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Beta-lactam - Wikipedia, the free encyclopedia Beta lactam is the square at the center. A beta-lactam ring (β-lactam) or penam is a lactam with a heteroatomic ring structure, consisting of three carbon atoms and one nitrogen atom. As a response to bacterial resistance to beta lactam drugs, there are drugs, such as Augmentin, which are designed to disable the beta-lactamase enzyme. en.wikipedia.org /wiki/Beta-Lactam   (228 words)

Method for producing pressure sensitive poly (N-vinyl lactam) - Patent 5409966 A hydrophilic, pressure-sensitive adhesive composition prepared by irradiating solid poly(N-vinyl lactam) with ionizing radiation to crosslink the poly(N-vinyl lactam) and thereafter mixing the radiation-crosslinked poly(N-vinyl lactam) with essentially unirradiated plasticizer in an amount sufficient to form a cohesive, pressure-sensitive adhesive composition. The crosslinked, cohesive, swellable polymeric matrix is formed from the free-radical polymerization of a precursor having a monomeric species of N-vinyl lactam, and a crosslinker of a multi-ethylenically unsaturated compound wherein the ethylenic groups are vinyl, allyl, or methallyl groups bonded to nitrogen or oxygen atoms. Poly(N-vinyl lactam) in a solid form can be a noncrosslinked homopolymer or a noncrosslinked copolymer containing N-vinyl lactam monomeric units, which after irradiation is swellable in a plasticizer biocompatible with mammalian skin. www.freepatentsonline.com /5409966.html   (8130 words)

PHA 421 - Infectious Disease Module Reaction of the peptidoglycan with the beta lactam thus results in an irreversible inhibition of the PBP, and results in lysis and death of the bacterial cell. When the beta lactam ring is attacked by a nucleophile, the electrons can flow to the acetoxy moiety, thus providing an electron sink and increasing the reactivity of the beta lactam ring. The beta lactam antibiotic thienamycin was isolated from the mold Streptomyces cattlea. wiz2.pharm.wayne.edu /module/betalactam.html   (2373 words)

FDA/CFSAN - Beta lactam Test Methods For Use Under Appendix N And Section 6 Of The Grade 'A' Pasteurized Milk Ordinance ... While it is preferred that monitoring for Beta lactams include all of these drugs, at this time, the Agency is recommending that methods be utilized that have been shown to detect at least four (4) of the six (6) Beta lactams identified above. This test is acceptable for use to detect Beta lactam residues when used with bovine pasteurized whole and skim milk. The SNAP BETA lactam TEST is being replaced by the New SNAP BETA lactam TEST and cannot be used after July 2, 2004. vm.cfsan.fda.gov /~ear/m-a-85.html   (1216 words)

[Frontiers in Bioscience 7, d752-764, March 1, 2002] Lactam 18 induces caspase activity associated with Hsp70 expression and p38 phosphorylation. M of lactam 1 or lactam 18 for 16 h, followed by Western blot analysis using specific antibodies to HSP70, p-p38, and Actin. A, Jurkat T and YT cells were treated with lactam 1 and lactam 18 at indicated concentration for 16 h, followed by measurement of cell-free caspase-3 activity by incubating whole cell extracts with caspase-3 substrate and measuring free AMCs. www.bioscience.org /2005/v10/af/1611/figures.htm   (455 words)

Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis We compared clinical outcomes for beta lactam-aminoglycoside combination therapy versus beta lactam monotherapy for sepsis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library, Issue 3, 2004); MEDLINE (1966 to July 2004); EMBASE (1980 to March 2003); LILACS (1982 to July 2004); and conference proceedings of the Interscience Conference of Antimicrobial Agents and Chemotherapy (1995 to 2003). www.cochrane.org /reviews/en/ab003344.html   (831 words)

{beta} lactam monotherapy versus {beta} lactam-aminoglycoside combination therapy for fever with neutropenia: ... {beta} lactam monotherapy versus {beta} lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis -- Paul et al. lactam, whereas there was major advantage with monotherapy In case of septic shock, beta lactam monotherapy would be dangerous bmj.bmjjournals.com /cgi/content/abstract/326/7399/1111   (338 words)

Synthesis of L-4,4-Difluoroglutamic Acid via Electrophilic Difluorination of a Lactam An enantiomerically pure bicyclic lactam proved to be an excellent substrate for electrophilic difluorination using N-fluorobenzenesulfonimide. The resulting difluorinated lactam can be easily converted into To the best of our knowledge, this is the first example of a synthetically useful electrophilic difluorination of an unactivated lactam. pubs.acs.org /cgi-bin/abstract.cgi/orlef7/1999/1/i13/abs/ol991150l.html   (98 words)

C4,C4'-Bis--lactam to Fused Bis--lactam Rearrangement   (Site not responding. Last check: 2007-10-29) The remaining bicyclic lactams have been chemically correlated to compound 1b- The presence of alkyl groups attached to the lactam nitrogen inhibits the rearrangement. -lactam systems gave the selective opening of the ring with the aromatic substituent attached to the lactam nitrogen. pubs.acs.org /cgi-bin/abstract.cgi/joceah/1996/61/i26/abs/jo960826c.html   (290 words)

Amazon.com: lactam   (Site not responding. Last check: 2007-10-29) beginning of an era of lactam antibiotics that continues to this... Biochemistry of Peptide Antibiotics: Recent Advances in the Biotechnology of B Lactams and Microbial Bioactive Peptides by Horst Kleinkauf and Hans Von Dohren (Hardcover - Jun 1990) The chemical assay based on lactam reaction with hydroxylamine (colorimetric test)... www.amazon.com /s?ie=UTF8&search-alias=aps&keywords=lactam&page=1   (462 words)

{beta} lactam monotherapy versus {beta} lactam-aminoglycoside combination therapy for sepsis in immunocompetent ... {beta} lactam monotherapy versus {beta} lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials -- Paul et al. lactam (1.02, 0.76 to 1.38), and 31 studies compared different Is combination therapy with betalactam plus aminoglycoside (AGL) improving the outcome of nosocomial meningitis in children? bmj.bmjjournals.com /cgi/content/abstract/328/7441/668   (355 words)

Definition of lactam - Merriam-Webster Online Dictionary   (Site not responding. Last check: 2007-10-29) Click here to search for another word in the Merriam-Webster Online Dictionary. For More Information on "lactam " go to Britannica.com Get the Top 10 Search Results for "lactam " www.bonus.com /contour/merriam_webster/http@@/www.m-w.com/dictionary/lactam   (56 words)

lactam - Dictionnaire Français-Anglais WordReference.com We found no English translation for 'lactam' in our French to English Dictionary. Or did you want to translate 'lactam' from English to French? Forum discussions with the word(s) 'lactam' in the title: www.wordreference.com /fren/lactam   (49 words)

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