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Topic: Kinetoplastid

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In the News (Mon 24 Jun 19)

The trypanosomes or kinetoplastid protozoa comprise a large group of parasitic flagellated cells that are the causal agents for a variety of human and animal diseases.
Kinetoplastid protozoa have a single mitochondrion that extends throughout the cell.
All mitochondrial tRNAs in kinetoplastid protozoa are encoded in the nucleus and imported from the cytosol.
dna.kdna.ucla.edu /simpsonlab/research.htm   (9945 words)

 Kinetoplastid Biology and Human Disease
Kinetoplastid DNA is relatively abundant and consists of mini-circles and maxi-circles.
However, the kinetoplastids exhibit several morphological forms which are defined by the position of the kinetoplast in relation to the nucleus and the length of the undulating membrane (see morphological forms).
The different forms are distinguished by the position of the kinetoplastid in relation to the nucleus and the presence or absence of an undulating membrane.
www.tulane.edu /~wiser/protozoology/notes/kinet.html   (8689 words)

 Kinetoplastid - Wikipedia, the free encyclopedia
The kinetoplastids are a group of flagellate protozoa, including a number of parasites responsible for serious diseases in humans and other animals, as well as various forms found in soil and aquatic environments.
There is also one family of kinetoplastids, the trypanosomes, which only have a single emergent flagellum, including several genera which are exclusively parasitic.
The kinetoplastids were first defined by Honigberg in 1963 as the flagellate order Kinetoplastida.
en.wikipedia.org /wiki/Kinetoplastid   (301 words)

 Kinetoplastid Molecular Cell Biology Meeting   (Site not responding. Last check: 2007-10-12)
Kinetoplastids are very appealing models for the study of flagellar function, particularly given the availability of extensive genome information.
The best characterized of these is the kinetoplastid PFR which is composed of two major proteins, PFR1 and PFR2, and several minor ones, most of which are uncharacterised.
The PFR is necessary for full motility in the kinetoplastids and provides support for metabolic regulators that may influence flagellar beating.
www.mbl.edu /kmcb/abstracts/abstract.php?id=125   (309 words)

 New drug targets for kinetoplastid drug discovery  
Of these, only three were for treatment of diseases caused by kinetoplastid organisms: eflornithine for African trypanosomiasis, and benznidazole and nifurtimox, both for Chagas disease.
Participants at the meeting presented work on several promising target molecules or metabolic pathways of kinetoplastids: trypanothione reductase and polyamine metabolism, farnesyl transferase and protein prenylation, sterol metabolism, topo-isomerases, proteases, and cAMP signalling pathways.
Scientists who believe they have projects that are relevant to drug discovery for any of the kinetoplastid diseases, and for which molecular targets and/or lead molecules have been identified, are urged to contact Richard Pink for advice and information on TDR’s potential ability to advance the project.
www.who.int /tdr/publications/tdrnews/news62/kinetoplastid.htm   (628 words)

 Bioline International Official Site (site up-dated regularly)
The kinetoplastid membrane protein 11 (KMP-11) has been recently described in Leishmania (Leishmania) donovani as a major component of the promastigote membrane.
Molecular characterization of the kinetoplastid membrane protein-11 from African trypanosomes.
The kinetoplastid membrane protein-11 of Leishmania donovani and African trypanosomes is a potent stimulator of T-lymphocyte proliferation.
www.bioline.org.br /request?oc98047   (4418 words)

 BioMed Central | about us | Press releases
Analysis of kinetoplastid research literature from the last 35 years shows that 25,000 articles were published, however, during this period there has been little success in developing therapeutics, prophylactics or even cheap effective diagnostics.
The result of this fragmentation of the research literature is that each discipline is largely ignorant of advances of the others, progress is impeded, and similar studies are often reproduced.
Kinetoplastid Biology and Disease aims to become a focus for the whole kinetoplastid research community.
www.biomedcentral.com /info/about/pr-releases?pr=20020816   (662 words)

 An updated view of kinetoplastid phylogeny using environmental sequences and a closer outgroup: proposal for a new ...
Positions with fl background correspond to signatures supporting the separation of basal bodonids and trypanosomatids from the rest of kinetoplastids (first alignment segment) or the basal position of the early emerging kinetoplastid sequences (second and third alignment segments).
Numbers at nodes are posterior probabilities except for the node concerning the split between the trypanosomatids and the apical bodonids, for which the PP and ML, MP and distance- (NJ) bootstrap proportions are shown (numbers in parentheses indicate that the node was not recovered in the MP and NJ analyses).
The sisterhood of kinetoplastids and diplonemids is in disagreement
ijs.sgmjournals.org /cgi/content/full/54/5/1861   (6630 words)

 Amazon.com: Kinetoplastid: Books   (Site not responding. Last check: 2007-10-12)
Kinetoplastids are small uni- or biflagellated cells with a distinctive and...
Crvptobia is a widely distributed group of 10 species of kinetoplastid flagellates that can colonize many freshwater or marine fish.
Kinetoplastid flagellates (family Bodonidae) have been reported from blowhole mucus of...
www.amazon.com /s?ie=UTF8&keywords=Kinetoplastid&tag=httpexplaguid-20&index=books&link_code=qs&page=1   (870 words)

 Pharmainfo.net - Protein trafficking in kinetoplastid protozoa   (Site not responding. Last check: 2007-10-12)
The kinetoplastid protozoa infect hosts ranging from invertebrates to plants and mammals, causing diseases of medical and economic importance.
Protein trafficking in kinetoplastids is in many respects similar to that in higher eucaryotes, including mammals and yeasts.
Some components of the normal array of trafficking mechanisms may be missing in most (if not all) kinetoplastids: examples are clathrin-coated vesicles, recycling receptors, and mannose 6-phosphate-mediated lysosomal targeting.
www.pharmainfo.net /sciences/microbiology/protein_trafficking_in_kinetoplastid_protozoa   (195 words)

 Genome Biology | Full text | A computational investigation of kinetoplastid trans-splicing
Kinetoplastid 5' UTRs are fairly short, ranging in length from 40 to 200 nucleotides (based on a survey of GenBank entries).
One of the challenges with gene prediction in the kinetoplastids is that the longest open reading frame present in a genomic segment does not necessarily correlate with the true open reading frame in the mRNA.
We propose that our method might be applied to refine gene prediction in kinetoplastid genomes by assisting in the identification of the true starts of coding regions.
genomebiology.com /2005/6/11/R95   (6884 words)

 Current Molecular Medicinal Volume 4, Number 6, 2004
Trypanosoma cruzi is responsible for the fatal Chagas disease in large parts of South America, the various species of Leishmania cause a number of different human diseases with millions of patients world-wide, and the African trypanosome Trypanosoma brucei is the agent of human sleeping sickness, a disastrously re-emerging epidemic of fatal infections in Sub-Saharan Africa.
The cAMP-specific phosphodiesterases of the kinetoplastids are rather similar to those of human cells and might function in similar ways.
The DNA microarray is a genomic technology, which is being applied to new gene discovery in kinetoplastid parasites.
www.bentham.org /cmm/contabs/cmm4-6.htm   (2709 words)

 The Evolutionary History of Kinetoplastids and Their Kinetoplasts -- Simpson et al. 19 (12): 2071 -- Molecular Biology ...
The length of the branch leading to kinetoplastids and its low bootstrap support (30%) are typical for the analyses with out-groups.
the length of the longest internal branch in kinetoplastids.
kinetoplastids between clade 1 and the other taxa (fig.
mbe.oxfordjournals.org /cgi/content/full/19/12/2071   (6394 words)

 Portal to Protistology: Kinetoplastids
The kinetoplastid protozoa comprise a large group of flagellated organisms that are thought to have had a common ancestor with the Euglenoid protozoa early in evolution of eukaryotic cells.
There is some evidence that the common ancestor contained a plastid derived from endosymbiosis of an algae, which was secondarily lost in the kinetoplastid lineage but some of the genes of which were transferred to the nucleus.
There are two major groups of kinetoplastid protists - the bodonids and the trypanomatids.
www.uga.edu /protozoa/portal/tryp.html   (368 words)

 Folding stability of the kinetoplastid membrane protein-11 (KMP-11) from Leishmania infantum -- Fuertes et al. 260 (2): ...   (Site not responding. Last check: 2007-10-12)
Folding stability of the kinetoplastid membrane protein-11 (KMP-11) from Leishmania infantum -- Fuertes et al.
Jardim, A., Funk, V., Caprioli, R.M. and Olafson, R.W. (1995) Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein.
Stebeck, C.E., Baron, G.S., Beecroft, R.P. and Pearson, T.W. (1996) Molecular characterization of the kinetoplastid membrane protein-11 from African trypanosomes.
content.febsjournal.org /cgi/content/full/260/2/559   (4109 words)

 UGA Cellular Biology | Faculty | Kojo Mensa-Wilmot
Using related (kinetoplastid) protozoan parasites, Leishmania major and Trypanosoma cruzi, as models, we have demonstrated that heterologous expression of GPI-PLC can lead to a GPI deficiency, resulting in replication defects in both Leishmania and T.
We are studying the biochemical mechanism(s) for rejection of kinetoplastid signal peptides by the mammalian translocation machinery.
We are also cloning trypanosome homologs of the mammalian protein that displayed defective interactions with the kinetoplastid signal sequences.
www.uga.edu /cellbio/mensa-wilmot.html   (961 words)

 [No title]
TCC263 [0] Herm.maria Herpetomonas mariadeanei ATCC 30708 (kinetoplastid) [0] Herm.megas Herpetomonas megaseliae ATCC 30209 (kinetoplastid) [0] Herm.musc2 Herpetomonas muscarum subsp.
NLB162 (kinetoplastid) LEPTOMONAS [0] Lept.sp Leptomonas sp.
El-CP (African trypanosome) [0] Tryp.trigl Trypanosoma triglae (trypanosome) [0] Tryp.vivax Trypanosoma vivax (trypanosome) [0] Leis.herri Leishmania herreri (kinetoplastid) BODONIDAE [0] 10RNasu2 unnamed organism [0] 10RNasut unnamed organism [0] Bodo_cauda Bodo caudatus str.
rdp8.cme.msu.edu /download/SSU_rRNA/SSU_Euk.phylo   (3500 words)

 Telomerase in kinetoplastid parasitic protozoa -- Cano et al. 96 (7): 3616 -- Proceedings of the National Academy of ...
Telomerase in kinetoplastid parasitic protozoa -- Cano et al.
Kinetoplastid telomeres, including those of human and animal pathogens, are composed of tandem, repeated copies of a 6-bp
In initial attempts to detect telomerase activity in parasite extracts, the one-tube PCR-based TRAP (18) was used.
www.pnas.org /cgi/content/full/96/7/3616   (4510 words)

 Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa -- Gadelha et al. 4 (3): 516 -- Eukaryotic ...
the PFR as a canonical organelle of kinetoplastids.
in the kinetoplastids restricted to a single clade.
Relationships between the major kinetoplastid paraflagellar rod proteins: a consolidating nomenclature.
ec.asm.org /cgi/content/full/4/3/516   (5033 words)

 Research in the Sabatini Laboratory - The Bay Paul Center Portal   (Site not responding. Last check: 2007-10-12)
Members of the family kinetoplastidae include organisms that cause a variety of deadly parasitic diseases: (i) the African trypanosome causes sleeping sickness in humans and a corresponding disease in cattle called nagana; (ii) Chagas’ disease of Latin America caused by T.
One of the main research goals in this laboratory is to understand how the trypanosome is able to escape the host immune system allowing the parasite to proliferate in the mammalian bloodstream and eventually cause disease.
Our hypothesis is that the novel thymine base modification represents an epigenetic factor involved in the regulation of kinetoplastid transcription and recombination.
jbpc.mbl.edu /research-sabatini.html   (846 words)

 guide RNA sequences   (Site not responding. Last check: 2007-10-12)
Species: gRNAs have been studied in various kinetoplastid species and their variants.
A comparative map of the maxicircle gene organization in different kinetoplastid organisms can be found as part of the RNA editing web site by L. Simpson, UCLA.
A graphical representation of the gRNA gene organization in different kinetoplastid organisms can be found as part of the RNA editing web site by L. Simpson, UCLA.
biosun.bio.tu-darmstadt.de /goringer/gRNA/ex-notes.html   (385 words)

 Uridylate Addition and RNA Ligation Contribute to the Specificity of Kinetoplastid Insertion RNA Editing -- Igo et al. ...
Kinetoplastid RNA editing is a form of mitochondrial (mt) mRNA maturation in which uridylate residues (U's) are inserted and
In vitro studies using mt extract from the kinetoplastid Trypanosoma brucei (8, 15, 25) indicate that RNA editing occurs
Kinetoplastid RNA editing does not require the terminal 3' hydroxyl of guide RNA, but modifications to the guide RNA terminus can inhibit in vitro U insertion.
mcb.asm.org /cgi/content/full/20/22/8447   (7726 words)

 Faculty - Donna Koslowsky, Ph.D.
Trypanosomes are a member of the kinetoplastid protozoa which cause tremendous medical and economic distress in Third World countries.
The mitochondrial genes are regulated primarily at the post-transcriptional level involving RNA editing.
The phenomenon of RNA editing in kinetoplastid protozoans is the most radical form of post-transcriptional alteration known to date.
www.msu.edu /dept/mic/faculty/koslowsky.htm   (366 words)

 A Proteomic screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania ...
A Proteomic screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death
Indeed, drug-induced PCD progression is altered in the SbV-resistant strain as determined using early and late markers of apoptosis.
Two proteins, the heat shock protein HSP83 and the small kinetoplastid calpain-related protein (SKCRP14.1) were shown to be intimately implicated in the drug-induced PCD phenotype.
www.mcponline.org /cgi/content/abstract/M600319-MCP200v1   (311 words)

 The Diplomonads, Parabasala, Euglenozoa, & Alveolata Hunt   (Site not responding. Last check: 2007-10-12)
The genus Trypanosoma is a main parasitic member of the kinetoplastid group of Euglenozoa prostists.
Explain key characteristics: the diseases caused by the species?Trypanosoma brucei and Trypanosoma cruzi, how the diseases are transmitted, and the impacts of the diseases on humans.
The life cycles of Euglenozoons varies according to the group; the life cycle of the Kinetoplastids differ from the Euglenoids.
www.kn.sbc.com /wired/fil/pages/hunteuglenozba.html   (785 words)

 American Society of Limnology and Oceanography   (Site not responding. Last check: 2007-10-12)
Experiments under vent conditions of high pressure and high concentrations of metals and sulfide showed that some of these species are very tolerant to extreme environmental conditions.
Deep-sea vent samples were both cultured to select for kinetoplastid flagellates and analyzed without culturing by denaturing gradient gel electrophoresis (DGGE) using PCR primers specific to the kinetoplastid clade.
PCR and DGGE were able to specifically isolate and amplify target DNA's from all cultured kinetoplastid species in matching vent samples, thus corroborating the findings of culturing.
aslo.org /meetings/albuquerque2001/338.html   (256 words)

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