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Lactoferrin Lactoferrin is a glycoprotein that belongs to the iron transporter or transferrin family. Lactoferrin appears to bind uniquely in the region of major histocompatability (MHC) proteins and the CD4 and CD8 determinants on T4 (helper) and T8 (suppressor) lymphocytes; it bears sequence homologies with the MHC Class II determinant. Lactoferrin is digested in the intestine to the bioactive peptide lactoferricin. www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/lac_0314.shtml   (868 words)

Lactoferrin Nature's Premier Immune-Boosting Protein   (Site not responding. Last check: 2007-11-07) Lactoferrin is also found in neutrophils (a type of leukocyte or white blood cell), and, to a lesser extent, in the secretions of tear glands, salivary glands and the prostate gland. The biological actions of lactoferrin under various experimental conditions are wide-ranging and include: inhibition of the survival or growth of many different pathogenic organisms; activation or stimulation of a variety of immune system cells; regulation of normal cell growth; and inhibition of abnormal tumor growth and spread of cancer cells in laboratory animals. Lactoferrin?s overwhelming margin of safety, along with a rapidly accumulating body of clinical data and anecdotal accounts of its effects when taken by humans, suggests significant benefit when lactoferrin is used as a nutritional supplement in a wide range of infectious and life-threatening illnesses. intelegen.com /ImmuneSystem/lactoferrin.htm   (2117 words)

Spice Plus Lactoferrin-General Info   (Site not responding. Last check: 2007-11-07) Lactoferrin has been shown to exert antibacterial activity against a wide array of pathogens both in vitro and in vivo such as salmonella, E. coli, H. pylori, and staph. Lactoferrin prevents virus entry to the host cell either by blocking cellular receptors or by direct binding to the virus particles. Studies have shown that lactoferrin enhances the bioavailability of iron and lowers the amount of iron needed to prevent iron deficiency while at the same time reducing the negative side effects due to excessive iron loads. www.truebotanica.com /page.asp?ID=49   (1818 words)

Dr. Murray's Natural Facts Lactoferrin is a fascinating biologically protein that is a key component of human and bovine colostrum. Lactoferrin was first thought to play a role in iron absorption in newborns, however, recent research seems to indicate that it does not regulate iron metabolism in normal circumstances. Lactoferrin exerts broad spectrum antimicrobial action as it has been shown to be effective in inhibiting the growth of disease causing protozoa, yeast, bacteria, and viruses. www.doctormurray.com /newsletter/2-14-2004.htm   (1584 words)

Lactoferrin 350 MG - 90 CP The first mechanism is by depriving the micro-organisms from iron needed for growth; the second mechanism is by direct binding to the microbial membrane, which alters the membrane permeability and leads to death of the organism. Lactoferrin in conjunction with other factors in milk likely contributes to this favorable microbial ecosystem in the gut. Lactoferrin's affinity for iron exceeds that of transferrin in the presence of the acid environment characteristic of inflamed tissues. www.healingedge.net /store/more_all_lactoferrin.html   (313 words)

Lactoferrin - Osteopenia Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. The mitogenic effect of lactoferrin in osteoblast-like cells is mediated mainly through LRP1, a member of the family of low-density lipoprotein receptor-related proteins that are primarily known as endocytic receptors. Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin. www.osteopenia3.com /Lactoferrin.html   (961 words)

Le Magazine, October 2000 - Report: Lactoferrin: The Bioactive Peptide That Fights Disease Lactoferrin appears to be the subfraction of whey with documented anti-viral, anti-microbial, anti-cancer and immune modulating/enhancing effects. Though a natural component of cows and human mothers milk, lactoferrin is found throughout the human body and occurs in all secretions that bathe mucous membranes such as saliva, tears, bronchial and nasal secretions, hepatic bile, pancreatic fluids, and is an essential factor in the immune response. Lactoferrin appears to be particularly important in the health and function of the intestinal tract and has been found to greatly reduce systemic and intestinal inflammation in such conditions as inflammatory bowel disease and others. www.lef.org /magazine/mag2000/oct2000_report_lactoferrin.html   (3664 words)

Lactoferrin to Prevent Experimental Escherichia coli Diarrhea in Weaned Pigs However, lactoferrin inhibited growth of the challenge strain in vitro, and the inhibition depended on the concentration of lactoferrin and bacteria. Lactoferrin at a concentration of 0.2 mg/mL inhibited 10 strains, and the remaining 9 strains were less sensitive but were inhibited by higher concentrations. Lactoferrin was purified from cheese whey or concentrated cheese whey by an expanded bed adsorption chromatography method described by Isomäki.19 Iron content of lactoferrin was approximately 8% to 15%.19 Lactoferrin was stored at 4°C until the day before administration, when the lactoferrin dose was diluted with 3 mL of sterile water. www.jarvm.com /articles/Vol1Iss4/Heinonen.htm   (3336 words)

Lactoferrin:The Bioactive Peptide that Fights Disease Exactly how lactoferrin exerts all of its immune modulating or immune enhancing functions is not entirely clear, but it is known to enhance the immune response both directly and indirectly (passively) in response to a wide range of immune challenges. Lactoferrin appears to be a subfraction of whey with the best documented anti-viral, anti-microbial, anti-cancer and immune modulating/enhancing effects.When we talk about whey we are actually referring to a complex protein made up of many smaller protein subfractions (peptides). Lactoferrin is found throughout the human body and occurs in all secretions that bathe mucous membranes such as saliva, tears, bronchial and nasal secretions, hepatic bile, pancreatic fluids, and is an essential factor in the immune response. www.health-marketplace.com /article-lactoferrin.htm   (4683 words)

Untitled Document   (Site not responding. Last check: 2007-11-07) Lactoferrin is also found in numerous sites throughout the body where it plays an important role in the primary defence system. In the mouth lactoferrin is one of the most important antimicrobial agents where it promotes the growth of commensal flora by inhibiting the activity of unwanted bacteria, helping to prevent infection. Lactoferrin is antibacterial, antiviral and antiparasitic and plays a key role in the modulation of the inflammatory-immune response. www.bioxhealthcare.com /molecules1.htm   (81 words)

Lactoferrin   (Site not responding. Last check: 2007-11-07) Lactoferrin is a substance belonging to the Cytokine family, Cytokines are responsible for coordinating the human cellular response that protects us from most infections, cancers and tumors. A second level of Lactoferrin defense is its unique ability to bind iron, an essential mineral used by a wide array of pathogens and tumors for reproduction and growth. Lactoferrin (chapter 11) When you hear what Lactoferrin does, it is amazing that it is not a standard treatment for any sort of cancer. www.alternativehealth.com.au /Articles/lactofer.htm   (3133 words)

Lactoferrin Lactoferrin is a minor glycoprotein component of whey. Lactoferrin is also found in exocrime secretions from mammals and is released from neutrophil granules during inflammation. First, Lactoferrin is believed to play a role in the uptake and absorption of iron through the intestinal mucosa. www.advance-health.com /lactoferrin.html   (1124 words)

Lactoferrin - Wikipedia, the free encyclopedia Lactoferrin (LF) is a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. en.wikipedia.org /wiki/Lactoferrin   (180 words)

Lactoferrin Research and Glycoprotein Research Lactoferrin Research is dedicated to using the Internet and its tools to share information and foster an open and informed discussion of the various functions and potential applications of lactoferrin. Lactoferrin research has revealed that lactoferrin is an iron-binding glycoprotein present at high levels in human milk and in the milk of other mammals. Lactoferrin is a multifunctional protein with a number of physiological possible roles. www.lactoferrinresearch.org   (216 words)

ImmunoPro, GlutImmune, HooDiat Mints, ImmunePro, RenewPro, Organic Colostrum. BioMolecular Sciences. Helps Chronic ...   (Site not responding. Last check: 2007-11-07) Lactoferrin is an iron-binding and iron-modulating protein found in bovine milk and even more prevalent in our whey protein concentrate. Lactoferrin is a very important bioactive molecule which can provide iron to those cells in need, and limit it to those in excess, maintaining an iron homeostasis within the body. The first major entrance of lactoferrin on the health scene was propted by a paper written by an AIDS researcher discussing the importance of lactoferrin as a regulator of the immune response in people with AIDS. biomolecularsciences.com /lactoferrin.php   (718 words)

Lactoferrin... Lactoferrin is a protein found in many mammals including humans and possesses the ability to bind iron. Lactoferrin is only active against Candida when it is free of iron since its mechanism of killing Candida is probably by starving it from iron. Lactoferrin is available as a supplement but because of the iron inactivation and digestion by the body's enzymes, I am unsure as to appropriate dosing. www.greatplainslaboratory.com /book/bk6sect2.html   (2843 words)

Lactoferrin and osteoporosis   (Site not responding. Last check: 2007-11-07) Lactoferrin not only inhibits bone breakdown but also boosts bone growth four times faster than normal when injected directly into bone, the scientists reported yesterday. Lactoferrin is found in both cows’ and human milk and is particularly concentrated in colostrum, the substance newborns receive at birth before breast milk is fully established. Lactoferrin is already sold as a nutritional supplement and ingredient in functional foods and along with other value added whey fractions, like lactoperoxidase, colostrum/IgG, a-lactalbumin, b-lactoglobulin and glycomacropeptides, is currently enjoying strong growth, hitting 20 per cent per year in some geographical areas, according to research from 3A Business Consulting. www.natural-woman.com /lactoferrin_osteoporosis.htm   (506 words)

Lactoferrin and Lysozyme Supplements - DrGreene.com Human lactoferrin and human lysozyme are both proteins that are important ingredients in breast milk. Lactoferrin is a milk protein that improves the functioning of the immune system, and also has direct antibacterial and antiviral properties. Lysozymes (and lactoferrins) may be divided into human lysozyme (and lactoferrin) and that from other sources in the plant and animal world. www.drgreene.com /21_1407.html   (573 words)

Lactoferrin - Natural Immune Support with Colostrum - Lactoferrin   (Site not responding. Last check: 2007-11-07) Lactoferrin is a protein belonging to the iron transporter family that occurs naturally in several bodily fluids such as tears, saliva, mucus and milk. Colostrum, in lactoferrin is the pre-milk fluid produced by mammals immediately after birthing. Lysozyme, an enzyme in lactoferrin, is a natural antagonist to harmful invaders. www.immunesupport.com /lactoferrin.htm   (143 words)

Remarks   (Site not responding. Last check: 2007-11-07) It is still not clear which are the conserved functions of lactoferrin, and which may be opportunistic, found for only one or two species as a result of sequence changes. Many studies compared the activities of lactoferrin with those of its antibacterial (lactoferricin) peptides, sometimes with an implicit assumption that their mechanisms of action are the same. We need to remember that this is not necessarily the case, given that the structure adopted by the isolated peptides appears not to be the same as the corresponding portion of the intact protein (depending on solution conditions and the exact sequences of the peptides). www.ucalgary.ca /~schryver/lactoferrin/remarks.html   (679 words)

Lactoferrin | Osteopenia | Osteoporosis information Summary: Lactoferrin found in human and bovine milk may have a place in Osteopenia or Osteoporosis remedies because it has been found to be effective in promoting bone growth. Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. Yes, there is a June 2005 study from Poland that states: "Lactoferrin (LF) exhibits antibacterial, anti fungal, antiviral, antiparasitice, and antitumoral activities. www.osteopenia3.com /Lactoferrin-Osteopenia-Osteoporosis.html   (585 words)

CIDRAP >> With FDA nod, lactoferrin to be used as antimicrobial for beef Lactoferrin is an iron-binding protein found in milk and many other bodily secretions, according to medical reference books. In its notice to the FDA, aLF Ventures said the amount of added lactoferrin that remains on beef carcasses after spraying is comparable to the amount that occurs naturally in beef, the FDA said. Hall said aLF is studying the use of lactoferrin as an antimicrobial treatment for "subprimal" cuts of meat (large pieces that are cut up further in retail stores), finished cuts, and ready-to-eat meats. www.cidrap.umn.edu /cidrap/content/fs/food/news/aug2803lactoferrin.html   (646 words)

Human Lactoferrin Binds and Removes the Hemoglobin Receptor Protein of the Periodontopathogen Porphyromonas gingivalis ... Lactoferrin is an iron-binding, acute-phase protein found in saliva, milk, and other exocrine secretions (17). Inhibition of hemoglobin adsorption to HbR by lactoferrin. After this procedure was repeated, the lactoferrin solution was passed over the chip for 60 s, followed by a wash of the acidic buffer alone for 240 s. www.jbc.org /cgi/content/full/275/39/30002   (5036 words)

Pharming takes step towards lactoferrin commercialisation   (Site not responding. Last check: 2007-11-07) The company's lactoferrin is produced in the mammary glands of transgenic cattle and then purified from the cows' milk. The protein has an identical structure to the lactoferrin produced by the body although there are some differences in the sugars that coat the protein. The current market for bovine lactoferrin is thought to be worth around €100 million per year, with growth of about 20 per cent, suggests Singh. www.nutraingredients-usa.com /news/ng.asp?n=64905-pharming-lactoferrin   (739 words)

Separating the Beef from Bacteria (Lactoferrin) - Health and Medical Information produced by doctors - MedicineNet.com Lactoferrin is one of the proteins responsible for providing protection to infants before their immune systems begin to function. Although aLF Ventures was not required to seek approval from FDA before it marketed lactoferrin, aLF Ventures provided FDA scientific data supporting the firm's conclusion that lactoferrin is "generally recognized as safe" (GRAS) and safe for the general population as well as for individuals who are allergic to milk. In its notice submitted to FDA, aLF Ventures noted that the amount of added lactoferrin that remains on the beef after spraying is comparable to the amount of lactoferrin that is naturally occurring in the beef. www.medicinenet.com /script/main/art.asp?articlekey=24105   (544 words)

Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models -- Wakabayashi et al. 46 (4): 595 -- ... Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models -- Wakabayashi et al. is that ingested lactoferrin or lactoferricin B-like peptides Antifungal properties of lactoferricin B, a peptide derived from the N-terminal region of bovine lactoferrin. jac.oxfordjournals.org /cgi/content/full/46/4/595   (3498 words)

Lactoferrin binding of lactoferrin was observed on strains that express either OmpC or PhoE. lactoferrin is now used as additive in toothpaste to fight against mouth bacteria responsible for cavities. Binding of human lactoferrin to Escherichia coli porins: a biochemical study. hometown.aol.com /fsallmann/myhomepageindex2.html   (363 words)

lactoferrin, Primary Sclerosing Cholangitis Literature   (Site not responding. Last check: 2007-11-07) D'Inca R, Dal Pont E, Di Leo V, Ferronato A, Fries W, Vettorato MG, Martines D, Sturniolo GC 2006 Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Kane SV, Sandborn WJ, Rufo PA, Zholudev A, Boone J, Lyerly D, Camilleri M, Hanauer SB 2003 Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation. Peen E, Enestrom S, Skogh T 1996 Distribution of lactoferrin and 60/65 kDa heat shock protein in normal and inflamed human intestine and liver. home.insightbb.com /~rhodesdavid/lactof.htm   (2333 words)

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