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Lactic acid Summary Lactic acid is utilized for the reformation of glucose in the process of gluconeogenesis and this occurs in the liver. Lactic acid, or 2-Hydroxypropanoic acid, is one of a family of organic carboxylic acids produced by biological organisms. Lactic acid is produced in active muscle tissue from the break down of glycogen, a carbohydrate used as an energy source for muscle movement. www.bookrags.com /Lactic_acid   (2286 words)

Lactic Acid   (Site not responding. Last check: 2007-10-24) This recent research shows that lactic acid is the most efficient source of energy for muscles. Since lactic acid is burned for energy in the mitochondria, anything that enlarges the mitochondria builds a bigger furnace and helps to increase endurance. Lactic acid is carried from the cells into the mitochondria by special proteins called lactate transporter molecules, so anything that increases these molecules will build endurance. www.drmirkin.com /fitness/lactic_acid_intervals.html   (334 words)

eMedicine - Lactic Acidosis : Article Excerpt by Sat Sharma In 1925, Clausen identified the accumulation of lactic acid in blood as a cause of acid-base disorder. Lactic acidosis is associated with major metabolic dysregulation, tissue hypoperfusion, effects of certain drugs or toxins, or congenital abnormalities in carbohydrate metabolism. Congenital lactic acidosis is secondary to inborn errors of metabolism, such as defects in gluconeogenesis, pyruvate dehydrogenase, the tricarboxylic acid (TCA) cycle, or the respiratory chain. www.emedicine.com /med/byname/lactic-acidosis.htm   (2092 words)

Escherichia coli D-lactate dehydrogenase The D-lactate dehydrogenase is coded for by the dld gene and appears to be the primary source of energy to drive the active transport of certain sugars and amino acids into the cell. "In vitro synthesis of the membrane-bound D-lactate dehydrogenase of Escherichia coli." Biochemistry 21(9);2085-91. Inactivation of D-lactate dehydrogenase and D-lactate dehydrogenase-coupled transport in Escherichia coli membrane vesicles by an acetylenic substrate." J Biol Chem 1972;247(24);7858-63. biocyc.org /getid?id=EcoCyc:DLACTDEHYDROGFAD-MONOMER   (491 words)

How it works One of these reactions (postulated) involves the removal of lactic acid, a chemical that is a major cause of muscle cramping. Lactic acid is the chemical produced by over-worked, under oxygenated muscle tissue. Lactic acid causes the ever so dreaded "forearm pump" that kills power and endurance of the athlete. www.racerscloset.com /max08-howitworks.htm   (910 words)

Semi-quantitative assay of metabolic acids - Patent 4351899 The present invention relates to determination of the concentration of specific metabolic acids in biological fluids, and in particular, the concentration of betahydroxybutyrate and lactic acid in biological fluids. Although lactic acidosis may be the most common form of metabolic acidosis, there is a problem in determining rapidly the concentration of lactate in biological fluids. The invention assays the concentration of a metabolic acid by oxidizing the acid enzymatically with a corresponding reduction of nicotinamide adenine dinucleotide (NAD) to NADH. www.freepatentsonline.com /4351899.html   (1947 words)

Lactic Acid Dehydrogenase (LD), Body Fluid Lactate dehydrogenase (LD) is a normal component of CSF. One application of LD measurement is the differential diagnosis of intracranial hemorrhage in neonates versus traumatic tap. Lactate dehydrogenase is elevated in proportion to severity of CNS hemorrhage, but unchanged by traumatic tap. www.labcorp.com /datasets/labcorp/html/chapter/mono/pr006100.htm   (168 words)

Microbial Cell Factories | Full text | Organic acid toxicity, tolerance, and production in Escherichia colibiorefining ... The report emphasized the importance of organic acids to the future of biorefining efforts (eight of the top twelve chemicals were organic acids, see Table 1 in additional file 1). Although many lactic acid bacteria strains have been studied extensively [37], the ability to produce optically pure L-lactic acid is hampered by the presence of both L and D lactate dehydrogenase genes [38]. Specifically, succinic acid production was optimized by redirecting the metabolic flux at the pyruvate node away from lactate and formate through inactivation of the pyruvate-formatelyase and lactate dehydrogenase [60,63]. www.microbialcellfactories.com /content/4/1/25   (4623 words)

Cofactors Coenzymes Vitamins Enzymes that utilize NAD+ are often named dehydrogenases.   They are generally named by first naming the substrate upon which they act and then dehydrogenase,  e.g. Lactic acid dehydrogenase would be an enzyme that catalyzes the reaction (oxidation) of lactic acid to pyruvic acid via the loss of hydrogen. www.cameron.edu /~teds/1Cofactors_files/slide0045.htm   (86 words)

Method of inhibiting the growth of malignant tumor cells - Patent 4620972 The method of inhibiting the development of cancer set forth in claim 1 in which the lactate dehydrogenase is extracted from the muscle of a primate selected from the group consisting of homo sapiens, monkeys and the family Pongidae. However, the presence of the enzyme lactate dehydrogenase or lactic acid dehydrogenase (hereinafter usually referred to as LDH in accordance with conventional usage) is essential for the completion of the reactions and the production of lactic acid. The anaerobic energy-yielding conversion of glucose to lactic acid thus is not completed since the reaction appears to be halted at the pyruvic acid stage. www.freepatentsonline.com /4620972.html   (1777 words)

04.19.2006 - Muscles burn lactic acid as well as carbos This rat muscle cell has been labeled with a red dye (left) that highlights an enzyme, lactate dehydrogenase, that catalyzes the conversion of lactate to energy, and a green dye (center) highlighting an enzyme, cytochrome oxidase, where oxygen is burned. Coaches and athletes don't realize it, says exercise physiologist George Brooks, UC Berkeley professor of integrative biology, but endurance training teaches the body to efficiently use lactic acid as a source of fuel on par with the carbohydrates stored in muscle tissue and the sugar in blood. Efficient use of lactic acid, or lactate, not only prevents lactate build-up, but ekes out more energy from the body's fuel. www.berkeley.edu /news/media/releases/2006/04/19_lactate.shtml   (978 words)

Lactic acid - Wikipedia, the free encyclopedia -lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. Lactic acid is used in a variety of food stuffs (such as yogurt) to act as an acidity regulator. en.wikipedia.org /wiki/Lactic_acid   (801 words)

Lactic Acid: An Underestimated Energy Source - Medgadget - www.medgadget.com Investigators from UC Berkeley have shown that athletic training teaches the body to efficiently utilize lactic acid as a source of fuel in stressful situations: Training helps people get rid of the lactic acid before it can build to the point where it causes muscle fatigue, and at the cellular level, Brooks said, training means growing the mitochondria in muscle cells. In fact, the cellular mitochondrial network, or reticulum, has a complex of proteins that allow the uptake and oxidation, or burning, of lactic acid. www.medgadget.com /archives/2006/04/lactic_acid_an.html   (578 words)

Definition of lactate dehydrogenase - NCI Dictionary of Cancer Terms Definition of lactate dehydrogenase - NCI Dictionary of Cancer Terms One of a group of enzymes found in the blood and other body tissues and involved in energy production in cells. lactic acid dehydrogenase, lactoferrin, lactose, lactose intolerance, laetrile cancertrials.nci.nih.gov /Templates/db_alpha.aspx?print=1&cdrid=354462   (71 words)

Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic ... Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic Escherichia coli -- Juárez Tomás et al. Lactic acid production by lactobacilli that are used by food acid were the same as those required for growth. jmm.sgmjournals.org /cgi/content/full/52/12/1117   (2741 words)

[No title] Researchers in Brussels, Belgium found that people who suffer from the metabolic syndrome should increase their intake of omega-3 fatty acids found in seafood, seeds and many vegetables. Omega-3 fatty acids help to reduce the amount of fat in the liver and muscles. Omega-3 fatty acids lower blood levels of triglycerides, and lowering triglycerides raises blood levels of the good HDL cholesterol. www.drmirkin.com /public/ezine072306.html   (808 words)

Worthington Lactate Dehydrogenase, L- (Cytochrome b2) Appleby, C., and Morton, R.: Lactic Dehydrogenase and Cytochrome b2 from Yeast. Appleby, C., and Morton, R.: Lactic Dehydrogenase and Cytochrome b2 of Bakers' Yeast. Suzuki, H., and Ogura, Y.: The Kinetic Behavior of the FMN and Protoheme Moieties of Yeast L-(+)-Lactate Dehydrogenase (Cytochrome b2), J Biochem (Tokyo) 67, 277, 1970 www.worthington-biochem.com /YLDHS/default.html   (1152 words)

Definition of lactic acid dehydrogenase - NCI Dictionary of Cancer Terms Definition of lactic acid dehydrogenase - NCI Dictionary of Cancer Terms An increased amount in the blood may be a sign of tissue damage and some types of cancer or other diseases. labial mucosa, laboratory study, laboratory test, lacrimal gland, lactate dehydrogenase www.nci.nih.gov /Templates/db_alpha.aspx?print=1&cdrid=354463   (63 words)

Train your muscles to use lactic acid as fuel | The Final Sprint (TFS) | The Internet’s Premier Running, Fitness, ... Train your muscles to use lactic acid as fuel Train your muscles to use lactic acid as fuel Tags: bloodstream, burn, burning, carbon dioxide, chemical reaction, endurance, energy, energy source, enzyme, fuel, increase endurance, interval training, lactate transporter, lactic acid, lactic acid dehydrogenase, lactic acid threshold, molecules, muscles, oxygen www.thefinalsprint.com /2007/01/train-your-muscles-to-use-lactic-acid-as-fuel   (1203 words)

Lactic Acid Dehydrogenase (LD) Since LD is found in virtually every tissue in the body, the diagnostic value of an elevated level is limited. Hemolysis elevates LD results; oxalate inhibits LD; ascorbic acid can decrease LD values. Winzelberg GG, Hull JD, Agar JW, et al, “Elevation of Serum Lactate Dehydrogenase Levels in Renal Infarction,” JAMA, 1979, 242(3):268-9. www.labcorp.com /datasets/labcorp/html/chapter/mono/pr006000.htm   (337 words)

MDAdvice.com - Health Library - Medical Tests Note: This is essentially the same test as total lactic acid dehydrogenase. After other enzymes have dropped to normal, hydroxybutyric dehydrogenase (HBD) remains elevated. Monitors cardiac-isoenzyme activity after lactic acid dehydrogenase (LDH) has been proved to be elevated. www.mdadvice.com /library/test/medtest219.html   (552 words)

PURIFICATION OF LACTIC ACID DEHYDROGENASE (LDH) Lactic Acid Dehydrogenase in an important enzyme in the anaerobic metabolism of glucose for the generation of ATP. For nucleic acid separations, the gel is most commonly agarose, while for proteins, the gel of choice is polyacrylamide. SDS not only denatures proteins, it is negatively charged and it binds to all proteins (well, most proteins) at a constant ratio of 1SDS/ 2 amino acids. www.acad.carleton.edu /curricular/BIOL/classes/bio380/lab_protocol.html   (3358 words)

Glossary of Cancer-Related Terms -- Siteman Cancer Center St. Louis Missouri A substance that is used to relieve pain by blocking signals at the nerve endings in skin. A gene hunting technique that traces patterns of disease in high-risk families, in an attempt to locate a disease-causing gene by identifying genetic markers of known chromosomal location that are co-inherited with the trait of interest. It is a rich source of omega-3 fatty acid, fiber, and a compound called lignin. www.siteman.wustl.edu /internal.aspx?id=1041   (5540 words)

Lactic acid dehydrogenase (LDH) - MSN Health & Fitness   (Site not responding. Last check: 2007-10-24) Lactic acid dehydrogenase (LDH) - MSN Health and Fitness Lactic acid dehydrogenase (LDH) is an enzyme that helps produce energy. MSN Health and Fitness does not provide medical or any other health care advice, diagnosis or treatment. health.msn.com /general/articlepage.aspx?cp-documentid=100058488   (208 words)

Carilion - Lactic acid dehydrogenase (LDH) - [Medical Test] Carilion - Lactic acid dehydrogenase (LDH) - [Medical Test] It is present in almost all of the tissues in the body and becomes elevated in response to cell damage. Healthwise and Thomson Healthcare disclaim any liability for the decisions you make based on this information. www.carilion.com /kbase/htm/tv69/85/tv6985.htm   (173 words)

Novel Systems for High Level Expression of Fungal Products   (Site not responding. Last check: 2007-10-24) In order to find more industrially favorable organisms, over 30 fungi belonging to the genera Aspergilli and Rhizopus were tested for their ability to ferment simple sugars as well as complex substrates to ethanol or lactic acid. Efforts are currently directed at increasing beta-glucosidase activity to maximize the efficiency of cellulose saccharification and improving the organisms ability to convert pyruvate to ethanol. Both Aspergillus and Fusarium are being used for expression of recombinant pyruvate decarboxylase and alcohol dehydrogenase genes. www.nal.usda.gov /ttic/biofuels/bothast2.htm   (614 words)

EC 1.1.1.27 -lactic acid dehydrogenase; lactate dehydrogenase; lactate dehydrogenase NAD-dependent; lactic dehydrogenase; NAD-lactate dehydrogenase Everse, J. and Kaplan, N.O. Lactate dehydrogenases: structure and function. I) Isolation and characterization of lactate dehydrogenases from thermophilic and mesophilic bacilli. www.chem.qmul.ac.uk /iubmb/enzyme/EC1/1/1/27.html   (89 words)

Definition of lactic - Merriam-Webster Online Dictionary 2 : involving the production of lactic acid Learn more about "lactic" and related topics at Britannica.com Find more about "lactic" instantly with Live Search www.m-w.com /cgi-bin/dictionary?book=Dictionary&va=lactic   (41 words)

How Cells Make ATP -Cellular Energetics converts free fatty acids in blood into to four steps for this mitochondrial dehydrogenase enzyme system... a long chain fatty acid by 2 carbons fig.cox.miami.edu /~cmallery/255/255atp/255makeatp.htm   (192 words)

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