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Critical Care | Full text | Bench-to-bedside review: Lactate and the kidney |
 | | The renal contribution to lactate removal thus increases from 16% at a pH of 7.45 to 44% at a pH of 6.75 [4]. |
 | | Lactate uptake is the major mechanism of renal lactate removal and appears to be essentially confined to the cortex [5,14], as shown by radioisotopic methods in isolated, perfused rat kidney [14]. |
 | | Lactate may thus be the major gluconeogenetic precursor in the kidney under some conditions, and contributes significantly to the glycemic impact of other renal-specific precursors of gluconeogenesis such as glycerol [17], alanine and glutamine [19]. |
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