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Effect of glandular kallikrein on distal nephron HCO- 3 secretion in rats and on HCO- 3 secretion in MDCK cells -- ... Lymphatic, renal, and urinary kallikrein in the rat. Involvement of renal kallikrein in the regulation of bicarbonate excretion in rats. Kallikrein and prekallikrein of the isolated basolateral membrane of rat kidney. ajprenal.physiology.org /cgi/content/full/273/5/F807   (4680 words)

Kinin-kallikrein system - Wikipedia, the free encyclopedia Bradykinin (BK), which acts on the B2 receptor and slightly on B1, is produced when kallikrein releases it from HMWK. Kallidin (KD) is released from LMWK by tissue kallikrein. Kallikreins (tissue and plasma kallikrein) are serine proteases that liberate kinins (BK and KD) from the kininogens. en.wikipedia.org /wiki/Kinin-kallikrein_system   (482 words)

Isolation and Characterization of the Porcine Tissue Kallikrein Gene Family Kallikreins are members of a multigene family of serine proteases that are widespread throughout living organisms. All kallikreins were expressed in the thymus suggesting that the thymus would be a good candidate tissue to study functional roles of kallikreins. The expression of kallikreins in an array of tissues suggests the involvement of tissue kallikreins in diverse physiological roles. www.ansi.okstate.edu /research/2005rr/2005rr/17/17.htm   (2057 words)

Kallikrein gene families The glandular or tissue kallikreins are a sub-family of serine proteases, with a high degree of substrate specificity and diverse expression in various tissues and biological fluids. Nowadays kallikrein enzymes are divided into two groups, plasma (EC 3.4.21.34) and tissue (EC 3.4.21.35) kallikreins, which differ significantly in their molecular weight, substrate specificity, immunological characteristics, gene structure, and type of the kinin released. Kallikreins are heat-stable glycoproteins with a single polypeptide chain, with molecular weight varying between 27 to 40 kDa (Clements 1989 and the references therein). herkules.oulu.fi /isbn9514267702/html/i1000444.html   (2894 words)

Kallikrein 14 antibody (ab3229) datasheet   (Site not responding. Last check: 2007-10-17) Kallikrein 14 was discovered by cloning the kallikrein locus on chromosome 19 and was found to be similar to the other kallikrein family genes. Kallikrein 14 is produced by a number of tissues, including the brain, spinal cord, esophagus, salivary gland, breast, prostate, uterus, lung, thymus and thyroid. Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. www.abcam.com /?datasheet=3229   (637 words)

Vascular remodeling and the kallikrein-kinin system -- Carretero 115 (3): 588 -- Journal of Clinical Investigation inactivation of the tissue kallikrein gene in mice induced endothelial Nolly, H., Carretero, O.A., and Scicli, A.G. Kallikrein release by vascular tissue. Renal kallikrein in venous effluent of filtering and non-filtering isolated kidneys. www.jci.org /cgi/content/full/115/3/588   (1655 words)

Localization and Expression of Tissue Kallikrein and Kallistatin in Human Blood Vessels -- Wolf et al. 47 (2): 221 -- ... Tissue kallikrein is a serine proteinase that cleaves kininogen Chao J, Schmaier A, Chen LM, Yang Z, Chao L (1996) Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease. Nolly HL, Scicli AG, Scicli G, Carretero OA (1985) Characterization of a kininogenase from rat vascular tissue resembling tissue kallikrein. www.jhc.org /cgi/content/full/47/2/221   (3241 words)

Detection of Kallikrein Gene Expression and Enzymatic Activity in Porcine Endometrium During the Estrous Cycle and ... Detection of Kallikrein Gene Expression and Enzymatic Activity in Porcine Endometrium During the Estrous Cycle and Early Pregnancy -- Vonnahme et al. Detection of Kallikrein Gene Expression and Enzymatic Activity in Porcine Endometrium During the Estrous Cycle and Early Pregnancy Kallikrein enzyme activity in endometrial culture media of uterine tissue collected from cyclic and pregnant gilts on Days 10, 12, and 15. www.biolreprod.org /cgi/content/full/61/5/1235   (4163 words)

Temporal and Tissue-Specific Expression of Kallikrein (Klk) Genes and Identification of a Novel Klk Messenger ... that is encoded by a kallikrein gene [24, 25]. Clements J, Mukhtar A. Glandular kallikreins and prostate-specific antigen are expressed in the human endometrium. Drinkwater C, Evans B, Richards R. Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding protein. www.biolreprod.org /cgi/content/full/61/3/621   (5092 words)

Role of kallikrein-kininogen system in insulin-stimulated glucose transport after muscle contractions -- Dumke et al. ... We studied the effects of SBTI and aprotinin, which are commonly used kallikrein inhibitors (11, 12, 24, 32). Kallikreins and kinins: molecular characteristics and cellular and tissue responses. Characterization of a kininogenase from rat vascular tissue resembling tissue kallikrein. jap.physiology.org /cgi/content/full/92/2/657   (4612 words)

Human Kallikrein 10 Expression in Normal Tissues by Immunohistochemistry -- Petraki et al. 50 (9): 1247 -- Journal of ... of kallikreins in the anterior lobe of the pituitary and in Magklara A, Cheung CC, Asa SL, Diamandis EP (2000) Expression of prostate-specific antigen and human glandular kallikrein 2 in the thyroid gland. Yousef GM, Obiezu CV, Luo LY, Black MH, Diamandis EP (1999b) Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. www.jhc.org /cgi/content/full/50/9/1247   (5552 words)

Prognostic Value of the Human Kallikrein Gene 15 Expression in Ovarian Cancer -- Yousef et al. 21 (16): 3119 -- Journal ... From the Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; National Center for Scientific Research "Demokritos," Athens, Greece; and Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, University of Turin, and Department of Pathology, S. Anna Hospital, Turin, Italy. Kallikreins are a subgroup of the serine protease family of Kim H, Scorilas A, Katsaros D, et al: Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer. www.jco.org /cgi/content/full/21/16/3119   (3413 words)

Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta -- Hart et al. 41 (7): 545 ... Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta -- Hart et al. Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE. jmg.bmjjournals.com /cgi/content/full/41/7/545   (3254 words)

Kallikrein/Kinin Protects against Myocardial Apoptosis after Ischemia/Reperfusion via Akt-Glycogen Synthase Kinase-3 ... the kallikrein gene increased phosphorylation of Src, Akt, glycogen kallikrein was expressed in rat heart after local gene delivery. Effects of kallikrein gene delivery on apoptosis and viability of cardiomyocytes subjected to H/R., quantitative analysis presented as a percentage of TUNEL-positive nuclei. www.jbc.org /cgi/content/full/280/9/8022   (4222 words)

Adenovirus-Mediated Kallikrein Gene Delivery Reduces Aortic Thickening and Stroke-Induced Death Rate in Dahl ... kallikrein was detected in rat serum and urine after gene transfer. Kallikrein activity is expressed as ng kinin released per mg protein per 30 minutes. Tissue kallikrein and kinins: regulation and roles in hypertensive and diabetic diseases. stroke.ahajournals.org /cgi/content/full/30/9/1925   (4778 words)

Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans -- Campbell et al. 281 (4): 1059 -- AJP - ... plasma kallikrein circulates predominantly as the zymogen prekallikrein Circulating levels of total tissue kallikrein and tissue prokallikrein in arterial blood sampled from the radial artery cannula Pre and after CPB in control subjects (open bars, n = 6) and in subjects who received aprotinin (solid bars, n = 5). Kallikrein levels are corrected for dilution by expression per milligram protein. ajpregu.physiology.org /cgi/content/full/281/4/R1059   (6818 words)

Prostate-specific kallikrein - Patent 6184357 This invention relates to nucleic acid and amino acid sequences of a novel prostate-specific kallikrein and to the use of these sequences in the diagnosis, prevention, and treatment of disorders of the prostate, including cancer and benign hyperplasia. Genes encoding the three human kallikreins, tissue kallikrein (KLK1), glandular kallikrein (KLK2), and APS are located in a cluster at chromosome map position 19q13.2-q13.4 (Riegmen P. (1992) Genomics 14: 6-11). KLK1, like the other kallikreins, is made as a pre-pro-protein and is processed into an active form of 238 amino acids by cleavage of a 24 amino acid terminal signal sequence (Fukushima D. et al. www.freepatentsonline.com /6184357.html   (16303 words)

Enzymatic action of human glandular kallikrein 2 (hK2): Substrate specificity and regulation by Zn2+ and extracellular ...   (Site not responding. Last check: 2007-10-17) Abbreviations: hK2, Human glandular kallikrein 2; PSA, prostate-specific antigen; proPSA, zymogen form of PSA; EGF, epidermal growth factor; NGF, nerve growth factor; BPH, benign prostatic hyperplasia; CAP, carcinoma of the prostate; PCI, protein C inhibitor; Sg, semenogelin; uPA, urokinase; AMC, 7-amino-4-methylcoumarin; serpin, serine proteinase inhibitor. kallikrein gene family to be identified in 1987 [4]. Espana, F., Fink, E., Sanchez-Cuenca, J., Gilabert, J., Estelles, A. and Witzgall, K. (1995) Complexes of tissue kallikrein with protein C inhibitor in human semen and urine. content.febsjournal.org /cgi/content/full/262/3/781   (5617 words)

New Nomenclature for the Human Tissue Kallikrein Gene Family -- Diamandis et al. 46 (11): 1855 -- Clinical Chemistry Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expended human kallikrein gene family cluster on chromosome 19q13.3-13.4. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells www.clinchem.org /cgi/content/full/46/11/1855   (3125 words)

{alpha}1-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1 -- Sulikowski et al. 11 ... Olson, S.T., Sheffer, R., and Francis, A.M. High molecular weight kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin: Role for antithrombin in the regulation of kallikrein. 1-antitrypsin Pittsburgh (Met 358 Arg) is a potent inhibitor of plasma kallikrein and activated factor XII fragment. Interaction of human plasma kallikrein and its light chain with C1 inhibitor. www.proteinscience.org /cgi/content/full/11/9/2230   (4117 words)

Kallikrein-binding protein is induced by growth hormone in the dwarf rat -- HATCHER et al. 13 (13): 1839 -- The FASEB ... Kallikrein binding protein is induced by growth hormone The unbound kallikrein and the high molecular mass complex (92 kDa) formed between kallikrein and KBP, indicated at the left, were visualized by autoradiography. Margolius, H. (1989) Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. www.fasebj.org /cgi/content/full/13/13/1839   (3759 words)

Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced ... Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats -- Montanari et al. Kallikrein gene delivery decreases circulating triglyceride and cholesterol levels. Kallikrein gene transfer increased Akt and GSK-3ß phosphorylation, leading to reduced GSK-3ß activity. diabetes.diabetesjournals.org /cgi/content/full/54/5/1573   (3919 words)

Anti-Kallikrein antibodies from RDI Divison of Fitzgerald Industries Intl Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. A novel Kallikrein gene Prostase/KLK-L1 (also known as KLK4) is expressed and is up-regulated by androgens and progestins. KLK 3 (also known as prostate specific antigen) is a marker for prostatic cancer and is involved in the pathogenesis and/or progression of prostate, breast, and possibly other malignancies. www.researchd.com /miscabs/kalikren.htm   (1118 words)

Quantitative Expression of the Human Kallikrein Gene 9 (KLK9) in Ovarian Cancer: A New Independent and Favorable ... Quantitative Expression of the Human Kallikrein Gene 9 (KLK9) in Ovarian Cancer: A New Independent and Favorable Prognostic Marker -- Yousef et al. Yousef G. M., Magklara A., Diamandis E. is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. Magklara A., Scorilas A., Catalona W. J., Diamandis E. The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately increased total PSA. cancerres.aacrjournals.org /cgi/content/full/61/21/7811   (5130 words)

Kallikrein-kininogen system activation and bradykinin (B2) receptors in indomethacin induced enterocolitis in ... HK cleavage to HKa by plasma kallikrein results in release of bradykinin, which directly binds to and stimulates B2 receptors. As kallikrein is a known chemoattractant for neutrophils and stimulates Human plasma kallikrein releases neutrophil elastase during blood coagulation. gut.bmjjournals.com /cgi/content/full/43/3/365   (5149 words)

Molecular Forms of Prostate-specific Antigen and Human Kallikrein 2 as Promising Tools for Early Diagnosis of Prostate ... Molecular Forms of Prostate-specific Antigen and Human Kallikrein 2 as Promising Tools for Early Diagnosis of Prostate Cancer -- Stephan et al. kallikreins are expressed more in noncancerous than in cancerous Tewari P. C., Bluestein B. Multiple forms of prostate specific antigen and the influences of immunoassay design on their measurement in patient serum. cebp.aacrjournals.org /cgi/content/full/9/11/1133   (8140 words)

UniProtKB/UNKNOWN entry P06870 [KLK1_HUMAN] Kallikrein-1 Angermann A. Bergmann C. Appelhans H. "Cloning and expression of human salivary-gland kallikrein in Escherichia coli."; Lottspeich F. Geiger R. Henschen A. Kutzbach C. "N-terminal amino acid sequence of human urinary kallikrein homology with other serine proteases."; : Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. www.expasy.org /uniprot/P06870   (486 words)

UniProtKB/UNKNOWN entry P20151 [KLK2_HUMAN] Kallikrein-2 Schedlich L.J. Bennetts B.H. Morris B.J. "Primary structure of a human glandular kallikrein gene."; Liu X.F. Essand M. Vasmatzis G. Lee B. Pastan I. "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing."; Gan L. Lee I. Smith R. Argonza-Barrett R. Lei H. McCuaig J. Moss P. Paeper B. Wang K. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."; www.expasy.org /uniprot/P20151   (578 words)

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease -- Yousef and Diamandis 22 ... The human tissue kallikrein gene family was, until recently, Human Tissue Kallikrein 5 Is a Member of a Proteolytic Cascade Pathway Involved in Seminal Clot Liquefaction and Potentially in Prostate Cancer Progression Tissue Kallikrein mK13 Is a Candidate Processing Enzyme for the Precursor of Interleukin-1beta in the Submandibular Gland of Mice edrv.endojournals.org /cgi/content/abstract/22/2/184   (2584 words)

Upregulation of tissue kallikrein, kinin B1 receptor, and kinin B2 receptor in mast and giant cells infiltrating ... Upregulation of tissue kallikrein, kinin B1 receptor, and kinin B2 receptor in mast and giant cells infiltrating oesophageal squamous cell carcinoma -- Dlamini and Bhoola 58 (9): 915 -- Journal of Clinical Pathology Abbreviations: DAB, diaminobenzidine; DIG, digoxygenin; HUK, human urinary kallikrein; PBS, phosphate buffered saline; PCR, polymerase chain reaction; SSC, saline sodium citrate; TK, tissue kallikrein; rTK, recombinant tissue kallikrein; TProK, tissue prokallikrein Keywords: tissue kallikrein; kinin B1and B2 receptors; oesophageal carcinoma; tissue prokallikrein; mast cells; giant tumour cells; kinins jcp.bmjjournals.com /cgi/content/abstract/58/9/915   (334 words)

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