
	Where results make sense

Topic: Kavalactones

In the News (Wed 30 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Kava Kava - Piper methysticum FORST
		For example in one study the absorption of the kavalactones was shown to be three to five times higher from the extract compared with an equal amount of isolated kavalactones.
		For example, studies have indicated that the kavalactones appear to act primarily on the limbic system, the primitive part of the brain that affects all other brain activities and is the principal seat of the emotions and of instinct).
		Based on clinical studies using pure kavalactones or kava extracts standardized for kavalactones, the dosage recommendation for anxiolytic effects is 45 to 70 mg of kavalactones three times daily.
	www.naturalessence.net /Products/KavaKava.html (2415 words)

	Kavalactone - Wikipedia, the free encyclopedia
		Kavalactone is the active ingredient found in kava.
		The amount of kavalactones consumed is not the same as the amout of kava consumed.
		Kavalactones, as the name suggests, are lactones that cause the psychoactive effects from a drink made of the roots of the kava, a shrub common on some Pacific Ocean islands.
	en.wikipedia.org /wiki/Kavalactones (165 words)

	Tang Center for Herbal Medicine Research (Site not responding. Last check: 2007-10-27)
		The kavalactones, also known as kavapyrones or -pyrones, are responsible for most of the pharmacological effects.
		The six major kavalactones that have been identified are kawain, dihydrokawain, methysticin, dihydromethysticin, yangomin, and desmethoxyyangonin.
		Kavalactones inhibit voltage-dependent sodium and calcium channels in vitro, possibly explaining the antiepileptic and local anesthetic effects.
	tangcenter.uchicago.edu /herbal_resources/kava.shtml (668 words)

	Sage Woman Herbs Store - Item Detail (Site not responding. Last check: 2007-10-27)
		For example in one study the absorption of the kavalactones was shown to be three to five times higher from the extract compared with an equal amount of isolated kavalactones.
		For example, studies have indicated that the kavalactones appear to act primarily on the limbic system, the primitive part of the brain that affects all other brain activities and is the principal seat of the emotions and of instinct).
		Based on clinical studies using pure kavalactones or kava extracts standardized for kavalactones, the dosage recommendation for anxiolytic effects is 45 to 60 mg of kavalactones three times daily.
	estores.infront.com /sagewomanherbs/item_info.asp?pid=182 (1844 words)

	Pu'u O Hoku Ranch, Molokai, Hawaii - Organic Farm
		Kavalactones are the major active ingredients found in 'awa plants.
		Kavalactones are found in all parts of the 'awa plant and are responsible for 'awa's medicinal and psychoactive properties.
		Kavalactone tests on this cultivar have shown a variation from 10.6% KL up to 15.5 KL and chemotype variation of 462351 and 426315.
	www.puuohoku.com /awa.html (405 words)

	Kava as Medicine
		The kavalactones have been the objects of chemical research since the mid-1800s, and much is known about their mode of activity.
		While today the analysis of the kavalactones is made easy by advanced analytical laboratory machinery, in the 1800s such research was slow and arduous.
		While work using the various isolated, synthesized kavalactones has yielded interesting results, the potency of each as a separate molecule is less significant than the potency of all the kavalactones taken together in their natural form.
	www.konakavafarm.com /articles/kava_as_medicine.html (2041 words)

	Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation. (Site not responding. Last check: 2007-10-27)
		Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.Pretreatment with kavalactones (300 microg/ml) or dihydrokavain (300 microM) significantly decreased the NTS inhibitory effects induced by muscimol (30 microM), approximately from 51 % to 36 %.
		Kavalactones or dihydrokavain induced inhibitory effects were not reduced after co-application of saclofen (10 microM; a selective GABA B receptor antagonist) or naloxone (100 nM; an opioid receptor antagonist).
		Application of kavalactones (300 microg/ml) and dihydrokavain (300 microM) into the brainstem compartment of the preparation also significantly reduced the discharge rate of these NTS neurons (39 % and 32 %, respectively, compared to the control level), and this reduction was partially reversed by bicuculline (10 microM).
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/9340138.html (199 words)

	KAVA KAVA : NATURE'S ANSWER TO ANXIETY,STRESS & INSOMNIA
		The active ingredients in Kava are called kavalactones and are found in the root of the plant.
		Kavalactones cause reactions in the brain similar to synthetic drugs commonly prescribed for anxiety,insomnia,and mood disorders.Kava's chemical constituents are thought to contain anesthetic, analgesic, anticonvulsive, antifungal and sleep inducing properties.
		The proper dosage for insomnia is 210 mg of kavalactones 1 hour before bedtime (Bratman et al.,2000).Some herbalists suggest using Kava extracts supplying 120—240 mg of kava-lactones per day in two or three divided doses.Length of treatment varies.
	www.selfgrowth.com /articles/Esparza2.html (1199 words)

	What is Kava
		Kavalactones are a group of compounds found in the Kava plant that are identified for its calming effect.
		The pharmaceutical standardized kavalactone extract (containing 70mg of total kavalactones in a 120mg capsule) when subjected to digestion and metabolism, will elicit different responses than a capsule with buffering components provided naturally within the juice.
		The ratios in the freeze dried juice are 18% kavalactones and 82% matrix, while standardized are 55-90% kavalactones and less than 10- 45% matrix.
	www.competitivehorse.com /Fear/what_is_kava.htm (1201 words)

	Toxicity of kava alkaloid pipermethystine to liver cells compared to kavalactones (Site not responding. Last check: 2007-10-27)
		The aim of this project was to test the in vitro effects of a major kava alkaloid, pipermethystine (PM) found mostly in leaves and stem peelings and kavalactones such as 7,8-dihydromethysticin (DHM), desmethoxyyangonin (DMY) that are abundant in the roots.
		Mechanistic studies indicate that in contrast to kavalactones, PM significantly decreased cellular ATP levels, mitochondrial membrane potential and induced apoptosis as measured by the release of caspase-3 after 24 h of treatment.
		These observations suggest that PM, rather than kavalactones, is capable of causing cell death, probably in part by disrupting mitochondrial function.
	www.biopsychiatry.com /kava.htm (252 words)

	Kava Kava: An introduction (Site not responding. Last check: 2007-10-27)
		Because the kavalactones content in crude preparations can vary between 3 and 20 percent, it is essential, when medicinal effects are desired, to utilize extracts standardized for kavalactone content.
		However, this high percentage of kavalactones may be sacrificing some of the other constituents that may contribute to the pharmacology of kava.
		Based on clinical studies using pure kavalactones or kava extracts standardized for kavalactones, the dosage recommendation for anxiolytic effects is 45 to 70 mg of kavalactones three times daily.
	www.iherb.com /iherb/kavkavin.html (2593 words)

	Kava Kava
		In kava, the kavalactones, the pharmacologically active compounds in the kava plant and beverage, act upon body and mind, while the relative proportions and potencies of the kavalactones from one variety to another determine the nature and intensity of psycho-somatic effects.
		While today the analysis of the kavalactones is made easy by advanced analytical laboratory machinery, in the 1800's such research was slow, arduous and painstaking.
		Parallell to the chemical investigation of the kavalactones, the study of their pharmacology, or drug activity, has also been of keen interest to researchers, and continues unabated to this day.
	www.medicinehunter.com /kava_kava.htm (5303 words)

	Kavalactones (Site not responding. Last check: 2007-10-27)
		The amount of kavalactones consumed is not the same as the amout of kava consumed.Potencies vary dramatically and are highest in liquid extractions.
		Kavalactones, as the name suggests, are lactones that cause the psychoactive effectsfrom a drink made of the roots of the kava, a shrub common on some Pacific Ocean islands.
		The rhizome and roots of the shurb are ground, grated andsteeped in water to produce a non-alcoholic drink whose consumption is part of ceremonial occasions on places like Fiji and Hawaii.
	www.therfcc.org /kavalactones-345580.html (149 words)

	DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE ...
		Rat hepatocytes were cultured in WEM for 48 h and then exposed to kavalactones (2 or 50 µM) or the same volume of DMSO for 48 h with a daily change of fresh medium and chemicals.
		Rat hepatocytes were treated with mixed kavalactones (15 µM for each) or DMY at 15, 75, or 90 µM for 48 h.
		Rat hepatocytes were treated with mixed kavalactones (15 µM for each) or DMS at 15, 75, or 90 µM for 48 h.
	dmd.aspetjournals.org /cgi/content/full/32/11/1317 (4628 words)

	Kava -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-27)
		Its active principal ingredients are the (additional info and facts about kavalactones) kavalactones, of which there are six major ones used to identify the chemotype of a particular variety.
		Kava is traditionally consumed as a 'tea'; that is, an infusion made from straining a mixture of water and shredded, pounded, dried, or fresh root and/or stump.
		The extract is an (A light-sensitive coating on paper or film; consists of fine grains of silver bromide suspended in a gelatin) emulsion, consisting of suspended kavalactone droplets in a starchy suspension.
	www.absoluteastronomy.com /encyclopedia/k/ka/kava.htm (833 words)

	Inhibition of human cytochrome P450 activities by kava extract and kavalactones. (Site not responding. Last check: 2007-10-27)
		Inhibition of human cytochrome P450 activities by kava extract and kavalactones.In the present work the inhibition of P450 enzymes by kava extract and individual kavalactones in human liver microsomes (HLMs) was investigated.
		Consistent with their potency as inhibitors, the two major kavalactones bearing a methylenedioxyphenyl moiety (M and DHM) formed "455 nm" metabolic intermediate complexes after incubation with HLMs and NADPH, but K and DMY did not.
		Whole kava extract (normalized to 100 microM total kavalactones) caused concentration-dependent decreases in P450 activities, with significant inhibition of the activities of CYP1A2 (56% inhibition), 2C9 (92%), 2C19 (86%), 2D6 (73%), 3A4 (78%), and 4A9/11 (65%) following preincubation for 15 min with HLMs and NADPH; CYP2A6, 2C8, and 2E1 activities were unaffected.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/9633095.html (256 words)

	Kava Review Page
		The kavalactones have been the objects of intensive chemical research since the mid 1800's, and much is known about their mode of activity.
		In 1959 Klohs, Keller and Williams isolated desmethoxy-yangonin, and in 1962, Mors, Magalhaes and Gottlieb reported the isolation of 5,6-dehydromethysticin, 11-methoxyyangonin and 11-methoxynoryangonin.
		To promote sleep, a dose of approximately 200 milligrams of kavalactones taken thirty to sixty minutes prior to retiring is recommended.
	www.pureworld.com /science/kava_review.html (4414 words)

	Erowid Kava Vault : NIH Kava Chemistry & Toxicology Executive Summary
		The toxicity of the kavalactone demethoxyyangonin was evaluated in male ICR mice and male Wistar rats.
		Hsu and coworkers (1994) reported that the kavalactone demethoxyyangonin was negative in the Ames assay however, no details of the study were given.
		The nine kavalactones identified were dihydrokawain, kawain, desmethoxyyangonin, tetrahydroxyangonin, dihydromethysticin, 11-methoxytetrahydroyangonin, yangonin, methylsticin, and dehydromethylsticin.
	www.erowid.org /plants/kava/kava_chemistry2.shtml (3682 words)

	Smart Basics - Kava Kava: Smart Basics (Site not responding. Last check: 2007-10-27)
		Kava was first mentioned in the scientific records in 1886, and by 1993 the active ingredients, Kavalactones, were detected by mass spectrometry.
		Over the past 100 years extensive analytical investigation of the Kava root has revealed that the active ingredients in Kava, the kavalactones, comprise 15% of the root.
		All kavalactones are physiologically active, though it is the fat-soluble kavalactones derived from kava resin that convey the main psychoactive activity.
	www.ehot.com /smartbasics/kava_c.html (626 words)

	[No title]
		The ratio of six major kavalactones was significantly different for the aqueous extract compared to the organic extracts.
		Irrespective of which organic extract was used, the ratio of the six major kavalactones was almost identical.
		The differences in the ratio of kavalactones suggest that commercial kava extracts may have a different biological activity from the traditional kava.
	www.herbalgram.org /bodywise/herbclip/review.asp?i=44144 (534 words)

	!-A Kava Kava (Site not responding. Last check: 2007-10-27)
		Of the fifteen lactones isolated from kava, there are six major lactones (kavalactones) known to provide psychoactive activity: kawain, methysticin, demethoxy-yangonin, dihydrokawain, dihydomethysicin, and yongonin.
		All kavalactones are physiologically active, though it is the fat-soluble kavalactones derived from kava resin that have the greatest effect on the central nervous system.
		Pharmacological studies show kava kava's active ingredients, kavalactones, produce physical and mental relaxation and a feeling of well being.
	www.nutrisana.com /html/kavaen.html (719 words)

	Kava-Kava Herbal Encyclopedia
		In Europe, kava extracts are often combined with pumpkin seed, for its diuretic effect, in the treatment of irritable bladder syndrome.
		One kavalactone produces a numbing effect in the mouth upon chewing the root or drinking kava preparations.
		Kavalactones have been shown to relax muscles by affecting muscular contractility rather than by blocking neurotransmitter signals in nerves.
	allnatural.net /herbpages/kava-kava.shtml (591 words)

	Kavasedon (Site not responding. Last check: 2007-10-27)
		Kavalactones like kavain, dihydro-kavain, methysticin, dihydromethysticin, yangonin and desmethoxy-yangonin are nitrogenfree C6-substituted 4-methoxy-alpha-pyrones.
		The clinically relevant effects of kavalactones result not only from the specific efficacy of the isolated substances but as well from synergism of all pharmacologically active kavalactones.
		The natural standardized kavalactones complex as a whole which is the active ingredient of Kavasedon Capsules/Drops is therefore pharmacologically superior to the isolated substances.
	www.harraspharma.de /html_medika/kavasedon_exp_e.html (517 words)

	Kava Kava Root - Clinical Studies, Safety, Side Effects, References and Overviews of Kava & Anxiety (Site not responding. Last check: 2007-10-27)
		Although the full workings of Kava are still being examined by experts, it is generally believed that Kavalactones exhibit a broad spectrum effect on the Limbic System, an area of the brain largely associated with the control of emotions, like fear and anxiety.
		In vitro studies have shown the absorption rate of Kavalactones to be remarkably rapid, though actual absorption in vivo has yet to be clinically determined.
		Additional [in vitro] study suggests that the sedative and anxiolytic effects characteristic of Kava may be attributable to reduced neuronal reuptake of Noradrenaline (Norepinephrine) and MAO-B, an enzyme responsible for the breakdown of Dopamine.
	www.clarocet-nri.com /kava.htm (494 words)

	Uka Kava
		The Hawaiian 'awa root powders have between 10% to 19% Kavalactones.
		The alcohol speeds the delivery of kavalactones to your body through the saliva glands.
		The same dosage may be placed in a hot or cold beverage, but the effects may take 5 to 10 minutes to kick in.
	www.mauikava.com /cat.html (1461 words)

	Kava
		Kavalactones (the active compound of Kava Kava) have been shown to promote a calming feeling, relax muscles, relieve anxiety and stress and provide a peaceful sleep.
		Kava Kava (Piper Methysticum) is an exciting botanical herb made from the root of the Piper Methysticum plant, a member of the pepper family.
		Kava is a relaxant and sleep aid, able to induce a feeling of relaxation, peace and contentment, along with a sharpening of the senses in the South Pacific, Kava was the beverage of choice during important meetings involving conflicts because it induced a state of relaxation and goodwill among parties trying to reconcile differences.
	www.holistic-online.com /select/kava.htm (590 words)

	Kava (Site not responding. Last check: 2007-10-27)
		GI distress/discomfort may develop especially at high dosage levels of kavalactones.
		Kava, as is the case with other anxiolytic/sedative drugs, may produce daytime drowsiness, impairment of motor coordination and cognitive function.
		In one double-blind study, a kavalactone was found to be equally effective with benzodiazepine anxiolytic in relieving the subjective symptoms of anxiety disorder.
	www.cami.usip.edu /monographs/kava.htm (411 words)

Try your search on: Qwika (all wikis)