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Topic: Kanamycin

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	Kantrex (Kanamycin) drug description - prescription drugs and medications at RxList
		As with other aminoglycosides, the major toxic effects of kanamycin sulfate are its action on the auditory and vestibular branches of the eighth nerve and the renal tubules.
		Kanamycin sulfate should not be given concurrently with potent diuretics (ethacrynic acid, furosemide, meralluride sodium, sodium mercaptomerin, or mannitol).
		Kanamycin sulfate Injection, USP, sterile solution for parenteral administration, contains respectively; kanamycin sulfate 75mg, 500 mg, and 1.0 g; sodium bisulfite, an antioxidant, 0.099%, 0.66%, and 0.45%; and sodium citrate, 0.33%, 2.2%, and 2.2% with pH of each dosage form adjusted to 4.5 with sulfuric acid.
	www.rxlist.com /cgi/generic/kanamycin.htm (655 words)

	Kanamycin: Drug Information Provided by Lexi-Comp: Merck Manual Professional
		The American Academy of Pediatrics considers kanamycin to be “usually compatible with breast-feeding”.
		Although kanamycin transfers into human milk, it is not well absorbed when taken orally.
		Hemodialysis or peritoneal dialysis may enhance kanamycin elimination; exchange transfusion may also be considered in the newborn infant.
	www.merck.com /mmpe/lexicomp/kanamycin.html (1860 words)

	Kanamycin - OpenWetWare
		The APHs inactivate kanamycin by transferring the γ-phosphate of ATP to the hydroxyl group in the 3' position of the pseudosaccharide.
		Several versions of this gene exist, with varying crossover resistance to other antibiotics such as neomycin or gentamycin.
		Stock solution is 35 mg/ml in water (kanamycin is insoluble in 50% alcohol).
	openwetware.org /wiki/Kanamycin (96 words)

	Definition of kanamycin - Merriam-Webster Online Dictionary
		Learn more about "kanamycin" and related topics at Britannica.com
		Find more about "kanamycin" instantly with Live Search
		See a map of "kanamycin" in the Visual Thesaurus
	www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=kanamycin (44 words)

	TopSearch10 - Search Results - function of kanamycin (Site not responding. Last check: )
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	function-of-kanamycin.tbl.sytes.net (48 words)

	Kanamycin - Wikipedia, the free encyclopedia
		Kanamycin (marketed under the brand name Kantrex®) is an aminoglycoside antibiotic, available in both oral and intravenous forms, and used to treat a wide variety of infections.
		Kanamycin works by affecting an unknown aspect of translocation (part of the translation process in which the mRNA is shifted one codon in relation to the ribosome), and by causing messenger RNA (mRNA) to be misread by the ribosome, causing a lethal level of translational errors.
		Common side effects include changes in hearing (either hearing loss or ringing in the ears), toxicity to kidneys, and allergic reactions to the drug.
	en.wikipedia.org /wiki/Kanamycin (129 words)

	Results of the search
		Expression of the kanamycin resistance gene in a kanamycin-producing strain of Streptomyces kanamyceticus.
		The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.
		Kanamycin acetyltransferase gene from kanamycin-producing Streptomyces kanamyceticus IFO 13414.
	invention.swmed.edu /trite/abstracts/user-1016144051/results.shtml (2777 words)

	Kanamycin Still Used and Cross-Reacts with New Antibiotics ISIS Report 27may01
		Kanamycin resistance genes are approved as selectable markers on grounds that the antibiotic is no longer in use.
		Kanamycin is used prior to endoscopy of colon and rectum [4] and to treat ocular infections [5].
		In conclusion, extensive use of kanamycin resistance marker genes in genetically modified crops is unjustifiable in the face of current medical applications.
	www.mindfully.org /GE/GE2/Kanamycin-Cross-Reacts.htm (604 words)

	Medical Dictionary: Kanamycin - WrongDiagnosis.com
		Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil.
		Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
		Kanamycin : aminoglycoside antibiotic complex effective against aerobic gram\-negative bacilli and some gram\-positive bacteria including mycobacteria.
	www.wrongdiagnosis.com /medical/kanamycin.htm (220 words)

	Regiospecificity Assignment for the Reaction of Kanamycin Nucleotidyltransferase from Staphylococcus aureus
		Regiospecificity Assignment for the Reaction of Kanamycin Nucleotidyltransferase from Staphylococcus aureus
		Kanamycin nucleotidyltransferase [ANT (4',4' ')-I] from Staphylococcus aureus confers resistance to numerous aminoglycosides with a 4' or 4' ' hydroxyl group in the equatorial position.
		The regiospecificity of the reaction catalyzed by kanamycin nucleotidyltransferase of kanamycin A with either ATP or m-nitrobenzyl triphosphate was determined directly by one- and two-dimensional hetero- and homonuclear NMR techniques.
	pubs.acs.org /cgi-bin/abstract.cgi/bichaw/2001/40/i09/abs/bi0025565.html (192 words)

	Veterinary Products... kanamycin
		SAFETY OF NEW FORMULATION Kanamycin sulfate Orally administered kanamycin sulfate is generally considered to be poorly absorbed systemically through intact intestinal mucosa, although the possibility of increased absorption through ulcerated or denuded areas should be considered especially when the dose is increased.
		Since orally administered kanamycin sulfate is not expected to reach therapeutic levels, Amforol should not be prescribed for treating Salmonella septicemia.
		A "Contraindication" appears on the labeling as follows: "Amforol is contraindicated in treatment of Salmonella septicemias." Bismuth subcarbonate Orally administered bismuth subcarbonate is an insoluble salt and generally not absorbed in significant amounts.
	www.betterchem.com /vet/kanamycin.htm (820 words)

	Drug Information: Kanamycin (Oral) (Print Version)
		Children—Although there is no specific information comparing use of oral kanamycin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		There is no specific information comparing use of oral kanamycin in the elderly with use in other age groups.
		Blockage of the bowel—Oral kanamycin should never be used in patients who have a blockage of the bowel
	www.nlm.nih.gov /medlineplus/print/druginfo/uspdi/202312.html (826 words)

	Kanamycin Sulfate (Site not responding. Last check: )
		KANAMYCIN SULFATE is a broad spectrum antibiotic that is bactericidal for gram-positive and gram-negative bacteria.
		Freshwater fishes absorb Kanamycin in a bath, resulting in rapid attainment of therapeutic blood serum levels.
		An approximation of the recommended treatment can be achieved by adding 1 level teaspoon to 20 gallons of water (this will produce a concentration of 20 ppm active Kanamycin) up to 1 teaspoon to 8 gallons (this will produce a concentration of 50 ppm active Kanamycin).
	www.novalek.com /aqvtc3.htm (379 words)

	A farewell to bacterial ARMs? - Nature Biotechnology
		One such factor is the reluctance of the medical community to treat bacterial infections with kanamycin or neomycin because of the severity of their side effects.
		Kanamycin, among the first aminoglycosides to be used clinically, has been superseded by other broader-range aminoglycosides, such as gentamicin, tobramycin and amikacin, whose side effects are less severe.
		It is therefore with enthusiasm that the results of the next phase of characterization of this selectable marker—mechanistic investigations of how it confers kanamycin resistance—are anxiously awaited by all factions of the plant biotechnology community, but especially those with special interests in genetically modified crops, phytoremediation or plant ABC transporters.
	www.nature.com /uidfinder/10.1038/nbt0905-1085 (1823 words)

	ACS :: Cancer Drug Guide: kanamycin sulfate
		Kanamycin sulfate is an antibiotic that belongs to the group of drugs called aminoglycosides.
		Kanamycin sulfate appears to prevent bacteria from making their cell walls, so the cells die.
		Kanamycin sulfate is usually given by an injection in a vein or muscle, but it can also be given by mouth.
	www.cancer.org /docroot/CDG/content/CDG_kanamycin_sulfate.asp (709 words)

	BD - Diagnostic Systems: CDC Anaerobe 5% Sheep Blood Agar with Kanamycin and Vancomycin (KV)
		CDC Anaerobe 5% Sheep Blood Agar with Kanamycin and Vancomycin is used for the selective isolation of fastidious and slow-growing, obligately anaerobic bacteria from a variety of clinical and nonclinical materials.
		CDC Anaerobe 5% Sheep Blood Agar with Kanamycin and Vancomycin was formulated by Dowell et al.
		The combination of kanamycin and vancomycin for use in selective isolation of gram-negative anaerobes was first described by Finegold et al.
	www.bd.com /ds/productCenter/221735.asp (788 words)

	Kanamycin Drug Information
		Children—Although there is no specific information comparing use of oral kanamycin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		There is no specific information comparing use of oral kanamycin in the elderly with use in other age groups.
		Blockage of the bowel—Oral kanamycin should never be used in patients who have a blockage of the bowel
	www.drugs.com /cons/Kanamycin.html (1181 words)

	Mutations Conferring Aminoglycoside and Spectinomycin Resistance in Borrelia burgdorferi -- Criswell et al. 50 (2): 445 ...
		kanamycin plates and one colony from a gentamicin plate.
		The DCKAN3 mutant was assayed for susceptibility to kanamycin
		phenotype is increased resistance to kanamycin and gentamicin.
	aac.asm.org /cgi/content/full/50/2/445 (4501 words)

	Kanamycin (Oral)
		Oral kanamycin has not been reported to cause birth defects or other problems in humans.
		Oral kanamycin has not been reported to cause problems in nursing babies.
		Although there is no specific information comparing use of oral kanamycin in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	allnutritionals.com /drugs/k/kanamycin-oral.shtml (824 words)

	Selection of RRE RNA binding peptides using a kanamycin antitermination assay -- PELED-ZEHAVI et al. 9 (2): 252 -- RNA
		Percent survival is plotted as a function of kanamycin concentration.
		Percent survival is plotted as a function of the total kanamycin amount applied to each filter disc.
		Percent survival at kanamycin concentrations resulting in 50% survival of the cognate pairs is plotted (375 µg/mL for N/boxB, 32 µg/mL for U1A/hpII, 9 µg/mL for Rev/RRE, and 13 µg/mL for BIV Tat/TAR).
	www.rnajournal.org /cgi/content/full/9/2/252 (5369 words)

	Solution 2
		To perform this experiment you isolate DNA from the resistant bacteria and transform bacteria that are sensitive to both antibiotics.
		If the bacteria have acquired the ability to grow on medium containing kanamycin, then they have received and incorporated the kanamycin resistance gene (kanR) in place of their original kanamycin sensitive allele (kanS).
		If the bacteria have acquired the ability to grow on medium containing both kanamycin and tetracyline, then they have received and incorporated both the tetracycline resistance gene (tetR) in place of their original tetracyline sensitive allele (tetS) and the kanamycin resistance gene (kanR) in place of their original kanamycin sensitive allele (kanS).
	www.mtsu.edu /~rseipelt/web212d/id166.htm (765 words)

	Kanamycin Susceptibility Testing of Mycobacterium tuberculosis Using Mycobacterium Growth Indicator Tube and a ...
		Kanamycin Susceptibility Testing of Mycobacterium tuberculosis Using Mycobacterium Growth Indicator Tube and a Colorimetric Method -- Bastian et al.
		Two novel systems were evaluated for performing indirect kanamycin susceptibility tests on 72 strains of Mycobacterium tuberculosis.
		Distribution of MICs of kanamycin by MAB assay for panel of 72 M.
	aac.asm.org /cgi/content/full/45/6/1934 (2168 words)

	"Protein fusions with the kanamycin resistance gene from transposon Tn5" (Site not responding. Last check: )
		The gene for the neomycin phosphotransferase II (NPT II) from transposon Tn5 was fused at the amino or carboxy terminus to foreign DNA sequences coding for 3-300 amino acids and the properties of the fused proteins were investigated.
		All amino-terminal fusions examined conferred kanamycin resistance to their host cell, but profound differences in their enzymatic activity and stability were detected.
		Fusions at the carboxy-terminal end of the NPT II protein did not always induce kanamycin resistance and their enzymatic activity depended more stringently
	www.biotech-info.net /protein_fusions.html (154 words)

	Kanamycin; (Kanamycin sulfate) from Roche Applied Science - Biocompare Buyer's Guide
		Kanamycin is an aminoglycosidic antibiotic that inhibits bacterial growth by inhibiting protein synthesis.
		Kanamycin is used for prevention and elimination of bacterial contaminants in cell culture.
		View all citations for Kanamycin; (Kanamycin sulfate) from Roche Applied Science.
	www.biocompare.com /itemdetails.asp?itemid=11992 (164 words)

	[No title] (Site not responding. Last check: )
		Gentekniknämnden skriver i sitt uttalande av 1999-11-03 om antibiotikaresistens korrekt att Kanamycin http://www.psrast.org/sw/genterupenn.htminte används i Sverige, och menar därför att Kanamycingenen är oproblematisk ur resistenssynpunkt.
		This argument ignores the fact that Kanamycin belongs to a group of antibiotics, within which there is considerable cross resistance (see e.g.
		In the treatment of serious infections, many of the most important other antibiotics damage the cell walls of bacteria in such a way that the toxins inside the bacteria are released into the body, which may be a serious threat in a condition of great weakness.
	www.psrast.org /sw/kanamycinres.htm (297 words)

	High-frequency gene transfer from the chloroplast genome to the nucleus -- Stegemann et al. 100 (15): 8828 -- ...
		Putative gene transfer plants (arrow) were selected on plant-regeneration medium containing 400 µg/ml kanamycin and typically appeared after 3–6 weeks of selection.
		Note that approximately one-third of the resistant seedlings display particularly rapid growth, suggesting that they are homozygous and thus show enhanced kanamycin resistance.
		Kanamycin (Kan) concentrations used for selection are indicated in micrograms per milliliter.
	www.pnas.org /cgi/content/full/100/15/8828 (3283 words)

	Practice Linkage and Mapping in Bacteria Solution 2
		Fill in the last column of the table by noting the genotype for each group of bacteria.
		What is the cotransfer index for the kanamycin and tetracycline resistance genes?
		Since we don't have any antibiotics in the "no antibiotics" medium, we can not tell what genotype they are.
	www.mtsu.edu /~rseipelt/web2120a/2120sol/2120sollinkbact2.htm (837 words)

	The Washington 1 Strain of Escherichia coli does not grow when treated with Kanamycin
		A new strain of Escherichia coli bacteria was discovered in a hospital in the Washington area.
		100-microliters of each sample containing both transformed cells and normal cells were placed on three different kinds of petri plate containing ampicillin, tetracycline, and kanamycin.
		dies) as the strain used in the lab, a course of kanamycin should be effective in treating the infection.
	members.tripod.com /quickbeam/bio10.html (1412 words)

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