before Hobbs joined their lab in the early 1980s, the two scientists had been studying familial hypercholesterolemia (FH), an inherited condition in which blood levels of LDL cholesterol are not only stratospheric but also resist any attempts at control through diet, medication, or lifestyle changes.
		In the early 1970s, Brown and Goldstein had discovered that the disease stems from a defect in the LDL receptor—a protein on the surface of cells that snatches LDL cholesterol from the bloodstream and helps it into the cell.
	www.hhmi.org /bulletin/spring2004/hobbs/hobbs2.html (2139 words)

	Joseph L. Goldstein Winner of the 1985 Nobel Prize in Medicine
		Joseph L. Goldstein Winner of the 1985 Nobel Prize in Medicine
		Joseph L. Goldstein — Biography (submitted by Helly)
		Joseph L. Goldstein Biography from Encyclopedia Britannica (submitted by www.britannica.com)
	www.almaz.com /nobel/medicine/1985b.html (98 words)

	Department of Biochemistry, Attie Lab
		Michael Brown and Joseph Goldstein upon learning that they were awarded the Nobel Prize in Medicine or Physiology in 1985.
		More recently, Brown and Goldstein have continued their outstanding research in cholesterol metabolism by elucidating the mechanism by which sterol responsive genes are transcriptionally regulated.
		Brown MS, Goldstein JL, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor., Cell 89: 3, 331-40 (1997).
	www.biochem.wisc.edu /attie/LDLR1.html (376 words)

	Joseph_goldstein (Site not responding. Last check: 2007-11-04)
		Goldstein Delivers What He Promises : What makes Joseph Goldstein's THE EXPERIENCE OF INSIGHT such an excellent book is that it lives up to its subtitle, "A Simple and Direct Guide to Buddhist Meditation." And yet at the same time it is both subtle and profound...
		As Buddhism continues to grow in the West, Goldstein shows us the value of uniting this movement rather than allowing it to become fractured by its subtle differences.
		Not as Significant a Book as the Title Might Suggest : Joseph Goldstein's latest book is basically a very good synopsis of his personal journey in the Buddha.Dharma and in his own practice...
	books.mysic.ca /Author/Joseph_Goldstein (810 words)

	Regulation of the mevalonate pathway
		Luskey, K. L., Faust, J. R., Chin, D. J., Brown, M. and Goldstein, J. biol.
		Goldstein, J. L., Dana, S. E., Faust, J. R., Beaudet, A. and Brown, M. biol.
		Gutierrez, L., Magee, A. I., Marshall, C. and Hancock, J. PubMed
	www.nature.com /doifinder/10.1038/343425a0 (780 words)

	Ferid Murad, M.D., Ph.D.,
		Johann Deisenhofer, Ph.D., of the UT Southwestern Medical Center at Dallas, who shared the 1988 prize in chemistry for the determination of the three-dimensional structure of a photosynthetic reaction center.
		Michael S. Brown, M.D., and Joseph L. Goldstein, M.D., of the UT Southwestern Medical Center at Dallas, who won the 1985 prize in physiology or medicine for discoveries involving cholesterol and cholesterol-related diseases.
		Steven Weinberg, Ph.D., of UT Austin, who shared the 1979 prize in physics for contributions to the theory of the unified weak and electromagnetic interaction between elementary particles.
	oac.hsc.uth.tmc.edu /radiology/murad.html (274 words)

	Joseph L. Goldstein (Site not responding. Last check: 2007-11-04)
		Goldstein Is Elected a Trustee of the Howard Hughes Medical Institute.
		Goldstein, M.D. Congressional Testimony April 28,1999 Thank you very much, Mr.
		Joseph L. Goldstein nació en Sumter, California del Sur, Estados Unidos el 18 de abril de 1940.
	enciclopedia.cc /Joseph_L._Goldstein (293 words)

	The Clinical Investigator: Bewitched, Bothered, and Bewildered ---But Still Beloved -- Goldstein and Brown 99 (12): ...
		Brown, M.S., and J.L. Goldstein (1986) A receptor-mediated pathway for cholesterol homeostasis.
		Goldstein, J.L., R.G.W. Anderson, and M.S. Brown (1979) Coated pits, coated vesicles, and receptor-mediated endocytosis.
		Hua, and J.L. Goldstein (1994) SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
	www.jci.org /cgi/content/full/99/12/2803 (6769 words)

	Overproduction of Cholesterol and Fatty Acids Causes Massive Liver Enlargement in Transgenic Mice Expressing Truncated ...
		The liver was removed, and 200-300 mg portions were saponified, and the digitonin-precipitable sterols were isolated as previously described (41).
		Yang, J., Sato, R., Goldstein, J.L., Brown, M.S. Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.
		Chin, D.J., Gil, G., Russell, D.W., Liscum, L., Luskey, K.L., Basu, S.K., Okayama, H., Berg, P., Goldstein, J.L., Brown, M.S. Nucleotide sequence of 3-hydroxy-3-methylglutaryl CoA reductase, a glycoprotein of the endoplasmic reticulum.
	www.jci.org /cgi/content/full/98/7/1575 (7976 words)

	Michael Brown and Joseph Goldstein: The Cholesterol Doctors - Robert G. Fenley
		In this disease, cholesterol accumulates in arterial walls, forming plaques that restrict blood flow, and the obstruction of an artery can eventually lead to heart attack or stroke: This much has been known for a long time.
		But it is the work of two Texas doctors--Michael S. Brown and Joseph L. Goldstein--that has delved into the how and why of life-threatening plaque formation.
		In striving to understand the mechanisms that regulate the levels of LDL cholesterol in the bloodstream, Brown and Goldstein discovered the central role that an intriguing cellular mechanism called the LDL receptor has in removing LDL cholesterol from the body's circulatory system.
	www.worldandi.com /specialreport/1989/january/Sa15894.htm (294 words)

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