Factbites
 Where results make sense
About us   |   Why use us?   |   Reviews   |   PR   |   Contact us  

Topic: Lactic acidosis


Related Topics

In the News (Sun 27 Dec 09)

  
  Simple FactSheet: Lactic Acidosis and Hepatic Steatosis
Lactic acid is a waste product made by cells that aren't getting enough energy from their mitochondria.
The majority of the cases were women, and the FDA reported that obesity seemed to increase the risk of developing lactic acidosis.
Measurements of lactic acid in the blood (called serum lactate levels) are taken.
www.aegis.com /factshts/network/simple/lactic.html   (652 words)

  
 Riomet Online, Description, Chemistry, Ingredients - Metformin Hcl - RxList Monographs
Lactic acidosis may also occur in association with a number of pathophysiologic conditions, including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia.
Lactic acidosis is characterized by elevated blood lactate levels (>5 mmol/L), decreased blood pH, electrolyte disturbances with an increased anion gap, and an increased lactate/pyruvate ratio.
The risk of lactic acidosis increases with the degree of renal dysfunction and the patient’s age.
www.rxlist.com /cgi/generic3/riomet.htm   (836 words)

  
 eMedicine - Lactic Acidosis : Article by Sat Sharma
Lactic acidosis is associated with major metabolic dysregulation, tissue hypoperfusion, effects of certain drugs or toxins, or congenital abnormalities in carbohydrate metabolism.
Congenital lactic acidosis is secondary to inborn errors of metabolism, such as defects in gluconeogenesis, pyruvate dehydrogenase, the tricarboxylic acid (TCA) cycle, or the respiratory chain.
Lactic acidosis is observed frequently in patients who are critically ill. Despite a large number of potential etiologies, tissue hyperfusion is by far the most common etiology.
www.emedicine.com /med/topic1253.htm   (5100 words)

  
 Lactic Acid
Lactic acid is a result of the breakdown of sugars (carbohydrates) for energy when the oxygen level in the body is low.
Lactic acid levels rise when strenuous exercise or other conditions—such as heart failure, a severe infection (sepsis), or shock—reduce the flow of blood and delivery of oxygen throughout the body.
Lactic acidosis can also occur in a person who takes metformin (Glucophage) to control diabetes when heart or kidney failure or a severe infection is also present.
www.webmd.com /hw/lab_tests/hw7871.asp   (1101 words)

  
 Aidsmap | Lactic acidosis / acidaemia
Lactic acidosis is a serious side-effect of the nucleoside analogue reverse transcriptase inhibitors (NRTIs), such as AZT (zidovudine, Retrovir) and d4T(stavudine, Zerit).
Lactic acidosis is the condition caused by over-accumulation of lactate in the body, which the body is unable to clear.
Lactic acidosis is thought to be caused by damage to mitochondrial DNA caused by NRTIs.
www.aidsmap.com /en/docs/0BFBE157-F1FB-40C4-8540-D6692F734438.asp   (5407 words)

  
 eMedicine - Lactic Acidosis : Article by Bret A Nicks, MD
Lactic acidosis, identified by a state of acidosis and a plasma lactate concentration significantly greater than the normal concentration of 1 mEq/L (typically 4-5 mmol/L), is one type of anion gap metabolic acidosis and may result from numerous sources.
Lactic acidosis rarely may present in the MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and strokelike episodes), which appears to be caused by a point mutation in mitochondrial DNA tRNALeu (UUR) gene.
Lactic acidosis is typically associated with tissue hypoperfusion and states of acute circulatory failure.
www.emedicine.com /emerg/topic291.htm   (2893 words)

  
 Lactic Acidosis   (Site not responding. Last check: 2007-10-03)
Lactic Acidosis is the buildup of lactic acid in the body.
The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain.
Lactic acidosis may be caused by diabetic ketoacidosis or liver or kidney disease.
www.paralumun.com /diabeteslactic.htm   (69 words)

  
 Metformin and Fatal Lactic Acidosis
Post-surgical lactic acidosis caused the death of a 70-year-old man whose metformin was not withdrawn at the time of surgery.
Ninety percent of metformin is excreted unchanged by the kidneys and lactic acidosis typically occurs in patients with renal insufficiency.
Significant renal impairment (serum creatinine >0.16 mmol/L) is a contraindication to the use of metformin, and mild renal disease increases the risk of lactic acidosis.
www.medsafe.govt.nz /profs/PUarticles/5.htm   (663 words)

  
 The Well Project: Lactic Acidosis and HIV
Lactic Acidosis is a buildup of lactic acid in the blood.
Because lactic acidosis is so rare, there have not been a lot of opportunities to study treatment.
Because there is a connection between liver problems and lactic acidosis, have your doctor check your liver function while you are taking NRTIs, especially if you have a history of heavy alcohol use or a liver problem.
www.thewellproject.org /Diseases_and_Conditions/Treatment_Related_Conditions/Lactic_Acidosis.jsp   (751 words)

  
 s000328a - D-Lactic Acidosis
The clinical presentation of d-lactic acidosis is: characterized by episodes of encephalopathy and metabolic acidosis.
D-Lactic acidosis was diagnosed on the basis of a D-lactate level of 8.2: mmol/L (normal, 0 to 0.25) obtained during an episode of confusion.
Since we had observed: that gram-positive bacteria, mainly lactobacilli, were abundant even in the absence of acidosis, we studied serum: concentrations and urinary excretions of D- and L-lactate in young and adult SB patients, especially during nonacidotic: periods.
www.emory.edu /WHSCL/grady/amreport/litsrch99/s000328b.html   (1668 words)

  
 Lactic Acidosis
Lactic acidosis is diagnosed through examination, lab tests, an abdominal CT scan or liver biopsy.
Although lactic acid in blood can be measured, it is not clear whether high levels increase the risk of lactic acidosis.
Because lactic acid increases even with any physical activity, confirmatory tests should always be taken after you have completely rested for at least 20 minutes.
www.pozireland.org /lactic_acidosis.htm   (541 words)

  
 Cattle Mutilations -- Severe Lactic Acidosis? copyright 2003 Kevin Sterns
Lactic Acidosis is a well-studied phenomenon, and numerous links can be found on the internet.
Lactic Acidosis is an affliction usually associated with feedlot cows.
Lactic Acidosis is typically associated with feedlot cattle, not range cattle.
skepdic.com /essays/sterns.html   (919 words)

  
 ► Lactic acidosis
Lactic acidosis occurs when lactic acid accumulates in the blood stream at a faster rate than it can be eliminated.
Lactic acid is produced in the presence of decreased oxygen.
The most common cause of increased lactic acid is intensive exercise in which the body builds up an oxygen debt.
www.umm.edu /ency/article/000391.htm   (123 words)

  
 eMedicine - Lactic Acidosis : Article by Stephen W Borron, MD, MS   (Site not responding. Last check: 2007-10-03)
Lactic acidosis results from an increase in blood lactate levels when body buffer systems are overcome.
Lactic acidosis rarely may present as the so-called MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and strokelike episodes), which appears to be caused by a point mutation in mitochondrial DNA tRNALeu (UUR) gene.
In lactic acidosis associated with ischemia, the blood lactate concentration has prognostic value, although the etiology of the shock state influences the probability of survival as well.
emedicine.com /emerg/topic291.htm   (1933 words)

  
 Lactic Acidosis Traced to Thiamine Deficiency Related to Nationwide Shortage of Multivitamins for Total Parenteral ...
Lactic acidosis of unknown etiology was diagnosed, and broad-spectrum antimicrobials were initiated after appropriate cultures were obtained.
These cases were characterized by low thiamine levels and rapid reversal after a single dose of IV thiamine, as well as by initially refractory lactic acidosis, hyperglycemia, and absence of sepsis.
The time for development of severe lactic acidosis in these and other reported episodes (range: 7-34 days) is consistent with the time required to deplete body stores of thiamine in healthy adults deprived of this vitamin.
www.cdc.gov /mmwr/preview/mmwrhtml/00047949.htm   (2018 words)

  
 Lactic - Lactic acidosis   (Site not responding. Last check: 2007-10-03)
Lactic acid bacteria have the property of producing lactic acid from sugars The taxonomy of lactic acid bacteria has been based on the gram reaction and
Lactic acid is a waste product which results from anaerobic glycolysis.
Lactic acid (a-hydroxypropionic acid) is a chemical compound that plays Lactic acid is quickly removed from muscles when they resume aerobic metabolism.
webinfosites.com /q/lactic.htm   (164 words)

  
 Lactic Acidosis: Symptoms and Laboratory Findings
Lactic acidosis, a rare and sometimes fatal complication of antiretroviral therapy, was first reported in the early 1990s.
In fact, elevated anion gap is not a sensitive or a specific way to look for lactic acidosis in patients suspected of having this syndrome.
Lactic acidosis and hepatic dysfunction associated with HAART: pathogenesis, clinical manifestations, and predictors.
www.hivandhepatitis.com /recent/metabolic/lactic_acidosis/1a.html   (202 words)

  
 Introduction: Lactic Acidosis - WrongDiagnosis.com
Lactic Acidosis: Lactic Acidosis (LA) is a dangerous condition where the blood gets too acidic (acidosis).
Researching symptoms of Lactic Acidosis: Further information about the symptoms of Lactic Acidosis is available including a list of symptoms of Lactic Acidosis, or alternatively return to research other symptoms in the symptom center.
Treatments for Lactic Acidosis: Various information is available about treatments available for Lactic Acidosis, or research treatments for other diseases.
www.wrongdiagnosis.com /l/lactic_acidosis/intro.htm   (222 words)

  
 Mitochondrial disruption and apoptosis in lymphocytes of an HIV infected patient affected by lactic acidosis after ...
Lactic acidosis and hepatic mitochondrial changes during a treatment with zidovudine.
Fatal lactic acidosis in a patient infected by HIV and treated with stavudine and didanosine.
Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases.
jcp.bmjjournals.com /cgi/content/full/56/2/147   (2305 words)

  
 Lactic Acidosis
Lactic acidosis (LA) in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs).
In the 3TC/d4T group, lactic acidosis was recognized a mean of 255 days after the start of both 3TC and d4T.
Lactic acidosis is a life-threatening complication of HAART occurring with increasing frequency
www.hivandhepatitis.com /hiv_and_aids/lipo/antiretro/lactic1.html   (1412 words)

  
 Lactic Acidosis
Increases in the level of lactic acid have been recognised in both HIV-positive adults and children and is linked to all nucleoside analogues as well as in people not using ARV treatment [1, 2].
Three of these patients were then found to have lactic acidosis, however, AG was elevated in only half the patients who presented with high lactate levels.
One case of lactic acidosis was diagnosed with a high AG of 30.3 (lactate 9 mmol/l) which resolved following discontinuation of ARVs and administration of carnitine, riboflavin, vitamin C, E and co-enzyme Q. Treatment was also interrupted in another with AG of 25.8 (lactate 4.2 mmol/l).
www.i-base.org.uk /pub/htb/vol1/htb7/htb7e.html   (629 words)

  
 Lactic acidosis definition - Medical Dictionary definitions of popular medical terms
Lactic acidosis: Acidosis (too much acid in the body) due to the buildup of lactic acid in the body.
Lactic acidois occurs when cells make lactic acid (from glucose) faster than it can be metabolized.
The key signs of lactic acidosis include unusually deep and rapid breathing, vomiting, and abdominal pain.
www.medterms.com /script/main/art.asp?articlekey=20521   (232 words)

  
 acidosis lactic singulair   (Site not responding. Last check: 2007-10-03)
itch elma serevent manufactorer case of lactic acidosis (accumulation of lactic acidosis February 12th, 2007 at 2:34 pm.
Thu Feb 08 03:00:02 PST 2007 metformin lactic acidosis / metformin lactic acidosis including unusual tiredness there is a rare, zcidosis lactic singulair but serious, plication that can occur due to a pH range between 6.8 and 7.8.
Changes in the body) singulair zyrtec periactin serevent advair brethine aerolate accolate phenergan pressure medication side effects acidosis lactic singulair but by the labor agitators, acidosis lactic singulair but by the banana stand.
acidosis-lactic-singulair.esblog.org   (202 words)

  
 Causes of Lactic Acidosis - WrongDiagnosis.com
Lactic Acidosis as a complication: Other conditions that might have Lactic Acidosis as a complication might be potential underlying causes of Lactic Acidosis.
What causes Lactic Acidosis?: Related information for Lactic Acidosis causes, as with all medical conditions, there may be many causal factors.
Further relevant information on causes of Lactic Acidosis may be found in the risk factors for Lactic Acidosis, medications that may cause Lactic Acidosis, contagiousness for Lactic Acidosis, genetics of Lactic Acidosis, and underlying causes of Lactic Acidosis.
www.wrongdiagnosis.com /l/lactic_acidosis/causes.htm   (244 words)

  
 What is Lactic Acidosis Syndrome and Mitochondrial Toxicity?
Lactic acidosis syndrome is a serious potential side effect of a class of HIV medications called nucleoside HIV reverse transcriptase inhibitors (NRTIs).
In the past, lactic acidosis syndrome was described as a very rare side effect of these medications leading to death in more than half of the cases despite aggressive medical care.
Lactic acidosis syndrome and hyperlactatemia are felt to be caused by the toxic effect of NRTIs on mitochondrial function.
www.natap.org /2000/lipo/lipo_rp4pt1whatislact092200.htm   (602 words)

  
 Lactic Acidosis Update for Critical Care Clinicians -- LUFT 12 (Supplement 1): 15 -- Journal of the American Society of ...
Lactic acidosis is a broad-anion gap metabolic acidosis caused
The possible causes of lactic acidosis are self-evident.
lactic acidosis with an elevated lactate/pyruvate ratio and decreased
www.jasn.org /cgi/content/full/12/suppl_1/S15   (2770 words)

  
 Metformin
Lactic acidosis has occurred most often in people whose kidneys were not working properly.
If you are over the age of 65 years, there may be an slight increase in the risk of developing lactic acidosis due to a natural decline in kidney function with advancing age.
Symptoms of lactic acidosis include a feeling of general discomfort or sickness; weakness; sore or aching muscles; trouble breathing; unusual drowsiness, dizziness or lightheadedness; unusual or unexplained stomach upset (after the initial stomach upset that may occur at the start of therapy with metformin); and the sudden development of a slow or irregular heartbeat.
www.drugs.com /metformin.html   (1622 words)

  
 The Body: Session 9Complications of Therapy: Mitochondrial Dysfunction/Lactic Acidosis
Lactic acidosis is another metabolic complication associated with antiretroviral therapy (ART) that is poorly understood.
We can certainly add severe lactic acidosis as well as nonacidotic mild hyperlactatemia to our list of metabolic complications associated with ART.
As a physician, I will now make sure I look for elevated lactic acid levels even in patients without obvious evidence of acidosis, especially when vague abdominal or GI symptoms occur.
www.thebody.com /confs/retro2000/fisher3.html   (547 words)

  
 Lactic acidosis -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-03)
Lactic acidosis -- Facts, Info, and Encyclopedia article
Lactic acidosis is a condition caused by the buildup of (A clear odorless hygroscopic syrupy carboxylic acid found in sour milk and in many fruits) lactic acid in the body.
B3: (Any of a number of diseases in which an inherited defect (usually a missing or inadequate enzyme) results in an abnormality of metabolism) Inborn error of metabolism
www.absoluteastronomy.com /encyclopedia/l/la/lactic_acidosis.htm   (134 words)

Try your search on: Qwika (all wikis)

Factbites
  About us   |   Why use us?   |   Reviews   |   Press   |   Contact us  
Copyright © 2005-2007 www.factbites.com Usage implies agreement with terms.