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| | Flavonoids |
 | | We hypothesize that quercetin has anti-proliferative activity and the mechanisms of quercetin action may be through modulation of cell cycle and cell growth regulatory genes. |
 | | To test this hypothesis, we treated endometrial cancer cells (Ishikawa cell line) with quercetin, and cell proliferation, expression of growth signal genes (EGF, VEGF, and TGF-α), cell cycle genes (p53, p21, p73, and cyclin D1), and apoptosisrelated genes (bcl-2 and bax) were analyzed. |
 | | Results of these experiments demonstrate that after a 7-day exposure to 1, 10 and 100 μM of quercetin, growth of Ishikawa cells was inhibited by 3, 51 and 87%, respectively. |
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