| | Ion channel Literature - Surface Charges of K channels. Effects of strontium on five cloned channels expressed in ... (Site not responding. Last check: 2007-10-13) |
 | | The effects of strontium (Sr2+; 7-50 mM) on five different cloned rat K channels (Kv1.1, Kv1.5, Kv1.6, Kv2.1, and Kv3.4), expressed in oocytes of Xenopus laevis, were investigated with a two-electrode voltage clamp technique. |
 | | The main effect was a shift of the Gk(V) curve along the potential axis, different in size for the different channels. |
 | | The estimated charge densities ranged from -0.37 (Kv1.1) to -0.11 (Kv3.4) e nm-2 and showed good correlation with the total net charge of the extracellularly located amino acid residues of the channel as well as with the charge of a specific region (the loop between the S5 segment and the pore forming segment). |
| www.ionchannels.org /showabstract.php?pmid=8894980 (227 words) |