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	K. Barry Sharpless - Wikipedia, the free encyclopedia
		Karl Barry Sharpless (born April 28, 1941) is an American chemist renowned for his work on organometallic chemistry.
		Sharpless became professor at the Massachusetts Institute of Technology, Stanford University, and the Scripps Research Institute, where he currently holds the W. Keck professorship in chemistry.
		Barry also has only one eye; the other was injured when, an NMR tube exploded in his face while he was observing the work of a graduate student.
	en.wikipedia.org /wiki/K._Barry_Sharpless (417 words)

	C&EN: COVER STORY - IN SITU CLICK CHEMISTRY
		Finn, one of Sharpless' collaborators, notes that a practical benefit of the strategy is that detecting a hit (an inhibitor of a protein target) "relies not upon characterizing the target protein's function in the presence of the candidate, but rather on detecting the production of a new small molecule.
		According to Sharpless, "The building blocks are effectively orthogonal, within limits, to the typical reactive groups and conditions encountered in enzymes and most other biological systems"--that is, they don't tend to cross-react with biomolecules.
		In the nonbiological area, Sharpless, Finn, and coworkers are collaborating with groups led by chemistry professors Paul S. Weiss and Raymond L. Funk of Penn State and James M. Tour of Rice University in an effort to develop surfaces with precise chemical patterns at the nanometer scale.
	pubs.acs.org /cen/coverstory/8006/8006clickchemistry.html (2432 words)

	K. Barry Sharpless is awarded the 2001 Noble Prize in chemistry
		Barry Sharpless, Ph.D., W.M. Keck Professor of Chemistry at The Skaggs Institute for Chemical Biology and the Department of Chemistry at The Scripps Research Institute (TSRI), has been awarded the 2001 Nobel Prize in Chemistry.
		Sharpless was awarded this year's prize in chemistry along with William S. Knowles of Monsanto and Ryoji Noyori of Nagoya University in Japan for the development of catalytic asymmetric synthesis.
		Sharpless was elected to the National Academy of Sciences in 1985.
	www.eurekalert.org /pub_releases/2001-10/sri-kbs101101.php (527 words)

	Sharpless epoxidation - Wikipedia, the free encyclopedia
		Sharpless epoxidation is a chemical reaction of an allylic alcohol with t-butylperoxide and titanium tetraisopropylate to form an epoxide.
		Epoxides can be easily converted into dialcohols, aminoalcohols or ethers, so formation of chiral epoxides is a very important step in the synthesis of natural products.
		Barry Sharpless shared the Nobel prize in 2001 for his work on asymmetric oxidations.
	en.wikipedia.org /wiki/Sharpless_epoxidation (106 words)

	Danforth Lecturer 2002- Sharpless
		Sharpless is best known for discovering three "name" reactions, general methods for catalytic asymmetric epoxidation, dihydroxlylation, and aminohydroxylation.
		Also in 2001, Sharpless turned 60, an event celebrated with a three-day symposium during the American Chemical Society's annual meeting; all of the symposium's 33 speakers were former members of Sharpless's research group.
		Sharpless is W.M. Keck Professor of Chemistry at the Scripps Research Institute.
	www.grinnell.edu /academic/chemistry/danforth/sharplessvisit/jnl (233 words)

	Sharpless, former MIT professor, wins Nobel in chemistry - MIT News Office
		It was at MIT that he fully developed the process now known as the Sharpless Asymmetic Epoxidation and it was also here that he and his coworkers discovered the Sharpless Asymmetric Dihydroxylation.
		"Barry's friends and former colleagues here at MIT are thrilled that his important contributions to chemistry have been recognized with this year's Nobel Prize in chemistry," said Rick L. Danheiser, A. Cope Professor and associate department head in chemistry.
		Sharpless is awarded half of the prize for developing chiral catalysts for oxidation reactions.
	web.mit.edu /newsoffice/2001/sharpless.html (566 words)

	SignOnSanDiego > News > Science -- Research is breakthrough
		Sharpless, a scientist at The Scripps Research Institute, shared the prestigious award with William S. Knowles of St. Louis and Ryoji Noyori of Japan's Nagoya University.
		Sharpless said he usually stays up late, and with only an hour's sleep he was disoriented when he answered the first congratulatory phone call, from Scripps colleague Ehud "Udi" Keinan.
		Sharpless acknowledged that as a youth, he was diagnosed with attention deficit disorder.
	www.signonsandiego.com /news/science/20011011-9999_7m11sharp.html (979 words)

	NIGMS GRANTEE K. BARRY SHARPLESS WINS NOBEL PRIZE FOR ADVANCES IN MIRROR-IMAGE CHEMISTRY - ...
		Barry Sharpless, a long-time grantee of the National Institute of General Medical Sciences, a component of the National Institutes of Health, was awarded the 2001 Nobel Prize in Chemistry today for his discovery of "chiral catalysts" -- molecules that enable researchers to selectively control chemical reactions.
		In 1990, NIGMS gave Dr. Sharpless a MERIT award, which provides investigators who have demonstrated superior competence and outstanding productivity with long-term, stable support to foster their continued research contributions.
		Early in his career, Dr. Sharpless also received fellowship support from what is now the National Heart, Lung, and Blood Institute.
	www.medicalnewsservice.com /fullstory.cfm?storyID=523&fback=yes (460 words)

	Fiftieth Annual NSTA Convention Underway in San Diego (Site not responding. Last check: 2007-10-08)
		Barry Sharpless, a 2001 Nobel Laureate in Chemistry; and Dr. John H. Marburger, who heads the White House Office of Science and Technology (OSTP).
		In a highly personal presentation, Sharpless described his journey of scientific discovery and professional growth, from his childhood in New Jersey to his college days at Dartmouth to his trip to Sweden for science's ultimate honor: the Nobel Prize.
		Interestingly, Sharpless admitted that he was not very engaged in science as a boy — his main pursuits were fishing and photography.
	www.nsta.org /main/news/stories/nsta_story.php?news_story_ID=46832 (742 words)

	Pomona College : News@Pomona (Site not responding. Last check: 2007-10-08)
		Barry Sharpless, who won the 2001 Nobel Prize in Chemistry, will give four lectures on his current research, as part of the 41st Fred J. Robbins Lectureship, at Pomona College.
		Sharpless is currently the W. Keck Professor of Chemistry at The Scripps Research Institute (TSRI) in La Jolla.
		Sharpless joined The Scripps Research Institute as the W. Keck Professor in 1990 and has worked at its Skaggs Institute for Chemical Biology since 1996.
	www.pomona.edu /events/news/NewsItems200203/012303robbins.shtml (459 words)

	K. Barry Sharpless Winner of the 2001 Nobel Prize in Chemistry
		Barry Sharpless Winner of the 2001 Nobel Prize in Chemistry
		Barry Sharpless' webpage at the Scripps Research Institute
		Barry Sharpless — Life In Science (submitted by Sam)
	almaz.com /nobel/chemistry/2001c.html (172 words)

	NIH Record--10/30/2001--NIH Grantees Win Nobel Prizes
		Two long-time NIH grantees have won Nobel Prizes: Dr. Leland H. Hartwell was awarded the 2001 Nobel Prize in Physiology or Medicine for his discovery of genes that control the cell division cycle; over the past 35 years, NIH has provided him more than $41 million in grant support.
		Barry Sharpless, a grantee of the National Institute of General Medical Sciences, who was honored for his discovery of "chiral catalysts" — molecules that enable researchers to selectively control chemical reactions.
		Early in his career, Sharpless also received fellowship support from what is now the National Heart, Lung, and Blood Institute.
	www.nih.gov /news/NIH-Record/10_30_2001/story03.htm (567 words)

	Chemistry professors lauded (Site not responding. Last check: 2007-10-08)
		Klaus Biemann and K. Barry Sharpless, professors of chemistry at MIT, were cited for outstanding research in chemistry by the American Chemical Society (ACS) last month.
		Sharpless was one of ten recipients of the annual Arthur C. Cope Scholar Award.
		Two past accomplishments which Sharpless values are receiving the ACS's Award for Creative Work in Synthetic Organic Chemistry in 1982 and being elected to the National Academy of Sciences in 1985.
	www-tech.mit.edu /V105/N44/chem.44n.html (458 words)

	SunSITE India : 2001 Nobel Chemistry prize (Site not responding. Last check: 2007-10-08)
		K. Barry Sharpless, on the other hand, is awarded half of the Prize for developing chiral catalysts for another important type of reaction - oxidation.
		The Laureates have opened up a completely new field of research in which it is possible to synthesise molecules and material with new properties.
		K. Barry Sharpless, 60 years, born 1941 Philadelphia, Pennsylvania, USA (US citizen).
	sunsite.iisc.ernet.in /nobel2001/che2001_rel.html (483 words)

	Ryoji Noyori - Wikipedia, the free encyclopedia (Site not responding. Last check: 2007-10-08)
		Noyori sided with pioneer working William S. Knowles for study of chirally catalyzed hydrogenations; the second half of the Prize went to K.
		Barry Sharpless for his study in chirally catalyzed oxidation reactions (Sharpless epoxidation).
		This page was last modified 12:07, 6 Jan 2005.
	www.americancanyon.us /project/wikipedia/index.php/Ryoji_Noyori (116 words)

	NIH News Release--NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry- - 10/10/2001
		Barry Sharpless, a long-time grantee of the National Institute of General Medical Sciences, a component of the National Institutes of Health, was awarded the 2001 Nobel Prize in Chemistry today for his discovery of "chiral catalysts" — molecules that enable researchers to selectively control chemical reactions.
		After more than a decade of trying, in 1980 Dr. Sharpless figured out how to force a chemical reaction to go one-handed.
		For comments on Dr. Sharpless' NIGMS-supported research, call Alison Davis in the NIGMS Office of Communications and Public Liaison at (908) 735-7207 to arrange an interview with NIGMS director Dr. Marvin Cassman.
	www.nih.gov /news/pr/oct2001/nigms-10.htm (544 words)

	K. Barry Sharpless is awarded the 2001 Noble Prize in chemistry (Site not responding. Last check: 2007-10-08)
		Barry Sharpless is awarded the 2001 Noble Prize in chemistry
		Email the release "K. Barry Sharpless is awarded the 2001 Noble Prize in chemistry."
		Your e-mail address, and that of your recipient(s), will be used only to let the recipient(s) know who sent the link and in the case of transmission errors.
	www.eurekalert.org /emailrelease.php?file=sri-kbs101101.php (62 words)

	Boston.com / Latest News / Nation
		Nobel Prize winners in chemistry from left: William S. Knowles, of St. Louis, Mo., Ryoji Noyori of Nagoya University in Japan and K. Barry Sharpless of the Scripps Research Institute in La Jolla, Calif. (AP)
		Barry Sharpless, 60, of the Scripps Research Institute in La Jolla, Calif., won the other half.
		They overcame a key problem in making drugs: The molecules of many substances used as drugs come in two forms that are mirror images of each other, just as the left hand mirrors the right.
	www.boston.com /news/daily/10/knowles.htm (696 words)

	Barry K. Sharpless - CIRS (Site not responding. Last check: 2007-10-08)
		The Sharpless Lab pursues useful new reactivity and general methods for selectively controlling chemical reactions.
		Though the focus has progressed from regio- to stereo- to asymmetric and, now, to connectivity control, the core chemistry remains unchanged: the oxidation of olefins, that single most versatile, powerful and reliable (KBS argues) chemical transformation.
		The Sharpless Lab was the first academic chemistry group with robotics, and the lesson from the combinatorial numbers game was the primacy of reliability.
	www.cirs.net /researchers/Chemistry/sharpless.htm (250 words)

	Forbes.com: Lexicon's Quest For A New Blockbuster (Site not responding. Last check: 2007-10-08)
		Barry Sharpless, one of this year's Nobel Laureates in chemistry, and run by Alan J. Main, who once ran research for Novartis (nyse: NVS - news - people).
		Nobel laureate Sharpless had brought a powerful set of insights to Coelecanth.
		Drug-like chemicals are broken down into 2,000 building blocks and classified according to what kind of proteins similar drugs have glommed onto in the past.
	www.forbes.com /2001/11/15/1115lexg.html (804 words)

	10 Oct History: This Date
		Barry Sharpless, The Scripps Research Institute, La Jolla, California, USA.
		Sharpless realised that there was a great need for catalysts for asymmetric oxidations.
		Many scientists have identified Sharpless' epoxidation as the most important discovery in the field of synthesis during the past few decades.
	www.safran-arts.com /42day/history/nobel/nob1010.html (8143 words)

	Science & Technology at Scientific American.com: Nobel Prize in Chemistry Awarded for Discovery of Catalytic ... (Site not responding. Last check: 2007-10-08)
		This year's recipients of the Nobel Prize in Chemistry—William S. Knowles, Ryoji Noyori and K. Barry Sharpless—are honored for their work developing chiral molecules as catalysts.
		Barry Sharpless(below at right) of the Scripps Research Institute in La Jolla, Calif., was honored for developing chiral catalysts for a different class of reactions known as oxidations.
		Of particular note is his development of a process to produce only one form of glycidol, a molecule used in the pharmaceutical industry to manufacture cardiac medications known as beta blockers.
	sciam.com /article.cfm?articleid=00063537-E5B2-1C63-B882809EC588ED9F (417 words)

	Ascribe Higher Education News Service: NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image ... (Site not responding. Last check: 2007-10-08)
		Ascribe Higher Education News Service: NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry.@ HighBeam Research
		NIGMS Grantee K. Barry Sharpless Wins Nobel Prize for Advances in Mirror-Image Chemistry.
		"Dr. Sharpless' creativity has helped the entire field of chemistry...
	www.highbeam.com /library/doc0.asp?docid=1G1:79808017&refid=ink_tptd_np (194 words)

	Academy Fellow K. Barry Sharpless Awarded Wolf Prize in Chemistry
		Fellow K. Barry Sharpless Awarded Wolf Prize in Chemistry
		January 15, 2001—Academy Fellow K. Barry Sharpless (Scripps Research Institute, La Jolla, California) has been named a recipient of the 2001 Wolf Foundation Prize in chemistry.
		Sharpless, elected to the Academy in 1984, joins 20 Fellows and Foreign Honorary members who are previous winners of the chemistry prize.
	www.amacad.org /news/wolfchem.aspx (254 words)

	K. Barry Sharpless - Autobiography
		Like Sir Derek, Sir John is one of our gods; I stand awed at having participated in these events honoring them.
		And, finally, if I had a crown, its jewels would be the 75-or-so former Sharpless Group members who are research professors.
		The training received in the group is neither predictable nor quantifiable; likewise, it is not intended to produce a product that, for example, industry wants.
	nobelprize.org /chemistry/laureates/2001/sharpless-autobio.html (1775 words)

	References for Chem242a Fall 2005
		Hartmuth C. Kolb, Pher G. Andersson, K. Barry Sharpless
		Reversal of Regioselection in the Sharpless Asymmetric Aminohydroxylation of Aryl Ester Substrates.
		Sharpless, K. Barry; Verhoeven, Thomas R. Aldrichimica Acta 1979, 12(4), 63-74.
	library.caltech.edu /collections/rpb/chemistry/jrefch24205.htm (1275 words)

	Scientists Share Nobel Prize In Chemistry For Their Development Of Catalytic Asymmetric Synthesis
		Barry Sharpless, on the other hand, is awarded half of the Prize for developing chiral catalysts for another important type of reaction — oxidation.
		Barry Sharpless, 60 years, born 1941 Philadelphia, Pennsylvania, USA (US citizen).
		Editor's Note: The original news release can be found here.
	www.sciencedaily.com /releases/2001/10/011010073855.htm (653 words)

	2001 Franklin Institute Awards: Sharpless Symposium (Site not responding. Last check: 2007-10-08)
		Laureate K. Barry Sharpless, Benjamin Franklin Medal in Chemistry
		Hartmuth Kolb, Vice President of Chemisty, Coelacanth Corporation, "The Application of Click Chemistry to the Generation of Compound Sets for Drug Discovery."
		Barry Sharpless, Laureate, "Engaging Enzymes in the Synthesis of Their Own Inhibitors"
	sln.fi.edu /tfi/exhibits/bower/Ssymp.html (84 words)

	S. Bruce King - Research Interests and Publications
		Huang, J.; Zou, Z.; Kim-Shapiro, D. Ballas, S. K.; King, S. Hydroxyurea Analogs as Kinetic and Mechanistic Probes of the Nitric Oxide Producing Reactions of Hydroxyurea and Oxyhemoglobin,” J.
		Huang, J.; Hadimani, S. Rupon, J. Ballas, S. K.; Kim-Shapiro, D. B.; King, S. “Iron Nitrosyl Hemoglobin Formation from the Reactions of Hemoglobin and Hydroxyurea,” Biochemistry, 2002, 41, 2466-2474.
		Huang, Z.; Louderback, J. G.; King, S. Ballas, S. K.; Kim-Shapiro, D. "In Vitro Exposure to Hydroxyurea Reduces Sickle Red Blood Cell Deformability" Am.
	www.wfu.edu /Academic-departments/Chemistry/faculty/king-pub.html (573 words)

	Dominic Vincent McGrath
		Barry Sharpless' research talk on work performed in his research group at the Scripps Research Institute.
		Electronic Effects in Amine-Accelerated Osmylations." Sharpless, K.B.; Nelson, D.W.; Gypser, A.; Ho, P.-T.; Kolb, H.C.; Kondo, T.; Kwong, H.-L.; McGRATH, D.V.; Rubin, E.A.; Norrby, P.-O.; Gable, K.P. Am.
		"Reinvestigation of the Infrared Spectra of Oxoosmium(VI) Esters by Isotopic Labeling." McGRATH, D.V.; Brabson, G.D.; Sharpless, K.B.; Andrews, L. Inorg.
	www.chem.arizona.edu /faculty/mcgr/mcgrathcv.html (3876 words)

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