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Topic: Kinetin

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	SENETEK - Anti-aging
		Kinetin is a cytokinin that, in clinical trials at the University of California, Irvine, has been shown to reduce the signs of aging that are due, primarily, to photo damage.
		Kinetin has been successfully licensed to leading cosmetic and pharmaceutical companies and is expected to have a significant impact on the world wide skincare market.
		Kinetin can be combined with a variety of compounds to produce innovative approaches to the prevention and treatment of aging skin.
	www.senetekplc.net /SENETEK/dermatological_therapeutics.html (429 words)

	Publications
		The biosynthetic pathway of kinetin involves the formation of furfural during hydroxyl radical oxidation of the deoxyribose in DNA, its reaction with the exocyclic amino groups of adenine residues, followed by dehydration and reduction of the intermediates leading to formation of N6-furfuryladenine [4, 5].
		The effects of kinetin on the prevention and treatment of those conditions occurring due to the damage to DNA (for example, cancers), and to proteins and other macromolecules resulting in the accumulation of abnormal proteins and lipids in various organs, tissues and cells (for example, cataract, maculopathy, Alzheimer’s disease and others) should be investigated.
		Rattan, S.I.S. N6-furfuryladenine or kinetin as an anti-aging molecule.
	origo.imsb.au.dk /~rattan/Kinetin.html (2094 words)

	The Science Advisory Board
		Kinetin is an amphoteric compound, which is soluble in strong acids, alkalis and glacial acetic acid, is slightly soluble in ethanol, butanol, acetone and ether, but is practically insoluble in distilled water.
		The effects of kinetin on the prevention and treatment of those conditions occurring due to the damage to DNA (e.g., cancers), and to proteins and other macromolecules resulting in the accumulation of abnormal proteins and lipids in various organs, tissues and cells (e.g, cataract, maculopathy, Alzheimer’s disease and others) should be examined.
		The usefulness of kinetin as a nutritional supplement in stimulating the maintenance and repair pathways in the body, as a general molecule of defense and as a component of the homeodynamic machinery also needs to be explored carefully.
	www.scienceboard.net /community/perspectives.39.html (1587 words)

	Botany online: Plant hormones - Phytohormones - Cytokinins
		Kinetin is physiologically extraordinary active, although it could not be isolated from any plant cell.
		The combined effects of IES and kinetin and their relative amounts decide whether a callus tissue of tobacco, for example, differentiates into a root or a shoot.
		At high amounts of kinetin and low amounts of IES is far more lignin than pectin produced, in the opposite case is the lignin/pectin ratio reversed, too.
	www.biologie.uni-hamburg.de /b-online/e31/31c.htm (899 words)

	FRANK MASSINO - SENETEK PLC (SNTK): 2-6/-4/
		Kinetin eliminates fine line wrinkles, coarse wrinkles, rough skin, mottled hyperpigmentation and has the unique property of improving moisture retention which is essential for maintaining healthy skin and unlike its competitors has virtually no side effects.
		Kinetin is endogenous to the human body and part of the DNA tissue repair process.
		We conducted the Kinetin clinical studies using the protocols established by the FDA for the approval of antiaging compounds.
	www.twst.com /ceos/sntk.html (3195 words)

	-- Minorsky 132 (3): 1135 -- PLANT PHYSIOLOGY
		kinetin acting as a strong antioxidant in vitro and in vivo.
		Kinetin is known to have anti-oxidative properties in plants,
		When kinetin was administered at 13 and 14 mg/kg in mice pre-treated
	www.plantphysiol.org /cgi/content/full/132/3/1135 (759 words)

	[No title]
		Kinetin has been demonstrated in clinical studies to delay the onset of aging in skin cells in vitro.
		Kinetin, which is not an exfoliant, is "bio-available," allowing it to work deep within skin's surface layers, without causing dryness or increased sun sensitivity commonly associated with retinoids and AHAs.
		It is demonstrated in clinical studies to increase skin smoothness and clarity by 57 percent and diminish the appearance of fine lines and wrinkles by 33 percent as well as visibly improve skin firmness and fade the look of brown spots.
	www.beautybuzz.com /SkinCare/detail.asp?ArticleID=89 (978 words)

	kinetin on Encyclopedia.com
		In some instances kinetin acts together with another hormone, indoleacetic acid, or auxin ; in other cases it acts in opposition to auxin.
		Senetek PLC Licenses Kinetin to Osmotics Corporation; Agreement Valued in Excess of $10 Million
		Controlled trial demonstrates benefits of kinetin lotion : Treatment of facial photodamage bolstered; product is alternative to retinoids, alpha hydroxy acids.
	www.encyclopedia.com /html/k1/kinetin.asp (295 words)

	Kinerase - UK (Site not responding. Last check: 2007-11-03)
		contains kinetin, a natural substance that actually slows the appearance of ageing in plant cells — and it has shown the same effect in human skin cells.
		Intensive Kinetin Eye Cream contains a higher concentration of kinetin to reduce the appearance of fine lines and wrinkles in the delicate skin around the eyes.
		Kinetin also has a strong antioxidant action towards the Reactive Oxygen Species (ROS) responsible for degradation of the polyunsaturated fatty acids that form the cellular membranes (lipoperoxidation).
	www.kinerase.com /uk/thescience.html (476 words)

	[No title]
		Kinetin is a plant growth factor and stable anti-oxidant.
		Almay boasts that kinetin has been "demonstrated in clinical studies to delay the onset of aging in skin cells in vitro." Almay says kinetin is "bio-available," meaning that it penetrates the skin's surface layers.
		Kinetin's popular Age Defying Daily Cream ($34) and Age Defying Daily Lotion ($34) contain SPF 15 (UVA/UVB) and have been accredited by the Canadian Dermatological Association, which means the association's logo will soon appear on its carton packaging.
	www.nsnews.com /issues03/w042703/045103/living/045103li2.html (319 words)

	Compare Prices and Read Reviews on Almay Skin Smoothing Foundation With Kinetin at Epinions.com
		But while there is plenty of research on the kinetin’s effects when it comes to plants, in test tubes and on flies, there is no published research regarding the ingredient applied topically on human or animal skin.
		Aside from the claims that kinetin improves skin, which may or may not be true, there is published research that kinetin may cause problems for skin cells.
		Kinetin is more difficult to find in trial sizes than their other foundations.
	www.epinions.com /content_66699562628 (1675 words)

	CGC3-30
		MS medium was used with the addition of casein hydrolysate (1 g/l), sucrose (20, 35 and 50 g/l), Difes Bacto agar (7.5 g/l), kinetin (0.1, 1 and 10 mg/l), and IAA (0.02 mg/l).
		The combination 10 mg/l kinetin + 5% sucrose induced the formation of small, thick, dark green cotyledons and sometimes hypocotyl extension growth and main root development.
		However, 10 mg/l kinetin induced development of normal plantlets, a number of which could be transferred into soil.
	cuke.hort.ncsu.edu /cgc/cgc03/cgc3-30.html (701 words)

	Controlled trial demonstrates benefits of kinetin lotion - DermatologyTimes
		Discrete and mottled pigmentation were improved 62 percent and 33 percent, respectively, with use of the kinetin-containing lotion, and 55 percent and 43 percent, respectively, by the retinol cream.
		Dr. Levy explained that kinetin, known chemically as N6-furfuryladenine, is a cytokinin plant growth regulator, and it is formed in response to free radical damage in human DNA.
		Rationale for its use in the treatment of photodamaged and aging skin is derived from in vitro studies that demonstrate it can delay a range of cellular changes associated with the aging of human cells.
	www.dermatologytimes.com /dermatologytimes/article/articleDetail.jsp?id=9364 (765 words)

	Noticiario de Recursos Fitogénéticos - Propagation of a threatened medicinal herb Aconitum atrox (Bruhl) Muk. through ... (Site not responding. Last check: 2007-11-03)
		Thus, a total of 16 segments of tubers (4 tubers×4 segments) were pre-soaked with 10 mg l –1aqueous solutions of GA 3, IBA and Kinetin in combination of three, any two or alone for 48 h at room conditions in 150×150×45 mm borosilicate glass trays containing 500 ml solution.
		GA 3 and Kinetin in combination produced 5.0±0.0 tubers from basal segments.
		Kinetin enhanced the number of sprouts, however, vigour of sprouts was weak.
	www.ipgri.cgiar.org /pgrnewsletter/article_es.asp?id_article=10&id_issue=135 (1964 words)

	Kinetin
		Kinetin is part of a group of similar plant hormones called cytokinins.
		Clinical study results demonstrate Kinetin reverses the signs of photo damaged skin and improves the overall appearance of the skin, making it smoother and more even in color and visibly diminishes the appearance of fine lines and wrinkles.
		The studies also prove Kinetin significantly improves the skin barrier function and helps the skin to retain more moisture, making the skin softer and smoother.
	www.greatvistachemicals.com /proteins-sugars-nucleotides/kinetin.html (249 words)

	CRYONICS Re: Anti-Ageing Discoveries
		Although kinetin and other cytokinins are well known to have anti-ageing effects in plants, in human cells it is the first time any such effects have been observed.
		Natural sources of kinetin related cytokinins are: very high levels in coconut water/milk; all germinating seeds and growing tips etc. Potential usages as nutrional supplement, anti-oxidative compounds, and rejuvenator.
		The paper: Kinetin delays the onset of ageing characteristics in human fibroblasts, by SIS Rattan and BFC Clark is in Biochemical Biophysical Research Communications, vol 201, pages not sure, 1994.
	www.cryonet.org /cgi-bin/dsp.cgi?msg=2833 (623 words)

	Kinetin (Site not responding. Last check: 2007-11-03)
		Kinetin is a plant-growth hormone, and its technical name is N6-furfuryladenine.
		What makes kinetin interesting are the in vitro and animal studies demonstrating its effect as a growth factor.
		I suspect that when it's applied topically, kinetin isn't of much use to the skin cell, and even if it could be utilized, there probably isn't enough kinetin in any product to have a negative or positive impact?but that is only a guess, no one knows for sure (Source: Dermatologic Clinics, October 2000, pages 609-615).
	www.cosmeticscop.com /learn/article.asp?PAGETYPE=ART&REFER=SKIN&ID=67 (301 words)

	Brudirect.com - Local News
		The Kinetin Skin Care products incorporate a powerful antioxidant Kinetin, which has been "clinically proven to help improve skin tone and texture," the release added.
		Kinetin has been found to even skin tone, smoothen rough texture and increase moisture retention after just four weeks of use, with continued improvement in results for up to 24 weeks.
		The Body Shop's Kinetin Skin Care products are non-acidic unlike alpha and beta hydroxy acids, and are formulated to eliminate the risk of peeling, stinging and irritation while aid in resisting "skin-damaging environmental elements, such as sun, smoke and air pollution."
	www.brudirect.com /DailyInfo/News/Archive/July04/280704/bb01.htm (127 words)

	Kinerase - UK (Site not responding. Last check: 2007-11-03)
		In plants, kinetin reduces the visible effects of ageing and improves moisture retention.
		• Kinetin is a naturally occurring essential plant growth factor and antioxidant ¹ that slows the appearance of ageing in plant cells — and it has shown the same effect in human skin cells
		Intensive Kinetin Skin Cream has been shown to improve overall skin texture and tone in an independent study.
	www.kinerase.com /uk/whatdoeskinerasedo.html (151 words)

	Osmotics Cosmeceuticals Kinetin Cellular Renewal Serum
		An unprecedented innovation in anti-aging skin care, this advanced serum features Kinetin (N5 - Furfuryladenine), a patented, natural plant growth factor that addresses signs of aging skin without irritation, exfoliation or sun sensitivity.
		Independent studies have found that when aging cells are exposed to solutions containing Kinetin, the cells regain their youthful appearance.
		Kinetin has been proven to help repair and prevent signs of aging and sun damage.
	www.drugstore.com /qxp74175_332828_sespider/osmotics/kinetin_cellular_renewal_serum.htm (261 words)

	Kinetin Skin Care and Body Care Products with UK Delivery (Site not responding. Last check: 2007-11-03)
		Almay Kinetin Skincare Advanced Anti-Aging Series formulas are proven to produce dramatic anti-aging results.
		Kinetin Skincare is gentle and improves your skin naturally.
		Contains Kinetin, a new way to prevent, delay and even reverse signs of ageing.
	www.bodycareshop.co.uk /kinetin.asp (335 words)

	Kinetin (Site not responding. Last check: 2007-11-03)
		kinetin and soy, which help thicken collagen and hide the blood vessels beneath the...
		KINETIN causes no increase in skin photosensitivity, which means that it...
		Kinetin's anti-aging effects were first discovered by scientists who revealed Kinetin prevents senescence (aging) of leaves in plants.
	www.all-cosmetic.com /directory/kinetin.html (289 words)

	No More Wrinkles, Ever? (Site not responding. Last check: 2007-11-03)
		A natural anti-oxidant found in leafy green plants, Kinetin actually delays the aging process of human skin cells when applied topically.
		Unlike Retin-A, Kinetin is not an exfoliant and therefore does not increase skin’s sensitivity to the sun.
		Kinetin is available in prescription strength (under the name Kinerase) or in lesser amounts in Almay’s new Kinetin skincare line.
	www.trendcentral.com /trends/trendarticle.asp?tcArticleId=75 (145 words)

	Interview with Frank Massino, Senetek PLC: TWST
		Kinetin was first introduced in the medical community by ICN Pharmaceuticals.
		ICN’s Kinetin product, Kinerase®, rivals J & J’s Renova®, which is the only FDA approved antiaging product on the market.
		We have achieved the successful commercialization of our lead skincare product, Kinetin, and established profitability — going from a loss in excess of $22 million in fiscal 1998 to a profit in 2001.
	www.twst.com /notes/articles/pav603.html (1151 words)

	Re: What are the cellular changes that occur when kinetin is added to Chlorophy
		So in reference to your question is that by the addition of kinetin to a cell more cells divide which in turn produce more chlorophyll.
		And since kinetin delays senescence, the chlorophyll in the other cells remains active longer in the leaves.
		So by these two outcomes of kinetin addition, chlorophyll remains in the leaves longer and more chlorophyll is being produced as additional cells divide.
	www.madsci.org /posts/archives/may2001/989184726.Bc.r.html (190 words)

	kinetin
		kinetin, one of a group of chemically similar plant hormones, the cytokinins, that promote cell division.
		Senetek's Kinetin Effective for Additional Clinical Indications, Researcher Stresses in Dermatology Times.
		Senetek PLC and Age Advantage Laboratories, Inc. Announce Signing of Kinetin License.
	www.infoplease.com /ce6/sci/A0827672.html (202 words)

	MASC 2001 - Overall Winner (Site not responding. Last check: 2007-11-03)
		Indole-3-acetic acid (IAA) and kinetin are expensive plant growth regulators commercially used in synthetic form to aid in the growth of plants.
		From the outcomes, it is evident that kinetin, indole-3-acetic acid, and dehydroepiandrosterone all affect growth in Phaseolus limensis.
		0.1 mM kinetin (s), 0.5 mM kinetin (s), and 0.001% IAA (water) did not prove to be significant at this alpha level.
	www.mville.edu /biology/abettica/MASCOVW11.HTML (592 words)

	Rescue of a human mRNA splicing defect by the plant cytokinin kinetin -- Slaugenhaupt et al. 13 (4): 429 -- Human ...
		The action of kinetin on IKBKAP splicing is dose and time dependent and results in an increase of IKAP protein in FD lymphoblast cell lines.
		Kinetin increases WT : MU IKBKAP in the presence of cycloheximide, which inhibits nonsense mediated decay.
		Kinetin enhances inclusion of exon 20 in both the MU and WT IKBKAP minigene.
	hmg.oxfordjournals.org /cgi/content/full/13/4/429 (4258 words)

	Control of Differentiation and Apoptosis of Human Myeloid Leukemia Cells by Cytokinins and Cytokinin Nucleosides, Plant ...
		Kinetin and IPA significantly induced NBT reduction in
		Effect of 5'-Amino-dAdo, an Inhibitor of Ado Kinase, on the Growth Inhibition and Differentiation Induced by Kinetin or Kinetin Riboside in HL-60 Cells.
		Reduction by 5'-amino-dAdo of the growth-inhibitory (A and C) and differentiation-inducing (B) effects of kinetin (A and B) and kinetin riboside (C).
	cgd.aacrjournals.org /cgi/content/full/13/1/19 (4156 words)

	Cotton Farming
		The product employs the use of kinetin, a manmade version of the plant hormone cytokinin.
		Kinetin has several “designated functions,” such as stimulating leaf expansion and bud formation.
		Too much kinetin overwhelms the growth-inhibiting characteristics of mepiquat chloride.
	www.cottonfarming.com /home/2005_JuneCF-PGR.html (396 words)

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